Caveolins and lung function.

Abstract:

:The primary function of the mammalian lung is to facilitate diffusion of oxygen to venous blood and to ventilate carbon dioxide produced by catabolic reactions within cells. However, it is also responsible for a variety of other important functions, including host defense and production of vasoactive agents to regulate not only systemic blood pressure, but also water, electrolyte and acid-base balance. Caveolin-1 is highly expressed in the majority of cell types in the lung, including epithelial, endothelial, smooth muscle, connective tissue cells, and alveolar macrophages. Deletion of caveolin-1 in these cells results in major functional aberrations, suggesting that caveolin-1 may be crucial to lung homeostasis and development. Furthermore, generation of mutant mice that under-express caveolin-1 results in severe functional distortion with phenotypes covering practically the entire spectrum of known lung diseases, including pulmonary hypertension, fibrosis, increased endothelial permeability, and immune defects. In this Chapter, we outline the current state of knowledge regarding caveolin-1-dependent regulation of pulmonary cell functions and discuss recent research findings on the role of caveolin-1 in various pulmonary disease states, including obstructive and fibrotic pulmonary vascular and inflammatory diseases.

journal_name

Adv Exp Med Biol

authors

Maniatis NA,Chernaya O,Shinin V,Minshall RD

doi

10.1007/978-1-4614-1222-9_11

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

157-79

eissn

0065-2598

issn

2214-8019

journal_volume

729

pub_type

杂志文章,评审
  • Heterogeneity of Stem Cells in the Thyroid.

    abstract::Identification of thyroid stem cells in the past few years has made important contributions to our understanding of the cellular and molecular mechanisms that induce tissue regeneration and repair. Embryonic stem (ES) cells and induced-pluripotent stem cells have been used to establish reliable protocols to obtain mat...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-24108-7_5

    authors: Zito G,Coppola A,Pizzolanti G,Giordano C

    更新日期:2019-01-01 00:00:00

  • Controversies in neonatal infection.

    abstract::Antibiotics are an important part of neonatal care, but we must be careful that a short-sighted approach to their use does not magnify the problems they are designed to prevent. Prevention of infections by good infection control practices and minimizing risk factors for sepsis is just as important as appropriate antib...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-8993-2_13

    authors: May ML,Isaacs D

    更新日期:2004-01-01 00:00:00

  • The role of proprioceptive feedback in the regulation and adaptation of locomotor activity.

    abstract::Feedback from muscle afferents is essential for locomotion to be functional under changing external conditions. In this article, we review the role of afferent feedback in adapting locomotor activity to transient and more sustained changes in sensory input in reduced and walking cat preparations. Much of the work on m...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-0713-0_40

    authors: Lam T,Pearson KG

    更新日期:2002-01-01 00:00:00

  • Posturography in patients with rheumatoid arthritis and osteoarthritis.

    abstract::The purpose of the paper was to investigate the usefulness of posturographic analysis in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). RA is a chronic inflammatory disorder responsible for destruction of active and passive components of joints. It is the most common autoimmune disease, and the secon...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2014_29

    authors: Sokołowska B,Czerwosz L,Hallay-Suszek M,Sadura-Sieklucka T,Księżopolska-Orłowska K

    更新日期:2015-01-01 00:00:00

  • Microglia-Müller glia crosstalk in the rd10 mouse model of retinitis pigmentosa.

    abstract::Retinitis pigmentosa refers to a large, genetically heterogeneous group of retinal dystrophies. This condition is characterized by the gradual onset of blindness due to progressive deterioration of the retina, a process that includes photoreceptor and retinal-pigmented-epithelium cell decay and death, microglial recru...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4614-3209-8_47

    authors: Arroba AI,Alvarez-Lindo N,van Rooijen N,de la Rosa EJ

    更新日期:2014-01-01 00:00:00

  • Promoter-associated long noncoding RNAs repress transcription through a RNA binding protein TLS.

    abstract::The majority of the human genome is found to be transcribed and generates mostly noncoding (nc) RNAs that do not possess protein information. MicroRNAs are one of the well-identified small ncRNAs, but occupy merely a fraction of ncRNAs. Long (large) ncRNAs are emerging as a novel class of ncRNAs, but knowledge of thes...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4614-0332-6_12

    authors: Kurokawa R

    更新日期:2011-01-01 00:00:00

  • Computerized histographic characterization of changes in tissue pO2 induced by erythropoietin.

    abstract::Anemia associated with malignancy is a common clinical problem, and has a negative effect on oxygen delivery and, therefore, response of tumors to radiotherapy. Erythropoietin (EPO) has been shown to increase the hematocrit of rodents when administered subcutaneously. The objectives of this study were to measure tumor...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-1875-4_113

    authors: Terris DJ,Minchinton AI

    更新日期:1994-01-01 00:00:00

  • Metalloproteinase Changes in Diabetes.

    abstract::Matrix metalloproteinases (MMPs) constitute a group of over 20 structurally-related proteins which include a Zn(++) ion binding site that is essential for their proteolytic activities. These enzymes play important role in extracellular matrix turnover in order to maintain a proper balance in its synthesis and degradat...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-33943-6_17

    authors: Abreu BJ,de Brito Vieira WH

    更新日期:2016-01-01 00:00:00

  • Steady state redox levels in cytochrome oxidase: relevance for in vivo near infrared spectroscopy (NIRS).

    abstract::In the visible/NIR (600-900 nm) three different redox centres are potentially detectable in vivo in mitochondrial cytochrome c oxidase: haem a (605nm), the binuclear haem a3/CuB centre (655 nm) and CuA (830 nm). In this paper we report changes in the steady state reduction of these centres following increases in the r...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-0-387-85998-9_19

    authors: Cooper CE,Sharpe MA,Mason MG,Nicholls P

    更新日期:2009-01-01 00:00:00

  • Rho Signaling-Directed YAP/TAZ Regulation Encourages 3D Spheroid Colony Formation and Boosts Plasticity of Parthenogenetic Stem Cells.

    abstract::Cell proliferation, apoptosis and differentiation are essential processes from the early phases of embryogenesis to adult tissue formation and maintenance. These mechanisms also play a key role in embryonic stem cells (ESCs) that are able to proliferate maintaining pluripotency and, at the same time, to give rise to a...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/5584_2019_423

    authors: Pennarossa G,Paffoni A,Ragni G,Gandolfi F,Brevini TAL

    更新日期:2020-01-01 00:00:00

  • NIRS measurement of O(2) dynamics in contracting blood and buffer perfused hindlimb muscle.

    abstract::In order to obtain evidence that Mb releases O(2) during muscle contraction, we have set up a buffer-perfused hindlimb rat model and applied NIRS to detect the dynamics of tissue deoxygenation during contraction. The NIRS signal was monitored on hindlimb muscle during twitch contractions at 1 Hz, evoked via electrosti...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-1241-1_46

    authors: Masuda K,Takakura H,Furuichi Y,Iwase S,Jue T

    更新日期:2010-01-01 00:00:00

  • T-lymphocyte activation by immunogenic determinants.

    abstract::Synthetic antigens have been of great value in elucidating the relationships between antigen structure and lymphocyte activation. The compound RAT behaves as a monofunctional antigen in guinea pigs and mice, inducing T-lymphocyte responses without appreciable circulating antibody, although the ABA-specific B cell popu...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-8858-0_8

    authors: Goodman JW,Fong S,Lewis GK,Kamin R,Nitecki DE,Der Balian G

    更新日期:1978-01-01 00:00:00

  • Intestinal Transporter-Associated Drug Absorption and Toxicity.

    abstract::Oral drug administration is the most favorable route of drug administration in the clinic. Intestinal transporters have been shown to play a significant role in the rate and extent of drug absorption of some, but not all, drug molecules. Due to the heterogeneous expression of multiple transporters along the intestine,...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-7647-4_8

    authors: Xue Y,Ma C,Hanna I,Pan G

    更新日期:2019-01-01 00:00:00

  • Molecular Basis and Regulation of Store-Operated Calcium Entry.

    abstract::Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that communicates the information about the amount of Ca2+ accumulated in the intracellular Ca2+ stores to the ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-12457-1_17

    authors: Lopez JJ,Jardin I,Albarrán L,Sanchez-Collado J,Cantonero C,Salido GM,Smani T,Rosado JA

    更新日期:2020-01-01 00:00:00

  • A serological survey of human coronavirus in pigs of the Tohoku District of Japan.

    abstract::A total of 2496 swine sera from 60 farms in the Tohoku District of Japan was examined for hemagglutination inhibiting (HI) antibodies to human coronavirus (HCV), swine hemagglutinating encephalomyelitis virus (HEV) and bovine coronavirus (BCV). HI antibodies to HCV OC43 strain and HEV 67N strain were highly prevalent ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-5331-1_63

    authors: Hirano N,Ono K

    更新日期:1998-01-01 00:00:00

  • Synthetic modulators of TRP channel activity.

    abstract::In humans, 27 TRP channels from 6 related families contribute to a broad spectrum of cellular functions, such as thermo-, pressure-, volume-, pain- and chemosensation. Pain and inflammation-inducing compounds represent potent plant and animal defense mechanisms explaining the great variety of the naturally occurring, ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-94-007-0265-3_4

    authors: Harteneck C,Klose C,Krautwurst D

    更新日期:2011-01-01 00:00:00

  • Allosteric Modulation of Intrinsically Disordered Proteins.

    abstract::The allosteric property of globular proteins is applauded as their intrinsic ability to regulate distant sites, and this property further plays a critical role in a wide variety of cellular regulatory mechanisms. Recent advancements and studies have revealed the manifestation of allostery in intrinsically disordered p...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-8719-7_14

    authors: Rehman AU,Rahman MU,Arshad T,Chen HF

    更新日期:2019-01-01 00:00:00

  • Acid-sensing ion channels in pathological conditions.

    abstract::Acid-sensing ion channels (ASICs), a novel family of proton-gated amiloride-sensitive cation channels, are expressed primarily in neurons of peripheral sensory and central nervous systems. Recent studies have shown that activation of ASICs, particularly the ASIC1a channels, plays a critical role in neuronal injury ass...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-4756-6_36

    authors: Chu XP,Xiong ZG

    更新日期:2013-01-01 00:00:00

  • Amoeba provide insight into the origin of virulence in pathogenic fungi.

    abstract::Why are some fungi pathogenic while the majority poses no threat to humans or other hosts? Of the more than 1.5 million fungal species only about 150-300 are pathogenic for humans, and of these, only 10-15 are relatively common pathogens. In contrast, fungi are major pathogens for plants and insects. These facts pose ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-5638-5_1

    authors: Casadevall A

    更新日期:2012-01-01 00:00:00

  • The Role of IGF-1 Signaling in Skeletal Muscle Atrophy.

    abstract::Insulin-like growth factor 1 (IGF-1) is a key anabolic growth factor stimulating phosphatidylinositol 3-kinase (PI3K)/Akt signaling which is well known for regulating muscle hypertrophy. However, the role of IGF-1 in muscle atrophy is less clear. This review provides an overview of the mechanisms via which IGF-1 signa...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-1435-3_6

    authors: Timmer LT,Hoogaars WMH,Jaspers RT

    更新日期:2018-01-01 00:00:00

  • Functional Connectome Analysis of the Striatum with Optogenetics.

    abstract::Neural circuit function is determined not only by anatomical connections but also by the strength and nature of the connections, that is functional or physiological connectivity. To elucidate functional connectivity, selective stimulation of presynaptic terminals of an identified neuronal population is crucial. Howeve...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-15-8763-4_27

    authors: Chuhma N

    更新日期:2021-01-01 00:00:00

  • Taxonomy of Yersinia pestis.

    abstract::This chapter summarized the taxonomy and typing works of Yersinia pestis since it's firstly identified in Hong Kong in 1894. Phenotyping methods that based on phenotypic characteristics, including biotyping, serotyping, antibiogram analysis, bacteriocin typing, phage typing, and plasmid typing, were firstly applied in...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-94-024-0890-4_3

    authors: Qi Z,Cui Y,Zhang Q,Yang R

    更新日期:2016-01-01 00:00:00

  • Measurement of arterial, venous, and interstitial pO2 during acute hypoxia in rat brain using a time-resolved luminescence-based oxygen sensor.

    abstract::This is the first publication using a fiber optic "optode" and a luminescence based pO2 detection method for assessing neural tissue oxygenation. The system was used to simultaneously monitor pO2 in tissue (PtO2) and venous blood (PvO2) during normoxia, hyperoxia and hypoxia. PaO2 was varied by changing inspired oxyge...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-4717-4_6

    authors: Dunn JF,Nwaigwe CI,Roche M

    更新日期:1999-01-01 00:00:00

  • Serological diagnosis of human polyomavirus infection.

    abstract::Measurement of antibody titres to the human polyomaviruses BK and JC has for many years had to rely on Hemagglutination inhibition. In recent years, viral serology based on virus-like particles (VLPs) in enzyme immunoassays (EIAs) has become widely used for a variety of viruses. We sought to establish a modern method ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/0-387-32957-9_7

    authors: Lundstig A,Dillner J

    更新日期:2006-01-01 00:00:00

  • An Australasian perspective on the role of reproductive technologies in world food production.

    abstract::Industries based on small ruminants are major contributors to world food supply but, in extensive grazing systems, reproductive technology is not directly relevant to most enterprises. More important is the need to respond to demand in high-profit export markets for products that are 'clean, green and ethical' (CGE). ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-8887-3_9

    authors: Martin GB

    更新日期:2014-01-01 00:00:00

  • On the seemingly diminished CO2-Bohr effect in hypoxic chemodenervated rabbits.

    abstract::In hypoxic rabbits, different levels of Pco2 before and after carotid chemodenervation were applied in order to get information about the acid-base status and the position of the O2-Hb dissociation curve (ODC). A CO2-induced change in pH caused a smaller change in the half-saturation pressure (P50) than was to be expe...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-1188-1_10

    authors: Kiwull-Schöne H,Gärtner B,Kiwull P

    更新日期:1984-01-01 00:00:00

  • Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.

    abstract::The apical plasma membrane domain of retinal pigment epithelial (RPE) cells in the eye faces the outer segment portions of rods and cones and the interphotoreceptor matrix in the subretinal space. Two important receptor-mediated interactions between the apical surface of the retinal pigment epithelium (RPE) and adjace...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-1399-9_15

    authors: Mallavarapu M,Finnemann SC

    更新日期:2010-01-01 00:00:00

  • Immunotherapy for Melanoma.

    abstract::While melanoma is less common than some other skin cancers, it is responsible for nearly 10,000 deaths in the USA each year alone. For many decades, very limited treatment options were available for patients with metastatic melanoma. However, recent breakthroughs have brought new hopes for patients and providers. Whil...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-41008-7_3

    authors: Albittar AA,Alhalabi O,Glitza Oliva IC

    更新日期:2020-01-01 00:00:00

  • Effects of Environment and Lifestyle Factors on Premature Ovarian Failure.

    abstract::Premature ovarian insufficiency (POI) or primary ovarian failure is defined as a cessation of the menstrual cycle in women younger than 40 years old. It is strictly defined as more than 4 months of oligomenorrhea or amenorrhea in a woman <40 years old, associated with at least two follicle-stimulating hormone (FSH) le...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-33-4187-6_4

    authors: Yang Y,Huang W,Yuan L

    更新日期:2021-01-01 00:00:00

  • Prognosis in adult AML is precisely predicted by the DISC-assay using the chemosensitivity-index Ci.

    abstract::We prospectively investigated the correlation between DISC-assay results and clinical response and also survival in patients with AML using a new method of evaluation. ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/978-1-4615-4811-9_47

    authors: Staib P,Lathan B,Schinköthe T,Wiedenmann S,Pantke B,Dimski T,Voliotis D,Diehl V

    更新日期:1999-01-01 00:00:00