Abstract:
:The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50-mL/kg dose of carbon tetrachloride (CCl4 ). Granulocyte colony-stimulating factor or vehicle of 150 µg/kg was given immediately after intoxicating the liver by CCl4 . The animals were divided into four groups of twelve each. Administration of G-CSF caused a decrease in the activity of liver enzymes, aminotransferases, compared with the untreated group.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Qujeq D,Abassi R,Faeizi F,Parsian H,Faraji AS,Taheri H,Tatar M,Elmi MM,Halalkhor Sdoi
10.1177/0748233712440136subject
Has Abstractpub_date
2013-07-01 00:00:00pages
498-503issue
6eissn
0748-2337issn
1477-0393pii
0748233712440136journal_volume
29pub_type
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