Effect of granulocyte colony-stimulating factor administration on tissue regeneration due to carbon tetrachloride-induced liver damage in experimental model.

Abstract:

:The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50-mL/kg dose of carbon tetrachloride (CCl4 ). Granulocyte colony-stimulating factor or vehicle of 150 µg/kg was given immediately after intoxicating the liver by CCl4 . The animals were divided into four groups of twelve each. Administration of G-CSF caused a decrease in the activity of liver enzymes,  aminotransferases, compared with the untreated group.

journal_name

Toxicol Ind Health

authors

Qujeq D,Abassi R,Faeizi F,Parsian H,Faraji AS,Taheri H,Tatar M,Elmi MM,Halalkhor S

doi

10.1177/0748233712440136

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

498-503

issue

6

eissn

0748-2337

issn

1477-0393

pii

0748233712440136

journal_volume

29

pub_type

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