Abstract:
OBJECTIVES:To develop a method that allows approximating the mass of monosodium uric acid (MSU) in a gouty tophus using phantom measurements and including tophus density into the calculation of the dual-energy computed tomography (DECT) tophus volumetry. METHODS:We prepared specimens of different concentrations of MSU placed in an epoxy-based phantom and an excised porcine foreleg. Density and volumetric measurements were performed in sequential single-source DECT scans acquired with increasingly higher tube currents. We developed a method for estimating the tophus mass by multiplying the detected tophus volume with its mean density and adding a specific gravimetric coefficient k. k was derived from the DECT scans by comparing the approximated MSU masses in the epoxy phantom with the known true MSU masses of the specimens. RESULTS:Comparison of the approximated MSU masses in the porcine foreleg scans with the true MSU masses of the syringe contents showed similar performance to sole volume measurement while providing additional information on the true uric acid burden: Over 70% of the true urate masses have been detected in MSU concentrations ≥ 45%, while the detection rate was much lower for MSU concentrations ≤ 40%. Retrospective analysis of patients with proven gouty arthritis confirmed the diagnostic potential of the mass approximation technique. CONCLUSIONS:We successfully established a method to include tophus density measurement for estimation of the uric acid burden in milligrams (instead of ml) in a phantom setting for MSU concentrations above 40%. Future studies should validate its use for follow-up in clinical practice. KEY POINTS:• Including tophus density measurement in dual-energy computed tomography scans in a phantom setting can be used for estimating the urate burden in milligrams, which might be useful for imaging follow-up. • The mass [mg] of the uric acid burden in a patient with gouty arthritis can be calculated by multiplying volume [ml] with mean density [HU] using a specific gravimetric coefficient. • Retrospective analysis of two patients with gouty tophi showed the relevance of measuring urate mass in addition to urate volume alone.
journal_name
Eur Radioljournal_title
European radiologyauthors
Kotlyarov M,Hermann KGA,Mews J,Hamm B,Diekhoff Tdoi
10.1007/s00330-019-06350-1subject
Has Abstractpub_date
2020-01-01 00:00:00pages
404-412issue
1eissn
0938-7994issn
1432-1084pii
10.1007/s00330-019-06350-1journal_volume
30pub_type
杂志文章abstract:OBJECTIVES:Most existing models that are in use to model hepatic function through assessment of hepatic gadoxetic acid enhancement kinetics do not consider quantitative measures of gadoxetic excretion. We developed a model that allows a simultaneous quantitation of uptake and excretion of liver specific contrast agents...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5500-5
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To review the role of imaging in the diagnosis of recurrent disease in previously treated non-small cell lung cancer (NSCLC) and discuss the imaging pitfalls. METHODS:A comprehensive review of published literature on CT and PET imaging of NSCLC recurrence was performed. Diagnostic and prognostic values are ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-011-2299-8
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:This prospective trial was performed to verify whether microwave ablation (MWA) in combination with chemotherapy could provide superior survival benefit compared with chemotherapy alone. MATERIALS AND METHODS:From March 1, 2015, to June 20, 2017, treatment-naïve patients with pathologically verified advance...
journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-019-06613-x
更新日期:2020-05-01 00:00:00
abstract::There is little published long-term survival data for patients with colorectal liver metastases treated with radiofrequency ablation (RFA). We present a multivariate analysis of 5-year survival in 309 patients (198 male, aged 64 (24-92)) treated at 617 sessions. Our standard protocol used internally cooled electrodes ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1258-5
更新日期:2009-05-01 00:00:00
abstract::The goal of this study was to analyze the diagnostic value of three-dimensional time-of-flight magnetic resonance angiography (3D TOF MRA), performed on a 0.5-T system in the detection of neurovascular compression in patients with trigeminal neuralgia (TN). One hundred seventy-two TN patients were examined using plain...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000596
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of an organ-based tube current modulation (OTCM) technique on organ absorbed dose and assess image quality in pediatric CT examinations. METHODS:Four physical anthropomorphic phantoms that represent the average individual as neonate, 1-year-old, 5-year-old, and 10-year-old were use...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06888-5
更新日期:2020-10-01 00:00:00
abstract::High-resolution computed tomography (HRCT) has improved our understanding of many lung diseases in adults. The technique is used less often in children due to concerns regarding radiation dose. However, HRCT may provide important diagnostic information in a variety of lung diseases in children including airways diseas...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300100865
更新日期:2001-01-01 00:00:00
abstract::Cardiovascular intervention, using MRI guidance, is challenging for clinical applications. Real-time imaging sequences with high spatial resolution are needed for monitoring intramyocardial delivery of drug, gene, or stem cell therapies. New generation MR scanners make local intramyocardial and vascular wall therapies...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2622-8
更新日期:2005-05-01 00:00:00
abstract::We report a case of renal cell carcinoma with solitary metachronous contralateral adrenal metastasis occurring 23 years after radical nephrectomy. The patient was treated with adrenalectomy. He is alive with no evidence of disease 1 year postoperatively. Solitary metachronous contralateral adrenal metastases from rena...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050204
更新日期:1997-01-01 00:00:00
abstract::The purpose of this study was to first evaluate Levovist (Schering, Berlin, Germany), an echo-contrast agent, during power Doppler sonography (PDS) in patients with synovitis using asymptomatic joints as controls. Then we evaluated the accuracy of this technique against contrast-enhanced MRI. Forty patients (19 men an...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s003300000650
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the delayed effects of irreversible electroporation (IRE) ablation on nerves. METHODS:The study was approved by the institutional animal care and use committee. CT-guided IRE-ablation (electric field per distance, 1,500 V/cm; pulse length, 70 μs; number of pulses, 90) of 6 sciatic nerves was perf...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2610-3
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:High radiation dose during CT perfusion (CTp) studies contributes to prevent CTp application in daily clinical practice. This work evaluates the consequences of scan delay on perfusion parameters and provides guidelines to help reducing the radiation dose by choosing the most appropriate delay. METHODS:Fift...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-019-06259-9
更新日期:2019-12-01 00:00:00
abstract::Management of trauma patients relies on a simple but obvious concept: Time is life! This is a challenge to the emergency radiologist in his evaluation of the radiological admission survey of severe trauma patients, since the latter need a quick and thorough survey of craniocerebral, cervical, thoracic, abdominal, and ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1385-3
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To evaluate a whole body (WB) continuous-table-movement (CTM) MR protocol for the assessment of multiple myeloma (MM) in comparison to a step-by-step WB protocol. METHODS:Eighteen patients with MM were examined at 1.5T using a WB CTM protocol (axial T2-w fs BLADE, T1-w GRE sequence) and a step-by-step WB pr...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1865-9
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To investigate the optimal imaging delay time of dynamic contrast-enhanced magnetic resonance (MR) imaging in women with endometrial cancer. MATERIALS AND METHODS:This prospective single-institution study was approved by the institutional review board, and informed consent was obtained from the participants. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3327-2
更新日期:2014-11-01 00:00:00
abstract::Rapid clinical dissemination of CT colonography (CTC) is occurring in parallel with continued research into technique optimisation and diagnostic performance. A need exists therefore for current guidance as to basic prerequisites for effective clinical implementation. A questionnaire detailing CTC technique, analysis,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0407-y
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic performance of full-field digital mammography (FFDM) with screen-film mammography (SFM) in a corporate screening programme including younger women. METHODS:Data were available on 14,946 screening episodes, 5010 FFDM and 9936 SFM. Formal analysis was by logistic regression, adjusting...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1968-3
更新日期:2011-04-01 00:00:00
abstract::Triage decisions in patients suffering from acute chest pain remain a challenge. The patient's history, initial cardiac enzyme levels, or initial electrocardiograms (ECG) often do not allow selecting the patients in whom further tests are needed. Numerous vascular and non-vascular chest problems, such as pulmonary emb...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-008-1231-3
更新日期:2009-04-01 00:00:00
abstract::The aim of this study was to describe and discuss the various forms of cystography and their clinical value. Conventional fluoroscopic voiding cystourethrography (VCU), radionuclide cystography and the various sonographic cystographic approaches, including echo-enhanced cystosonography (EECS), are described. Their ind...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1430-2
更新日期:2002-12-01 00:00:00
abstract::Ultrasound has emerged as the primary imaging modality in conditions where either renal obstruction or renal medical disease is suspected on the basis of clinical and laboratory findings. In urinary tract obstruction, pathophysiologic changes affecting the pressure in the collecting system and kidney perfusion are wel...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300101011
更新日期:2001-01-01 00:00:00
abstract::Lymphoma is a spectrum of malignant neoplasms of the lymphoid system. The appearances radiologically are diverse with almost all organs susceptible to involvement. The condition is challenging as it can mimic the appearance of almost all other neoplasms. This review highlights in a general way the diversity of the rad...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1632-7
更新日期:2003-05-01 00:00:00
abstract::Cross-sectional imaging has revolutionised the radiological diagnosis of pleural collections. Not only can the precise location and volume of a pleural effusion be established, but also features specific for the aetiology of the effusion can be demonstrated. Increasingly, radiologists are called upon to perform image-...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1512-1
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the association between tumour FDG uptake on preoperative PET/CT and axillary lymph node metastasis (ALNM) according to breast cancer subtype. METHODS:The records of 671 patients with invasive breast cancer who underwent (18) F-FDG PET/CT and surgery were reviewed. Using immunohistochemistry, tu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3452-y
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:To compare 0.15 mmol/kg gadobutrol for late gadolinium enhancement (LGE) imaging of chronic myocardial infarction with a relaxivity-adjusted dose of gadoterate meglumine (Gd-DOTA). METHODS:Seventeen patients with suspected chronic myocardial infarction underwent LGE imaging at 1.5 T, acquiring an inversion-...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2563-6
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To evaluate early post-operative magnetic resonance (EPMR) as a prognostic tool after resection of glioblastoma. METHODS:Sixty EPMR examinations were evaluated for perioperative infarct, tumour growth between diagnosis and EPMR, contrast enhancement pattern, and extent of resection (EOR). The EOR was approa...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3914-x
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Assessing the advantage of x-ray dark-field contrast over x-ray transmission contrast in radiography for the detection of developing radiation-induced lung damage in mice. METHODS:Two groups of female C57BL/6 mice (irradiated and control) were imaged obtaining both contrasts monthly for 28 weeks post irradia...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07459-4
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:We present our initial experience with a new biodegradable (BD) esophageal stent in two patients, one for a therapy-resistant benign esophageal stricture, and the other as a temporary measure during curative radiotherapy for oesophageal carcinoma. METHODS:The BD stents need to be loaded into a conventional ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1662-5
更新日期:2010-05-01 00:00:00
abstract::While high-resolution T1-weighted sequences, such as three-dimensional magnetization-prepared rapid gradient-echo imaging, are widely available, there is a lack of an equivalent fast high-resolution sequence providing T2 contrast. Using fast high-performance gradient systems we show the feasibility of three-dimensiona...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1846-3
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:To assess if the administration of gadoxetate disodium (Gd-EOB-DTPA) significantly affects hepatic magnetic resonance elastography (MRE) measurements in the delayed hepatobiliary phase (DHBP). METHODS:A total of 47 patients (15 females, 32 males; age range 23-78 years, mean 54.28 years) were assigned to sta...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5616-7
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Radiomic involves testing the associations of a large number of quantitative imaging features with clinical characteristics. Our aim was to extract a radiomic signature from axial T2-weighted (T2-W) magnetic resonance imaging (MRI) of the whole prostate able to predict oncological and radiological scores in ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07105-z
更新日期:2021-02-01 00:00:00