Abstract:
BACKGROUND:The 6-minute walk (6 MW) is the most commonly applied measure of endurance walking capacity in persons with multiple sclerosis (MS); however, we are not aware of a quantitative synthesis of 6 MW performance in MS. RESEARCH QUESTION:We undertook a meta-analysis quantifying the overall magnitude of difference in 6 MW performance between MS and healthy controls (HCs), and then within MS as a function of disability status. We further examined possible moderator variables of 6 MW performance. METHODS:The systematic search was conducted for articles that included the 6 MW in persons with MS and involved comparison groups (i.e., HCs or MS disability subgroups (i.e., mild vs moderate-to-severe disability status)). The mean and standard deviation of the distance traveled during the 6 MW as well as sample sizes were entered into Comprehensive Meta-Analysis software and we estimated the overall effect size (Cohen's d) using a random effects model and examined categorical variables as possible moderators (e.g., instruction protocol, provision of encouragement, method of distance measurement, and course description). RESULTS:Thirty-four studies met inclusion criteria with a total sample size of 3204 persons (MS: 2683; HC: 521) yielding 42 total comparisons. Persons with MS walked a shorter distance than HCs (mean difference = -177.2 ± 19.1 m) with a large effect size (d = - 1.87). Persons with mild disability walked further than those with moderate-to-severe disability (mean difference = 185.19 ± 9.2 m) with a large effect (d = 1.83). The categorical variables of provision of encouragement and course layout moderated the effect of MS and course layout moderated the effect of disability status on 6 MW performance. SIGNIFICANCE:This meta-analysis of 6 MW performance defines mean difference in 6 MW performance in MS compared with HCs and provides an estimate of the disease-related effect of MS on endurance walking capacity for application within clinical research and practice.
journal_name
Gait Posturejournal_title
Gait & postureauthors
Cederberg KLJ,Sikes EM,Bartolucci AA,Motl RWdoi
10.1016/j.gaitpost.2019.07.125subject
Has Abstractpub_date
2019-09-01 00:00:00pages
147-153eissn
0966-6362issn
1879-2219pii
S0966-6362(19)30112-2journal_volume
73pub_type
杂志文章,meta分析相关文献
GAIT & POSTURE文献大全abstract:BACKGROUND:Studies have found that toe-in gait reduced the peak knee adduction moment (KAM) during early stance, while toe-out gait reduced the peak KAM during late stance. However, some other studies found that toe-in or toe-out gait could reduce the KAM throughout stance phase. There is still a divergence of opinion ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2020.06.027
更新日期:2020-09-01 00:00:00
abstract::The aim of this study was to investigate the effect of an arm sling on balance in patients with, hemiplegia following a stroke. Twenty-six patients with hemiplegia (11 men, 15 women) who had, shoulder subluxation were enrolled in the study. Balance was evaluated by the Berg Balance Scale, the, Functional Reach test, a...
journal_title:Gait & posture
pub_type: 临床试验,杂志文章
doi:10.1016/j.gaitpost.2010.09.008
更新日期:2010-10-01 00:00:00
abstract::Maintenance of a vertically aligned posture of the head and trunk in sitting is a fundamental skill that demonstrates the presence of neuromotor control. Clinical assessments of posture are generally subjective. Studies have quantified posture using different technologies, but the application of such technologies in a...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2016.10.012
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Energetic cost contributes to movement impairments observed during stair negotiation in persons with knee osteoarthritis. Specifically, the intersegmental mechanical energy exchange may be diminished in the presence of pathologies. RESEARCH QUESTION:The purpose of this study was to evaluate mechanical energ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2019.01.009
更新日期:2019-03-01 00:00:00
abstract::In this study, the influence of different prosthetic alignments and components on oxygen consumption and the important biomechanical characteristics of the normal gait pattern of leg amputees was investigated. With 15 transtibial and 12 transfemoral amputees, the oxygen consumption during walking on a treadmill was an...
journal_title:Gait & posture
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0966-6362(02)00008-5
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Walking and mobility are essential for a satisfactory quality of life. However, individuals with transfemoral amputations have difficulties in preventing falls due to prosthetic knee buckling, defined as the sudden loss of postural support during weight-bearing activities. The risk of prosthetic knee bucklin...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2020.01.002
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION:Stroke survivors often fall during walking. To reduce fall risk, gait testing and training with avoidance of virtual obstacles is gaining popularity. However, it is unknown whether and how virtual obstacle crossing is associated with fall risk. AIM:The present study assessed whether obstacle crossing char...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2017.09.013
更新日期:2017-10-01 00:00:00
abstract::We aimed to investigate the relationship between postoperative leg length/offset (LL/OS) reconstruction and gait performance after total hip arthroplasty (THA). In the course of a prospective randomized controlled trial, 60 patients with unilateral hip arthrosis received cementless THA through a minimally-invasive ant...
journal_title:Gait & posture
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.gaitpost.2016.07.011
更新日期:2016-09-01 00:00:00
abstract::Equinus is the commonest deformity in cerebral palsy (CP). Many different surgical procedures have been described for the treatment of spastic equinus. In long standing equinus deformities the tibialis anterior muscle becomes elongated which is one reason for muscle weakness. Surgical tendon shortening of the tibialis...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2010.11.002
更新日期:2011-02-01 00:00:00
abstract:AIM:To investigate lower limb biomechanical strategy during stair walking in patients with diabetes and patients with diabetic peripheral neuropathy, a population known to exhibit lower limb muscular weakness. METHODS:The peak lower limb joint moments of twenty-two patients with diabetic peripheral neuropathy and thir...
journal_title:Gait & posture
pub_type: 评论,杂志文章
doi:10.1016/j.gaitpost.2016.03.007
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Postural balance assessments are performed in both clinical and basic research settings on a daily basis. During a 24-h time span our physiology and physical performance undergo radical changes as we are influenced by the circadian rhythm. The time-of-day interaction on postural balance is unknown in older a...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2011.12.018
更新日期:2012-04-01 00:00:00
abstract::Bradykinesia is a prominent problem for persons with Parkinson's disease (PD) and has been studied extensively with upper extremity tasks; however there is a lack of research examining bradykinesia in targeted lower extremity tasks related to mobility. Navigating steps and curbs are challenging tasks for older adults ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2017.05.030
更新日期:2017-09-01 00:00:00
abstract::This study investigates whether aging has an influence on the dynamics of the fluctuations of the displacement of the center of pressure (COP), during quiet standing. Two groups of healthy subjects were compared (11 young and 12 elderly) for two visual feedback conditions (eyes open and eyes closed). The data were ana...
journal_title:Gait & posture
pub_type: 临床试验,杂志文章
doi:10.1016/j.gaitpost.2009.05.005
更新日期:2009-08-01 00:00:00
abstract::We investigated the relationship of hip, knee and ankle function to gait speed in healthy elderly subjects. We hypothesized that the hip extension moment would make a significantly smaller contribution to propulsion power in the elderly than in healthy young subjects even when the elders were ambulating at speeds comp...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/s0966-6362(01)00133-3
更新日期:2001-12-01 00:00:00
abstract::Cerebral palsy (CP) impairs an individual's ability to move and control one's posture. Unfortunately, the signs and symptoms of CP may not be apparent before age two. Evaluating sitting posture is a potential way to assess the developing mechanisms that contribute to CP. The purpose of this project was to determine th...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2017.04.031
更新日期:2017-07-01 00:00:00
abstract::Differences in the kinematics and kinetics of overground running have been reported between boys with and without developmental coordination disorder (DCD). This study compared the kinematics of overground and treadmill running in children with and without DCD to determine whether any differences in technique are main...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2014.05.054
更新日期:2014-07-01 00:00:00
abstract::Functional reach (FR) is a clinical measure, defined as the maximum distance one can reach, forward beyond arm's length, able to identify elderly subjects at risk of recurrent falls. Subjects, exhibiting the same FR can perform the motor task in different ways: a kinematic analysis of the FR, task can help to identify...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2013.08.035
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect deriving from neurotoxic chemotherapeutic agents. The underlying nerve injury can affect proprioception causing impaired postural control, gait difficulties and a higher risk of falling. Overall, the symptoms and functional limitation...
journal_title:Gait & posture
pub_type: 临床试验,杂志文章
doi:10.1016/j.gaitpost.2020.01.012
更新日期:2020-03-01 00:00:00
abstract:UNLABELLED:Patients with diabetes have been shown to suffer from increased fall risk. However, authors disagree as to whether only diabetic patients with neuropathy, or also those without neuropathy, present gait alterations. Existing studies evaluate gait indoors, i.e. in specialized gait laboratories. This study eval...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2008.11.012
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The gait pattern in Parkinson´s disease (PD) is characterized by a deficit in the internal regulation of stride length (SL), while the control of cadence (Cad) remains intact. The use of the treadmill as a gait rehabilitation tool has provided novel options for treatment of gait impairments in PD. However, i...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2018.11.025
更新日期:2019-02-01 00:00:00
abstract::The purpose of the present experiment was to investigate whether, with vision, the magnitude of the effect of calf muscles fatigue on postural control during bipedal quiet standing depends on the eye-visual target distance. Twelve young university students were asked to stand upright as immobile as possible in three v...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2005.07.011
更新日期:2006-10-01 00:00:00
abstract::Although total hip arthroplasty (THA) is known to be a successful surgical procedure to alleviate hip pain and to improve health-related quality of life, these outcome measures in THA patients do not reach those of the general population. As a result, several investigators have assessed THA patients' gait mechanics, b...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2010.05.007
更新日期:2010-06-01 00:00:00
abstract::Plantar heel pain is aggravated by weight-bearing, yet limited evidence exists regarding how people with heel pain load their feet during walking. Knowledge of loading patterns in people with plantar heel pain would enhance the understanding of their foot function and assist in developing intervention strategies. Plan...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2015.01.025
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Although walking speed is the most common measure of gait performance post-stroke, improved walking speed following rehabilitation does not always indicate the recovery of paretic limb function. Over the last decade, the measure paretic propulsion (Pp, defined as the propulsive impulse generated by the paret...
journal_title:Gait & posture
pub_type: 杂志文章,评审
doi:10.1016/j.gaitpost.2018.10.027
更新日期:2019-02-01 00:00:00
abstract::Research has demonstrated clear advantages of using an external focus of attention in postural control tasks, presumably since it allows a more automatic control of posture to emerge. However, the influence of cognitive tasks on postural stability has produced discordant results. This study aimed to compare the effect...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2014.11.009
更新日期:2015-02-01 00:00:00
abstract::Exercise related lower limb injuries (ERLLI), are common in the recreational and competitive sporting population. Although ERLLI are thought to be multi-factorial in aetiology, one of the critical predisposing factors is known to gait abnormality. There is little published evidence comparing walking and running gait i...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2009.08.003
更新日期:2010-01-01 00:00:00
abstract::Specific patterns of pelvic and thorax motions are required to maintain stability during walking. This cross-sectional study explored older-adults' gait kinematics and their kinematic adaptations to different walking speeds, with the purpose of identifying mechanisms that might be related to increased risk for falls. ...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2016.12.004
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Wearable inertial sensors have been shown to provide valid mean gait characteristics assessments, however, assessment of variability is less convincingly established. RESEARCH QUESTION:What level of concurrent validity, and session-to-session reliability does an ankle-worn inertial measurement unit (IMU)-ba...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2019.08.006
更新日期:2019-10-01 00:00:00
abstract::Balance-recovery reactions that involve rapid step or reach-to-grasp movements are prevalent and functionally important responses to instability. Successful use of these reactions to recover balance in daily life requires a capacity to modulate the reaction to deal with the continual variation in environmental constra...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/j.gaitpost.2008.08.011
更新日期:2009-02-01 00:00:00
abstract::Tripping over obstacles and imbalance during gait were reported as two of the most common causes of falls in the elderly. Imbalance of the whole body during obstacle crossing may cause inappropriate movement of the lower extremities and result in foot-obstacle contact. Thus, this study was performed to investigate the...
journal_title:Gait & posture
pub_type: 杂志文章
doi:10.1016/s0966-6362(00)00087-4
更新日期:2001-02-01 00:00:00