Impact of rituximab on stem cell mobilization following ACVBP regimen in poor-risk patients with diffuse large B-cell lymphoma: results from a large cohort of patients.

Abstract:

BACKGROUND:The ACVBP regimen is an efficient induction regimen for poor-risk patients with diffuse large B-cell lymphoma (DLBCL) before consolidative autologous stem cell transplantation. Adjunction of the monoclonal anti-CD20 antibody rituximab (R-ACVBP) was recently found to be superior to ACVBP alone. This study assessed the impact of rituximab on stem cell mobilization in two similar consecutive groups of patients treated with ACVBP in two prospective, controlled trials. STUDY DESIGN AND METHODS:The first trial (LNH-98B-3) involved 137 patients treated with ACVBP alone. In the second trial (LNH-03-3B), 91 patients received an R-ACVBP regimen. Stem cell mobilization was performed after a course of (R)-ACVBP. RESULTS:The median peak numbers of blood CD34+ cell counts recorded before the first apheresis procedure in the ACVBP and R-ACVBP groups were 69×10(6) and 63×10(6) /L, respectively (p=0.55). The median numbers of CD34+ cells collected were 7.1×10(6) and 6.0×10(6) CD34+ cells/kg for the ACVBP and R-ACVBP groups, respectively (p=0.13). The median number of apheresis procedures required for gathering the minimum amount of CD34+ cells (2×10(6) /kg) was the same in the two groups. CONCLUSION:When compared with ACVBP alone, adjunction of rituximab does not impair stem cell mobilization.

journal_name

Transfusion

journal_title

Transfusion

authors

Lefrère F,Bastit-Barrau D,Hequet O,Bourin P,Mathieu-Nafissi S,Bohbot A,Tilly H,Salles G,Fermé C,Lapierre V,Fornecker L,Micléa JM,Isebaert L,Bologna S,Fitoussi O,Mounier N,Haioun C

doi

10.1111/j.1537-2995.2012.03683.x

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

115-22

issue

1

eissn

0041-1132

issn

1537-2995

journal_volume

53

pub_type

杂志文章
  • Implementation of a blood irradiation program at a community cancer center.

    abstract:BACKGROUND:Blood component irradiation is an accepted method of preventing transfusion-associated GVHD. Previous publications have largely focused on the technical aspects of the irradiation process itself, but relatively little attention has been paid to the details associated with the implementation of a blood irradi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41121610.x

    authors: Patton GA,Skowronski MG

    更新日期:2001-12-01 00:00:00

  • Sensitivity of hepatitis C virus core antigen and antibody combination assays in a global panel of window period samples.

    abstract:BACKGROUND:Hepatitis C virus (HCV) antigen and antibody combination assays have been launched as a cost-effective alternative to nucleic acid testing (NAT) for reducing the antibody-negative window period (WP). Later, a HCV antigen chemiluminescence immunoassay (CLIA) became available. STUDY DESIGN AND METHODS:A panel...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13179

    authors: Laperche S,Nübling CM,Stramer SL,Brojer E,Grabarczyk P,Yoshizawa H,Kalibatas V,El Elkyabi M,Moftah F,Girault A,van Drimmelen H,Busch MP,Lelie N

    更新日期:2015-10-01 00:00:00

  • First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany.

    abstract:BACKGROUND:In February 2007, a 63-year-old man underwent surgery. Retrospective testing with nucleic acid testing (NAT) showed that the patient was human immunodeficiency virus Type 1 (HIV-1) positive 10 days after transfusion. The transfusion-transmitted infection had been identified by a donor-related lookback starte...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02203.x

    authors: Schmidt M,Korn K,Nübling CM,Chudy M,Kress J,Horst HA,Geusendam G,Hennig H,Sireis W,Rabenau HF,Doerr HW,Berger A,Hourfar MK,Gubbe K,Karl A,Fickenscher H,Tischer BK,Babiel R,Seifried E,Gürtler L

    更新日期:2009-09-01 00:00:00

  • Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions.

    abstract:BACKGROUND:After multiple transfusions, the serologic typing of autologous blood group phenotypes is difficult, because of mixed RBC populations. The genotyping of ABO, Rh, Kell, Kidd, and Duffy systems could be used to determine autologous blood group antigen status. STUDY DESIGN AND METHODS:Blood samples from patien...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40080936.x

    authors: Rozman P,Dovc T,Gassner C

    更新日期:2000-08-01 00:00:00

  • Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons.

    abstract:BACKGROUND:Qualitative RHD variants are the result of the replacement of RHD exons by their RHCE counterparts or of point mutations in RHD causing amino acid substitutions. For RHD typing, the use of at least two RHD typing polymerase chain reaction (PCR) assays directed at different regions of RHD is advised to preven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38111299056309.x

    authors: Maaskant-van Wijk PA,Faas BH,de Ruijter JA,Overbeeke MA,von dem Borne AE,van Rhenen DJ,van der Schoot CE

    更新日期:1998-11-01 00:00:00

  • Platelet storage lesion of WBC-reduced, pooled, buffy coat-derived platelet concentrates prepared in three in-process filter/storage bag combinations.

    abstract:BACKGROUND:With the implementation of universal WBC reduction in the United Kingdom, in-process WBC-reduction filters for pooled buffy coat (BC)-derived platelet concentrates (PCs) are used in routine production. The effects of three filter/storage bag combinations on platelet activation and microvesiculation and on th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41020243.x

    authors: Krailadsiri P,Seghatchian J,Williamson LM

    更新日期:2001-02-01 00:00:00

  • A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.

    abstract:BACKGROUND:Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions. The purpose of this study was to prospectively compare the risk of transfusion reactions in hematology/oncology patients who receive acetaminophen with diphenhydramine or placebo before transfu...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1537-2995.2008.01858.x

    authors: Kennedy LD,Case LD,Hurd DD,Cruz JM,Pomper GJ

    更新日期:2008-11-01 00:00:00

  • Cytokine generation in stored, white cell-reduced, and bacterially contaminated units of red cells.

    abstract:BACKGROUND:Proinflammatory cytokines were measured in the supernatant portion of stored, bacterially contaminated, and/or white cell (WBC)-reduced units of red cells (RBCs). Previous studies from this laboratory and others have shown that cytokines are generated in platelet concentrates during storage. This earlier wor...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.35395184274.x

    authors: Stack G,Baril L,Napychank P,Snyder EL

    更新日期:1995-03-01 00:00:00

  • Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products.

    abstract:BACKGROUND:The majority of reports on transfusion reactions address adult patients. Less is known about the types, incidence, and other clinical details of transfusion reactions in pediatric populations. Furthermore, to our knowledge, there have been no previous reports directly comparing these aspects between adults a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12827

    authors: Oakley FD,Woods M,Arnold S,Young PP

    更新日期:2015-03-01 00:00:00

  • Leukocyte depletion of red cell units at the bedside by transfusion through a new filter.

    abstract::Standard packed red cell (PRC) units can be depleted of leukocytes and platelets if they are transfused through a blood administration set in which the usual 170-mu filter has been replaced by a leukocyte removal filter (Sepacell R-500). During a 6-month period, 1550 PRC units were transfused through this filter in 61...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27587320533.x

    authors: Sirchia G,Rebulla P,Parravicini A,Carnelli V,Gianotti GA,Bertolini F

    更新日期:1987-09-01 00:00:00

  • Human platelets target dendritic cell differentiation and production of proinflammatory cytokines.

    abstract:BACKGROUND:Dendritic cells (DCs) are the most potent antigen-presenting cells that initiate and regulate immune responses. They are unique in their feature to produce bioactive interleukin (IL)-12, a major proinflammatory cytokine connecting innate and adaptive immunity. Platelets (PLTs) are highly reactive components ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00802.x

    authors: Kissel K,Berber S,Nockher A,Santoso S,Bein G,Hackstein H

    更新日期:2006-05-01 00:00:00

  • Adoption trends of point of issue Verax PGD rapid test for bacterial screening of platelets between 2013 and 2018 among hospitals supplied by the American Red Cross and impact on platelet availability.

    abstract:BACKGROUND:Point-of-issue tests, such as the Verax Pan Genera Detection (PGD) test, can be used to mitigate the occurrence of septic reactions. Little is known about how widespread the adoption of the PGD test is across US hospitals. STUDY DESIGN/METHODS:The Red Cross hemovigilance database was used to determine the n...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15817

    authors: Rios J,Westra J,Dy B,Young PP

    更新日期:2020-07-01 00:00:00

  • The use of recombinant activated factor VII in three patients with central nervous system hemorrhages associated with factor VII deficiency.

    abstract:BACKGROUND:Recombinant activated factor VII (rFVIIa) is being tested to improve hemostasis in a variety of bleeding disorders. Clinical indications and efficacy are still being evaluated for this product. CASE REPORT:Over a 17-month period, rFVIIa was used to treat central nervous system hemorrhage in three patients w...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04080.x

    authors: Huang WY,Kruskall MS,Bauer KA,Uhl L,Shaz BH

    更新日期:2004-11-01 00:00:00

  • Creating a uniform donor medical history questionnaire.

    abstract::Blood Centers of California, Inc. (BCC) is a consortium of 19 independent blood centers that collectively draw approximately 800,000 units of whole blood each year. Over the past several years, a committee of BCC, composed primarily of medical and nursing directors at member institutions, developed a Uniform Donor Med...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31491213302.x

    authors: Kolins J,Silvergleid AJ

    更新日期:1991-05-01 00:00:00

  • Investigation of whether the acute hemolysis associated with Rh(o)(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model.

    abstract:BACKGROUND:Immune thrombocytopenic purpura and secondary thrombocytopenia patients treated with Rh(o)(D) immune globulin intravenous (human; anti-D IGIV) have experienced acute hemolysis, which is inconsistent with the typical presentation of extravascular hemolysis -- the presumed mechanism of action of anti-D IGIV. A...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.02083.x

    authors: Gaines AR,Lee-Stroka H,Byrne K,Scott DE,Uhl L,Lazarus E,Stroncek DF

    更新日期:2009-06-01 00:00:00

  • Buffering and dilution in red blood cell storage.

    abstract:BACKGROUND:Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution. STUDY DESIGN AND METHODS:In the first study, 12 units of packed CP2D RBCs were pooled in groups of four, re-aliquoted, and a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00672.x

    authors: Hess JR,Rugg N,Joines AD,Gormas JF,Pratt PG,Silberstein EB,Greenwalt TJ

    更新日期:2006-01-01 00:00:00

  • Frequent blood donation and offspring scholastic attainment: an assessment of long-term consequences of prenatal iron deficiency.

    abstract:BACKGROUND:Due to physiological demands, children and premenopausal women are at risk of developing iron deficiency. In premenopausal women, the risk may be further increased by repeated whole blood donations. Short-term consequences of iron deficiency in infancy include impaired cognitive development and lower IQ scor...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15193

    authors: Rigas AS,Pedersen OB,Rostgaard K,Sørensen E,Erikstrup C,Hjalgrim H,Ullum H

    更新日期:2019-05-01 00:00:00

  • Plateletapheresis program. I. Donor recruitment and commitment.

    abstract::A dedicated cytapheresis donor program was developed to meet the need for granulocytes and single-donor platelets. A study was undertaken to determine the most effective way to recruit a panel of 500 HLA-typed committed volunteer cytapheresis donors. Factors analyzed included ease of donor recruitment, information nec...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24484275565.x

    authors: Meyer DM,Hillman RS,Slichter SJ

    更新日期:1984-07-01 00:00:00

  • Isolated platelet concentrate transfusion during surgery: a single-center observational cohort study.

    abstract:BACKGROUND:Surgical patients receive platelet concentrates (PCs) for a variety of indications. However, there is limited evidence for efficacy or dosing of PCs. STUDY DESIGN AND METHODS:We performed a retrospective cohort study of surgical patients receiving isolated PC transfusion at a single academic tertiary medica...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15156

    authors: Anders M,Rock P,Cartron A,Chow J,Henderson R,Martz D,Tanaka K,Mazzeffi M

    更新日期:2019-05-01 00:00:00

  • Relationship of epitope glycosylation and other properties of blood group proteins to the immunogenicity of blood group antigens.

    abstract:BACKGROUND:The intrinsic properties of polypeptide blood group antigens that determine their relative immunogenicities are unknown. Because size, composition, charge, dose, and epitope glycosylation affect the immunogenicity of other polypeptides, we examined whether similar properties were related to the immunogenicit...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14609

    authors: Howe JG,Stack G

    更新日期:2018-07-01 00:00:00

  • Transfusion and blood donation on the screen.

    abstract:BACKGROUND:In the 20th century, blood transfusion has become an indispensable therapy in carrying out and improving many medical and surgical applications. Its scope of influence goes well beyond that of medicine, because blood donation, an action with high social significance, is completely connected to progress in th...

    journal_title:Transfusion

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1537-2995.2007.01634.x

    authors: Danic B,Lefrère JJ

    更新日期:2008-05-01 00:00:00

  • Evaluating DNA tests of motherless cases using a Philippine genetic database.

    abstract:BACKGROUND:In 5 percent of paternity determination cases, only DNA samples from the alleged father and child pairs are tested. The absence of the mother's DNA increases the probability of false paternity inclusions, which affects laboratories that use a limited number of DNA markers. The effect of coincidental matches ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00152.x

    authors: De Ungria MC,Frani AM,Magno MM,Tabbada KA,Calacal GC,Delfin FC,Halos SC

    更新日期:2002-07-01 00:00:00

  • Prospective-concurrent audits and medical consultation for platelet transfusions.

    abstract::Prospective-concurrent audits and medical consultation were associated with a 56 percent decrease in the use of platelet concentrates at a tertiary care medical center. This study documents that mandatory pretransfusion review of component requests can alter hospital transfusion practices. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27287150198.x

    authors: Simpson MB

    更新日期:1987-03-01 00:00:00

  • "Naturally-occurring" anti-K1: possible association with mycobacterium infection.

    abstract::We report a case of "naturally-occurring" (nonred blood cell stimulated) anti-K1. The patient had never received a blood transfusion. Red blood cell antibody screening panels showed agglutination with K:1 red blood cells at room temperature and not in the anti-globulin test. Testing with 2-mercaptoethanol showed the a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251244.x

    authors: Kanel GC,Davis I,Bowman JE

    更新日期:1978-07-01 00:00:00

  • Blood preservation. XXIX. Pyruvate maintains normal red cell 2,3-DPG for six weeks of storage in CPD-adenine.

    abstract::Pyruvate was placed in experimental CPD-adenine (0.25 mM) blood preservative mixtures in four concentrations ranging from 40 to 320 mM. In the 320 mM pyruvate preservative, 2,3-DPG levels were elevated above normal for six weeks of whole blood storage at 4 C. The lower pyruvate concentrations maintained elevated or no...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1980.20280169965.x

    authors: Dawson RB,Hershey RT,Myers CS

    更新日期:1980-03-01 00:00:00

  • Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma.

    abstract:BACKGROUND:A single injection of pegfilgrastim has been shown to be equivalent to daily filgrastim in enhancing neutrophil recovery after chemotherapy, whereas the experiences with pegfilgrastim in mobilization of peripheral blood progenitor cells (PBPCs) are limited. STUDY DESIGN AND METHODS:Forty unselected patients...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2006.00911.x

    authors: Kroschinsky F,Hölig K,Platzbecker U,Poppe-Thiede K,Ordemann R,Blechschmidt M,Oelschlaegel U,Schaich M,Hänel M,Bornhäuser M,Ehninger G

    更新日期:2006-08-01 00:00:00

  • Effects of colloidal resuscitation fluids on the neutrophil respiratory burst.

    abstract:BACKGROUND:Experimental studies have revealed that gelatin and HES produce increased neutrophil respiratory burst activity. It was investigated whether 3-percent gelatin (MW 35,000) and three types of 6-percent HES (MW 70,000; degree of substitution, 0.5; 200,000/0.5; 450,000/0.7) preparations can influence superoxide ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.2001.41081064.x

    authors: Jaeger K,Heine J,Ruschulte H,Jüttner B,Scheinichen D,Kuse ER,Piepenbrock S

    更新日期:2001-08-01 00:00:00

  • IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins.

    abstract::Three cases of IgA kappa cold agglutinins (CAs) were studied. One had anti-Pr1 specificity, one had anti-Pra, and one had anti-Sa. The CAs recognize O-glycans of glycophorins. The findings supplement previous data on anti-Pr1 specificities of four IgA kappa CAs. Because all IgA kappa CAs described recognize O-glycans ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33693296808.x

    authors: Roelcke D,Hack H,Kreft H,MacDonald B,Pereira A,Habibi B

    更新日期:1993-06-01 00:00:00

  • Storage time affects umbilical cord blood viability.

    abstract:BACKGROUND:Cryopreserved umbilical cord blood (CB) is increasingly used as a cell source to reconstitute marrow in hematopoietic stem cell transplant patients. Delays in cryopreservation may adversely affect cell viability, thereby reducing their potential for engraftment after transplantation. STUDY DESIGN AND METHOD...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12481

    authors: Guttridge MG,Soh TG,Belfield H,Sidders C,Watt SM

    更新日期:2014-05-01 00:00:00

  • UMC, another Cromer-related blood group antigen.

    abstract::An antibody found in the serum of a Japanese blood donor detects a new high-frequency red cell antigen named UMC. UMC is absent from Inab phenotype cells, weakly expressed on Dr(a-) cells, and destroyed by alpha-chymotrypsin but not trypsin treatment of red cells. UMC is, therefore, a Cromer-related antigen. Immunoblo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1989.29990070184.x

    authors: Daniels GL,Okubo Y,Yamaguchi H,Seno T,Ikuta M

    更新日期:1989-11-01 00:00:00