Essential Oil and Ethanol Extract of Oregano (Origanum vulgare L.) from Armenian Flora as a Natural Source of Terpenes, Flavonoids and other Phytochemicals with Antiradical, Antioxidant, Metal Chelating, Tyrosinase Inhibitory and Antibacterial Activity.

abstract：:Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative bacteria component lipopolysaccharide (LPS), which induces the activation of innate immune ...

journal_title：Current pharmaceutical design

authors： de Almeida OP Jr,Toledo TR,Rossi D,Rossetto Dde B,Watanabe TF,Galvão FC,Medeiros AI,Zanelli CF,Valentini SR

更新日期：2014-01-01 00:00:00

abstract：:Genetic variation in the receptors and other intracellular targets that mediate the pharmacodynamic effects of drugs can affect therapeutic outcomes. However, at present greater knowledge is available concerning the extent of gene variation in drug metabolizing enzymes that determine drug pharmacokinetics and, in turn...

journal_title：Current pharmaceutical design

authors： Crettol S,Petrovic N,Murray M

更新日期：2010-01-01 00:00:00

abstract：:Prostaglandin (PG) D(2), the major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is thought to contribute to the pathogenesis of allergic diseases due to its various inflammatory effects. However, the lack of PGD(2) (DP) receptor antagonists has limited the study of its essential role...

journal_title：Current pharmaceutical design

authors： Mitsumori S

更新日期：2004-01-01 00:00:00

abstract：:The mechanisms underlying neurodegeneration in amyotrophic lateral sclerosis (ALS) are multifactorial and include genetic and environmental factors. Nowadays, it is well accepted that neuronal loss is driven by non-cell autonomous toxicity. Non-neuronal cells, such as astrocytes, have been described to significantly c...

journal_title：Current pharmaceutical design

authors： Johann S

更新日期：2017-01-01 00:00:00

abstract：:Macrolides have broad antibacterial spectrum and proven efficacy in the management of respiratory tract infections. Over the past decade there has been progressive interest in these agents for their potential role as tissue modifying, anti-inflammatory agents. Increasingly, the effect of macrolides on numerous cell ty...

journal_title：Current pharmaceutical design

authors： Martinez FJ,Simon RH

更新日期：2004-01-01 00:00:00

abstract：:Protein kinases are potential targets of drugs to treat many human diseases. Intensive efforts have been made to develop protein kinase inhibitors, but a major challenge is achieving specificity. Exploiting regulatory elements outside the ATP binding pocket, such as the substrate binding site, may provide an alternati...

journal_title：Current pharmaceutical design

authors： Licht-Murava A,Eldar-Finkelman H

更新日期：2012-01-01 00:00:00

abstract：:Curcumin is a natural polyphenol product derived from the rhizome of the Curcuma longa. In vivo and in vitro studies have uncovered many important bioactivities of curcumin, such as antioxidant activity, inducing cell apoptosis, inhibiting cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti...

journal_title：Current pharmaceutical design

authors： Fan X,Zhang C,Liu DB,Yan J,Liang HP

更新日期：2013-01-01 00:00:00

abstract：:This manuscript provides an overview for analysts, medical and scientific investigators, and laboratory administrators, the range of factors that should be considered to implement best practice forensic toxicology. These include laboratory influence over the collection of specimens, their proper transport and chain-of...

journal_title：Current pharmaceutical design

authors： Drummer OH

更新日期：2017-01-01 00:00:00

abstract：:Over the last several years, it has become increasingly clear that dendritic cells (DC) are not only critical for the initiation of T cell immunity, but these cells also determine the course of the subsequent immune response (i.e. tolerance vs. immunity, Th1 vs. Th2). However, the mechanisms by which DC can influence ...

journal_title：Current pharmaceutical design

authors： Wan Y,Bramson J

更新日期：2001-07-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel member of the secretin/glucagon/vasoactive intestinal peptide (VIP) superfamily. In vertebrates, including avians, it occurs in two forms: PACAP(38) and PACAP(27). PACAP structure is well conserved during evolution, being identical in mammals, and s...

journal_title：Current pharmaceutical design

authors： Nowak JZ,Zawilska JB

更新日期：2003-01-01 00:00:00

abstract：:microRNAs (miRNAs) comprise a recently discovered class of non-coding RNAs with regulatory functions in post-transcriptional gene expression control. Many miRNAs are located in genomic regions that are frequently deleted in cancer, or are subject to epigenetic and transcriptional deregulation in cancer cells. The miRN...

journal_title：Current pharmaceutical design

authors： Schmid CA,Craig VJ,Müller A,Flori M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Heat shock proteins are powerful endogenous cytoprotective proteins which help cells to survive recurrent cellular stress events. Identifying the underlying molecular mechanisms and molecular targets is especially interesting since it may help to develop new therapeutic strategies for the treatment of diseas...

journal_title：Current pharmaceutical design

authors： Golenhofen N,Bartelt-Kirbach B

更新日期：2016-01-01 00:00:00

abstract：:The CCN family of growth factors is composed of six structurally related proteins including the cysteine-rich 61 (Cyr61), connective tissue growth factor (CTGF), nephroblastoma overexpressed (NOV), Wnt-1 induced secreted protein-1 (WISP-1), WISP-2 and WISP-3. Each family member consists of four conserved cysteine rich...

journal_title：Current pharmaceutical design

authors： Desnoyers L

更新日期：2004-01-01 00:00:00

abstract：:Transpeptidation reactions result in the formation of new peptide bonds and this can occur between two separate peptides or within the one peptide. These reactions are catalyzed by enzymes and when the N- and C-terminus of the one peptide are joined it results in the formation of cyclic proteins. Cyclization via head-...

journal_title：Current pharmaceutical design

authors： Conlan BF,Anderson MA

更新日期：2011-12-01 00:00:00

abstract：:A small but increasing number of gene expression based biomarkers are becoming available for routine clinical use, principally in oncology and transplantation. These underscore the potential of gene expression arrays and RNA sequencing for biomarker development, but this potential has not yet been fully realized and m...

journal_title：Current pharmaceutical design

authors： Flint SM,McKinney EF,Lyons PA,Smith KG

更新日期：2015-01-01 00:00:00

abstract：:Biodegradable particles have important applications in Drug Delivery Systems (DDS) of protein/peptide drugs. And recently, particle systems have also showed to be powerful for vaccine delivery (adjuvant) in order to solve the difficulties when conventional Alum adjuvant was used. However, in above applications, the pr...

journal_title：Current pharmaceutical design

authors： Wang L,Yang T,Ma G

更新日期：2015-01-01 00:00:00

abstract：:Peroxynitrite, the product of the reaction between nitric oxide and superoxide, is spontaneouly formed within most mammalian cells under physiological conditions. Initial work addressing the pathophysiology of peroxynitrite afforded the generally accepted notion that this compound would be the long-term neurotoxic nit...

journal_title：Current pharmaceutical design

authors： Bolanos JP,García-Nogales P,Almeida A

更新日期：2004-01-01 00:00:00

abstract：:The apoptosis inducing factor (AIF) was first discovered as a caspase-independent apoptosis effector that promoted cell death upon release from the mitochondria (triggered by pro-apoptotic stimuli) and relocalization into the nucleus, where it promotes chromatin condensation and DNA fragmentation. AIF is a mammalian m...

journal_title：Current pharmaceutical design

authors： Ferreira P,Villanueva R,Cabon L,Susín SA,Medina M

更新日期：2013-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) has been widely used as a target for novel anticancer agents, such as blocking antibodies and small molecular weight tyrosine kinase compounds. In spite of recent advances in cancer cell biology, leading to the introduction of clinically active new drugs, such as cetuximab, ...

journal_title：Current pharmaceutical design

authors： Bianco R,Damiano V,Gelardi T,Daniele G,Ciardiello F,Tortora G

更新日期：2007-01-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a cluster of risk factors, each one individually associated with increased cardiovascular disease risk. Treatment of all components of MetS is expected to result in reduced risk. Treatment of MetS mainly includes lifestyle changes. In addition, drug therapy may be considered, especially co...

journal_title：Current pharmaceutical design

authors： Florentin M,Elisaf MS,Mikhailidis DP,Liberopoulos EN

更新日期：2009-01-01 00:00:00

abstract：:The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The fir...

journal_title：Current pharmaceutical design

authors： Tsoucalas G,Papaioannou T,Panayiotakopoulos G,Saridaki Z,Vrachatis DA,Karamanou M

更新日期：2018-01-01 00:00:00

abstract：:The frequency of neuropsychiatric disorders is greater than that of cancer, cardiovascular disease, and diabetes combined, and is growing at a faster rate than any other ailments in the United States or Europe. Despite a considerable need for the development of treatments for central nervous system disorders, pharmace...

journal_title：Current pharmaceutical design

authors： Schroeder RA,Wecker L,Philpot RM

更新日期：2016-01-01 00:00:00

abstract：:Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to antibiotics motivated by growing problems with multi-drug resistant pathogens. aPDT uses non-toxic dyes or photosensitizers (PS) in combination with harmless visible of the correct wavelength to be absorbed by the PS. The excited state PS can form...

journal_title：Current pharmaceutical design

authors： Sharma SK,Dai T,Kharkwal GB,Huang YY,Huang L,De Arce VJ,Tegos GP,Hamblin MR

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Glioma is the most common human central nervous system tumour with a high degree of malignancy. Some Rab GTPases have significant effects on glioma. OBJECTIVE:This study aimed to investigate the effect of Rab3b (Rab GTPase3b) on human glioma cell proliferation and apoptosis by silencing Rab3b and to initial...

journal_title：Current pharmaceutical design

authors： Luo Q,Liu Y,Yuan Z,Huang L,Diao B

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:Discovery and development of BCS class 1 drugs through high throughput screening is one of the biggest challenge faced by formulation scientist. METHODS:There are a number of approaches that have been exploited to enhance the solubility and permeability of drugs. Among them, development of nanosuspension ha...

journal_title：Current pharmaceutical design

authors： Arora D,Khurana B,Rath G,Nanda S,Goyal AK

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study is to answer the following question: What are the typical features of abnormal bodily experiences (ABEs) in persons affected by acute first-episode schizophrenia? Our overall objective is to contribute to enhance early diagnosis of schizophrenia, and providing supplementary diagnostic criteri...

journal_title：Current pharmaceutical design

authors： Stanghellini G,Ballerini M,Fusar Poli P,Cutting J

更新日期：2012-01-01 00:00:00

abstract：:While pharmacological blockade of dopamine D2 receptor can effectively suppress the psychotic or positive symptoms of schizophrenia, there is no satisfactory medication for the negative and cognitive symptoms of schizophrenia in spite of the proliferation of second generation antipsychotic drugs. Excitements over a ne...

journal_title：Current pharmaceutical design

authors： Singer P,Dubroqua S,Yee BK

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The application of an ion selective technique for the determination of analyte concentrations is considered one of the most economical techniques for quality control purposes. OBJECTIVE:To elaborate and investigate the construction and general performance characteristics of potentiometric PVC membrane senso...

journal_title：Current pharmaceutical design

authors： Mansour MF,El-Moety MMA,El Kady EF,El Guindi NM,Schepdael AV,Aly SME

更新日期：2018-01-01 00:00:00

abstract：:The Hereditary Spastic Paraparesis (HSP) or Strumpell-Lorrain disease is a heterogeneous neurodegenerative disease of the spinal cord. It is genetically transmitted and characterized by a progressive muscle weakness, spasticity of the lower limbs and awkward gain. There is no specific pharmacological treatment. The ph...

journal_title：Current pharmaceutical design

authors： Riccardo M,Angela L,Angela D,Vita P,Giulio L,Pietroq F,Giancarlo I,Marisa M

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:High prevalence of Dental and periodontal problems during the gestation period may have a negative effect on oral health-related quality of life (OHRQoL) in pregnant women. This systematic review aimed to perform a quality assessment and provide a critical overview of the current research available on OHRQoL ...

journal_title：Current pharmaceutical design

authors： Fakheran O,Saied-Moallemi Z,Khademi A,Sahebkar A

更新日期：2020-01-01 00:00:00