Coxiella subversion of intracellular host signaling.

Abstract:

:Coxiella burnetii is a highly infectious bacterial pathogen that replicates in a specialized vacuole inside eukaryotic cells. Due to a prolonged growth cycle, Coxiella continuously manipulates cellular processes to generate this parasitophorous vacuole (PV) and promote host cell viability. Here, we discuss recent findings that indicate Coxiella modulates several host signaling pathways to influence survival and ensure intracellular replication. The pathogen actively inhibits apoptotic cell death and activates the pro-survival kinases Akt and Erk1/2 to promote host viability. Coxiella's anti-apoptotic activity also involves the interface between autophagy and apoptosis, which is regulated by the interaction of autophagy-related Beclin-1 and anti-apoptotic Bcl-2. Additionally, Coxiella requires host kinase activity for PV biogenesis and maintenance. Thus, signaling modulation by Coxiella is critical for multiple aspects of host cell parasitism. Collectively, recent signaling studies have enhanced our understanding of the unique Coxiella-host cell interaction. Identification of bacterial factors that regulate signaling events will further our ability to model this intriguing infectious process.

journal_name

Adv Exp Med Biol

authors

Hussain SK,Voth DE

doi

10.1007/978-94-007-4315-1_7

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

131-40

eissn

0065-2598

issn

2214-8019

journal_volume

984

pub_type

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