Abstract:
:Vandetanib is a once-daily oral multikinase inhibitor that targets the rearranged during transfection (RET) tyrosine kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor. Among its observed toxicity profile is QT prolongation, diarrhea, and rash, including photosensitivity. This article presents 3 patients with photoinduced cutaneous side effects of vandetanib, including both photoallergic and phototoxic reactions. We review the spectrum of cutaneous photosensitivity reactions and the necessity of histopathologic evaluation to distinguish photoallergic and phototoxic reactions. Given its high prevalence of specifically photoinduced side effects and the variety of the histologic and clinical presentations, reinforcing attentive sun protection could potentially prevent dose reduction or drug cessation in patients treated with vandetanib.
journal_name
Cutisjournal_title
Cutisauthors
Doan HQ,Hu MI,Goldstein J,Piha-Paul SA,Subbiah V,Patel ABsubject
Has Abstractpub_date
2019-05-01 00:00:00pages
E24-E29issue
5eissn
0011-4162issn
2326-6929journal_volume
103pub_type
杂志文章,评审相关文献
CUTIS文献大全abstract::Irritant contact dermatitis to sulfite hair preparations most commonly occurs when users do not follow instructions. Allergic eczematous reactions are very rare; immediate urticarial reactions seem to occur principally in patients with asthma. Pretesting should be done in such patients in a physician's office where me...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The right torso of a 55-year-old woman showed diffuse skin and soft-tissue changes suggestive of cellulitis. However, several clinical and radiologic features, including the subacute and non-toxic nature of the illness and the patient's lack of response to antibiotic therapy, indicated a noninfectious etiology. Malign...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::We describe a case of a 44-year-old woman with biopsy-proven female androgenic alopecia (FAGA), or female pattern alopecia, who was nonresponsive to topical minoxidil. After careful consideration and discussion with the patient, the decision was made to introduce oral finasteride 1.25 mg daily. After only 3.5 months o...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2012-08-01 00:00:00
abstract::A patient with leprosy and an anesthetic left hand noted a hornlike nail on his index finger after recurrent trauma and infection had resulted in acral bone loss. This case illustrates the importance of an intact terminal phalanx in the formation of a normal nail plate. ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::A 13-month-old child with lamellar ichthyosis and numerous cutaneous and systemic infections died following an abrupt episode of severe hypotension. Postmortem examination revealed white matter vacuolation in the brain stem tegmentum and cerebellar hemispheres similar to that seen in toxicity from hexachlorophene, to ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Some sun safety activities have included only non-Hispanic white individuals, even though individuals in other ethnoracial groups may be at risk for skin cancer. The objectives of this study were to investigate distributions of self-reported Fitzpatrick skin type within 5 ethnoracial groups and substantiate each group...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::A 52-year-old Chinese man was found to have a benign thymoma and pemphigus erythematosus (PE). Initially, most of his skin lesions appeared on the scars of the surgical incisions and suture sites three months after he underwent thymectomy. To our knowledge, this is the first report documenting the skin lesions of PE o...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Although there are limited data available on gender as an outcome variable in the treatment of onychomycosis, differences in disease prevalence and impact in males versus females have been observed. This article provides a gender subgroup analysis based on results from recent studies evaluating the efficacy, safety, a...
journal_title:Cutis
pub_type: 杂志文章,meta分析,多中心研究
doi:
更新日期:2015-09-01 00:00:00
abstract::Condom sales rose in the 1980s because condoms protect against the spread of sexually transmitted diseases and AIDS. In anticipation of corresponding increase in the incidence of condom dermatitis, a dermatologist prepared a brief overview of the condition and ways to treat it to prepare health professional for the a...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract::Submental fat (SMF) accumulation is a cosmetically distressing concern for which there have been recent advances in minimally invasive and noninvasive therapeutic options. In this article, we review the newest treatments available for SMF, including laser-assisted lipolysis (LAL), radiofrequency (RF)-assisted lipolysi...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2017-01-01 00:00:00
abstract::Malignant atrophic papulosis (MAP), or Degos syndrome, is a rare disorder of unknown etiology. It is characterized by a deep subcutaneous vasculopathy resulting in atrophic, porcelain-white papules. We report the case of a 42-year-old woman with a history of progressive systemic sclerosis who presented with painful su...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
abstract::An outbreak of KS has been observed in young homosexual men. These patients are different from those with classical KS for the following reasons: 1. geographic distribution (clustering in New York and California); 2. age (younger, mean--39 years); 3. higher incidence; 4. sexual preference (homosexual); 5. distribution...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Tissue expansion in dermatologic surgery has gained wide acceptance. We report the case of a patient with basal cell carcinoma in whom a Foley catheter was used for immediate intraoperative tissue expansion. Wound tension was decreased significantly and primary closure obtained. This technique is appropriate for offic...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::We report a case of generalized tuberous xanthoma with type IV hyperlipoproteinemia in a 42-year-old woman who had multiple, grouped, yellowish brown nodules bilaterally on the trunk, knees, elbows, palms, soles, and dorsal sides of multiple interphalangeal joints. On laboratory examination, serum triglyceride levels ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::The case of a patient with yellow nail syndrome (YNS), an infiltrating duct carcinoma of the breast, and giant cell interstitial pneumonitis (GIP) is presented. YNS has not been previously described in association with GIP. There was improvement of the yellow fingernails following surgery and chemotherapy for the brea...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1986-05-01 00:00:00
abstract::Acne vulgaris is one of the most common dermatologic diseases, ranging from comedonal or inflammatory papules to large, painful, disfiguring cysts. Numerous treatment approaches are available, each with their own risks and benefits that must be weighed when selecting the best option for an individual patient. Active-d...
journal_title:Cutis
pub_type: 杂志文章
doi:10.12788/cutis.0057
更新日期:2020-07-01 00:00:00
abstract::Folliculitis decalvans is a rare follicular inflammatory disease of the scalp. It is characterized by initial perifollicular inflammatory changes followed by peripheral extension and eventual circumscribed patches of cicatricial alopecia. The disease is known for its resistance to treatment, resulting in an unfavorabl...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::The antistaphylococcal properties of orally administered minocycline and penicillin-V were compared for one hundred and fifteen patients receiving minocycline and one hundred and twenty-eight receiving penicillin-V for various types of cutaneous infections. The majority of bacterial isolates were staphylococcal organi...
journal_title:Cutis
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1979-05-01 00:00:00
abstract::Psoriasis is a complex, multifactorial chronic skin disease. As in other chronic disorders, various lifestyle factors have been associated with its morbidity. We have pointed to the significance of the patient's lifestyle practices as they relate to psoriasis outcome. Several reports in the literature suggest that exo...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::My approach to vasculitis and vasculopathy includes: (1) Determine the level of care the patient needs. If I am not sure, I will order a basic laboratory evaluation while I decide on the more specific laboratory tests to order and of course do a skin biopsy. (2) Determine if the eruption represents vasculitis or vascu...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2012-05-01 00:00:00
abstract::We present a case of eosinophilic fasciitis, or Shulman syndrome, in a 35-year-old man and discuss its clinical and histopathologic aspects, as well as its relationship to scleroderma. Although controversial, the tendency is to set Shulman syndrome apart from all other sclerodermiform states. ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract::Lobomycosis is a deep fungal disease of the skin without involvement of internal organs or mucous membranes. The disease is characterized by skin nodules and plaques resembling keloid involving the earlobes, distal parts of the upper and lower extremities, and buttocks. In severe cases, large skin areas can be covered...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract::Three independent clinical studies were conducted in more than 1250 patients with moderate to moderately severe acne vulgaris to evaluate the efficacy and safety of a new combination gel that stably combines 5% benzoyl peroxide and 1% clindamycin. The results indicated that the benzoyl peroxide/clindamycin combination...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy on the bilateral neck. Results from histopathology revealed changes consistent with elastosis perforans serpiginosa (EPS). The idiopathic form of EPS occurs rarely in children....
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Lichen planus (LP) is a chronic and remitting dermatosis that may be idiopathic or associated with underlying systemic diseases, such as hepatitis C virus. Although numerous cases of LP resolve spontaneously, many cases require systemic treatment. Several therapeutic advances have occurred in the last 10 years: acitre...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2011-03-01 00:00:00
abstract::Cutaneous fungal infections in immunocompromised patients can be aggressive and difficult to treat. To determine the safety and efficacy of oral terbinafine for the treatment of tinea corporis or tinea cruris in subjects with human immunodeficiency virus (HIV) infection or diabetes, 2 prospective, randomized, open-lab...
journal_title:Cutis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2001-07-01 00:00:00
abstract::We assess the safety and efficacy of imiquimod cream 3.75% and 2.5% in men with external genital warts (EGWs). Two multicenter, randomized, double-blind, placebo-controlled studies were conducted in a total of 447 (225 from study 1 and 222 from study 2) male patients (aged ≥12 years) with 2 to 30 EGWs and a total wart...
journal_title:Cutis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
更新日期:2015-10-01 00:00:00
abstract::Although actinic keratosis (AK) has been linked to the development of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), increased awareness regarding diagnosis and treatment may be an important component for reducing morbidity and even mortality from AK and NMSC. We used the National Ambulato...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
abstract::Soft tissue lesions are among the most commonly occurring pathologic conditions in the oral cavity. The causes of these lesions can vary from immunologic and viral reactions to underlying systemic disease, dermatologic lesions, or neoplasms. The diagnosis of these conditions is usually based on the history, clinical a...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Erythema gyratum repens (EGR) is a rare and poorly understood dermatosis. The relationship of superficial dermatophytic infection to EGR-like eruptions in mycosis fungoides (MF) is unclear. We present a case of an EGR-like eruption in a patient with Sézary syndrome (SS). Histopathologic examination revealed both a sup...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00