Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity.

Abstract:

:Adiponectin is an important insulin-sensitizing adipokine with multiple beneficial effects on obesity-associated medical complications. It is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). Each oligomeric form of adiponectin exerts non-overlapping biological functions, with the HMW oligomer possessing the most potent insulin-sensitizing activity. In this study, we reported that emodin, a natural product and active ingredient of various Chinese herbs, activates AMPK in both 3T3-L1 adipocytes and 293T cells. Activation of AMPK by emodin promotes the assembly of HMW adiponectin and increases the ratio of HMW adiponectin to total adiponectin in 3T1-L1 adipocytes. Emodin might activate AMPK by an indirect mechanism similar to berberine. We also found that emodin activates PPARγ and promotes differentiation and adiponectin expression during differentiation of 3T3-L1 preadipocytes. Therefore, emodin is a novel AMPK activator with PPARγ-agonist activity. Our results demonstrate that the effects of emodin on adiponectin expression and multimerization are the ultimate effects resulting from both AMPK activation and PPARγ activation. The dual-activity makes emodin or the derivatives potential drug candidates for the treatment of type 2 diabetes and other obesity-related metabolic diseases.

journal_name

J Cell Biochem

authors

Chen Z,Zhang L,Yi J,Yang Z,Zhang Z,Li Z

doi

10.1002/jcb.24232

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

3547-58

issue

11

eissn

0730-2312

issn

1097-4644

journal_volume

113

pub_type

杂志文章
  • Stimulation of pp60c-src tyrosyl kinase activity in polyoma virus-infected mouse cells is closely associated with polyoma middle tumor antigen synthesis.

    abstract::We have examined the effect of polyoma virus infection of primary mouse embryo cells on the tyrosyl kinase activity associated with the cellular src gene product, pp60c-src. The results of our studies demonstrate that infection of mouse cells with wild-type polyoma virus or viral mutants capable of transforming rodent...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240270209

    authors: Bolen JB,Lewis AM Jr,Israel MA

    更新日期:1985-01-01 00:00:00

  • Involvement of NYD-SP15 in growth and oxidative-stress responses of ARPE-19.

    abstract::The aim of this study was to investigate the role of NYD-SP15 in the growth and oxidative-stress responses of ARPE-19 cells. ARPE-19 cell lines overexpressing wild type or RNA interference against NYD-SP15 were established via lentivirus transfection. Cell growth and proliferation, migration, apoptosis, and cell cycle...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27104

    authors: Xu Y,Wang L,Cao L,Chen L,Liu Q

    更新日期:2018-10-28 00:00:00

  • High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.

    abstract::Matrix metalloproteinase-1 (MMP-1) is one of only a few enzymes with the ability to degrade the stromal collagens (types I and III) at neutral pH, and high expression of MMP-1 has been associated with aggressive and invasive cancers. We recently reported a single nucleotide insertion/deletion polymorphism (SNP) in the...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10225

    authors: Benbow U,Tower GB,Wyatt CA,Buttice G,Brinckerhoff CE

    更新日期:2002-01-01 00:00:00

  • Transcriptional regulation of Runx2 by HSP90 controls osteosarcoma apoptosis via the AKT/GSK-3β/β-catenin signaling.

    abstract::Osteosarcoma (OS) is the most malignant primary bone tumor in children and adolescents with limited treatment options and poor prognosis. Recently, aberrant expression of Runx2 has been found in OS, thereby contributing to the development, and progression of OS. However, the upstream signaling molecules that regulate ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26260

    authors: Liang GH,Liu N,He MT,Yang J,Liang ZJ,Gao XJ,Rahhal AH,He QY,Zhang HT,Zha ZG

    更新日期:2018-01-01 00:00:00

  • Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest.

    abstract::Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. While Gemcitabine-based chemotherapy is the first-line treatment for locally advanced pancreatic cancer, its resistance is a large obstacle in the field. Understanding the molecular basis of gemcitabine resistance is therefore ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25921

    authors: Peng T,Dou QP

    更新日期:2017-09-01 00:00:00

  • Modification of blood group A antigen expression in a pancreatic cancer cell line (PC-1) by inhibitors of N-glycan processing.

    abstract::Pancreatic adenocarcinomas induced in Syrian hamsters by treatment with N-nitrosobis(2-oxopropyl) amine express blood group A antigen, which is absent in normal pancreatic cells. On membrane glycoproteins purified from tumors, blood group A antigen has been found to be expressed on multiantennary Asn-linked complex gl...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240500105

    authors: Hirota M,Mogaki M,Pour PM,Chaney WG

    更新日期:1992-09-01 00:00:00

  • Response regulation in bacterial chemotaxis.

    abstract::The signal transduction system that mediates bacterial chemotaxis allows cells to modulate their swimming behavior in response to fluctuations in chemical stimuli. Receptors at the cell surface receive information from the surroundings. Signals are then passed from the receptors to cytoplasmic chemotaxis components: C...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240510109

    authors: Lukat GS,Stock JB

    更新日期:1993-01-01 00:00:00

  • Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts.

    abstract::Cigarette smoking has been suggested as a risk factor for several periodontal diseases. It has also been found that smokers respond less favorably than non-smokers to periodontal therapy. Previous work in our lab has shown that nicotine inhibits human gingival cell migration. Since myofibroblasts play an important rol...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20473

    authors: Fang Y,Svoboda KK

    更新日期:2005-08-15 00:00:00

  • The Ultrastructural Signature of Human Embryonic Stem Cells.

    abstract::The epigenetics and molecular biology of human embryonic stem cells (hES cells) have received much more attention than their architecture. We present a more complete look at hES cells by electron microscopy, with a special emphasis on the architecture of the nucleus. We propose that there is an ultrastructural signatu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25736

    authors: Underwood JM,Becker KA,Stein GS,Nickerson JA

    更新日期:2017-04-01 00:00:00

  • Intrinsic or acquired drug resistance and metastasis: are they linked phenotypes?

    abstract::Evidence is reviewed which suggests a linkage may exist between certain forms of de novo or acquired drug resistance and metastasis. This includes the finding that expression of certain dominantly acting mutant oncogenes or tumor suppressor genes, i.e., genes which normally act to "drive" tumor progression and metasta...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240560108

    authors: Kerbel RS,Kobayashi H,Graham CH

    更新日期:1994-09-01 00:00:00

  • Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells.

    abstract::Individual protein kinase C (PKC) isoforms fulfill distinct roles in the regulation of the commitment to differentiation, cell cycle arrest, and apoptosis in both monocytes and T-cells. The human monocyte like cell line U937 and T-cells were exposed to microgravity, during spaceflight and the translocation (a critical...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10273

    authors: Hatton JP,Gaubert F,Cazenave JP,Schmitt D

    更新日期:2002-01-01 00:00:00

  • Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells.

    abstract::Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by bone and exerts its function in the target organs by binding the FGF receptor (FGFR) and Klotho. Since recent studies suggested that extracellular inorganic phosphate (Pi) itself triggers signal transduction and regulates gene expression in some...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22842

    authors: Yamazaki M,Ozono K,Okada T,Tachikawa K,Kondou H,Ohata Y,Michigami T

    更新日期:2010-12-01 00:00:00

  • Fibronectin assembly regulates lumen formation in breast acini.

    abstract::Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self-assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial-to-mesenchymal transition. ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29885

    authors: Magdaleno C,House T,Pawar JS,Carvalho S,Rajasekaran N,Varadaraj A

    更新日期:2021-01-13 00:00:00

  • Catabolite repression in the gram-positive bacteria: generation of negative regulators of transcription.

    abstract::Operons subject to catabolite repression (CR) in the gram-positive bacteria appear to be transcriptionally regulated by negative acting catabolite repressors. Cis elements within the promoter regions of a few CR operons have been identified as the target sequences for these repressors. It has also been proposed that s...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240510106

    authors: Stewart GC

    更新日期:1993-01-01 00:00:00

  • Peptidomic Analysis of Maternal Serum to Identify Biomarker Candidates for Prenatal Diagnosis of Tetralogy of Fallot.

    abstract::Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expre...

    journal_title:Journal of cellular biochemistry

    pub_type: 临床试验,杂志文章

    doi:10.1002/jcb.26204

    authors: Zhuang B,Hu Y,Fan X,Li M,Zhu J,Liu H,Cao L,Liang D,Zhang J,Yu Z,Han S

    更新日期:2018-01-01 00:00:00

  • Suberoylanilide Hydroxamic Acid Restores Estrogen Reduced-cTnI Expression in Neonatal Hearts of Mice.

    abstract::Diastolic cardiac dysfunction can be caused by abnormality in cTnI expression during cardiogenesis. In this study, we investigated the effects of estrogen on the abnormal expression of cTnI in the hearts of neonatal mice and its potential epigenetic mechanisms. We then evaluated suberoylanilide hydroxamic acid (SAHA),...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25535

    authors: Peng C,Luo X,Xing Q,Sun H,Huang X

    更新日期:2016-10-01 00:00:00

  • Analysis of synonymous codon usage pattern of genes in unique non-blood-sucking leech Whitmania pigra.

    abstract::Whitmania pigra is a unique, fluid-sucking ectoparasite and an anticoagulant medical leech. The codon usage bias (CUB) is the nonuniform usage of synonymous codons in which some codons are more preferred than others. Here, we performed a comprehensive analysis of CUB of genes in W. pigra, analyzing 140 780 transcripts...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28267

    authors: Khan MS,Guan DL,Ma LB,Xie JY,Xu SQ

    更新日期:2019-06-01 00:00:00

  • Effects of hyperprolactinemia on testosterone production in rat Leydig cells.

    abstract::The pathogenesis of hyperprolactinemia (hyperPRL) induced hypogonadism has been suggested to be related with a dysfunction of hypothalamus-pituitary-testis axis. While the direct inhibitory effects of prolactin (PRL) on testosterone (T) release have been demonstrated, the mechanism is still unclear. Our previous study...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/1097-4644(20010301)80:3<313::aid-jcb30>3.0

    authors: Huang WJ,Yeh JY,Kan SF,Chang LS,Wang PS

    更新日期:2001-01-01 00:00:00

  • Exploring the concentration-dependent actions of interferon-τ on bovine neutrophils to understand the process of implantation.

    abstract::Interferon-τ (IFNT) is a major cytokine produced by the ruminant trophoectoderm during the peri-implantation period exerting immunomodulatory actions on various cells including neutrophils. The current in vitro study was undertaken to analyze the concentration-dependent effects of IFNT on neutrophil gene dynamics to u...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27345

    authors: Manjari P,Hyder I,Kapoor S,Senthilnathan M,Dang AK

    更新日期:2018-12-01 00:00:00

  • Interaction between miRNAs and signaling cascades of Wnt pathway in chronic lymphocytic leukemia.

    abstract::Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.29683

    authors: Bhattacharya M,Sharma AR,Sharma G,Patra BC,Lee SS,Chakraborty C

    更新日期:2020-11-01 00:00:00

  • Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycle.

    abstract::Cyclin-dependent kinases (cdks) are the catalytic subunits of a large family of serine/threonine protein kinases whose best-characterized members are key regulators of eukaryotic cell cycle progression. They are activated by binding to regulatory subunits generally termed as cyclins. Cdk10 is a cdc2-related kinase tha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20981

    authors: Bagella L,Giacinti C,Simone C,Giordano A

    更新日期:2006-10-15 00:00:00

  • DJ1 and microRNA-214 act synergistically to rescue myoblast cells after ischemia/reperfusion injury.

    abstract::Ischemia/reperfusion injury is a tissue injury occurring post-reperfusion of tissues with pre-existing ischemia. A good blood supply to tissues aids in the survival of ischemic tissue, however, due to prolonged ischemia the levels of ATP decrease and pH declines leading to acidosis. Reduced ATP leads to an increase in...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26842

    authors: Ghaderi S,Alidadiani N,SoleimaniRad J,Heidari HR,Dilaver N,Heim C,Ramsperger-Gleixner M,Baradaran B,Weyand M

    更新日期:2018-09-01 00:00:00

  • Molecular interactions between p-coumaric acid and snake venom toxins.

    abstract::A large number of natural compounds, such as phenolic compounds, have been scientifically evaluated in the search for enzyme inhibitors. The interactions between the phenolic compound p-coumaric acid and the enzymes present in snake venoms (used as research tools) were evaluated in vitro and in silico. The p-coumaric ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28721

    authors: Cesar PHS,Cardoso Trento MV,Sales TA,Marques TR,Braga MA,Ramalho TC,Marcussi S

    更新日期:2019-09-01 00:00:00

  • Nucleolar spindle-associated protein 1 promotes tumorigenesis and predicts poor prognosis in human esophageal squamous cell carcinoma.

    abstract::The microtubule binding protein, nucleolar spindle-associated protein 1 (NUSAP1), has a crucial function in mitosis and its expression is closely associated with carcinogenesis. Herein, we aimed to determine the function of NUSAP1 in the development of human esophageal squamous cell carcinoma (ESCC), and the associati...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28452

    authors: Guan C,Liu Z,Lu C,Xiao M,Shi H,Ni R,Bian Z

    更新日期:2019-02-21 00:00:00

  • Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer.

    abstract::Colorectal cancer is the third most common cancer with a 5-year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal cancer suggesting anti-EGFR therapy ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.22905

    authors: Chen J,Huang XF,Katsifis A

    更新日期:2010-12-01 00:00:00

  • Shikonin Inhibited Migration and Invasion of Human Lung Cancer Cells via Suppression of c-Met-Mediated Epithelial-to-Mesenchymal Transition.

    abstract::Epithelial-to-mesenchymal transition (EMT) is a major process to regulate cell migration and invasion. Inhibition of epidermal growth factor receptor (EGFR)-mediated EMT by tyrosine kinase inhibitors (TKIs) is a strategy to prevent lung cancer invasion. However, drug resistance is emerged and accelerated invasion thro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26128

    authors: Hsieh YS,Liao CH,Chen WS,Pai JT,Weng MS

    更新日期:2017-12-01 00:00:00

  • Merosin (laminin-2/4)-driven survival signaling: complex modulations of Bcl-2 homologs.

    abstract::We have shown previously that the promotion of myofiber survival by the basement membrane component merosin (laminin-2 [alpha2beta1gamma1]/laminin-4 [alpha2beta2gamma1]) is dependent on the activity of the tyrosine kinase Fyn, whereas myofiber anoikis induced by merosin deficiency is dependent on the stress-activated ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10581

    authors: Laprise P,Vallée K,Demers MJ,Bouchard V,Poirier EM,Vézina A,Reed JC,Rivard N,Vachon PH

    更新日期:2003-08-15 00:00:00

  • Further characterization of the human cell multiprotein DNA replication complex.

    abstract::Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240590111

    authors: Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

    更新日期:1995-09-01 00:00:00

  • Automated Analysis of Cell Cycle Phase-Specific DNA Damage Reveals Phase-Specific Differences in Cell Sensitivity to Etoposide.

    abstract::The comet assay is one of the most widely used approaches for detecting DNA damage; generally, it provides information on the cell population-averaged level of DNA damage. Here, we present an automatic technique for easy measurement of standard comet characteristics and an annotation of the cell cycle phase of each co...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25615

    authors: Luzhin AV,Velichko AK,Razin SV,Kantidze OL

    更新日期:2016-10-01 00:00:00

  • Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy.

    abstract:BACKGROUND AND AIM:Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, is very critical to health maintenance, for a wide range of human chronic diseases, including cancers. AMP-activated protein kinase (AMPK) has been implicated in the activation of autophagy in distinct tissues. This study wa...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27491

    authors: Zhang Y,Liu S,Feng Q,Huang X,Wang X,Peng Y,Zhao Z,Liu Z

    更新日期:2018-10-30 00:00:00