Tropism and pathogenicity of rickettsiae.

Abstract:

:Rickettsiae are obligate intracellular parasitic bacteria that cause febrile exanthematous illnesses such as Rocky Mountain spotted fever, Mediterranean spotted fever, epidemic, and murine typhus, etc. Although the vector ranges of each Rickettsia species are rather restricted; i.e., ticks belonging to Arachnida and lice and fleas belonging to Insecta usually act as vectors for spotted fever group (SFG) and typhus group (TG) rickettsiae, respectively, it would be interesting to elucidate the mechanisms controlling the vector tropism of rickettsiae. This review discusses the factors determining the vector tropism of rickettsiae. In brief, the vector tropism of rickettsiae species is basically consistent with their tropism toward cultured tick and insect cells. The mechanisms responsible for rickettsiae pathogenicity are also described. Recently, genomic analyses of rickettsiae have revealed that they possess several genes that are homologous to those affecting the pathogenicity of other bacteria. Analyses comparing the genomes of pathogenic and non-pathogenic strains of rickettsiae have detected many factors that are related to rickettsial pathogenicity. It is also known that a reduction in the rickettsial genome has occurred during the course of its evolution. Interestingly, Rickettsia species with small genomes, such as Rickettsia prowazekii, are more pathogenic to humans than those with larger genomes. This review also examines the growth kinetics of pathogenic and non-pathogenic species of SFG rickettsiae (SFGR) in mammalian cells. The growth of non-pathogenic species is restricted in these cells, which is mediated, at least in part, by autophagy. The superinfection of non-pathogenic rickettsiae-infected cells with pathogenic rickettsiae results in an elevated yield of the non-pathogenic rickettsiae and the growth of the pathogenic rickettsiae. Autophagy is restricted in these cells. These results are discussed in this review.

journal_name

Front Microbiol

authors

Uchiyama T

doi

10.3389/fmicb.2012.00230

subject

Has Abstract

pub_date

2012-06-25 00:00:00

pages

230

issn

1664-302X

journal_volume

3

pub_type

杂志文章
  • Variation in the nuclear effects of infection by different human rhinovirus serotypes.

    abstract::Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localization of host proteins. A number of studies have identified differences between HRV serotypes, with respect to host response, protease activity and replica...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00875

    authors: Walker EJ,Jensen LM,Croft S,Ghildyal R

    更新日期:2015-08-24 00:00:00

  • Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor.

    abstract::Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia. We recently reported that BRSV infection significantly increased PM adherence to bovine lower respiratory tract epithelial cells. However, the molecular mechanis...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01676

    authors: Sudaryatma PE,Saito A,Mekata H,Kubo M,Fahkrajang W,Mazimpaka E,Okabayashi T

    更新日期:2020-07-31 00:00:00

  • Long term seasonal dynamics of synechococcus population structure in the gulf of aqaba, northern red sea.

    abstract::Spatial patterns of marine Synechococcus diversity across ocean domains have been reported on extensively. However, much less is known of seasonal and multiannual patterns of change in Synechococcus community composition. Here we report on the genotypic diversity of Synechococcus populations in the Gulf of Aqaba, Nort...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2011.00131

    authors: Post AF,Penno S,Zandbank K,Paytan A,Huse SM,Welch DM

    更新日期:2011-06-20 00:00:00

  • Host Gender and Androgen Levels Regulate Gut Bacterial Taxa in Pigs Leading to Sex-Biased Serum Metabolite Profiles.

    abstract::Gut microbiota regulates host metabolism and immunity. The phylogenetic composition of gut microbiota is influenced by diverse factors that include host gender. In this study, the effects of gender on gut microbial composition and its subsequent influence on serum metabolites in pigs were evaluated. The bacterial comp...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01359

    authors: He M,Gao J,Wu J,Zhou Y,Fu H,Ke S,Yang H,Chen C,Huang L

    更新日期:2019-06-18 00:00:00

  • A Chip for Detecting Tuberculosis Drug Resistance Based on Polymerase Chain Reaction (PCR)-Magnetic Bead Molecule Platform.

    abstract::Objective: A Tag Array chip was used to detect plasmids of different template concentration, and then analyzed for sensitivity and specificity. Drug resistance genes from tuberculosis clinical specimens were detected, giving comparative phenotypic resistance results to explore the feasibility and value of clinical app...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02106

    authors: Lyu J,Wu W,Cheng P,Liu X,Luo F,Zhang Z,Tang K,Xu J

    更新日期:2018-09-07 00:00:00

  • Host Matters: Medicinal Leech Digestive-Tract Symbionts and Their Pathogenic Potential.

    abstract::Digestive-tract microbiota exert tremendous influence over host health. Host-symbiont model systems are studied to investigate how symbioses are initiated and maintained, as well as to identify host processes affected by resident microbiota. The medicinal leech, Hirudo verbana, is an excellent model to address such qu...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.01569

    authors: Marden JN,McClure EA,Beka L,Graf J

    更新日期:2016-10-13 00:00:00

  • Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.

    abstract::Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has emerged as a global pandemic worldwide. In this study, we used ARTIC primers-based amplicon sequencing to profile 225 SARS-CoV-2 genomes from India. Phylogenetic analysis of 202 high-quality assem...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.594928

    authors: Raghav S,Ghosh A,Turuk J,Kumar S,Jha A,Madhulika S,Priyadarshini M,Biswas VK,Shyamli PS,Singh B,Singh N,Singh D,Datey A,Avula K,Smita S,Sabat J,Bhattacharya D,Kshatri JS,Vasudevan D,Suryawanshi A,Dash R,Senapati

    更新日期:2020-11-23 00:00:00

  • Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection.

    abstract::Peptidoglycan (PGN) recognition proteins (PGLYRPs) are a highly conserved group of host defense proteins in insects and mammals that sense bacterial cell wall PGN and act bactericidally or cleave PGN by amidase function. Streptococcus (S.) pneumoniae is one of the top five killers worldwide and causes, e.g., pneumonia...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00199

    authors: Dabrowski AN,Conrad C,Behrendt U,Shrivastav A,Baal N,Wienhold SM,Hackstein H,N'Guessan PD,Aly S,Reppe K,Suttorp N,Zahlten J

    更新日期:2019-02-19 00:00:00

  • Alternaria Toxins: Potential Virulence Factors and Genes Related to Pathogenesis.

    abstract::Alternaria is an important fungus to study due to their different life style from saprophytes to endophytes and a very successful fungal pathogen that causes diseases to a number of economically important crops. Alternaria species have been well-characterized for the production of different host-specific toxins (HSTs)...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2017.01451

    authors: Meena M,Gupta SK,Swapnil P,Zehra A,Dubey MK,Upadhyay RS

    更新日期:2017-08-08 00:00:00

  • Emerging Priorities for Microbiome Research.

    abstract::Microbiome research has increased dramatically in recent years, driven by advances in technology and significant reductions in the cost of analysis. Such research has unlocked a wealth of data, which has yielded tremendous insight into the nature of the microbial communities, including their interactions and effects, ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2020.00136

    authors: Cullen CM,Aneja KK,Beyhan S,Cho CE,Woloszynek S,Convertino M,McCoy SJ,Zhang Y,Anderson MZ,Alvarez-Ponce D,Smirnova E,Karstens L,Dorrestein PC,Li H,Sen Gupta A,Cheung K,Powers JG,Zhao Z,Rosen GL

    更新日期:2020-02-19 00:00:00

  • Silencing of Anopheles stephensi Heme Peroxidase HPX15 Activates Diverse Immune Pathways to Regulate the Growth of Midgut Bacteria.

    abstract::Anopheles mosquito midgut harbors a diverse group of endogenous bacteria that grow extensively after the blood feeding and help in food digestion and nutrition in many ways. Although, the growth of endogenous bacteria is regulated by various factors, however, the robust antibacterial immune reactions are generally sup...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01351

    authors: Kajla M,Choudhury TP,Kakani P,Gupta K,Dhawan R,Gupta L,Kumar S

    更新日期:2016-08-31 00:00:00

  • Transcriptional Regulation of the Type VI Secretion System 1 Genes by Quorum Sensing and ToxR in Vibrio parahaemolyticus.

    abstract::Vibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis, harbors two separate T6SSs on chromosomes 1 and 2, i.e., T6SS1 (VP1386-1420) and T6SS2 (VPA1025-1046). T6SS1 contains at least 7 putative operons: VP1386-1387, VP1388-1390, VP1392-1391, VP1393-1406, VP1400-1406, VP1409-1407, and VP1410-1...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02005

    authors: Zhang Y,Gao H,Osei-Adjei G,Zhang Y,Yang W,Yang H,Yin Z,Huang X,Zhou D

    更新日期:2017-10-16 00:00:00

  • Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK) protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain.

    abstract::Helicobacter pylori does not encode the classical DsbA/DsbB oxidoreductases that are crucial for oxidative folding of extracytoplasmic proteins. Instead, this microorganism encodes an untypical two proteins playing a role in disulfide bond formation - periplasmic HP0231, which structure resembles that of EcDsbC/DsbG, ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01065

    authors: Bocian-Ostrzycka KM,Łasica AM,Dunin-Horkawicz S,Grzeszczuk MJ,Drabik K,Dobosz AM,Godlewska R,Nowak E,Collet JF,Jagusztyn-Krynicka EK

    更新日期:2015-10-08 00:00:00

  • Interactions Between Thiamethoxam and Deformed Wing Virus Can Drastically Impair Flight Behavior of Honey Bees.

    abstract::Exposure to multiple stress factors is believed to contribute to honey bee colony decline. However, little is known about how co-exposure to stress factors can alter the survival and behavior of free-living honey bees in colony conditions. We therefore studied the potential interaction between a neonicotinoid pesticid...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00766

    authors: Coulon M,Dalmon A,Di Prisco G,Prado A,Arban F,Dubois E,Ribière-Chabert M,Alaux C,Thiéry R,Le Conte Y

    更新日期:2020-04-30 00:00:00

  • Genomic Characterization of Sulphite Reducing Bacteria Isolated From the Dairy Production Chain.

    abstract::Anaerobic sporeformers, specifically spoilage and pathogenic members of the genus Clostridium, are a concern for producers of dairy products, and of powdered dairy products in particular. As an alternative to testing for individual species, the traditional, and still current, approach to detecting these sporeformers, ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01507

    authors: Doyle CJ,O'Toole PW,Cotter PD

    更新日期:2018-07-05 00:00:00

  • Role of Dilution Rate and Nutrient Availability in the Formation of Microbial Biofilms.

    abstract::We revisited the mathematical model of the chemostat and examined consequences of considerably decreasing the concentration of limiting nutrient in the inflow for the growth of both the planktonic and biofilm cells in the chemostat tank (fermenter). The model predicts a substantially lower steady-state biomass of plan...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00916

    authors: Legner M,McMillen DR,Cvitkovitch DG

    更新日期:2019-04-30 00:00:00

  • Responses of beneficial Bacillus amyloliquefaciens SQR9 to different soilborne fungal pathogens through the alteration of antifungal compounds production.

    abstract::Bacillus amyloliquefaciens SQR9 exhibited predominantly antagonistic activities against a broad range of soilborne pathogens. The fungi-induced SQR9 extracts possess stronger antifungal activities compared with SQR9 monoculture extracts. To investigate how SQR9 fine-tunes lipopeptides (LPs) and a siderophore bacilliba...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00636

    authors: Li B,Li Q,Xu Z,Zhang N,Shen Q,Zhang R

    更新日期:2014-11-21 00:00:00

  • Silver As Antibacterial toward Listeria monocytogenes.

    abstract::Listeria monocytogenes is a serious foodborne pathogen that can contaminate food during processing and can grow during food shelf-life. New types of safe and effective food contact materials embedding antimicrobial agents, like silver, can play an important role in the food industry. The present work aimed at evaluati...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00307

    authors: Belluco S,Losasso C,Patuzzi I,Rigo L,Conficoni D,Gallocchio F,Cibin V,Catellani P,Segato S,Ricci A

    更新日期:2016-03-07 00:00:00

  • RskA Is a Dual Function Activator-Inhibitor That Controls SigK Activity Across Distinct Bacterial Genera.

    abstract::It has been previously shown that RskA, the anti-Sigma factor K of Mycobacterium tuberculosis, inhibits SigK and that mutations in RskA promote high expression of the SigK regulon. The latter observation led us to hypothesize that RskA mutations lead to loss of the anti-Sigma factor function. In this report, we used n...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.558166

    authors: Veyrier FJ,Nieves C,Lefrancois LH,Trigui H,Vincent AT,Behr MA

    更新日期:2020-09-09 00:00:00

  • The Russian Doll Model: How Bacteria Shape Successful and Sustainable Inter-Kingdom Relationships.

    abstract::Successful inter-kingdom relationships are based upon a dynamic balance between defense and cooperation. A certain degree of competition is necessary to guarantee life spread and development. On the other hand, cooperation is a powerful tool to ensure a long lasting adaptation to changing environmental conditions and ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2020.573759

    authors: Pessione E

    更新日期:2020-10-20 00:00:00

  • Characterization of Vibrio cholerae's Extracellular Nuclease Xds.

    abstract::The Gram-negative bacterium Vibrio cholerae encodes two nucleases, Dns and Xds, which play a major role during the human pathogen's lifecycle. Dns and Xds control three-dimensional biofilm formation and bacterial detachment from biofilms via degradation of extracellular DNA and thus contribute to the environmental, in...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02057

    authors: Pressler K,Mitterer F,Vorkapic D,Reidl J,Oberer M,Schild S

    更新日期:2019-09-10 00:00:00

  • Gene Turnover Contributes to the Evolutionary Adaptation of Acidithiobacillus caldus: Insights from Comparative Genomics.

    abstract::Acidithiobacillus caldus is an extremely acidophilic sulfur-oxidizer with specialized characteristics, such as tolerance to low pH and heavy metal resistance. To gain novel insights into its genetic complexity, we chosen six A. caldus strains for comparative survey. All strains analyzed in this study differ in geograp...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01960

    authors: Zhang X,Liu X,He Q,Dong W,Zhang X,Fan F,Peng D,Huang W,Yin H

    更新日期:2016-12-06 00:00:00

  • From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products.

    abstract::The new era of multidrug resistance of pathogens against frontline antibiotics has compromised the immense therapeutic gains of the 'golden age,' stimulating a resurgence in antimicrobial research focused on antimicrobial and immunomodulatory components of botanical, fungal or microbial origin. While much valuable inf...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2019.02470

    authors: Sadgrove NJ,Jones GL

    更新日期:2019-10-31 00:00:00

  • A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni.

    abstract::The bipolar flagella of the foodborne bacterial pathogen Campylobacter jejuni confer motility, which is essential for virulence. The flagella of C. jejuni are post-translationally modified, but how this process is controlled is not well understood. In this work, we have identified a novel PAS-domain containing regulat...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00770

    authors: Reuter M,Periago PM,Mulholland F,Brown HL,van Vliet AH

    更新日期:2015-07-30 00:00:00

  • Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework.

    abstract::Paracoccidioidomycosis (PCM) is the most prevalent endemic mycosis in Latin America. The disease is caused by fungi of the genus Paracoccidioides and mainly affects low-income rural workers after inhalation of fungal conidia suspended in the air. The current arsenal of chemotherapeutic agents requires long-term admini...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01301

    authors: de Oliveira AA,Neves BJ,Silva LDC,Soares CMA,Andrade CH,Pereira M

    更新日期:2019-06-12 00:00:00

  • The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome.

    abstract::The human gut is inhabited by diverse microorganisms that play crucial roles in health and disease. Gut microbiota dysbiosis is increasingly considered as a vital factor in the etiopathogenesis of irritable bowel syndrome (IBS), which is a common functional gastrointestinal disorder with a high incidence all over the ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2019.01894

    authors: Gu Y,Zhou G,Qin X,Huang S,Wang B,Cao H

    更新日期:2019-08-21 00:00:00

  • Microbial Community Structure and the Persistence of Cyanobacterial Populations in Salt Crusts of the Hyperarid Atacama Desert from Genome-Resolved Metagenomics.

    abstract::Although once thought to be devoid of biology, recent studies have identified salt deposits as oases for life in the hyperarid Atacama Desert. To examine spatial patterns of microbial species and key nutrient sources, we genomically characterized 26 salt crusts from three sites along a fog gradient. The communities ar...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01435

    authors: Finstad KM,Probst AJ,Thomas BC,Andersen GL,Demergasso C,Echeverría A,Amundson RG,Banfield JF

    更新日期:2017-07-28 00:00:00

  • Detection and Genetic Characterization of Atypical Porcine Pestivirus in Piglets With Congenital Tremors in Southern China.

    abstract::Atypical porcine pestivirus (APPV) is an RNA virus newly discovered from swine in Asia, Europe, and the Americas. This novel virus has been confirmed as the cause of congenital tremor (CT) in piglets, which causes extensive economic losses to the swine industry. To investigate the genetic diversity and evolutionary re...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01406

    authors: Xie Y,Wang X,Su D,Feng J,Wei L,Cai W,Li J,Lin S,Yan H,He D

    更新日期:2019-06-20 00:00:00

  • Characterization of Two Novel Bacteriophages Infecting Multidrug-Resistant (MDR) Acinetobacter baumannii and Evaluation of Their Therapeutic Efficacy in Vivo.

    abstract::Acinetobacter baumannii is emerging as a challenging nosocomial pathogen due to its rapid evolution of antibiotic resistance. We report characterization of two novel bacteriophages, PBAB08 and PBAB25, infecting clinically isolated, multidrug-resistant (MDR) A. baumannii strains. Both phages belonged to Myoviridae of C...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00696

    authors: Cha K,Oh HK,Jang JY,Jo Y,Kim WK,Ha GU,Ko KS,Myung H

    更新日期:2018-04-10 00:00:00

  • MALDI-TOF MS Affords Discrimination of Deinococcus aquaticus Isolates Obtained From Diverse Biofilm Habitats.

    abstract::Matrix-assisted Laser Desorption Ionization-Time of Flight Mass Spectroscopy (MALDI-TOF MS) has been used routinely over the past decade in clinical microbiology laboratories to rapidly characterize diverse microorganisms of medical importance both at the genus and species levels. Currently, there is keen interest in ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02442

    authors: Tuohy JM,Mueller-Spitz SR,Albert CM,Scholz-Ng SE,Wall ME,Noutsios GT,Gutierrez AJ,Sandrin TR

    更新日期:2018-10-15 00:00:00