H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine.

abstract：:Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons. Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem. Mice lacking Zfhx4 died shortly after birth from an apparent inabil...

journal_title：Journal of molecular cell biology

authors： Zhang M,Du S,Ou H,Cui R,Jiang N,Lin Y,Ge R,Ma D,Zhang J

更新日期：2021-01-20 00:00:00

abstract：:Bacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group ...

journal_title：Journal of molecular cell biology

authors： Perera IC,Grove A

更新日期：2010-10-01 00:00:00

abstract：:HIV-Tat-interacting protein of 60 kDa (TIP60) is a lysine acetyltransferase and known to be downregulated in multiple cancers. Among various signalling pathways, TIP60 is implicated in regulating epithelial-mesenchymal transition (EMT). Here, we show that TIP60 expression abrogates cell migration and metastatic potent...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Subbaiah VK,Rajagopalan D,Tham CY,Abdullah LN,Toh TB,Gong M,Tan TZ,Jadhav SP,Pandey AK,Karnani N,Chow EK,Thiery JP,Jha S

更新日期：2016-10-01 00:00:00

abstract：:Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets t...

journal_title：Journal of molecular cell biology

authors： Han H,Li W,Shen H,Zhang J,Zhu Y,Li Y

更新日期：2016-10-01 00:00:00

abstract：:Understanding the mechanism of how cholangiocytes (liver ductal cells) are activated upon liver injury and specified to hepatocytes would permit liver regenerative medicine. Here we achieved long-term in vitro expansion of mouse liver organoids by modulating signaling pathways with a combination of three small-molecul...

journal_title：Journal of molecular cell biology

authors： Wang X,Ni C,Jiang N,Wei J,Liang J,Zhao B,Lin X

更新日期：2020-08-01 00:00:00

abstract：:Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly know...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Chen Y,Zheng J,Wang J,Duan S,Zhang W,Yan X,Zhu X

更新日期：2019-05-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targe...

journal_title：Journal of molecular cell biology

authors： Liu S,Wang Z,Liu Z,Shi S,Zhang Z,Zhang J,Lin H

更新日期：2018-08-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can gen...

journal_title：Journal of molecular cell biology

authors： Qiu J,Fan X,Wang Y,Jin H,Song Y,Han Y,Huang S,Meng Y,Tang F,Meng A

更新日期：2016-08-01 00:00:00

abstract：:Human colon carcinomas (CCs) represent a growing worldwide problem. One of the pathways that has been negatively implicated in the genesis of CCs is triggered by bone morphogenetic protein (BMP) ligands, which activate BMP receptors leading to the function of SMAD proteins in the nucleus. BMP signaling is altered in f...

journal_title：Journal of molecular cell biology

authors： Lorente-Trigos A,Varnat F,Melotti A,Ruiz i Altaba A

更新日期：2010-12-01 00:00:00

abstract：:The activity of dopaminergic neurons are thought to be increased by stimuli that predict reward and decreased by stimuli that predict aversive outcomes. Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of d...

journal_title：Journal of molecular cell biology

authors： Frank MJ,Surmeier DJ

更新日期：2009-10-01 00:00:00

abstract：:For patients with COVID-19 caused by SARS-CoV-2, the damages to multiple organs have been clinically observed. Since most of current investigations for virus-host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected pr...

journal_title：Journal of molecular cell biology

authors： Feng L,Yin YY,Liu CH,Xu KR,Li QR,Wu JR,Zeng R

更新日期：2020-07-08 00:00:00

abstract：:Normal tissues are organized in a hierarchical model, whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies, leading to normal development and homeostasis. Alike, tumors are organized in a hierarchical manner, with cancer SCs residin...

journal_title：Journal of molecular cell biology

authors： Koifman G,Aloni-Grinstein R,Rotter V

更新日期：2019-07-19 00:00:00

abstract：:The cranial neural crest (CNC) cells play a vital role in craniofacial development and regeneration. They are multi-potent progenitors, being able to differentiate into various types of tissues. Both pre-migratory and post-migratory CNC cells are plastic, taking on diverse fates by responding to different inductive si...

journal_title：Journal of molecular cell biology

authors： Shao M,Liu C,Song Y,Ye W,He W,Yuan G,Gu S,Lin C,Ma L,Zhang Y,Tian W,Hu T,Chen Y

更新日期：2015-10-01 00:00:00

abstract：:The involvement of microRNAs (miRNAs) in the development of the neural crest (NC) cells and other neuronal differentiation is still poorly understood. Here, we investigated the global function of miRNAs in embryonic development by examining the Wnt1-cre-mediated Dicer knockout mice. Dicer ablation resulted in malforma...

journal_title：Journal of molecular cell biology

authors： Huang T,Liu Y,Huang M,Zhao X,Cheng L

更新日期：2010-06-01 00:00:00

abstract：:Our earlier studies have demonstrated that the cigarette smoke in the form of cigarette smoke condensate (CSC) causes growth arrest of a mouse spermatocyte cell line [GC-2spd(ts)] through activation of the AHR-NRF2 pathway. The present study demonstrates the CSC-activated p38 and ERK MAPK signaling in GC-2spd(ts) via ...

journal_title：Journal of molecular cell biology

authors： Esakky P,Hansen DA,Drury AM,Moley KH

更新日期：2015-02-01 00:00:00

abstract：:We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear. Here, we examined the vital functions of HBV-miR-3 in the innate immu...

journal_title：Journal of molecular cell biology

authors： Zhao X,Sun L,Mu T,Yi J,Ma C,Xie H,Liu M,Tang H

更新日期：2020-05-18 00:00:00

abstract：:The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological pro...

journal_title：Journal of molecular cell biology

authors： Gonzalez-Pecchi V,Kwan AK,Doyle S,Ivanov AA,Du Y,Fu H

更新日期：2020-07-03 00:00:00

abstract：:As many human sensory and cognitive diseases are caused by irreversible damage or loss of certain types of neurons, methodologies aimed at replacement of lost neurons are key to restore lost sensation. Recent advances in generation of ear-cell progenitors, optic-cup structures and cortical neurons from human embryonic...

journal_title：Journal of molecular cell biology

authors： Zhang K,Yi F,Liu GH,Belmonte JC

更新日期：2013-04-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase that plays key roles in cellular regulation. It forms complexes with additional proteins. The best-understood one is mTOR complex 1 (mTORC1). The regulation and cellular functions of mTORC1 have been the subjects of intense study; despite this, many question...

journal_title：Journal of molecular cell biology

authors： Wang X,Proud CG

更新日期：2011-08-01 00:00:00

abstract：:We present a computational study of tissue transcriptomic data of 14 cancer types to address: what may drive cancer cell division? Our analyses point to that persistent disruption of the intracellular pH by Fenton reactions may be at the root of cancer development. Specifically, we have statistically demonstrated that...

journal_title：Journal of molecular cell biology

authors： Sun H,Zhang C,Cao S,Sheng T,Dong N,Xu Y

更新日期：2018-10-01 00:00:00

abstract：:SRY-related HMG-box gene 2 (SOX2) is one of the key regulatory genes that maintain the pluripotency and self-renewal properties in embryonic stem cells. Here we used immunohistochemistry to analyze the expression of SOX2 in human prostate tissues and found it contributed to tumorigenesis and correlated with histologic...

journal_title：Journal of molecular cell biology

authors： Jia X,Li X,Xu Y,Zhang S,Mou W,Liu Y,Liu Y,Lv D,Liu CH,Tan X,Xiang R,Li N

更新日期：2011-08-01 00:00:00

abstract：:Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the...

journal_title：Journal of molecular cell biology

authors： Wu M,Lin Z,Ma S,Chen T,Jiang R,Wong WH

更新日期：2017-12-01 00:00:00

abstract：:RAD9 regulates multiple cellular processes that influence genomic integrity, and for at least some of its functions the protein acts as part of a heterotrimeric complex bound to HUS1 and RAD1 proteins. RAD9 participates in DNA repair, including base excision repair, homologous recombination repair and mismatch repair,...

journal_title：Journal of molecular cell biology

authors： Lieberman HB,Bernstock JD,Broustas CG,Hopkins KM,Leloup C,Zhu A

更新日期：2011-02-01 00:00:00

abstract：:Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression, yet the underlying mechanisms and functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature ...

journal_title：Journal of molecular cell biology

authors： Liu L,Wu Y,Zhang C,Zhou C,Li Y,Zeng Y,Zhang C,Li R,Luo D,Wang L,Zhang L,Tu S,Deng H,Luo S,Chen YG,Xiong X,Yan X

更新日期：2020-09-01 00:00:00

abstract：:Mycobacterium tuberculosis is one of the most notorious killers worldwide. These pathogens have evolved to infect human beings in a so-called dormant form that is extremely difficult to treat. New work, however, suggests that mycobacterial proteasomes, multicomponent structures that protect the microbe from damaging e...

journal_title：Journal of molecular cell biology

authors： Cheng Y,Pieters J

更新日期：2010-08-01 00:00:00

abstract：:Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark. However, a complete...

journal_title：Journal of molecular cell biology

authors： Cao L,Xia X,Kong Y,Jia F,Yuan B,Li R,Li Q,Wang Y,Cui M,Dai Z,Zheng H,Christensen J,Zhou Y,Wu X

更新日期：2020-09-01 00:00:00

abstract：:Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed inn...

journal_title：Journal of molecular cell biology

authors： Aning OA,Cheok CF

更新日期：2019-03-01 00:00:00

abstract：:Mammalian fertilization involves membrane events-adhesion, fusion, sperm engulfment, membrane block to polyspermy-whose causes remain largely unknown. Recently, specific oscillations of the sperm in contact with the egg were shown to be necessary for fusion. Using a microfluidic chip to impose the venue for the encoun...

journal_title：Journal of molecular cell biology

authors： Ravaux B,Favier S,Perez E,Gourier C

更新日期：2018-12-01 00:00:00

abstract：:Dying cells actively attract professional phagocytes by sending out soluble 'find-me' signals. The characterization and identification of the corresponding molecular entities have revealed that 'find-me' signals come in different flavors, including peptides, proteins, lipids and complex structures, such as apoptotic m...

journal_title：Journal of molecular cell biology

authors： Peter C,Wesselborg S,Lauber K

更新日期：2010-04-01 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show how specific modification of HDAC1 by SUMO1, but not by SUMO2, facilitates HDAC1 degradation. ...

journal_title：Journal of molecular cell biology

authors： Citro S,Jaffray E,Hay RT,Seiser C,Chiocca S

更新日期：2013-12-01 00:00:00