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Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete.

Abstract：

OBJECTIVES:Timely and comprehensive reporting of clinical trial results builds the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs). STUDY DESIGN AND SETTING:For all German UMCs, we tracked all registered trials completed between 2009 and 2013. The results and an interactive website benchmark German UMCs regarding their performance in result dissemination. RESULTS:We identified and tracked 2,132 clinical trials. For 1,509 trials, one of the German UMCs took the academic lead. Of these 1,509 "lead trials," 39% published their results (mostly via journal publications) in a timely manner (<24 months after completion). More than 6 years after study completion, 26% of all eligible lead trials still had not disseminated results. CONCLUSION:Despite substantial attention from many stakeholders to the topic, there is still a strong delay or even absence of result dissemination for many trials. German UMCs have several opportunities to improve this situation. Further research should evaluate whether and how a transparent benchmarking of UMC performance in result dissemination helps to increase value and reduce waste in medical research.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Wieschowski S,Riedel N,Wollmann K,Kahrass H,Müller-Ohlraun S,Schürmann C,Kelley S,Kszuk U,Siegerink B,Dirnagl U,Meerpohl J,Strech D

doi

10.1016/j.jclinepi.2019.06.002

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

37-45

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(18)31063-1

journal_volume

115

pub_type

杂志文章

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