Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.

Abstract:

:Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Zhang Y,Kutateladze TG

doi

10.1016/j.molcel.2019.05.013

subject

Has Abstract

pub_date

2019-06-06 00:00:00

pages

862-863

issue

5

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(19)30385-5

journal_volume

74

pub_type

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