Abstract:
:Prostate cancer is a significant health concern. In the early stages, prostate cancer cells depend on androgens for growth and survival, hence androgen-ablation therapy at this time may be effective in causing tumor regression. However, treatment options for advanced hormone-refractory prostate cancers are still relatively inefficient. This study aimed to investigate the possible effects of TRPM8 on the proliferation and angiogenesis of androgen-independent cancer PC-3 cells in vivo. Thirty male nude mice were divided into three groups: the PC-3, PC-3-vector and PC-3-TRPM8 groups. PC-3, PC-3-vector and PC-3-TRPM8 cells were respectively inoculated in the right flank to establish a transplanted tumor model. The mice were treated daily for four weeks and each group was examined by histology and immunohistochemical staining for CD34, FAK and PCNA. A CD34 marked microvascular density (MVD) test was performed. Western blot analysis was used to detect the VEGF protein expression level. Compared to the PC-3 and PC-3-vector groups, the PC-3-TRPM8 group revealed a decrease in tumor volume (P=0.000 and P=0.000, respectively), MVD (P=0.045 and P=0.041, respectively), VEGF (P=0.000 and P=0.000, respectively), FAK and PCNA. The correlation between MVD and VEGF was positive (r=0.419; P=0.021). These data show that the overexpression of TRPM8 had a negative effect on the proliferation and angiogenesis progression of PC-3 cells in vivo.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhu G,Wang X,Yang Z,Cao H,Meng Z,Wang Y,Chen Ddoi
10.3892/ol.2011.410subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1213-1217issue
6eissn
1792-1074issn
1792-1082pii
ol-02-06-1213journal_volume
2pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::In the present study, the effect of immunophenotyping on the prognoses of patients with multiple myeloma (MM) treated with bortezomib plus dexamethasone was investigated. The study involved 46 patients with MM, and analyzed the prognostic significance of the expression of cluster of differentiation (CD)45, CD56 and ma...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5920
更新日期:2017-05-01 00:00:00
abstract::Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5449
更新日期:2017-01-01 00:00:00
abstract::Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3193
更新日期:2015-07-01 00:00:00
abstract::The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5325
更新日期:2016-12-01 00:00:00
abstract::A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endotheli...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2104
更新日期:2014-07-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) are identified to serve key functions in the progression of various tumors. miR-214 is aberrantly expressed in various types of cancer. In the present study, the function of miR-214 and its feasibility as a potential non-invasive biomarker for patients with prostate cancer (PCa) in a hyperplasi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9522
更新日期:2019-01-01 00:00:00
abstract::Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in orde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5761
更新日期:2017-04-01 00:00:00
abstract::Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5099
更新日期:2016-11-01 00:00:00
abstract::Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic mar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10982
更新日期:2019-12-01 00:00:00
abstract::In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1398
更新日期:2013-08-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1983
更新日期:2014-06-01 00:00:00
abstract::Long non-coding RNA (lncRNA) has been implicated in various types of human cancer. However, the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in gastric cancer remains unclear. In the present study, MALAT1 expression was significantly upregulated in gastric tumors compared with adjacen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10253
更新日期:2019-06-01 00:00:00
abstract::Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10021
更新日期:2019-04-01 00:00:00
abstract::The present study describes the case of a 48-year-old man who was diagnosed with lung adenocarcinoma with an epidermal growth factor receptor (EGFR) 21 L858R mutation. The patient received surgery and adjuvant chemotherapy. When multiple lung metastases appeared, icotinib was administered. Following resistance to icot...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8040
更新日期:2018-04-01 00:00:00
abstract::Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and as a potential target for cancer therapy. In this study, F§FJ-5, a characterized naphthoquinone modifier of mollugin, was synthesized in order to investigate its anticancer activity and the potential mechanisms. It was observed...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5522
更新日期:2017-02-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in different types of cancer, including gastric cancer. Although altered lncRNAs profiles have been observed in or around gastric cancer tissues, the diagnostic value of circulating lncRNAs in gastric cancer remains unclear. In the present study, a n...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9199
更新日期:2018-10-01 00:00:00
abstract::Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6050
更新日期:2017-06-01 00:00:00
abstract::The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3969
更新日期:2016-01-01 00:00:00
abstract::Nordihydroguaiaretic acid (NDGA) and its derivatives possess anti-cancer effects on various types of cancer via the induction of apoptosis or cell cycle arrest. This study proved that NDGA inhibited cervical cancer SiHa cell growth and induced cell cycle arrest at the G(1) phase, which may be a consequence of cell cyc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2010.205
更新日期:2011-01-01 00:00:00
abstract::The present study aimed to address the pharmacogenetic role of BAG1 in platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) and in cultured human lung adenocarcinoma A549 cells. A total of 108 NSCLC patients (stages I-IIIA) were treated with a standard chemotherapy regimen of cisplatin plus vinor...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4003
更新日期:2016-02-01 00:00:00
abstract::Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6645
更新日期:2017-09-01 00:00:00
abstract::The aim of this study was to discuss the antitumor effect of Tegafur combined with Barbadian on S-180 tumor-bearing mice. A murine tumor model was prepared by subcutaneous injection of S-180 sarcoma cells to the armpit of the right limb of healthy female SPF KM mice. The 24 tumor-bearing mice were randomly divided int...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9373
更新日期:2018-11-01 00:00:00
abstract::MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8557
更新日期:2018-06-01 00:00:00
abstract::The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4568
更新日期:2016-07-01 00:00:00
abstract::The aim of this study was to investigate the effect of dexmedetomidine (Dex) on the respiratory function during anesthesia induction in pediatric patients undergoing retinoblastoma (RB) resection. A total of 87 pediatric patients who underwent RB resection in Yidu Central Hospital of Weifang were recruited into this s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9893
更新日期:2019-03-01 00:00:00
abstract::Leptomeningeal metastasis (LM) is an uncommon presentation of relapse in breast cancer, which is associated with poor clinical outcomes and poor prognosis. Notably, LM most commonly occurs in breast cancer. The aim of the present review was to investigate the occurrence of LM as the primary presentation of relapse fol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4745
更新日期:2016-08-01 00:00:00
abstract::Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6844
更新日期:2017-11-01 00:00:00
abstract::Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6479
更新日期:2017-09-01 00:00:00
abstract::Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare aggressive malignant neoplasms that exclusively occur within the wall of the gastrointestinal tract. The GNET was first described as an 'osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma (CCS) of soft parts...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10060
更新日期:2019-04-01 00:00:00
abstract::No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1217
更新日期:2013-05-01 00:00:00