Abstract:
:The pathophysiologic mechanisms responsible for the clinical features of the anophthalmic socket are poorly understood. Atrophy of orbital fat has been thought to be a major contributing cause of enophthalmos and the superior sulcus deformities that develop after enucleation, but it has never been demonstrated histopathologically or confirmed by scientific analysis. This study was undertaken to investigate the changes that occur in the orbital fat compartment of the anophthalmic socket in an animal model by measuring orbital soft tissue mass and evaluating adipocyte cell size. Instead of reduction in the tissue mass, a statistically significant greater weight of the fat and connective tissue compartment was found in the anophthalmic orbit by nearly 13% compared to the control orbit in the animals in the long-term group. No significant change in the mean maximal diameter of adipocytes developed 7 months after enucleation. These analyses do not support the concept that orbital fat atrophy or a reduction of metabolic activity occurs in the anophthalmic socket in this animal model. From these results and our previous findings that the circulation dynamics and blood flow to orbital tissues do not change after enucleation, we propose that the pathophysiologic basis of the problems associated with anophthalmos is a disturbance in the spatial architecture and interrelationships of the multiple tissue components of the orbit, not a change in the orbital blood flow or development of fat atrophy.
journal_name
Ophthalmic Plast Reconstr Surgjournal_title
Ophthalmic plastic and reconstructive surgeryauthors
Kronish JW,Gonnering RS,Dortzbach RK,Rankin JH,Reid DL,Phernetton TM,Pitts WC,Berry GJdoi
10.1097/00002341-199006000-00002subject
Has Abstractpub_date
1990-01-01 00:00:00pages
88-95issue
2eissn
0740-9303issn
1537-2677journal_volume
6pub_type
杂志文章abstract::A 64-year-old woman presented with periorbital induration of 6 months' duration. Computed tomography (CT) revealed enlargement of extraocular muscles. A biopsy specimen of the orbicularis muscle and indurated preaponeurotic fat demonstrated an infiltrating carcinoma, and immunoperoxidase studies for surface antigens s...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199112000-00003
更新日期:1991-01-01 00:00:00
abstract::First described by Malherbe and Chenantais in 1880, pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells. Clinically, it manifests as a firm, solitary, slow growing, painless nodule of the dermis, more frequently located in the head, neck, and upper extremities. It is typically a tumor o...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e318160681d
更新日期:2008-01-01 00:00:00
abstract::Computed tomography (CT) is far superior to plain radiography or xeroradiography in the detection of orbital foreign bodies and in defining altered anatomic relationships in this region. We present a case in which CT was instrumental in the management of orbital cellulitis in a patient who had forgotten that an eye pr...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-198501030-00006
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:This review aims to substantiate attributions of priority for the discovery and first description of the levator palpebrae superioris (LPS) muscle to Matteo Realdo Colombo [Columbus] (1516-1559), and to describe the history of this muscle from ancient to modern times. METHODS:Relevant chapters on eyelid and ey...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001867
更新日期:2020-12-09 00:00:00
abstract::A 33-year-old man presented with a solid lesion encompassing the entire left upper eyelid. Multiple biopsies revealed lipogranuloma consistent with chalazion. The induration resolved after multiple triamcinolone injections. This is the only case report to our knowledge of a chalazion that involved the entire upper eye...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000176266.14388.6b
更新日期:2005-09-01 00:00:00
abstract::A 6-year-old boy with Schwartz-Jampel syndrome and severe myotonia-induced blepharospasm and ptosis did not respond to botulinum toxin A injections in the orbicularis muscle. The clinical diagnosis was further supported by electromyography. Surgical management using a combination of techniques in one operation produce...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000195008.15872.a0
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To measure tarsal plates across various age-groups, to determine whether tarsal size changes with increasing age and whether size correlates with involutional ectropion and entropion. METHODS:Comparative, observational, case-control study design. Data were obtained for length and height of tarsus in each of th...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-200003000-00008
更新日期:2000-03-01 00:00:00
abstract::The vast majority of periocular squamous cell carcinoma spreads intraorbitally along the supraorbital and infraorbital nerves into the cavernous sinus. A patient presented with a history of resected squamous cell carcinoma and pain in the zygomatic distribution. She was found to have temporalis involvement of the mali...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e31829bb288
更新日期:2014-03-01 00:00:00
abstract::Orbital location of teratoma is extremely rare. The differential diagnosis can be difficult and they may be mistaken for other tumors as they may have both cystic and solid areas. The authors report a case of a 7-day-old neonate with a massive congenital orbital teratoma in which it was decided to apply a surgical tec...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001581
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:The goal of this study is to evaluate parameters on orbital CT as predictors of visual outcome in orbital compartment syndrome from retrobulbar hematoma or orbital cellulitis. The study will assess the assertion that certain patients are anatomically predisposed to vision loss in these conditions. METHODS:A re...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e31822672c4
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To determine by a survey of ophthalmic plastic surgeons with specific expertise in blepharoplasty surgery the perceived role of Schirmer testing and other evaluation features in determining patient predisposition to postoperative dry-eye complaints. METHODS:A literature review of tear production tests was perf...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,评审
doi:10.1097/IOP.0b013e3181a1d4a5
更新日期:2009-05-01 00:00:00
abstract::A 53-year-old woman presented with an apocrine cystadenoma of the right upper eyelid. Histologic examination revealed proliferating epithelial cells with apocrine snouts and occasional mitotic figures. Immunohistochemical analysis revealed a Ki-67 index of 15% and positive staining for synaptophysin, chromogranin, est...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000416
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To compare the sensation recovery, scar formation, and histopathologic aspects of upper blepharoplasty eyelid incision performed with radiofrequency or scalpel. METHODS:In a prospective, randomized, blind, comparative, interventional study, 46 eyelids from 23 subjects underwent upper blepharoplasty using radio...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1097/IOP.0b013e31818acfce
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To evaluate current trends in the management of the anophthalmic socket after primary enucleation and evisceration. METHODS:The active membership of the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) was surveyed regarding primary enucleations and eviscerations performed between Jan...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000129528.16938.1e
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:The great majority of children with nasolacrimal duct (NLD) obstruction are successfully treated with probing or conventional silicone tube intubation. A small percentage of patients fail to have their NLD obstruction resolved with these procedures and require dacryocystorhinostomy (DCR). This study was conduct...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.IOP.0000103004.71978.0C
更新日期:2004-01-01 00:00:00
abstract::A 28-year-old woman with a history of an hydroxyapatite implantation performed 2 years earlier, presented with complaints of a poorly fitting prosthesis, and fullness of the left upper eyelid accompanied by eyelid erythema. Computed tomography scan showed a mass adjacent to the implant medially. Surgical removal of th...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3182696577
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:To highlight features of lateral canthal tendon disinsertion (LCTD), provide an algorithm for systematic assessment, and describe the anatomic genesis of signs and symptoms. METHODS:Retrospective case series of consecutive patients with lateral canthal tendon disinsertion, who underwent lateral canthal tendon ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000552
更新日期:2016-09-01 00:00:00
abstract::A 52-year-old woman suffered from progressive proptosis and vision loss due to a large tumor in her right orbit. Multiple recurrences of the tumor were treated with surgical excision. The pathologic diagnosis in each recurrence was neurofibroma, and the tumor transformed to malignant peripheral nerve sheath tumor in t...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e318182b00f
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To report female representation within the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) at all levels of career achievement over 50 years. METHODS:Data were extrapolated from published ASOPRS directories and the 50th anniversary booklet. Fellowship, membership, leadership, and awa...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001764
更新日期:2020-07-13 00:00:00
abstract:PURPOSE:To evaluate retrospectively the cosmetic and functional effects on success of lacrimal diaphragm and periosteum suturation after the anastomosis of anterior flaps before skin closure in external dacryocystorhinostomy (ext-DCR). METHODS:During ext-DCR, lacrimal diaphragm was separated from periosteum over anter...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181bb5942
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To determine and compare the amount of force required to disrupt the integrity of various orbital implants. METHODS:Compression tests were carried out by using a servo-electrical universal testing system on orbital implants including aluminum oxide (Bioceramic implant, FCI, Issy-Les-Moulineaux, France), corall...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000162959.30970.0d
更新日期:2005-05-01 00:00:00
abstract::Ocular tick infestation is a rare occurrence. The authors report a case that is unique for being the first published example from New England, for its chronic presentation, and for the inclusion of histopathologic analysis in its diagnostic workup. A 75-year-old man was evaluated for a persistent eyelid growth seconda...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000231
更新日期:2016-05-01 00:00:00
abstract::A 74-year-old man was diagnosed with thymic carcinoid metastatic to the mediastinum. Two years later, he developed left and then right facial palsy. Four additional episodes of facial palsy developed within 2 years, followed by an occurrence of nonarteritic ischemic optic neuropathy. While recurrent facial palsy is un...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.IOP.0000056025.65389.C3
更新日期:2003-03-01 00:00:00
abstract::The authors report the case of a 7-year old child with failed probing with stent intubation, who was found to have an unusual curvature of the nasolacrimal duct on the symptomatic side. CT imaging revealed a permanent maxillary canine tooth adjacent to the duct. It appeared that the relationship of the tooth bud to th...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001289
更新日期:2019-01-01 00:00:00
abstract::A 16-year-old girl presented with diplopia and gradual-onset, painless proptosis of the left eye. Orbital CT showed a well-circumscribed, enhancing, extraconal mass in the superior orbit, and the surgical excision was performed. Histopathology was interpreted as capillary hemangioma. Five years later, her symptoms rec...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181b39a15
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To address the efficacy of fat-removal orbital decompression to reduce intraocular pressure in patients with Graves disease. METHODS:This cohort study included 64 eyes of 39 patients with Graves disease. Thirteen men and 36 women, with a mean age of 52.5 years (range, 27 to 80 years), underwent fat-removal orb...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000203737.67334.d3
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To describe the use of an endovascular therapeutic technique in the management of a giant carotid cavernous aneurysm. METHODS:We reviewed the clinical and neuroradiologic findings of a patient with an unusual case of carotid cavernous aneurysm and intraorbital rupture. The medical literature was searched for s...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-200101000-00013
更新日期:2001-01-01 00:00:00
abstract::Aspergillus niger infection of an exenterated orbit is a very rare occurrence. Treatment includes extensive surgical debridement with socket lavage with 0.6% hydrogen peroxide, oral itraconazole, and local amphotericin B. We describe a case of A. niger infection in an exenterated orbit, unresponsive to local amphoteri...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181610443
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To determine surgical outcomes after transcranial decompression of the superior orbit in patients with progressive compressive optic neuropathy (CON) secondary to Graves' orbitopathy (GO) who had previously been treated with 3-wall decompression. METHODS:Approval from the West Virginia University Institution R...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000052
更新日期:2014-05-01 00:00:00
abstract::The authors describe a spindle cell lipoma that occurred in the anterior lamellae of the eyelid in a 47-year-old man. This benign tumor was reported previously only once within that location and poses histologic challenges when a "low fat" or "fat free" variant is present. ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000492
更新日期:2017-05-01 00:00:00