Does dopamine play a role in schizophrenia?

Abstract:

:Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets of these drugs for the mental and the extrapyramidal actions respectively. Dopaminergic hyperfunction, induced by amphetamines or dopa, may lead to a disturbance mimicking paranoid schizophrenia, lending further support for a key role of dopamine in mental functions. While a primary disturbance in dopamine function in schizophrenia cannot be ruled out, the intimate relationship between dopaminergic and other neuronal systems must be emphasized. The possible involvement of other amine, aminoacid or peptide transmitters in schizophrenia cannot be disregarded.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Carlsson A

doi

10.1017/s003329170000622x

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

583-97

issue

4

eissn

0033-2917

issn

1469-8978

journal_volume

7

pub_type

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