Abstract:
:Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets of these drugs for the mental and the extrapyramidal actions respectively. Dopaminergic hyperfunction, induced by amphetamines or dopa, may lead to a disturbance mimicking paranoid schizophrenia, lending further support for a key role of dopamine in mental functions. While a primary disturbance in dopamine function in schizophrenia cannot be ruled out, the intimate relationship between dopaminergic and other neuronal systems must be emphasized. The possible involvement of other amine, aminoacid or peptide transmitters in schizophrenia cannot be disregarded.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Carlsson Adoi
10.1017/s003329170000622xsubject
Has Abstractpub_date
1977-11-01 00:00:00pages
583-97issue
4eissn
0033-2917issn
1469-8978journal_volume
7pub_type
杂志文章abstract::The SIDAM--a new instrument for the symptomatic diagnosis and measurement of dementia according to DSM-III-R and ICD-10--is described. It comprises a brief structured clinical interview, a range of cognitive tests (e.g. including the Mini-Mental State (Folstein et al. 1975)) which constitute a short neuropsychological...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700014811
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Cognitive theory points to the importance of negative self-schemas in the onset and maintenance of depression and anxiety disorders. Hereby, it is important to distinguish between automatic and explicit self-schemas, reflecting different cognitive-motivational systems. This study tested whether patients with...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991371
更新日期:2010-07-01 00:00:00
abstract::Taxometric procedures have been used extensively to investigate whether individual differences in personality and psychopathology are latently dimensional or categorical ('taxonic'). We report the first meta-analysis of taxometric research, examining 317 findings drawn from 183 articles that employed an index of the c...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000183X
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Psychiatric rehabilitation (PR) can improve functioning in people with severe mental illness (SMI), but outcomes are still suboptimal. Cognitive impairments have severe implications for functioning and might reduce the effects of PR. It has been demonstrated that performance in cognitive tests can be improve...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S003329171800418X
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) develops in a minority of traumatized individuals. Attention biases to threat and abnormalities in fear learning and extinction are processes likely to play a critical role in the creation and/or maintenance of PTSD symptomatology. However, the relationship between these...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001565
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Urban birth, a risk factor for schizophrenia, is more frequent among second-generation immigrants. The aim of the current study was to determine whether the increased risk for schizophrenia found in second-generation immigrants is explained by the degree of urbanization of birthplace and/or factors related t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291706009652
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Civilian suicide rates vary by occupation in ways related to occupational stress exposure. Comparable military research finds suicide rates elevated in combat arms occupations. However, no research has evaluated variation in this pattern by deployment history, the indicator of occupation stress widely consid...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001294
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Expressed emotion (EE) measured from relatives and informal carers has been consistently demonstrated to be associated with clinical outcome in schizophrenic patients. There have also been published studies that have investigated EE in professional carers that have suggested that the quality of the relations...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001579
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Executive functions have been proposed as endophenotypes for attention deficit hyperactivity disorder (ADHD); however, data regarding visual memory are lacking. We therefore assessed visual memory in adolescents with ADHD and their unaffected siblings compared with controls. METHOD:The participants included...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711000857
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior ci...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720000859
更新日期:2020-04-24 00:00:00
abstract::There is little evidence of a curvilinear relationship between pre-operative emotionality and post-operative adjustment, as predicted by a model which supposes that moderate preoperative anxiety assists adjustment. This paper suggests that the negative affect, or stress, associated with the work of worry should be dis...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700041246
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND:Refugees commonly experience difficulties with emotional processing, such as alexithymia, due to stressful or traumatic experiences. However, the functional connectivity of the amygdala, which is central to emotional processing, has yet to be assessed in refugees. Thus, the present study investigated the res...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000175
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that major depressive disorders are associated with a breakdown in the organization of ultradian rhythm in sleep EEG. The present study used cross-spectral analysis of sleep EEG to confirm this finding, in a larger-scale study, evaluating the influence of gender and age on ultra...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001300
更新日期:1999-11-01 00:00:00
abstract::A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001984x
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Research suggests that the personality factor of self-critical or maladaptive perfectionism may be implicated in chronic fatigue syndrome (CFS). However, it is not clear whether self-critical perfectionism (SCP) also predicts daily symptoms in CFS. Method In the present study we investigated whether SCP pred...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001936
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Oral contraceptive use has been previously associated with an increased risk of suicidal behavior in some, but not all, samples. The use of large, representative, longitudinally-assessed samples may clarify the nature of this potential association. METHODS:We used Swedish national registries to identify wom...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003475
更新日期:2020-10-21 00:00:00
abstract::Couples in whom the main complaint was of a lack of female sexual response were treated using a practical counselling approach. A number of pre-treatment measures were studied to determine which factors were predictive of treatment outcome. While age and chronicity were not predictive, the quality of the general relat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170000920x
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder which frequently persists into adulthood. The primary goal of the current study was to (a) investigate attentional functions of stimulant medication-naïve adults with ADHD, and (b) investigate the effects of 6 weeks of methylphe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003628
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Chronic fatigue is a common symptom of multiple sclerosis (MS). A randomized controlled trial (RCT) showed that cognitive behavioural therapy (CBT) was more effective in reducing MS fatigue than relaxation training (RT). The aim of the current study was to analyse additional data from this trial to determine...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291711000924
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Converging evidence implicates basal ganglia alterations in impulsivity and suicidal behavior. For example, D2/D3 agonists and subthalamic nucleus stimulation in Parkinson's disease (PD) trigger impulse control disorders and possibly suicidal behavior. Furthermore, suicidal behavior has been associated with ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002133
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Retrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs. We investigated the association between suboptimal parenting and parent conflict in childhood and BPD s...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000542
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Electroconvulsive therapy (ECT) is widely applied to treat severe depression resistant to standard treatment. Results from previous studies comparing the cost-effectiveness of this technique with treatment alternatives such as repetitive transcranial magnetic stimulation (rTMS) are conflicting. METHOD:We co...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291714002554
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date. METHOD:We conducted a first-episode follow-up study of 97 patients with DSM-IV schizop...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170800336X
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of othe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002288
更新日期:2018-04-01 00:00:00
abstract::In a retrospective case note study, 73 young females with anorexia nervosa were compared with 88 young females with affective psychosis. These groups of patients did not differ in terms of place of residence, birth order or social class. They differed very significantly, however, in terms of age at onset of symptoms, ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700013295
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Previous studies of the dimensional structure of panic attack symptoms have mostly identified a respiratory and a vestibular/mixed somatic dimension. Evidence for additional dimensions such as a cardiac dimension and the allocation of several of the panic attack symptom criteria is less consistent. Clarifyin...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291714002803
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Although alcohol use disorder (AUD) is associated with future risk for psychosocial dysfunction, the degree to which this arises from a direct causal effect of AUD on functioning v. from correlated risk factors (also known as confounders) is less clearly established. METHOD:AUD was assessed from Swedish med...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716003032
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Chronic fatigue is a common condition, frequently presenting in primary care. The aim of this study was to compare the cost-effectiveness of cognitive behavioural therapy (CBT) and graded exercise therapy (GET), and to compare therapy with usual care plus a self-help booklet (BUC). METHOD:Patients drawn fro...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291704001928
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Several lines of evidence indicate a role of the brain-derived neurotrophic factor (BDNF) in the modulation of eating behaviour. Therefore, alterations in the physiology of this neurotrophin may be involved in the pathogenesis of eating disorders. In the present study, we investigated serum levels of BDNF in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003368
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Previous studies on assortment for psychiatric disorders have reported discrepant findings. We aimed to test whether there is a significant association for psychiatric diagnoses, including alcoholism, generalized anxiety disorder, major depressive disorder, panic disorder and phobias between husbands and wiv...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007326
更新日期:1998-11-01 00:00:00