Living the high life: Could gut microbiota matter for adaptation to high altitude?

Abstract:

:At high altitude, the reduced availability of thermal energy and oxygen poses major challenges to organisms. Different species or populations have evolved similar solutions to these challenges, such as blood flow regulation in animals (Bouverot, 1985). Previous studies investigating such convergent adaptations have primarily looked at changes in host genomes (e.g., see Scheinfeldt & Tishkoff, 2010), but have rarely considered the potential role of the gut microbiome in mediating host adaptation. As gut microbes can indirectly regulate host blood pressure (Pluznick, 2014) and energy intake efficiency, it has been hypothesized that they could help maintain normal energy production and/or optimize nutritional assimilation in high-altitude hypoxic environments (e.g., Li & Zhao, 2015). However, it has been hard to (a) show that there is a direct effect of altitude on the gut microbiota, because of the many potential confounding effects of altitude (e.g., diet is correlated to altitude, as well as to the microbiome) and to (b) understand the mechanisms by which the microbiota could mediate host hypoxic and thermoregulatory stresses. In this issue of Molecular Ecology, Suzuki, Martins, and Nachman (2018) show that, independently of diet, taxonomic composition and functions of mouse gut microbiota converge in independent high-altitude environments and propose the intriguing hypothesis that some of these functional convergences might be beneficial to their host.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Mazel F

doi

10.1111/mec.15093

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

2119-2121

issue

9

eissn

0962-1083

issn

1365-294X

journal_volume

28

pub_type

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