Microbial regulation of allergic responses to food.

Abstract:

:The incidence of food allergy in developed countries is rising at a rate that cannot be attributed to genetic variation alone. In this review, we discuss the environmental factors that may contribute to the increasing prevalence of potentially fatal anaphylactic responses to food. Decreased exposure to enteric infections due to advances in vaccination and sanitation, along with the adoption of high-fat (Western) diets, antibiotic use, Cesarean birth, and formula feeding of infants, have all been implicated in altering the enteric microbiome away from its ancestral state. This collection of resident commensal microbes performs many important physiological functions and plays a central role in the development of the immune system. We hypothesize that alterations in the microbiome interfere with immune system maturation, resulting in impairment of IgA production, reduced abundance of regulatory T cells, and Th2-skewing of baseline immune responses which drive aberrant responses to innocuous (food) antigens.

journal_name

Semin Immunopathol

authors

Feehley T,Stefka AT,Cao S,Nagler CR

doi

10.1007/s00281-012-0337-5

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

671-88

issue

5

eissn

1863-2297

issn

1863-2300

journal_volume

34

pub_type

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