当前位置： SCI文献检索 > Journal of Proteomics期刊下所有文献 > Proteomic identification of immunodominant chlamydial antigens in a mouse model.

Proteomic identification of immunodominant chlamydial antigens in a mouse model.

Abstract：

:Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen in the world. To identify new vaccine candidates a protein microarray was constructed by expressing the open reading frames (ORFs) from Chlamydia mouse pneumonitis (MoPn). C57BL/6, C3H/HeN and BALB/c mice were immunized either intranasally or intravaginally with live MoPn elementary bodies (EB). Two additional groups were immunized by the intramuscular plus subcutaneous routes with UV-treated EB, using CpG and Montanide as adjuvants to favor a Th1 response, or Alum, to elicit a Th2 response. Serum samples collected from the three strains of mice were tested in the microarray. The array included the expression of 909 proteins from the 921 ORFs of the MoPn genome and plasmid. A total of 530 ORFs were recognized by at least one serum sample. Of these, 36 reacted with sera from the three strains of mice immunized with live EB. These antigens included proteins that were previously described as immunogenic such as MOMP and HSP60. In addition, we uncovered new immunogens, including 11 hypothetical proteins. In summary, we have identified new immunodominant chlamydial proteins that can be tested for their ability to induce protection in animal models and subsequently in humans.

journal_name

J Proteomics

journal_title

Journal of proteomics

authors

Teng A,Cruz-Fisher MI,Cheng C,Pal S,Sun G,Ralli-Jain P,Molina DM,Felgner PL,Liang X,de la Maza LM

doi

10.1016/j.jprot.2012.08.017

subject

Has Abstract

pub_date

2012-12-21 00:00:00

pages

176-86

eissn

1874-3919

issn

1876-7737

pii

S1874-3919(12)00635-5

journal_volume

77

pub_type

杂志文章

相关文献

Journal of Proteomics文献大全
  • A comparative study of the Se/S substitution in methionine and cysteine in Se-enriched yeast using an inductively coupled plasma mass spectrometry (ICP MS)-assisted proteomics approach.

    abstract：UNLABELLED:A proteomics approach based on 2D gel electrophoresis followed by HPLC-electrospray Orbitrap MS/MS was developed to investigate the replacement and the degree of the Se/S substitution in methionine and cysteine in Se-rich yeast. Capillary HPLC-inductively coupled plasma mass spectrometry (ICP-MS), employed i...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2013.05.010

    authors： Bierla K,Bianga J,Ouerdane L,Szpunar J,Yiannikouris A,Lobinski R

    更新日期：2013-07-11 00:00:00

  • Comparative proteomics of respiratory exosomes in cystic fibrosis, primary ciliary dyskinesia and asthma.

    abstract：:Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are pulmonary genetic disorders associated with inflammation and heterogeneous progression of the lung disease. We hypothesized that respiratory exosomes, nanovesicles circulating in the respiratory tract, may be involved in the progression of inflammation-rela...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2018.07.001

    authors： Rollet-Cohen V,Bourderioux M,Lipecka J,Chhuon C,Jung VA,Mesbahi M,Nguyen-Khoa T,Guérin-Pfyffer S,Schmitt A,Edelman A,Sermet-Gaudelus I,Guerrera IC

    更新日期：2018-08-15 00:00:00

  • Non-additive effects of ocean acidification in combination with warming on the larval proteome of the Pacific oyster, Crassostrea gigas.

    abstract：UNLABELLED:Increasing atmospheric carbon dioxide results in ocean acidification and warming, significantly impacting marine invertebrate larvae development. We investigated how ocean acidification in combination with warming affected D-veliger larvae of the Pacific oyster Crassostrea gigas. Larvae were reared for 40h u...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.12.001

    authors： Harney E,Artigaud S,Le Souchu P,Miner P,Corporeau C,Essid H,Pichereau V,Nunes FLD

    更新日期：2016-03-01 00:00:00

  • Glycoproteomics of paclitaxel resistance in human epithelial ovarian cancer cell lines: towards the identification of putative biomarkers.

    abstract：:Glycosylation, one of the most common post translational modifications (PTMs) of proteins, is often associated with carcinogenesis and tumor malignancy. Ovarian cancer is the sixth cause of cancer-related death in Western countries. Currently, it is treated by debulking surgery followed by chemotherapy based on paclit...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2009.11.012

    authors： Di Michele M,Marcone S,Cicchillitti L,Della Corte A,Ferlini C,Scambia G,Donati MB,Rotilio D

    更新日期：2010-03-10 00:00:00

  • Profiling of local disease-sparing responses to bovine respiratory syncytial virus in intranasally vaccinated and challenged calves.

    abstract：:Bovine and human respiratory syncytial viruses (BRSV, HRSV) are primary causes of pneumonia in calves and children respectively, with vaccination offering protection via antibody and cellular immune responses. However, with no vaccines currently licensed for human use, evaluation of local responses to BRSV vaccination...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2019.103397

    authors： Gray D,Ellis JA,Gow SP,Lacoste SR,Allan GM,Mooney MH

    更新日期：2019-07-30 00:00:00

  • Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen.

    abstract：UNLABELLED:Understanding of the avian male gamete biology is essential to improve the conservation of genetic resources and performance in farming. In this study, the chicken semen peptidome/proteome and the molecular phenotype related to sperm quality were investigated. Spermatozoa (SPZ) and corresponding seminal plas...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2014.07.024

    authors： Labas V,Grasseau I,Cahier K,Gargaros A,Harichaux G,Teixeira-Gomes AP,Alves S,Bourin M,Gérard N,Blesbois E

    更新日期：2015-01-01 00:00:00

  • Deregulation of smooth muscle cell cytoskeleton within the human atherosclerotic coronary media layer.

    abstract：UNLABELLED:Fatal events derived from coronary atherosclerosis are the major cause of mortality in the developed countries. Proteomic analysis of the atherosclerotic coronary artery has been mainly carried out with whole tissue extracts, making it difficult to distinguish the alterations present in every region of the p...

    journal_title：Journal of proteomics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jprot.2013.01.032

    authors： de la Cuesta F,Zubiri I,Maroto AS,Posada M,Padial LR,Vivanco F,Alvarez-Llamas G,Barderas MG

    更新日期：2013-04-26 00:00:00

  • An integrated immunoproteomics and bioinformatics approach for the analysis of Schistosoma japonicum tegument proteins.

    abstract：UNLABELLED:Schistosomiasis remains one of the major neglected tropical diseases (NTDs) causing morbidity of humans residing in the tropical countries. Much effort has been devoted to the development of vaccines, since it is recognized that vaccines can be served as an important supplementary component alongside chemoth...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2014.01.010

    authors： Chen JH,Zhang T,Ju C,Xu B,Lu Y,Mo XJ,Chen SB,Fan YT,Hu W,Zhou XN

    更新日期：2014-02-26 00:00:00

  • Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.

    abstract：UNLABELLED:Clostridial collagenases are among the most efficient degraders of collagen. Most clostridia are saprophytes and secrete proteases to utilize proteins in their environment as carbon sources; during anaerobic infections, collagenases play a crucial role in host colonization. Several medical and biotechnologic...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2013.10.004

    authors： Eckhard U,Huesgen PF,Brandstetter H,Overall CM

    更新日期：2014-04-04 00:00:00

  • Vitamin D-binding protein as a biomarker of active disease in acute intermittent porphyria.

    abstract：UNLABELLED:Acute intermittent porphyria (AIP) is an autosomal dominant metabolic disorder caused by a deficiency of hepatic porphobilinogen deaminase (PBGD). The disease is characterized by life threatening acute neurovisceral attacks. The aim of this study was to identify metabolites secreted by the hepatocytes that r...

    journal_title：Journal of proteomics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jprot.2015.05.004

    authors： Serrano-Mendioroz I,Sampedro A,Mora MI,Mauleón I,Segura V,Enríquez de Salamanca R,Harper P,Sardh E,Corrales FJ,Fontanellas A

    更新日期：2015-09-08 00:00:00

  • Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: A quantitative proteomics approach.

    abstract：UNLABELLED:Marine bioadhesives have unmatched performances in wet environments, being an inspiration for biomedical applications. In sea urchins specialized adhesive organs, tube feet, mediate reversible adhesion, being composed by a disc, producing adhesive and de-adhesive secretions, and a motile stem. After tube foo...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2016.02.026

    authors： Lebesgue N,da Costa G,Ribeiro RM,Ribeiro-Silva C,Martins GG,Matranga V,Scholten A,Cordeiro C,Heck AJ,Santos R

    更新日期：2016-04-14 00:00:00

  • PlantPReS: A database for plant proteome response to stress.

    abstract：UNLABELLED:About 75% of plant yield potential has been estimated to be lost to environmental stresses, even in developed agricultures. To facilitate the biotechnological improvement of crop productivity, genes and proteins that control crop adaptation to a wide range of environments will need to be identified. Due to t...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2016.03.009

    authors： Mousavi SA,Pouya FM,Ghaffari MR,Mirzaei M,Ghaffari A,Alikhani M,Ghareyazie M,Komatsu S,Haynes PA,Salekdeh GH

    更新日期：2016-06-30 00:00:00

  • Proteomics survey of Solanaceae family: Current status and challenges ahead.

    abstract：:Solanaceae is one of the major economically important families of higher plants and has played a central role in human nutrition since the dawn of human civilization. Therefore, researchers have always been interested in understanding the complex behavior of Solanaceae members to identify key transcripts, proteins or ...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2017.05.016

    authors： Ghatak A,Chaturvedi P,Paul P,Agrawal GK,Rakwal R,Kim ST,Weckwerth W,Gupta R

    更新日期：2017-10-03 00:00:00

  • Structural characterisation of medically relevant protein assemblies by integrating mass spectrometry with computational modelling.

    abstract：:Structural mass spectrometry with its various techniques is a powerful tool for the structural elucidation of medically relevant protein assemblies. It delivers information on the composition, stoichiometries, interactions and topologies of these assemblies. Most importantly it can deal with heterogeneous mixtures and...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2017.04.019

    authors： Politis A,Schmidt C

    更新日期：2018-03-20 00:00:00

  • Comparative phosphoproteomic analysis of intestinal phosphorylated proteins in active versus aestivating sea cucumbers.

    abstract：UNLABELLED:The sea cucumber Apostichopus japonicus is becoming an excellent model marine invertebrate for studies of environmentally-induced aestivation. Reversible protein phosphorylation as a regulatory mechanism in aestivation is known for some terrestrial aestivators but has never before been documented in sea cucu...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.09.016

    authors： Chen M,Zhu A,Storey KB

    更新日期：2016-03-01 00:00:00

  • Bioactive peptides in plant-derived foodstuffs.

    abstract：UNLABELLED:A literature survey covering the presence of bioactive peptides in plant-derived foodstuffs is presented. Examples are given of plant peptides associated with a beneficial effect on human health. The main bioactive effects of these peptides are defined and their mechanism of action described, when known. Cur...

    journal_title：Journal of proteomics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jprot.2016.03.048

    authors： Maestri E,Marmiroli M,Marmiroli N

    更新日期：2016-09-16 00:00:00

  • Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis.

    abstract：:Xenotropic murine leukemia virus-related virus (XMRV) is a virus generated under artificial conditions by the recombination of 2 murine leukemia virus (MLV) proviruses, PreXMRV-1 and PreXMRV-2, during the in vivo passage of human prostate cancer cells in athymic nude mice. The molecular etiology of XMRV infection has ...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2012.05.047

    authors： Matsunaga S,Sawasaki T,Ode H,Morishita R,Furukawa A,Sakuma R,Sugiura W,Sato H,Katahira M,Takaori-Kondo A,Yamamoto N,Ryo A

    更新日期：2012-08-03 00:00:00

  • Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma.

    abstract：UNLABELLED:We attempted to identify biomarkers that would predict responsiveness of osteosarcoma (OS) to induction chemotherapy. Tumor tissues obtained by open biopsy before induction chemotherapy were investigated. On the basis of histological observations at the time of surgery and the Huvos grading system, 7 patient...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2013.07.022

    authors： Kubota D,Mukaihara K,Yoshida A,Tsuda H,Kawai A,Kondo T

    更新日期：2013-10-08 00:00:00

  • The in planta proteome of wild type strains of the fire blight pathogen, Erwinia amylovora.

    abstract：UNLABELLED:Erwinia amylovora is a Gram-negative plant pathogen that causes fire blight. This disease affects most members of the Rosaceae family including apple and pear. Here, an infection model is introduced to study proteomic changes in a highly virulent E. amylovora strain upon interaction with its host as compared...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2016.02.018

    authors： Holtappels M,Vrancken K,Noben JP,Remans T,Schoofs H,Deckers T,Valcke R

    更新日期：2016-04-29 00:00:00

  • Proteomic analysis of Yersinia enterocolitica biovar 1A under iron-rich and iron-poor conditions indicate existence of efficiently regulated mechanisms of iron homeostasis.

    abstract：UNLABELLED:The pathogenicity of Yersinia enterocolitica biovar 1A strains is controversial as these lack most of the known virulence factors. Acquisition of iron and presence of well-regulated iron homeostasis in bacteria represents an important virulence trait. Differential abundance of proteins was examined under iro...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.04.015

    authors： Kanaujia PK,Bajaj P,Kumar S,Singhal N,Virdi JS

    更新日期：2015-06-21 00:00:00

  • Identification of 4-hydroxynonenal-modified proteins in human osteoarthritic chondrocytes.

    abstract：:The α,β-unsaturated aldehyde 4-hydroxynonenal (HNE) is formed through lipid peroxidation during oxidative stress. As a highly reactive electrophile, it is able to form adducts with various biomolecules, including proteins. These protein modifications could modulate many signaling pathways, as well as cell differentiat...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2020.104024

    authors： Geib T,Iacob C,Jribi R,Fernandes J,Benderdour M,Sleno L

    更新日期：2021-02-10 00:00:00

  • Validation of serum protein profiles by a dual antibody array approach.

    abstract：:In recent years, affinity-based technologies have become important tools for serum profiling to uncover protein expression patterns linked to disease state or therapeutic effects. In this study, we describe a path towards the production of an antibody microarray to allow protein profiling of biotinylated human serum s...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2009.09.009

    authors： Rimini R,Schwenk JM,Sundberg M,Sjöberg R,Klevebring D,Gry M,Uhlén M,Nilsson P

    更新日期：2009-12-01 00:00:00

  • Quantitative proteomics analysis of differentially expressed proteins in ruptured and unruptured cerebral aneurysms by iTRAQ.

    abstract：:The underlying pathophysiological mechanisms involved in cerebral aneurysms rupture remain unclear. This study was performed to investigate the differentially expressed proteins between ruptured and unruptured aneurysms using quantitative proteomics. The aneurysmal walls of six ruptured aneurysms and six unruptured an...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2018.05.001

    authors： Jiang P,Wu J,Chen X,Ning B,Liu Q,Li Z,Li M,Yang F,Cao Y,Wang R,Wang S

    更新日期：2018-06-30 00:00:00

  • Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis.

    abstract：INTRODUCTION:Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic autoimmune diseases with variable clinical outcomes. We investigated whether the synovial fluid (SF) proteome could distinguish a subset of patients in whom disease extends to affect a large number of joints. METHODS:SF sam...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2012.06.024

    authors： Gibson DS,Newell K,Evans AN,Finnegan S,Manning G,Scaife C,McAllister C,Pennington SR,Duncan MW,Moore TL,Rooney ME

    更新日期：2012-09-18 00:00:00

  • Schistosome infections induce significant changes in the host biliary proteome.

    abstract：UNLABELLED:Schistosomiasis is a disease caused by blood trematodes affecting man and animals that represents an important human health and veterinary problem. Main damages caused by this infection are a consequence of the host inflammatory reaction against the parasite eggs trapped inside the liver. Despite that the he...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2014.11.009

    authors： de la Torre-Escudero E,Pérez-Sánchez R,Manzano-Román R,Oleaga A

    更新日期：2015-01-30 00:00:00

  • pI-based fractionation of serum proteomes versus anion exchange after enhancement of low-abundance proteins by means of peptide libraries.

    abstract：:The pre-treatment of biological extracts with the aim of detecting very low-abundance proteins generates complexity requiring a proper fractionation. Therefore the success of identifying all newly detectable species depends on the selected fractionation methods. In this context and starting from a human serum, where t...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2009.06.014

    authors： Restuccia U,Boschetti E,Fasoli E,Fortis F,Guerrier L,Bachi A,Kravchuk AV,Righetti PG

    更新日期：2009-08-20 00:00:00

  • Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study.

    abstract：:Renal cell carcinoma (RCC) is one of the most lethal type of tumors and is twice more frequent in men than in women. Initial symptoms are unspecific and belated thus increasing mortality. Moreover, current diagnostic and monitoring tools are harmful for the patient and unspecific in low-grade tumors. Therefore, novel ...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2020.103723

    authors： Oto J,Fernández-Pardo Á,Roca M,Plana E,Solmoirago MJ,Sánchez-González JV,Vera-Donoso CD,Martínez-Sarmiento M,España F,Navarro S,Medina P

    更新日期：2020-04-30 00:00:00

  • Priming integrin alpha 5 promotes the osteogenic differentiation of human periodontal ligament stem cells due to cytoskeleton and cell cycle changes.

    abstract：:To seek a potential target for periodontal tissue regeneration, this study aimed to explore the role of Integrin alpha 5 (ITGA5) in human periodontal ligament stem cells (PDLSCs). Transwell assay, Cell Counting Kit 8 (CCK8) assay, cell cycle assay, alkaline phosphatase (ALP) activity, alizarin red staining, and wester...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2018.03.008

    authors： Wang H,Li J,Zhang X,Ning T,Ma D,Ge Y,Xu S,Hao Y,Wu B

    更新日期：2018-05-15 00:00:00

  • Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS.

    abstract：:Neurotransmitter:sodium symporters (NSS) are integral membrane proteins (IMP), responsible for reuptake of neurotransmitters from the synaptic cleft. Due to challenges in production of mammalian NSS in their active form, the prokaryotic hydrophobic amino acid transporter, LeuT, served here as a steadfast model for elu...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2020.103845

    authors： Möller IR,Merkle PS,Calugareanu D,Comamala G,Schmidt SG,Loland CJ,Rand KD

    更新日期：2020-08-15 00:00:00

  • Quantitative proteomic study of Aspergillus Fumigatus secretome revealed deamidation of secretory enzymes.

    abstract：UNLABELLED:Aspergillus sp. plays an essential role in lignocellulosic biomass recycling and is also exploited as cell factories for the production of industrial enzymes. This study profiled the secretome of Aspergillus fumigatus when grown with cellulose, xylan and starch by high throughput quantitative proteomics usin...

    journal_title：Journal of proteomics

    pub_type： 杂志文章

    doi：10.1016/j.jprot.2015.02.007

    authors： Adav SS,Ravindran A,Sze SK

    更新日期：2015-04-24 00:00:00