Abstract：
INTRODUCTION:Trichinellosis is a severe zoonosis involving the activation of inflammatory cells, accompanied by the prominent expressions of proinflammatory cytokines in the host. Semen vaccariae, the seeds of Vaccaria segetalis (Neck.) Garcke. ex Asch. (Caryophyllaceae), is a famous traditional herb that is rich in vaccaria n-butanol extract (VNE). Vaccarin is one major active component of VNE, and it is reported in the treatment of stranguria disease. Hypaphorine is another main active component of VNE and has good anti-inflammatory effect, whereas the potential bioactivity of VNE in trichinellosis treatment is still unknown. MATERIALS AND METHODS:This study was designed to evaluate the potential anthelmintic and anti-inflammatory activity of VNE toward T. spiralis infection. ICR mice were used to assess the effect of VNE on repression larvae and adult worms in vivo. Immunohistochemistry analysis was performed to evaluate the expression levels of IL-1β, IL-6, TNF-α, and COX-2. RESULTS:Our results showed that VNE could effectively depress the expressions of proinflammatory cytokines, including IL-1β, IL-6, TNF-α, and COX-2. The adult worms were decreased by 79.53%, while the muscle larvae were diminished by 77.70% as compared to the control. CONCLUSION:These results demonstrated that VNE may be a promising therapeutic agent against the inflammation and diseases caused by T. spiralis infection.
journal_name
Acta Parasitoljournal_title
Acta parasitologicaauthors
Xu F,Hou B,Zhu X,Liu Y,Shi X,Li S,Li Z,Cai W,Zhou Y,Qiu Ldoi
10.2478/s11686-019-00064-6subject
Has Abstractpub_date
2019-09-01 00:00:00pages
520-527issue
3eissn
1230-2821issn
1896-1851pii
10.2478/s11686-019-00064-6journal_volume
64pub_type
杂志文章abstract：BACKGROUND:Parasitism is a complex problem that is often ignored in companion animals, including birds, unless it develops into a severe clinical disorder. The present study was, therefore, aimed to investigate the presence of the gastrointestinal nematode infecting the domestic pigeon and provide a complete morphologi...
journal_title：Acta parasitologica
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更新日期：2020-03-01 00:00:00
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更新日期：2020-09-01 00:00:00
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journal_title：Acta parasitologica
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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更新日期：2016-04-01 00:00:00
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更新日期：2019-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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更新日期：2013-03-01 00:00:00
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更新日期：2014-06-01 00:00:00
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更新日期：2020-11-22 00:00:00
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更新日期：2020-06-01 00:00:00
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-03-26 00:00:00
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更新日期：2016-09-01 00:00:00
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doi：10.2478/s11686-019-00108-x
更新日期：2019-12-01 00:00:00
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更新日期：2013-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1515/ap-2018-0004
更新日期：2018-03-26 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-07-20 00:00:00
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-12-20 00:00:00
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journal_title：Acta parasitologica
pub_type： 杂志文章
doi：10.2478/s11686-014-0209-3
更新日期：2014-03-01 00:00:00
abstract：:With the development of anthelmintic resistance of parastic nematodes, it is necessary to isolate and study nematophagous fungi to screen out the native isolates for their potential in the biocontrol of domestic animal nematodosis. This study aimed to isolate the Arthrobotrys sinense (Monacrosporium sinense) of nemato...
journal_title：Acta parasitologica
pub_type： 杂志文章
doi：10.1515/ap-2018-0037
更新日期：2018-06-26 00:00:00
