Effects of plasma on the platelet antiaggregatory action of prostacyclin in pregnancy.

Abstract:

:Platelet-poor plasma from 13 nonpregnant, 33 normally pregnant, and eight preeclamptic women was incubated with prostacyclin. The ability of platelet-poor plasma to diminish the antiaggregatory effect of prostacyclin was assessed by measuring this effect on arachidonic acid-induced platelet aggregation. Platelet aggregation greater than 95% in response to arachidonic acid was observed when incubated plasma without exogenous prostacyclin was assayed. When prostacyclin and platelet-poor plasma were preincubated together, subsequent arachidonic acid-induced platelet aggregation measured 9.6% in samples from nonpregnant patients, 40.3% in samples from normally pregnant patients, and 78.2% in samples from patients with preeclampsia. The ability of exogenous prostacyclin to inhibit arachidonic acid-induced platelet aggregation was significantly different in the presence of plasma from nonpregnant, normally pregnant, and preeclamptic women. These observations suggest that a plasma factor may affect the action of prostacyclin during pregnancy.

journal_name

Am J Obstet Gynecol

authors

Baker VV,Kort B,Cefalo RC

doi

10.1016/0002-9378(87)90370-x

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

974-7

issue

4

eissn

0002-9378

issn

1097-6868

pii

0002-9378(87)90370-X

journal_volume

156

pub_type

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