Abstract：
:Bleeding typically results as a consequence of derangements of primary hemostasis, secondary hemostasis, or both, and can be dramatically amplified by the presence of other predisposing conditions, especially inherited bleeding disorders. Life-threatening hemorrhages are, however, almost exclusively caused by penetrating wounds, blunt traumas of chest and abdomen, suicide attempts, amputations, bone fractures with concomitant injury to internal organs and blood vessels, and shearing forces from sudden rotation, violent flexion, extension, or deceleration injuries. The pathogenesis of posttraumatic bleeding is complex and multifaceted. The most dramatic phenomenon that always accompanies major hemorrhages is the abrupt and considerable loss of intravascular volume, that further leads to hypovolemic shock, also known as hemorrhagic shock, culminating with peripheral ischemia, especially in those tissues where oxygen delivery is more critical (i.e., central nervous system and myocardium). The mortality rate of severe posttraumatic bleeding can be as high as 50%, especially when an appropriate treatment is not established in a timely manner. The damage control sequence basically entails a four-step approach including damage control surgery, damage control resuscitation with fluid restoration, and hemocomponents administration, as well as correction of the coagulopathy with platelets, antifibrinolytic (e.g., tranexamic acid), and/or procoagulant agents such as fresh frozen plasma, prothrombin complex concentrate, or recombinant-activated Factor VII.
journal_name
Semin Thromb Hemostjournal_title
Seminars in thrombosis and hemostasisauthors
Lippi G,Favaloro EJ,Cervellin Gdoi
10.1055/s-0032-1328936subject
Has Abstractpub_date
2013-02-01 00:00:00pages
83-93issue
1eissn
0094-6176issn
1098-9064journal_volume
39pub_type
杂志文章,评审abstract：:This article explores the application of viscoelastic tests (VETs) in trauma-induced coagulopathy and trauma resuscitation. We describe the advantages of VETs over conventional coagulation tests in the trauma setting and refer to previous disciplines in which VET use has reduced blood product utilization, guided prohe...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0040-1702171
更新日期：2020-03-01 00:00:00
abstract：:Congenital thrombotic thrombocytopenic purpura (TTP) or Upshaw-Schulman syndrome is caused by homozygous or compound heterozygous mutations in the ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) gene. We investigated 30 patients with congenital TTP and analyzed clinical da...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0034-1376152
更新日期：2014-06-01 00:00:00
abstract：:Patients with end-stage renal disease suffer from complex hemostatic disorders. Uremic patients show a bleeding diathesis that is mainly due to abnormalities of primary hemostasis; in particular, platelet dysfunction and impaired platelet-vessel wall interaction. However, despite decreased platelet function, these pat...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2004-835678
更新日期：2004-10-01 00:00:00
abstract：:As the understanding of the genetic basis of the inherited thrombophilias has increased over recent years, their routine diagnostic genetic analysis has also matured. This review considers methods used to test for the factor V (F5) Leiden mutation and prothrombin 20210A (F2 c.*97G>A) allele, and analysis of the SERPIN...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1321491
更新日期：2012-09-01 00:00:00
abstract：:Molecular genetic analysis of families with hemophilia and other heritable bleeding disorders is a frequently requested laboratory investigation. In the United Kingdom, laboratories undertaking genetic testing must participate in a recognized external quality assessment scheme for formal accreditation. The UK National...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0034-1365843
更新日期：2014-03-01 00:00:00
abstract：:Central venous catheters (CVCs) are important for the treatment of patients with cancer, especially in the perioperative and palliative care settings. These devices not only allow for the administration of chemotherapy, parenteral nutrition, and other intravenous therapies, but they may also improve the patients' qual...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0034-1371005
更新日期：2014-04-01 00:00:00
abstract：:Of all the coagulation factor deficiencies, only deficiency of factor XIII (FXIII) and fibrinogen are associated with pregnancy loss. FXIII deficiency and a complete or partial deficiency of fibrinogen are associated with bleeding since childhood, impaired wound repair, and recurrent spontaneous abortions. Both FXIII ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2003-38832
更新日期：2003-04-01 00:00:00
abstract：:Rapid and accurate risk stratification is critical in determining the optimal treatment strategy for patients with acute pulmonary embolism (PE). Early identification of patients with normal blood pressure and a favorable prognosis (low-risk PE) might select a subset of patients for outpatient treatment, which is asso...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1597287
更新日期：2017-07-01 00:00:00
abstract：:Platelet aggregometry has been the reference method employed to detect, diagnose, and monitor qualitative platelet disorders since the early 1960s. Lumiaggregometry and impedance-based whole blood lumiaggregometry have advantages over light transmittance aggregometry in that they provide for enhanced specimen manageme...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0029-1220325
更新日期：2009-03-01 00:00:00
abstract：:The international classification of functioning (ICF) has provided a basic framework for the measurement of outcomes in any health condition. This includes the assessment of the level of activity, participation, and the quality of life of an individual with hemophilia. The measure of activity is an assessment of the i...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0035-1552564
更新日期：2015-11-01 00:00:00
abstract：:The key reason behind the success of heparin in thrombosis and beyond is its polypharmacological sites of action for the prevention and treatment of multifactorial diseases that will only benefit slightly with single pharmacological mechanism-based agents. Thromboembolic disorders are driven by hypercoagulable, hypera...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-982084
更新日期：2007-07-01 00:00:00
abstract：:D-dimer is the biochemical gold standard for diagnosing a variety of thrombotic disorders, but result reporting is heterogeneous in clinical laboratories. A specific five-item questionnaire was developed to gain a clear picture of the current standardization of D-dimer test results. The questionnaire was opened online...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0035-1549092
更新日期：2015-04-01 00:00:00
abstract：:From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombo...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-995828
更新日期：1998-01-01 00:00:00
abstract：:It has been well known for many years that the ABO blood group has a major influence on hemostasis, through its influence on von Willebrand factor and, consequently, factor VIII plasma levels. Although the relationship between non-O blood type and the risk of venous thromboembolism is nowadays also well established, t...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,meta分析,评审
doi：10.1055/s-0033-1363460
更新日期：2014-02-01 00:00:00
abstract：:Low-molecular-weight heparins (LMWHs) are now universally accepted as drugs of choice for postsurgical prophylaxis and treatment of deep vein thrombosis (DVT). Currently, these agents are also being developed for the treatment of various cardiovascular conditions. Because of manufacturing differences, each of the LMWH...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2004-823007
更新日期：2004-02-01 00:00:00
abstract：:Eradication of factor VIII (FVIII) specific neutralizing antibodies (also known as inhibitors) by the traditional method of immune tolerance induction (ITI) is costly and unsuccessful in one out of three patients. Furthermore, effective inhibitor prevention strategies are presently lacking. An overview is given in thi...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0038-1666823
更新日期：2018-09-01 00:00:00
abstract：:The risk for both arterial and venous thrombosis increases with age. Despite the increasing burden of strokes related to atrial fibrillation (AF) and venous thromboembolism (VTE) among older adults, the use of anticoagulant therapy is limited in this population due to the parallel increase in risk of serious hemorrhag...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0034-1389083
更新日期：2014-09-01 00:00:00
abstract：:Near-infrared spectroscopy (NIRS) has been used as a noninvasive method for monitoring the real-time oxygenation status in areas such as the brain and striated muscle. Because the oxygenation status of the placenta is closely related to the fetal condition, monitoring placental oxygenation through the maternal abdomen...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2005-872435
更新日期：2005-06-01 00:00:00
abstract：:The contribution of platelet dysfunction to the impaired hemostasis after cardiac surgery remains to be established, because there is no sensitive method to assess platelet function. Measurement of the shear-induced pathway of platelet function, an important mechanism in inducing hemostasis, became possible by a novel...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0032-1313605
更新日期：1995-01-01 00:00:00
abstract：:Unfractionated heparin and LMMH were substituted with different lipophilic organic compounds. Specifically endpoint attached (LMMH-tyramine and LMMH-tyramine-FITC) and nonspecifically substituted heparins (acylated heparins, and LMMH-biotin and LMMH-cholesterol hemisuccinate) were obtained. The lipophilically substitu...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2007-1001902
更新日期：1994-01-01 00:00:00
abstract：:Several studies have suggested that patients with non-O blood group have an increased risk of both venous and arterial thromboembolic events. On the contrary, the role of ABO blood group on the risk of bleeding complications remains unclear. Thus, we performed a meta-analysis of the literature with the aim of assessin...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,meta分析,评审
doi：10.1055/s-0032-1329550
更新日期：2013-02-01 00:00:00
abstract：:The delicate biochemistry of coagulation and anticoagulation is greatly affected by deviations from the optimal temperature required for the interactions between various coagulation enzymes, cellular receptors, and intracellular mechanisms. Hyperthermia will lead to a prothrombotic state and, if sufficiently severe su...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0038-1648231
更新日期：2018-10-01 00:00:00
abstract：:Platelet-lowering therapy in myeloproliferative disorders includes cytostatic drugs, mainly hydroxyurea, interferon alpha, and anagrelide. Anagrelide is the latest addition to the therapeutic arsenal, and the basis for its use is reviewed. The platelet-lowering efficacy is 70 to 80% in essential thrombocythemia, and t...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2006-939437
更新日期：2006-04-01 00:00:00
abstract：:Multislice detector spiral computed tomography (MSCT) is a noninvasive modality for visualization and evaluation of atherosclerosis in vivo in different arterial beds. Rapid technical advances led to a significant improvement of the diagnostic accuracy of coronary MSCT angiography. The most popular clinical applicatio...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-969035
更新日期：2007-03-01 00:00:00
abstract：:The two components of biological variability are interindividual variability, which is the variability due to the heterogeneity of physiologic influences among subjects, and intraindividual variability, which is due to the variability in the same individual over time. Analysis of biological variation is crucial for es...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0029-1214155
更新日期：2009-02-01 00:00:00
abstract：:The management of childhood acute idiopathic thrombocytopenic purpura is controversial, with recent guidelines highlighting the lack of suitable evidence upon which to base management decisions. Three European centers have used an expectant policy and results over the past decade demonstrate that this is safe and conv...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2001-15256
更新日期：2001-06-01 00:00:00
abstract：:Polycystic ovarian syndrome (PCOS) affects 12 to 19% of women and has reproductive and metabolic features (endothelial dysfunction, increased diabetes, and cardiovascular risk factors). It also appears to have altered coagulation and fibrinolysis with a prothrombotic state with epidemiological evidence of increased ve...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 临床试验,杂志文章
doi：10.1055/s-0035-1564837
更新日期：2016-02-01 00:00:00
abstract：:Arterial and venous thromboses are sustained by development of intraluminal thrombi, respectively, within the venous and arterial systems. The composition and structure of arterial and venous thrombi have been historically considered as being very different. Arterial thrombi (conventionally defined as "white") have be...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0037-1607202
更新日期：2018-04-01 00:00:00
abstract：:Statins are approved by the Food and Drug Administration (FDA) for the treatment of hypercholesterolemia and have shown remarkable activity in preventing cardiovascular morbidity and mortality. The versatility of statins is increasingly being appreciated, however, and lowering cholesterol is only one attribute among m...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2003-40964
更新日期：2003-06-01 00:00:00
abstract：:In order to obtain a global assessment of circulating clopidogrel-related products and of the excretion of the drug, the pharmacokinetic behavior and the excretion balance of 14C radioactivity following the administration of a single dose of 75 mg of 14C-labeled clopidogrel were compared in 6 clopidogrel-free healthy ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-01-01 00:00:00
