Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study.

Abstract:

BACKGROUND:Cardiac troponins are associated with cardiovascular risk in the general population, but whether temporal changes in cardiac troponin I provide independent prognostic information remains uncertain. Using a large community-based cohort with follow-up close to the present day, we aimed to investigate the associations between temporal changes in cardiac troponin and cardiovascular events. METHODS:We measured cardiac troponin I with a high-sensitivity assay (hs-cTnI) in 4805 participants attending both the second (HUNT 2, 1995-97) and third wave (HUNT 3, 2006-2008) of the prospective observational Nord-Trøndelag Health (HUNT) Study. We constructed statistical models with both relative and absolute changes of hs-cTnI from HUNT 2 to HUNT 3. A composite end point of cardiovascular death or first admission for myocardial infarction or heart failure was generated. RESULTS:Participants with relative decrease in hs-cTnI were more frequently younger and female and had lower blood pressure and body mass index. Participants with relative increase in hs-cTnI more frequently were older and male, with higher systolic blood pressure. The adjusted hazard ratio (HR) for relative increase in hs-cTnI was 1.68 (95% CI, 1.16-2.42) and the adjusted HR for relative decrease was 1.19 (95% CI, 0.84-1.68). Absolute increases in hs-cTnI exhibited similar prognostic properties as relative increases in hs-cTnI. The most recent measurement of hs-cTnI outperformed the change variables in discrimination and reclassification models. CONCLUSIONS:Both relative and absolute increases in hs-cTnI are independently associated with cardiovascular risk. For refinement of risk prediction models, the most recent measurement of hs-cTnI should be preferred in clinical practice.

journal_name

Clin Chem

journal_title

Clinical chemistry

authors

Lyngbakken MN,Røsjø H,Holmen OL,Dalen H,Hveem K,Omland T

doi

10.1373/clinchem.2018.301069

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

871-881

issue

7

eissn

0009-9147

issn

1530-8561

pii

clinchem.2018.301069

journal_volume

65

pub_type

杂志文章
  • Description of a computer program to assess cancer antigen 15.3, carcinoembryonic antigen, and tissue polypeptide antigen information during monitoring of metastatic breast cancer.

    abstract::It is time-consuming to process and compare the clinical and marker information registered during monitoring of breast cancer patients. To facilitate the assessment, we developed a computer program for interpreting consecutive measurements. The intraindividual biological variation, the analytical precision profile, th...

    journal_title:Clinical chemistry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sölétormos G,Schiøler V

    更新日期:2000-08-01 00:00:00

  • Simultaneous assay of corticosterone and cortisol in plasma by reversed-phase liquid chromatography.

    abstract::We have developed a simple, specific, and sensitive reversed-phase liquid-chromatographic method for accurate and simultaneous analysis of corticosterone and cortisol in human plasma. We achieved a detection limit of 300 ng/L for both steroids by modifying the old solid-phase extraction method to make use of "Tef Elut...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Hariharan M,Naga S,VanNoord T,Kindt EK

    更新日期:1992-03-01 00:00:00

  • Clinical and laboratory studies of a new immunoradiometric assay of parathyroid hormone-related protein.

    abstract::Parathyroid hormone-related protein (PTHrP) was measured in plasma by a new immunoradiometric assay (IRMA) from Nichols Institute. The assay is specific for PTHrP and shows excellent parallelism when measuring keratinocyte fluid, samples with high PTHrP content, and PTHrP-supplemented plasma. A precision profile estab...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Fraser WD,Robinson J,Lawton R,Durham B,Gallacher SJ,Boyle IT,Beastall GH,Logue FC

    更新日期:1993-03-01 00:00:00

  • Multicenter evaluation of [-2]proprostate-specific antigen and the prostate health index for detecting prostate cancer.

    abstract:BACKGROUND:Total prostate-specific antigen (tPSA) is flawed for prostate cancer (PCa) detection. [-2]proprostate-specific antigen (p2PSA), a molecular isoform of free PSA (fPSA), shows higher specificity compared with tPSA or percentage of free PSA (%fPSA). The prostate health index (Phi), a measure based on p2PSA and ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,多中心研究

    doi:10.1373/clinchem.2012.195784

    authors: Stephan C,Vincendeau S,Houlgatte A,Cammann H,Jung K,Semjonow A

    更新日期:2013-01-01 00:00:00

  • High-throughput mitochondrial genome screening method for nonmelanoma skin cancer using multiplexed temperature gradient capillary electrophoresis.

    abstract:BACKGROUND:We explored the utility of multiplexed temperature gradient capillary electrophoresis (TGCE) as a screening tool for identifying genetic changes in the human mitochondrial genome. We examined changes in mitochondrial DNA (mtDNA) in nonmelanoma skin cancers (NMSCs), using TGCE to resolve genetic differences c...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2004.040311

    authors: Girald-Rosa W,Vleugels RA,Musiek AC,Sligh JE

    更新日期:2005-02-01 00:00:00

  • Endotoxin binding to platelets in blood from patients with a sepsis syndrome.

    abstract::Endotoxin, the lipopolysaccharide cell wall constituent of Gram-negative bacteria, produces symptoms of the Gram-negative sepsis syndrome. By measuring endotoxin in blood from septic patients it may be possible to select a subpopulation of patients in which mortality can be prevented by treatment with anti-endotoxin a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Salden HJ,Bas BM

    更新日期:1994-08-01 00:00:00

  • Estimating fat in feces by near-infrared reflectance spectroscopy.

    abstract::We describe use of near-infrared reflectance spectroscopy (NIRRS) to estimate the amount of fat in feces, for diagnosis of steatorrhea. After sample homogenization, the spectrum of the fecal homogenate is scanned over the near-infrared region. Assay of 94 samples of feces having a known concentration of fat showed the...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Koumantakis G,Radcliff FJ

    更新日期:1987-04-01 00:00:00

  • Development of a stable reference material for prostatic acid phosphatase.

    abstract::We describe the development of a stable reference material for prostatic acid phosphatase, derived from human prostatic tissue and human seminal fluid. The enzyme was purified by an L-tartramic acid affinity-chromatography technique. Two-dimensional electrophoresis revealed essentially no contaminating proteins, and s...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Duncan PH,Van Etten RL,MacNeil ML,Shaw LM

    更新日期:1984-08-01 00:00:00

  • Determination of beta 2-microglobulin in human urine and serum by latex immunoassay.

    abstract::This highly sensitive method for determination of beta 2-microglobulin (beta 2-m) in human urine or serum is based on direct agglutination by beta 2-m of latex particles on which an antibody against beta 2-m is adsorbed. The agglutination is quantified by counting the remaining unagglutinated particles, or by turbidim...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Bernard AM,Vyskocil A,Lauwerys RR

    更新日期:1981-06-01 00:00:00

  • Changes in biliary (high-molecular-mass) and liver isoforms of alkaline phosphatase after baboon-to-human liver transplantation.

    abstract::We report a case of hyperphosphatasemia in a 35-year-old patient with hepatitis B who underwent an orthotopic xenogeneic liver transplant. Marked increases in total alkaline phosphatase (ALP; EC 3.1.3.1) activity began 5 days posttransplantation (six times human normal) and increased to approximately 17 times normal a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Mercer D,Tang M,Marino IR,Demetris A,Fung J,Starzl T,Warty V

    更新日期:1994-07-01 00:00:00

  • Real-time PCR technology for cancer diagnostics.

    abstract:BACKGROUND:Advances in the biological sciences and technology are providing molecular targets for diagnosing and treating cancer. Current classifications in surgical pathology for staging malignancies are based primarily on anatomic features (e.g., tumor-node-metastasis) and histopathology (e.g., grade). Microarrays to...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Bernard PS,Wittwer CT

    更新日期:2002-08-01 00:00:00

  • Addition of triglyceride to serum for use in quality control and reference.

    abstract::We describe a simple method in which a water-soluble mixture of triocatanoin and a surfactant, "Triton X-114," are used in preparing solutions of triglycerides (triacylglycerols) in either human serum, solutions of albumin, or water. Analytical recovery added triglyceride was quantitative by two methods. The addition ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Bonderman DP,Proksch GJ,Bonderman PW

    更新日期:1976-08-01 00:00:00

  • Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9.

    abstract::We describe a solid-phase radioimmunometric sandwich assay for a new tumor marker defined by a monoclonal antibody (19-9). This antibody reacts with a carbohydrate antigenic determinant (CA 19-9) found at low concentrations in sera from healthy individuals but frequently increased in sera from patients with adenocarci...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Del Villano BC,Brennan S,Brock P,Bucher C,Liu V,McClure M,Rake B,Space S,Westrick B,Schoemaker H,Zurawski VR Jr

    更新日期:1983-03-01 00:00:00

  • Single-reagent polarization fluoroimmunoassay for barbiturates in urine.

    abstract::We describe a rapid polarization fluoroimmunoassay for screening for the presence of barbiturates in urine. The single reagent is prepared by pre-mixing antiserum with a fluorescein-labeled barbiturate derivative as tracer. Use of a mixture of two sheep antisera, raised against different barbiturate immunogens, result...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Colbert DL,Smith DS,Landon J,Sidki AM

    更新日期:1984-11-01 00:00:00

  • Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes.

    abstract:BACKGROUND:Several compounds in the choline oxidation pathway are associated with insulin resistance and prevalent diabetes; however, prospective data are scarce.We explored the relationships between systemic and urinary choline-related metabolites and incident type 2 diabetes in an observational prospective study amon...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2015.250761

    authors: Svingen GF,Schartum-Hansen H,Pedersen ER,Ueland PM,Tell GS,Mellgren G,Njølstad PR,Seifert R,Strand E,Karlsson T,Nygård O

    更新日期:2016-05-01 00:00:00

  • Applications of MALDI Mass Spectrometry in Clinical Chemistry.

    abstract:BACKGROUND:MALDI-TOF mass spectrometry (MS) is set to make inroads into clinical chemistry because it offers advantages over other analytical platforms. These advantages include low acquisition and operating costs, ease of use, ruggedness, and high throughput. When coupled with innovative front-end strategies and appli...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:10.1373/clinchem.2015.239491

    authors: Duncan MW,Nedelkov D,Walsh R,Hattan SJ

    更新日期:2016-01-01 00:00:00

  • Multiplex SNaPshot genotyping for detecting loss of heterozygosity in the mismatch-repair genes MLH1 and MSH2 in microsatellite-unstable tumors.

    abstract:BACKGROUND:In the workup of patients with suspected hereditary nonpolyposis colorectal cancer (HNPCC), detection of loss of heterozygosity (LOH) could help pinpoint the mismatch-repair (MMR) gene carrying the germline mutation, but analysis of microsatellite markers has proved unreliable for this purpose. We developed ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2008.108902

    authors: Bujalkova M,Zavodna K,Krivulcik T,Ilencikova D,Wolf B,Kovac M,Karner-Hanusch J,Heinimann K,Marra G,Jiricny J,Bartosova Z

    更新日期:2008-11-01 00:00:00

  • Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.

    abstract::Synovial fluid samples were collected from 45 patients with rheumatoid arthritis, spondylarthropathy, or osteoarthritis, to study their content of elastase (EC 3.4.21.37) and of cysteine proteinases (EC 3.4.22.1, 3.4.22.15). We measured both elastase complexed with alpha 1-proteinase inhibitor and elastase activity to...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Huet G,Flipo RM,Richet C,Thiebaut C,Demeyer D,Balduyck M,Duquesnoy B,Degand P

    更新日期:1992-09-01 00:00:00

  • Gas-liquid chromatographic determination of bupivacaine and lidocaine in plasma.

    abstract::A modified gas-liquid chromatographic method for determining plasma concentrations of bupivacaine and lidocaine is described, with cyclizine as an internal standard. The extraction procedure requires no solvent evaporation, thus overcoming the problem of drug volatility. Concentrations as low as 0.1 mg/liter can be de...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Zylber-Katz E,Granit L,Levy M

    更新日期:1978-09-01 00:00:00

  • Radioimmunoassay of thyroxine in 10 microliters of serum, with use of aggregated antithyroxine antibodies.

    abstract::We describe a sensitive radioimmunoassay for rapidly determining the concentration of thyroxine in 10 microL of human serum. Aggregated antithyroxine antibodies are used to separate bound and free hormone. This speeds the assay and economizes on reagents without loss of sensitivity, specificity, or precision. Results ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Collins S,Brooks M,Bermes EW

    更新日期:1980-03-01 00:00:00

  • Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients.

    abstract::Diabetic patients in poor glycemic control show increased glycation of total plasma proteins, but little is yet known about the relative extents to which the various individual proteins are glycated. Thus, we studied the non-enzymic glycation of several major plasma proteins and plasma protein fractions in normal and ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Austin GE,Mullins RH,Morin LG

    更新日期:1987-12-01 00:00:00

  • Clinical pharmacology of anti-epileptic drugs: a summary of current information.

    abstract::This compendium represents what we believe to be the most current and reliable pharmacological data on anticonvulsant drugs. The information presented is derived from determinations of the drugs in plasma or serum by gas--liquid chromatography in studies of the efficacy of anti-epileptic agents. We present information...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Leal KW,Troupin AS

    更新日期:1977-11-01 00:00:00

  • Manual fluorometry of phenylalanine from blood specimens collected on filter paper: a modified procedure.

    abstract::In this manual fluorometric method, blood samples are used that have been impregnated on the filter paper, a convenient collection technique that is widely used to screen newborns for phenylketonuria. The modified procedure, based on the method of McCaman and Robins [J. Lab Clin. Med. 59, 885 (1962)], includes elution...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Wu JT,Wu LH,Ziter FA,Ash KO

    更新日期:1979-03-01 00:00:00

  • Evaluation of four assay methods for determination of tobramycin in human serum.

    abstract::Four assay procedures for tobramycin in serum--enzyme immunoassay (I), substrate-labeled fluorescent immunoassay (II), radioimmunoassay (III), and bioassay (IV)--were compared and evaluated by replicate and analytical recovery studies. I and II were about 50% more precise than III and IV. II was substantially more nea...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Acton WJ,Van Duyn OM,Allen LV,Flournoy DJ

    更新日期:1982-01-01 00:00:00

  • Serum thyrotropin as measured with a one-step monoclonal-antibody radioimmunometric assay compared with two commercial radioimmunoassay kits.

    abstract::We compared results obtained with a commercial immunoradiometric assay kit for human thyrotropin in which monoclonal antibodies are used (Tandem -R TSH (ONE STEP) ImmunoRadioMetricAssay; Hybritech Inc.) with those obtained with two commercial radioimmunoassay methods: GAMMA-DAB [125I]HS-hTSH RIA (Clinical Assays) and ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Pekary AE,Hershman JM

    更新日期:1986-06-01 00:00:00

  • Measurement of glycosylated hemoglobin on cellulose acetate membranes by mobile affinity electrophoresis.

    abstract::In this method for separating glycosylated from nonglycosylated hemoglobin in blood by electrophoresis on cellulose acetate membranes, we exploit the affinity of low-molecular-mass dextran sulfate for the nonglycosylated fraction, which increases the mobility of the latter relative to that of glycosylated hemoglobin. ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Ambler J,Janik B,Walker G

    更新日期:1983-02-01 00:00:00

  • Growth hormone (GH) receptor isoform in acromegaly: lower concentrations of GH but not insulin-like growth factor-1 in patients with a genomic deletion of exon 3 in the GH receptor gene.

    abstract:BACKGROUND:A genomic deletion of exon 3 (d3-GHR) of the growth hormone (GH) receptor (GHR) has been linked to the effectiveness of GH therapy in children with GH deficiency. Carriers of the d3-GHR genotype had higher GH-induced growth rates than children homozygous for the full-length (fl)-GHR. The aim of this study wa...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2007.085712

    authors: Schmid C,Krayenbuehl PA,Bernays RL,Zwimpfer C,Maly FE,Wiesli P

    更新日期:2007-08-01 00:00:00

  • Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC.

    abstract:BACKGROUND:Hemoglobin-based oxygen carriers (HBOCs) are being developed as potential substitutes for the oxygen-carrying functions of erythrocytes, but athletes may obtain and experiment with HBOCs as an illicit means of enhancing oxygen transport. An electrophoretic technique has been developed to screen for the prese...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2003.026591

    authors: Varlet-Marie E,Ashenden M,Lasne F,Sicart MT,Marion B,de Ceaurriz J,Audran M

    更新日期:2004-04-01 00:00:00

  • Photodiode array detection for liquid chromatographic profiling of carboxylic acids in physiological fluids: 3-hydroxy-3-methylglutaric aciduria.

    abstract::3-Hydroxy-3-methylglutaric aciduria was detected in a newborn. The progress of the dietary therapy for the disorder was monitored by dual-column "high-performance" liquid chromatography with a computer-controlled photodiode array spectrophotometric detector. This procedure is a quick way to detect and monitor the prog...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Buchanan DN,Thoene JG

    更新日期:1986-01-01 00:00:00

  • Identification of alpha(1)-antitrypsin variants in plasma with the use of proteomic technology.

    abstract:BACKGROUND:Proteomic technology permits the investigation of genetic metabolic diseases at the level of protein expression. Changes in the expression, polypeptide structure, and posttranslational modification of individual proteins can be detected in complex mixtures of proteins. METHODS:We used high-resolution two-di...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Mills K,Mills PB,Clayton PT,Johnson AW,Whitehouse DB,Winchester BG

    更新日期:2001-11-01 00:00:00