Abstract：
PURPOSE:Prophylactic laxative regimens may prevent constipation but may increase diarrhea and subsequent rectal tube insertion. Our aim was to compare three prophylactic laxative regimens on the rate of rectal tube insertion (primary outcome) and major constipation- or diarrhea-associated complications. MATERIAL AND METHODS:We conducted a cluster-crossover trial. Three pods in a single ICU were each randomized to one of three regimens for four months with rolling cross-over. All mechanically-ventilated and enterally-fed adult patients received either regimen: A) one coloxyl with senna BD from day one; B) two coloxyl with senna +20 ml lactulose BD commencing on day 3; or C) two coloxyl with senna tablets +20 ml lactulose BD commencing on day 6. RESULTS:We enrolled 570 patients (A = 170, B = 205, C = 195) with similar baseline features. Overall, 53 (9.3%) patients received a rectal tube, and insertion rate was not statistically different between the three regimens (A = 12.9%, B = 7.8%, C = 7.7%; p = 0.15). The proportions of patients with other major constipation- or diarrhea-associated complications were similar, as were major patient-centred outcomes. CONCLUSION:Earlier commencement of a prophylactic coloxyl-based laxative regimen (day 1 or 3) did not affect the rates of complications associated with constipation or diarrhea when compared to delayed introduction (day 6).
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Hay T,Deane AM,Rechnitzer T,Fetterplace K,Reilly R,Ankravs M,Bailey M,Fazio T,Anstey J,D'Costa R,Presneill JJ,MacIsaac CM,Bellomo Rdoi
10.1016/j.jcrc.2019.04.010subject
Has Abstractpub_date
2019-08-01 00:00:00pages
86-91eissn
0883-9441issn
1557-8615pii
S0883-9441(18)31855-0journal_volume
52pub_type
杂志文章,随机对照试验abstract：PURPOSE:The prognostic value of hyperlactatemia in septic shock is unquestionable. However, as current definitions do not include hyperlactatemia as a mandatory criterion, some hypotensive patients may be diagnosed as having septic shock despite exhibiting normolactatemia. The significance of persistent sepsis-induced ...
journal_title：Journal of critical care
pub_type： 杂志文章
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abstract：PURPOSE:Nebulized heparin may reduce fibrin cast formation and reduce the degree of airway obstruction in burn inhalation injury. METHODS:Twenty-nine patients admitted to burn intensive care unit (ICU) within 24 hours of burn inhalation injury were included in this prospective double-blinded randomized study. Group H5...
journal_title：Journal of critical care
pub_type： 杂志文章,随机对照试验
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abstract：PURPOSE:Severe sepsis is a time-dependent disease, and implementation of early treatment has been associated with mortality rate reduction. However, the literature is controversial regarding cost-effectiveness analysis of this intervention. The aim was to assess the cost-effectiveness of a managed protocol for the trea...
journal_title：Journal of critical care
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journal_title：Journal of critical care
pub_type： 杂志文章
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journal_title：Journal of critical care
pub_type： 杂志文章,随机对照试验
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pub_type： 共识发展会议,杂志文章
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journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.09.014
更新日期：2016-02-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2014-04-01 00:00:00
abstract：PURPOSE:This study was designed to determine the recompression strategy and the potential risk factors associated with the development of severe diving-related spinal cord decompression sickness (DCS). MATERIAL AND METHODS:Sixty-three injured recreational divers (52 men and 11 women; 46 +/- 12 years) presenting with s...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2009.05.011
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abstract：PURPOSE:The prevalence and clinical significance of lactic acidosis in diabetic ketoacidosis (DKA) are understudied. The objective of this study was to determine the prevalence of lactic acidosis in DKA and its association with intensive care unit (ICU) length of stay (LOS) and mortality. METHODS:Retrospective, observ...
journal_title：Journal of critical care
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doi：10.1016/j.jcrc.2011.07.071
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pub_type： 杂志文章,随机对照试验
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journal_title：Journal of critical care
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journal_title：Journal of critical care
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doi：10.1016/j.jcrc.2007.03.002
更新日期：2007-12-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Journal of critical care
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更新日期：2016-02-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：Journal of critical care
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更新日期：2018-02-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2005.06.005
更新日期：2005-09-01 00:00:00
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journal_title：Journal of critical care
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journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Journal of critical care
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