Abstract:
OBJECTIVE:Comprehensive data on Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections to guide screening services among transgender women (TGW) are limited. We studied the burden of CT/NG infections in pharyngeal, rectal and urethral sites of Thai TGW and determined missed CT/NG diagnoses if selected site screening was performed. METHODS:Thai TGW were enrolled to the community-led test and treat cohort. CT/NG screening was performed from pharyngeal swab, rectal swab and urine using nucleic acid amplification test. CT/NG prevalence in each anatomical site was analysed, along with the relationships of CT/NG among the three anatomical sites. RESULTS:Of 764 TGW included in the analysis, 232 (30.4%) had CT/NG infections at any anatomical site, with an overall incidence of 23.7 per 100 person-years. The most common CT/NG infections by anatomical site were rectal CT (19.5%), rectal NG (9.6%) and pharyngeal NG (8.1%). Among 232 TGW with CT/NG infections at any anatomical site, 22%-94.4% of infections would have been missed if single anatomical site testing was conducted, depending on the selected site. Among 668 TGW who tested negative at pharyngeal site, 20.4% had either rectal or urethral infections. Among 583 TGW who tested negative at the rectal site, 8.7% had either pharyngeal or urethral infections. Among 751 TGW who tested negative at the urethral site, 19.2% had either pharyngeal or rectal infections. CONCLUSION:Almost one-third of Thai TGW had CT/NG infections. All-site screening is highly recommended to identify these infections, but if not feasible rectal screening provides the highest yield of CT/NG diagnoses. Affordable molecular technologies and/or CT/NG screening in pooled samples from different anatomical sites are urgently needed. TRIAL REGISTRATION NUMBER:NCT03580512.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Hiransuthikul A,Janamnuaysook R,Sungsing T,Jantarapakde J,Trachunthong D,Mills S,Vannakit R,Phanuphak P,Phanuphak Ndoi
10.1136/sextrans-2018-053835subject
Has Abstractpub_date
2019-11-01 00:00:00pages
534-539issue
7eissn
1368-4973issn
1472-3263pii
sextrans-2018-053835journal_volume
95pub_type
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journal_title:Sexually transmitted infections
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journal_title:Sexually transmitted infections
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doi:10.1136/sti.2006.020941
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
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journal_title:Sexually transmitted infections
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2013-11-01 00:00:00
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journal_title:Sexually transmitted infections
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doi:10.1136/sextrans-2013-051229
更新日期:2014-06-01 00:00:00
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journal_title:Sexually transmitted infections
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更新日期:2002-08-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
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更新日期:2016-02-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-06-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2018-053825
更新日期:2019-11-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.031468
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2009.041293
更新日期:2010-10-01 00:00:00