MDR1 in paroxetine-induced sexual dysfunction.

Abstract:

:Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).

journal_name

J Sex Marital Ther

authors

Zourková A,Slanař O,Jarkovský J,Palčíková I,Pindurová E,Cvanová M

doi

10.1080/0092623X.2012.668514

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

71-8

issue

1

eissn

0092-623X

issn

1521-0715

journal_volume

39

pub_type

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