Management of fetal alloimmune thrombocytopenia by weekly in utero platelet transfusions.

abstract：:Platelet concentrates (PC) prepared from pooled buffy coat (BC-PC) contain a variable number of leukocytes from different donors. We questioned whether storage of BC-PC can lead to a lymphocyte activation in the sense of a mixed lymphocyte reaction. BC-PC were prepared from four ABO-identical buffy coats and we undert...

journal_title：Vox sanguinis

authors： Klüter H,Müller-Steinhardt M,Danzer S,Wilhelm D,Kirchner H

更新日期：1995-01-01 00:00:00

abstract：:A large 81 member, four-generation black family with hereditary angioedema is reported with regards to its clinical course and the association with the histocompatibility system. No mortality was seen related directly to the disease. Assuming that this trait is autosomal dominant it appeared to have no linkage with th...

journal_title：Vox sanguinis

authors： Blumenthal MN,Dalmasso AP,Roitman B,Kelly J,Noreen H,Emmy L,Mendell NR,Yunis EJ

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Photochemical treatment (PCT) of platelet concentrates using photosensitizers and ultraviolet light illumination reduces the proliferation potential of pathogens by damaging biomolecules. MATERIALS AND METHODS:The impact of riboflavin (RF-PRT)- and amotosalen (AS-PCT)-based pathogen inactivation on platelet...

journal_title：Vox sanguinis

authors： Van Aelst B,Feys HB,Devloo R,Vanhoorelbeke K,Vandekerckhove P,Compernolle V

更新日期：2015-05-01 00:00:00

abstract：:Interest in immunogenetics originated from two streams: (a) histocompatibility in mouse and man, and (b) inheritance of specific immune responses in the guinea pig and mouse. In the mouse, there are genes associated with the major histocompatibility complex (MHC) which (i) code for antigens determining allograft respo...

journal_title：Vox sanguinis

authors： Mackay IR,Wittingham S,Tait B

更新日期：1977-01-01 00:00:00

abstract：:Early and regular blood transfusion therapy in patients with homozygous beta-thalassaemia decreases the complications of severe anaemia and prolongs survival. In the long term, however, the beneficial effects of transfusions are limited by the organ damage resulting from iron overload, a consequence of the body's limi...

journal_title：Vox sanguinis

authors： Prati D

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The absence of the red cell antigens P, P1 and Pk , known as 'p', represents an extremely rare red cell phenotype. Individuals with this phenotype spontaneously form anti-PP1Pk isoantibodies, associated with severe haemolytic transfusion reactions, recurrent spontaneous abortion and haemolytic disease of the...

journal_title：Vox sanguinis

authors： Di Ciaccio P,Cutts B,Alahakoon TI,Dennington PM,Soo LA,Curnow J

更新日期：2020-12-16 00:00:00

abstract：:Serum from a pregnant woman with the May-Hegglin anomaly contained a platelet-specific antibody. The serum reacted in the platelet indirect immunofluorescence test (PIIFT) with 97.6% of random donor platelets and those of the father but not with the mother's own platelets. This antibody induced a moderate thrombocytop...

journal_title：Vox sanguinis

authors： Bettaieb A,Fromont P,Rodet M,Godeau B,Duedari N,Bierling P

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glycocalicin (GC) is a proteolytic fragment of GpIb and can conveniently be measured in supernatants of platelet concentrates (PCs) by means of a sandwich ELISA. Because of the convenience of the assay and easy sample storage, we tested its suitability as a sensitive platelet activation parame...

journal_title：Vox sanguinis

authors： Kostelijk EH,Folman CC,Gouwerok CW,Kramer CM,Verhoeven AJ,de Korte D

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Host- or donor-derived alloimmune thrombocytopenia can develop after non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT). We report the first case of host-derived HPA-1a antibodies. CASE REPORT:A 52-year-old male patient received HSCT from his human leucocyte antigen ...

journal_title：Vox sanguinis

authors： Macher S,Schallmoser K,Staber PB,Neumeister P,Posch U,Lanzer G,Panzer S

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A 2-year-old female with neuroblastoma needed In(b-), E- red blood cells (RBCs). No units were available at the blood centre (BC) nor in the rare donor programme member's inventories. BC's Immunohematology Reference Laboratory (IRL) and its marketing department concentrated on recruiting and t...

journal_title：Vox sanguinis

authors： Gammon RR,Tyler L,Alvarez H,Benitez N,Nance S,Burton A,Delk A,Bright F,Sawh D,Forbes S

更新日期：2020-12-21 00:00:00

abstract：:We developed a new filter, 'Sepacell-PL', consisting of a blood administration set for the preparation of leukocyte-poor platelet concentrates at the patient's bedside. This filter is packed with 1.8 microns polyester fibers coated with a new polymer, and has a volume of 14 ml. Sepacell-PL removed more than 99% of the...

journal_title：Vox sanguinis

authors： Miyamoto M,Sasakawa S,Ishikawa Y,Ogawa A,Nishimura T,Kuroda T

更新日期：1989-01-01 00:00:00

abstract：:Routine screening of blood donations for anti-HIV commenced in the UK during October 1985 and by the end of February 1987 approximately 3.7 million donations had been tested. Seventy-two were confirmed anti-HIV positive, i.e. 0.002%. Of the anti-HIV-positive donors interviewed to date, the majority are young homosexua...

journal_title：Vox sanguinis

authors： Gunson HH,Rawlinson VI

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The amino acid substitutions caused by ABO gene variants are usually predicted to impact the glycosyltransferase function. Here, the effect of an amino acid substitution in the vicinity of the catalytic active region of the B-glycosyltransferase was explored in vitro and in silico study, which is important f...

journal_title：Vox sanguinis

authors： Ying Y,Hong X,Xu X,Zhang J,He J,Zhu F,Xie X

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Leucocyte-derived cytokines accumulate in stored whole blood. Pre-storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non-haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesize...

journal_title：Vox sanguinis

authors： Chudziak D,Sireis W,Pfeiffer HU,Henschler R,Seifried E,Bönig H

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pr1,2,3, PrM, Sa and Sia-l1, -b1, -lb1 are sialic acid (NeuNAc)-dependent antigens recognized by human cold agglutinins. Pr and Sa antigens are the O-glycans of glycophorins containing alpha 2,3NeuNAc (to galactose) and/or alpha 2,6NeuNAc (to galactosamine). The antigens of the Sia-l1, -b1, -l...

journal_title：Vox sanguinis

authors： Roelcke D,Hack H,Kreft H,Gross HJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Polymorphonuclear neutrophils (PMNs) play important roles in the host immune defence. This study was performed to identify roles of PMNs other than those already known. MATERIALS AND METHODS:PMNs were separated from the peripheral blood of healthy individuals and stored in vitro for 24 h in t...

journal_title：Vox sanguinis

authors： Nishimura M,Mitsunaga S,Juji T

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A major requirement of a hepatitis C virus (HCV) RNA nucleic acid amplification technology (NAT) assay validation is the ability of the assay to detect the six major genotypes of HCV with equivalent sensitivities. The aim of this study was to characterize and calibrate an HCV genotype panel fo...

journal_title：Vox sanguinis

authors： Saldanha J,Heath A,Collaborative Study Group.

更新日期：2003-01-01 00:00:00

abstract：:Serum IgE was determined by radioimmunoassay in 28 subjects affected by homozygous beta thalassemia (14 males and 14 females, aged 3-19 years, mean age 7 +/- 5.6 years). They were given transfusions with packed red cells and chelant therapy. Blood samples were taken just before a transfusion (basal value) and at 10-da...

journal_title：Vox sanguinis

authors： La Rosa M,Pavone L,Musumeci S,Mollica F,Ronchetti R

更新日期：1983-01-01 00:00:00

abstract：:The effect on cryoprecipitate factor VIII recovery of three imortant variables has been investigated. The design of the study was such as to eliminate, for the purpose of internal comparisons, spurious effects such as those due to the variation in factor VIII levels in donor plasma. The choice of anticoagulant was sho...

journal_title：Vox sanguinis

authors： Wensley RT,Snape TJ

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Capillary samples can provide blood for cell counts in haematologic patients and blood donors. However, some accept only values from venous blood. This study compares capillary and venous blood counts to verify the hypothesis that they are equivalent. MATERIALS AND METHODS:We analysed 463 cap...

journal_title：Vox sanguinis

authors： Schalk E,Heim MU,Koenigsmann M,Jentsch-Ullrich K

更新日期：2007-11-01 00:00:00

abstract：:A method of pasteurising a concentrate of factor I (C3b inactivator) prepared from human blood plasma is described. As well as obtaining a high yield of factor I by this virus inactivation procedure it is furthermore possible, by adjustment of the stabiliser concentration, to obtain a very pronounced reduction in the ...

journal_title：Vox sanguinis

authors： Alsøe KO,Kihl J

更新日期：1989-01-01 00:00:00

abstract：:There is an ongoing debate whether platelet concentrates (PCs) prepared from either whole-blood donations or by plateletpheresis are superior. Usage of these two product types varies greatly between countries and individual institutions. Some use mainly apheresis PCs; others prefer pooled PCs which are produced from w...

journal_title：Vox sanguinis

authors： Schrezenmeier H,Seifried E

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to assess potentially relevant clinical characteristics which influence the decision to transfuse red cells in critically ill patients with low haemoglobin concentrations (6.0-10.0 g/dl). MATERIALS AND METHODS:This was a retrospective observational cohort study of pa...

journal_title：Vox sanguinis

authors： Kranenburg FJ,le Cessie S,Caram-Deelder C,van der Bom JG,Arbous MS

更新日期：2019-11-01 00:00:00

abstract：:As part of a programme to establish a panel of individuals with high titres of anticytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect haemagglutination assay, enzyme immunoassay, and complement fixation. The indirect haemagglutination assay ...

journal_title：Vox sanguinis

authors： Chung A,Chang W,Leung MK,Ofosu FA,Moore BP

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:The risk of transmitting hepatitis C (HCV) by transfusion of anti-HCV-negative screened blood was estimated for the blood donor population of Baden-Württemberg (southwestern Germany). METHODS:The data from the blood donors screened for anti-HCV and for HBsAg during 1990-1995 were analyzed. RESULTS:The preva...

journal_title：Vox sanguinis

authors： Koerner K,Cardoso M,Dengler T,Kerowgan M,Kubanek B

更新日期：1998-01-01 00:00:00

abstract：:Prolonged storage of red blood cells (RBCs) at 4 degrees C results in decreased intracellular ATP levels with diminished posttransfusion survival. Meryman described a preservative medium, exceptional in its capacity to increase these intracellular levels during the first weeks of storage and later in maintaining adequ...

journal_title：Vox sanguinis

authors： Mazor D,Dvilansky A,Meyerstein N

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:For some unknown reason humans may 'spontaneously' produce high amounts of neutralizing autoantibodies to a number of growth factors and cytokines. Reaching a certain high level the antibodies render the person cytokine deficient, mostly without overt clinical manifestations. The autoantibodies in question a...

journal_title：Vox sanguinis

authors： Hansen MB,Galle P,Salomo M,Svenson M,Dickmeiss E,Gimsing P

更新日期：2007-04-01 00:00:00

abstract：:The use of granulocyte transfusions in profoundly neutropenic patients has increased markedly in recent years. Whenever a pulmonary infiltrate develops during the course of these transfusions, the question arises as to what role the transfusions are playing and whether the transfusions should be discontinued to preven...

journal_title：Vox sanguinis

authors： Karp DD,Ervin TJ,Tuttle S,Gorgone BC,Lavin P,Yunis EJ

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments may cause human leucocyte antigen (HLA) immunization in recipients. We investigated the occurrence and production of WBC fragments in platelet concentrates (PCs) and plasma units, during storage and filtration, by using real-time polymerase chain reaction (PCR)...

journal_title：Vox sanguinis

authors： Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Huijgens PC,van der Meer PF,Reesink HW

更新日期：2004-11-01 00:00:00

abstract：:The clinical course and laboratory findings of a patient with autoimmune haemolytic anaemia due to anti-phospholipid antibodies and secondary to a systemic lupus erythematosus-like syndrome are described. IgG and IgM with anti-phospholipid activity coexisted in both sera and acid eluates prepared from the patient's re...

journal_title：Vox sanguinis

authors： Arvieux J,Schweizer B,Roussel B,Colomb MG

更新日期：1991-01-01 00:00:00