Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome.

Abstract:

PURPOSE:We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals. METHODS:Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were recruited in this cross-sectional and comparative study. The thickness of the pre-ocular tear film, corneal epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium were measured on the corneal apex. Anterior scleral thickness was measured at distances of 1 mm and 3 mm from the limbus. The anterior segment module of spectral-domain optical coherence tomography was used to measure thicknesses of pre-ocular tear film, corneal layers, and anterior sclera. RESULTS:Tear film thickness, Schirmer's test, and tear break up time values were significantly lower in the Sjögren's disease group than in the healthy controls (p<0.05). The thickness measurements of corneal layers and sclera were similar between the groups. Tear film thickness was moderately correlated with the Schirmer's test results (r=0.34, p=0.001), but there was no correlation between the Schirmer's test results and tear break up time (r=0.18, p=0.09). CONCLUSIONS:Pre-ocular tear film, as measured by anterior segment optical coherence tomography, was thinner in patients with primary Sjögren's syndrome than in the healthy controls. The thicknesses of corneal layers and anterior sclera were similar between the groups.

journal_name

Arq Bras Oftalmol

authors

Pekel G,Taşçı M,Bahar A,Pekel E,Çetin EN,Martin Ç,Çobankara V

doi

10.5935/0004-2749.20190054

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

270-274

issue

4

eissn

0004-2749

issn

1678-2925

pii

S0004-27492019005006101

journal_volume

82

pub_type

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