A thickened formula does not reduce apneas related to gastroesophageal reflux in preterm infants.

Abstract:

BACKGROUND:Apnea of prematurity (AOP) occurs frequently in preterm infants and a variable proportion of AOP can be induced by gastroesophageal reflux (GER). Conservative treatment, including dietary modifications, should be the first-line approach for both GER and GER-related apneas in this population. OBJECTIVES:To evaluate the efficacy of a starch-thickened preterm formula (PF) in reducing the frequency of apneas related to GER. METHODS:Preterm infants with AOP were studied by combined impedance and pH monitoring and polysomnography. The 6-hour study period included two feeds, one of a commercially available PF and one of the same formula thickened with amylopectin (TPF). GER indexes, apneas and GER-related apneas detected after TPF and PF feeds were compared by Wilcoxon signed-rank test. RESULTS:24 infants were studied. During 140 h of registration, 289 apneas (147 after TPF and 142 after PF; p = 0.876), and 861 GER episodes (400 after TPF and 461 after PF; p = 0.465) were recorded. No difference in the number of AOP was found between TPF and PF. A significant reduction in acid exposure was found after TPF; there was no influence on non-acid GER indexes. The frequency of GER-related apneas did not differ between TPF and PF. CONCLUSIONS:A formula thickened with amylopectin did not reduce the number of AOP or GER-related apneas. It reduced acid GER features but had no effect on non-acid GER indexes. Future research should focus on exploring different conservative strategies to treat GER-related apneas in preterm infants.

journal_name

Neonatology

journal_title

Neonatology

authors

Corvaglia L,Spizzichino M,Aceti A,Legnani E,Mariani E,Martini S,Battistini B,Faldella G

doi

10.1159/000342703

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

98-102

issue

2

eissn

1661-7800

issn

1661-7819

pii

000342703

journal_volume

103

pub_type

杂志文章
  • Inhaled Glucocorticoids and Pneumonia in Preterm Infants: Post Hoc Results from the NEuroSIS Trial.

    abstract:BACKGROUND:Inhaled glucocorticoids may increase the risk of pneumonia in adults. Thus, respiratory infections may be a potential explanation for the non-significantly increased mortality seen in the glucocorticoid group in the largest randomized trial on inhaled glucocorticoids for preventing bronchopulmonary dysplasia...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000468507

    authors: Koch A,Kreutzer K,von Oldershausen G,Poets CF,Bassler D,NEuroSIS Trial Group.

    更新日期:2017-01-01 00:00:00

  • A Randomized Controlled Trial of Immediate versus Delayed Umbilical Cord Clamping in Multiple-Birth Infants Born Preterm.

    abstract:BACKGROUND:Delayed cord clamping (DCC) improves placental transfusion and increases blood volume in preterm infants when compared with immediate cord clamping (ICC). However, evidence to support DCC in multiple-birth preterm infants is still lacking. OBJECTIVE:To compare the outcomes of ICC versus DCC in preterm infan...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000494132

    authors: Ruangkit C,Bumrungphuet S,Panburana P,Khositseth A,Nuntnarumit P

    更新日期:2019-01-01 00:00:00

  • The use of the WINROP screening algorithm for the prediction of retinopathy of prematurity in a Chinese population.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a gestational age (GA)-related illness that can lead to blindness in premature infants. Timely screening of premature infants could improve visual prognosis. OBJECTIVE:To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population. METHODS:...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000351297

    authors: Sun H,Kang W,Cheng X,Chen C,Xiong H,Guo J,Zhou C,Zhang Y,Hellström A,Löfqvist C,Zhu C

    更新日期:2013-01-01 00:00:00

  • Effects of bilirubin on neutrophil responses in newborn infants.

    abstract:BACKGROUND:Newborns are susceptible to inflammatory diseases due to defects in clearing activated immune cells from tissues. Therefore, mechanisms have likely evolved to protect neonates from leukocyte-mediated cytotoxicity. Bilirubin has antioxidant activity, and it is possible that it also exerts effects on cellular ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000343097

    authors: Weinberger B,Archer FE,Kathiravan S,Hirsch DS,Kleinfeld AM,Vetrano AM,Hegyi T

    更新日期:2013-01-01 00:00:00

  • Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Early host-microbe interaction provides important maturational stimuli for the developing immune system. The role of prenatal microbial contact remains elusive. OBJECTIVES:Our aim was to investigate whether microbes in placenta or amniotic fluid affect fetal innate immune gene expression during late pregnan...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000339182

    authors: Rautava S,Collado MC,Salminen S,Isolauri E

    更新日期:2012-01-01 00:00:00

  • Volume expansion does not alter cerebral tissue oxygen extraction in preterm infants with clinical signs of poor perfusion.

    abstract:BACKGROUND:Preterm infants with signs of poor perfusion are often treated with volume expansion, although evidence regarding its effect on cerebral perfusion is lacking. Moreover, the effect is questionable in preterm infants with an adequate cerebrovascular autoregulation (CAR). A useful measure to assess perfusion is...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000346383

    authors: Kooi EM,van der Laan ME,Verhagen EA,Van Braeckel KN,Bos AF

    更新日期:2013-01-01 00:00:00

  • Predictive value of the parent-completed ASQ for school difficulties in preterm-born children

    abstract:BACKGROUND:Preterm infants are at greater risk of developmental impairment and require close follow-up for early and optimal care. OBJECTIVES:The objective of the present study was to determine from which age the parental Ages and Stages Questionnaire (ASQ) allows detection of school difficulties in preterm children <...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000363216

    authors: Halbwachs M,Muller JB,Nguyen The Tich S,Gascoin G,Chauty-Frondas A,Branger B,Rouger V,Roze JC,Flamant C

    更新日期:2014-01-01 00:00:00

  • History of the ductus arteriosus: 1. Anatomy and spontaneous closure.

    abstract::Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo...

    journal_title:Neonatology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000308367

    authors: Obladen M

    更新日期:2011-01-01 00:00:00

  • Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns.

    abstract:OBJECTIVE:Therapeutic hypothermia (HT) is the standard treatment for newborns after perinatal asphyxia. Preclinical studies report that HT is more effective when started early. METHODS:Eighty cooled newborns were analyzed and grouped according to when cooling was started after birth: early (≤180 min) or late (>181 min...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000353948

    authors: Thoresen M,Tooley J,Liu X,Jary S,Fleming P,Luyt K,Jain A,Cairns P,Harding D,Sabir H

    更新日期:2013-01-01 00:00:00

  • Congenital ichthyosis in severe type II Gaucher disease with a homozygous null mutation.

    abstract::This paper describes a neonate with type II Gaucher disease. The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure. Electron microscopy of the skin revealed lamellar body contents in the stratum corneum interstices, appearances consider...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000324116

    authors: Haverkaemper S,Marquardt T,Hausser I,Timme K,Kuehn T,Hertzberg C,Rossi R

    更新日期:2011-01-01 00:00:00

  • Early transient hypoglycemia is associated with increased albumin nitration in the preterm infant.

    abstract:BACKGROUND:The clinical significance of early transient hypoglycemia (ETH), a frequent event in preterm newborns, is a highly controversial issue. In experimental models, hypoglycemia has been reported to cause oxidative stress. Among the reactive species, early generated peroxynitrite is responsible for protein nitrat...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000326936

    authors: Wayenberg JL,Cavedon C,Ghaddhab C,Lefèvre N,Bottari SP

    更新日期:2011-01-01 00:00:00

  • Prospective volumetric analysis of gallbladders in critically ill newborns: the impact of nutrition.

    abstract:BACKGROUND:Neonatal reference values of gallbladder size have been assessed in healthy newborns with enteral feeding regimen. Their applicability to critically ill patients under total parenteral nutrition (TPN) remains to be questioned. OBJECTIVE:Our aim was to evaluate the impact of short-term TPN versus enteral nut...

    journal_title:Neonatology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000102058

    authors: Schmidt B,Roth B,Stützer H,Benz-Bohm G

    更新日期:2007-01-01 00:00:00

  • Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.

    abstract:BACKGROUND:Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate. Therefore, co-trea...

    journal_title:Neonatology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000499330

    authors: Favié LMA,Groenendaal F,van den Broek MPH,Rademaker CMA,de Haan TR,van Straaten HLM,Dijk PH,van Heijst A,Simons SHP,Dijkman KP,Rijken M,Zonnenberg IA,Cools F,Zecic A,van der Lee JH,Nuytemans DHGM,van Bel F,Egberts TCG,

    更新日期:2019-01-01 00:00:00

  • Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity.

    abstract:BACKGROUND:Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP). OBJECTIVE:To evaluate the effect of doxapram on long-term neurodevelopmental outcome in preterm infants as its safety still needs to be established. METHODS:From a retrospective cohort of preterm infants with a gestationa...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000444006

    authors: Ten Hove CH,Vliegenthart RJ,Te Pas AB,Brouwer E,Rijken M,van Wassenaer-Leemhuis AG,van Kaam AH,Onland W

    更新日期:2016-01-01 00:00:00

  • Hemolysis and Glucose-6-Phosphate Dehydrogenase Deficiency-Related Neonatal Hyperbilirubinemia.

    abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency affecting more than 300 million individuals worldwide. Extreme neonatal hyperbilirubinemia, with its severe sequelae of bilirubin neurotoxicity and the potential of death, is the most devastating manifestation of G6PD deficienc...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000489820

    authors: Kaplan M,Wong RJ,Stevenson DK

    更新日期:2018-01-01 00:00:00

  • Social Birth: Rites of Passage for the Newborn.

    abstract::Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewi...

    journal_title:Neonatology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000477955

    authors: Obladen M

    更新日期:2017-01-01 00:00:00

  • Pressure versus Sudden Wean from Nasal Continuous Positive Airway Pressure in Preterm Infants: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Nasal continuous positive airway pressure (NCPAP) is a well-studied treatment for respiratory problems in preterm infants. However, the best strategy for NCPAP weaning is unknown. OBJECTIVE:We aimed to compare the success of progressive pressure wean versus sudden wean for discontinuation of NCPAP in preter...

    journal_title:Neonatology

    pub_type: meta分析

    doi:10.1159/000507863

    authors: Lemieux-Bourque C,Piedboeuf B,Fontela PS,Bornais K,Beltempo M

    更新日期:2020-01-01 00:00:00

  • Volume not guaranteed: closed endotracheal suction compromises ventilation in volume-targeted mode.

    abstract:BACKGROUND:Closed endotracheal suction interferes with mechanical ventilation received by infants, but the change to ventilation may be different when ventilator modes that target expired tidal volume (VT(e)) are used. OBJECTIVE:To measure airway pressure and tidal volume distal to the endotracheal tube (ETT) during a...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000316854

    authors: Kiraly NJ,Tingay DG,Mills JF,Dargaville PA,Copnell B

    更新日期:2011-01-01 00:00:00

  • The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations.

    abstract:BACKGROUND:Serum ferritin measurements are used in clinical populations to estimate total body iron stores and the risk of subsequent iron deficiency or overload. The lack of normative newborn serum ferritin concentration data between 23 and 41 weeks has led to difficulty in establishing the incidence and degree of abn...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000100805

    authors: Siddappa AM,Rao R,Long JD,Widness JA,Georgieff MK

    更新日期:2007-01-01 00:00:00

  • Nurse-to-patient ratios and neonatal outcomes: a brief systematic review.

    abstract:BACKGROUND:Higher patient-to-nurse ratios and nursing workload are associated with increased mortality in the adult intensive care unit (ICU). Most neonatal ICUs (NICUs) in the United Kingdom do not meet national staffing recommendations. The impact of staffing on outcomes in the NICU is unknown. OBJECTIVE:To determin...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000353458

    authors: Sherenian M,Profit J,Schmidt B,Suh S,Xiao R,Zupancic JA,DeMauro SB

    更新日期:2013-01-01 00:00:00

  • Variability of influenza AH1N1 infections in a neonatal unit in Spain.

    abstract::We describe three positive influenza AH1N1 cases in a neonatal unit during the influenza pandemic in Spain. One term baby presented with an upper respiratory tract infection, another preterm infant with an apnea episode following nosocomial infection, and thirdly, a term infant of a mother with influenza AH1N1 had sev...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000324232

    authors: Calvo C,Gonzalez-Carrasco E,Quevedo S,García-García ML,Rando A,Ledesma J,Calderon A,Pozo F,Pérez-Breña P,Casas I

    更新日期:2011-01-01 00:00:00

  • Diagnostic value of an interleukin-6 bedside test in term and preterm neonates at the time of clinical suspicion of early- and late-onset bacterial infection.

    abstract:BACKGROUND:For quick detection or exclusion of neonatal early-onset bacterial infection (EOBI) or late-onset bacterial infection (LOBI), interleukin (IL)-6 is used. Its clinical use is sometimes limited due to prolonged recall times. Therefore, an IL-6 bedside test was established. OBJECTIVE:To compare the diagnostic ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000336632

    authors: Batfalsky A,Lohr A,Heussen N,Neunhoeffer F,Orlikowsky TW

    更新日期:2012-01-01 00:00:00

  • Effect of Phototherapy on the Reliability of Transcutaneous Bilirubin Devices in Term and Near-Term Infants: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Transcutaneous bilirubin (TcB) devices are commonly used for screening of hyperbilirubinemia in term and near-term infants not exposed to phototherapy. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. OBJECTIVES:To conduct a systematic review of studies comparing TcB devic...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000442195

    authors: Nagar G,Vandermeer B,Campbell S,Kumar M

    更新日期:2016-01-01 00:00:00

  • Ventilation-Induced Brain Injury in Preterm Neonates: A Review of Potential Therapies.

    abstract::Mechanical ventilation is a risk factor for cerebral inflammation and brain injury in preterm neonates. The risk increases proportionally with the intensity of treatment. Recent studies have shown that cerebral inflammation and injury can be initiated in the delivery room. At present, initiation of intermittent positi...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000444918

    authors: Barton SK,Tolcos M,Miller SL,Christoph-Roehr C,Schmölzer GM,Moss TJ,Hooper SB,Wallace EM,Polglase GR

    更新日期:2016-01-01 00:00:00

  • Hyperglycaemic Preterm Babies Have Sex Differences in Insulin Secretion.

    abstract:BACKGROUND:Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. OBJECTIVE:To determine insulin secret...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000381206

    authors: Dickson JL,Chase JG,Pretty CG,Gunn CA,Alsweiler JM

    更新日期:2015-01-01 00:00:00

  • Survey of practices regarding utilization of inhaled steroids in 223 German neonatal units.

    abstract:BACKGROUND:No survey has been published in recent years which primarily focuses on the prescription of inhaled corticosteroids in neonatal practice. Thus, the utilization rate of inhaled corticosteroids is unknown. OBJECTIVES:To elucidate the current utilization rate of inhaled corticosteroids in the prevention and th...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000316978

    authors: Maas C,Poets CF,Bassler D

    更新日期:2010-01-01 00:00:00

  • Body Composition in Very Preterm Infants: Role of Neonatal Characteristics and Nutrition in Achieving Growth Similar to Term Infants.

    abstract:BACKGROUND:The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. OBJECTIVES:As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and to explore relationships betw...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000450882

    authors: Tremblay G,Boudreau C,Bélanger S,St-Onge O,Pronovost E,Simonyan D,Marc I

    更新日期:2017-01-01 00:00:00

  • Assessment of Risk Indicators for Targeted Cytomegalovirus Screening in Neonates.

    abstract:BACKGROUND:In the absence of universal screening for congenital cytomegalovirus (cCMV) infection, the aim of this study was to assess the outcomes of a targeted screening protocol based on maternal and neonatal risk indicators. METHODS:The medical records of 2,623 neonates born in our maternal hospital between June 20...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000512525

    authors: Levit Y,Dym L,Yochpaz S,Manor Y,Adler A,Halutz O,Grisaru-Soen G,Herzlich J,Marom R

    更新日期:2020-12-22 00:00:00

  • Reduced Cerebellar Size at Term-Equivalent Age Is Related to a 17% Lower Mental Developmental Index in Very Preterm Infants without Brain Injury.

    abstract:INTRODUCTION:Cerebellar injury is increasingly recognized as a relevant complication of premature birth. However, the prevalence of reduced cerebellar growth and its consequences for neurodevelopmental outcome in preterm infants without overt brain injury remain to be defined in detail. The aim of this study was to ass...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000502491

    authors: Hammerl M,Zagler M,Griesmaier E,Janjic T,Gizewski ER,Kiechl-Kohlendorfer U,Neubauer V

    更新日期:2020-01-01 00:00:00

  • The Specificity of the WINROP Algorithm Can Be Significantly Increased by Reassessment of the WINROP Alarm.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinati...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000435770

    authors: Lundgren P,Stoltz Sjöström E,Domellöf M,Smith L,Wu C,VanderVeen D,Hellström A,Löfqvist C

    更新日期:2015-01-01 00:00:00