Genome-wide association study for body weight in cattle populations from Siberia.

Abstract:

:Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Igoshin AV,Yudin NS,Belonogova NM,Larkin DM

doi

10.1111/age.12786

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

250-253

issue

3

eissn

0268-9146

issn

1365-2052

journal_volume

50

pub_type

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