C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children.

Abstract:

:Our objective was to determine if C-reactive protein (CRP) and ferritin values alone and in combination are associated with mortality among hospitalized children. All hospitalized patients at our institution with a CRP or ferritin assay in 2015 and 2016 were included. Area under the receiver operating curves (AUROC) were examined, optimal cut-points determined, and patients were stratified into low-, intermediate-, or high-risk groups based on elevation of zero, one, or both biomarkers. A total of 14 928 CRP and 653 ferritin values were obtained, with both obtained for 172 patients. AUROC for maximum CRP value was 0.76 (0.68-0.85) with a cut-point of 7.1 mg/dL for in-hospital mortality and 0.90 (0.83-0.98) for maximum ferritin with a cut-point of 373 ng/mL. Elevation of both ferritin and CRP was associated with the highest inpatient mortality (21.7%) and greatest organ dysfunction, followed by either biomarker alone. Additional prospective study of these biomarkers in combination is warranted.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Horvat CM,Bell J,Kantawala S,Au AK,Clark RSB,Carcillo JA

doi

10.1177/0009922819837352

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

752-760

issue

7

eissn

0009-9228

issn

1938-2707

journal_volume

58

pub_type

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