Abstract:
:Our objective was to determine if C-reactive protein (CRP) and ferritin values alone and in combination are associated with mortality among hospitalized children. All hospitalized patients at our institution with a CRP or ferritin assay in 2015 and 2016 were included. Area under the receiver operating curves (AUROC) were examined, optimal cut-points determined, and patients were stratified into low-, intermediate-, or high-risk groups based on elevation of zero, one, or both biomarkers. A total of 14 928 CRP and 653 ferritin values were obtained, with both obtained for 172 patients. AUROC for maximum CRP value was 0.76 (0.68-0.85) with a cut-point of 7.1 mg/dL for in-hospital mortality and 0.90 (0.83-0.98) for maximum ferritin with a cut-point of 373 ng/mL. Elevation of both ferritin and CRP was associated with the highest inpatient mortality (21.7%) and greatest organ dysfunction, followed by either biomarker alone. Additional prospective study of these biomarkers in combination is warranted.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Horvat CM,Bell J,Kantawala S,Au AK,Clark RSB,Carcillo JAdoi
10.1177/0009922819837352subject
Has Abstractpub_date
2019-06-01 00:00:00pages
752-760issue
7eissn
0009-9228issn
1938-2707journal_volume
58pub_type
杂志文章abstract::Headache is a highly prevalent condition and is the leading cause for school absences. Despite the rich literature supporting behavioral treatments for headache, many child psychologists mistakenly perceive that they lack appropriate training to treat children with headache. Likewise, many physicians feel underprepare...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922816638665
更新日期:2017-01-01 00:00:00
abstract::Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophagea...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922806295400
更新日期:2007-05-01 00:00:00
abstract::A 6-year-old boy with fever, vomiting, abdominal pain, and leucocytosis was found to have a small nodule of heterotopic pancreatic tissue in the wall of the jejunum. Leakage of pancreatic enzymes caused inflammation and hemorrhagic necrosis of adjacent smooth muscle. Excision of the lesion was followed by prompt and p...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288602500913
更新日期:1986-09-01 00:00:00
abstract::The objective was to determine the prevalence of therapies used by parents to manage acute diarrhea in their children and determine extent of parental adherence to current management guidelines and utilization of functional foods. Parents (N=623) of children with diarrhea were surveyed in a tertiary care pediatric eme...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922808327057
更新日期:2009-04-01 00:00:00
abstract::Although still considered to be a rare and mostly fatal illness, the reported incidence of neonatal bacterial endocarditis has increased during the past decade. This parallels the establishment of intensive supportive management of severely ill newborns with multiple medical problems. An extremely difficult diagnostic...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289002900707
更新日期:1990-07-01 00:00:00
abstract::Although asthma treatment guidelines recommend daily inhaled corticosteroid (ICS) use for all persistent asthma, pediatricians may recommend alternative treatment plans for children with mild persistent disease. The authors administered a survey of pediatricians to describe prescribing patterns for mild persistent ast...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922807312184
更新日期:2008-06-01 00:00:00
abstract::Objective. To investigate if parental background affects acceptance of behavior guidance techniques. Background. Behavior guidance techniques are used for the safe and effective treatment of pediatric patients. Acceptance of these techniques may vary by racial and ethnic background. Methods. A total of 142 parents wer...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922819845897
更新日期:2019-08-01 00:00:00
abstract::A case of an 11-year-old girl with autoimmune hypothyroidism and a positive sweat test is presented. When the hypothyroidism was corrected the sweat test reverted to normal. ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288902801110
更新日期:1989-11-01 00:00:00
abstract::Bedwetting is the most common urologic complaint among children. Wetting frequency at age 7 years varies from 5% to 15%. Treatment has been multimodal: drugs to depress bladder activity, increase urethral resistance, or modulate sleep; electrophysiologic treatment; and, recently, urine production modulation. All of th...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/0009922893032001s02
更新日期:1993-07-01 00:00:00
abstract::Care coordination (CC) has shown positive outcomes among children with special health care needs (CSHCN); however, the association between CC and well-child care (WCC) visits is unknown. We hypothesize that CSHCN who receive CC are more likely to attend the recommended WCC visits. A retrospective cohort analysis was c...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922820910823
更新日期:2020-06-01 00:00:00
abstract::A 12-hour fasting lipid profile was obtained from 88 otherwise healthy obese (BMI > or = 95%) adolescents (age 16 +/- 1 years, BMI 36 +/- 1 kg/m(2), 55 males, 33 females, 57% Hispanic, 23% African American, 19% Caucasian, 1% Asian American). About 56% of the obese adolescents exhibited lipid abnormalities based on cut...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922809341076
更新日期:2010-01-01 00:00:00
abstract::In a review of 17 adolescents and children (excluding newborns) with definite clinical signs, symptoms, and laboratory findings of hypothyroidism, 11 patients (65%) had anemia. The mean corpuscular volume (MCV) of the red blood cells was either macrocytic or normocytic. The hemoglobin did not correlate with the serum ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102001102
更新日期:1981-11-01 00:00:00
abstract::An eight-year-old boy developed staphylococcal endocarditis. He was treated initially with nafcillin and gentamicin, but he remained febrile. The minimum bactericidal concentration (MBC) of nafcillin was 130 times the minimum inhibitory concentration (MIC). Following the addition of rifampin to the antibiotic regimen,...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288202100414
更新日期:1982-04-01 00:00:00
abstract::In this retrospective case series, we report clinical factors associated with pediatric peritonsillar abscess (PTA), with hopes of contributing to the design of an evidenced-based, economic treatment approach. Charts were examined for presenting symptoms and signs. Each of these were analyzed for association with the ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922818778048
更新日期:2018-10-01 00:00:00
abstract::Premature delivery is common in pregnancies complicated by maternal diabetes. However, the outcome of very-low-birth-weight infants (VLBWI) born to mothers with diabetes is not known. Employing a matched double-cohort design, we investigated the influence of maternal diabetes on the outcome of VLBWI born in Winnipeg f...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280204100705
更新日期:2002-09-01 00:00:00
abstract::Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections of varying severity. It is also responsible for producing a wide spectrum of nonpulmonary manifestations including neurologic, hepatic, cardiac, and hematologic diseases. The neurologic manifestations are reported to be the most co...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992280003900401
更新日期:2000-04-01 00:00:00
abstract::The Vaccines for Children (VFC) program distributes one half of all vaccines administered to US children. Compared with commercial vaccine distribution, VFC distribution is more complex. This prospective observational study compares the delivery and administration of VFC versus non-VFC influenza vaccine in US pediatri...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922812470868
更新日期:2013-03-01 00:00:00
abstract::A 13-year old boy with acute lymphoblastic leukemia on chemotherapy developed neutropenia and acute cellulitis progressing to fulminating septicemia due to Pseudomonas pseudomallei. Septicemic melioidosis should be considered in the differential diagnosis of a febrile illness in children who are susceptible to infecti...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288001901012
更新日期:1980-10-01 00:00:00
abstract::Pediatricians are expected to discuss the hazards of passive smoking and provide smoking cessation counseling (SCC) because passive smoking is known to have a direct negative effect on children's health. We conducted a cross-sectional survey of pediatric and medicine- pediatric residents at 2 training programs to iden...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922807308182
更新日期:2008-04-01 00:00:00
abstract::Ninety low socioeconomic adolescent females (aged 16-22 years, means 18.6 years) were screened for rubella immunity using a rubella IgG enzyme immunoassay. Data concerning past immunizations (with documentation, if possible), prior rubella disease, and previous pregnancies were gathered through direct interviews. Resu...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288502400705
更新日期:1985-07-01 00:00:00
abstract::Henoch-Schönlein purpura (HSP) is the most common vasculitis occurring in childhood. Clinical presentation involves the classic tetrad of abdominal pain, nonthrombocytopenic purpura, arthritis, and renal involvement. Dermatological manifestations of HSP are characteristic of the condition and consist of palpable purpu...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922810374977
更新日期:2010-11-01 00:00:00
abstract::This study was undertaken to evaluate trends and toxicity of pediatric methylphenidate exposures; 1993 to 1999 national poison center data were analyzed. There were 12,917 exposures, increasing from 927 in 1993 to 2,445 in 1999. The majority of children during the entire study period experienced no effect (60.3%) or m...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280304200210
更新日期:2003-03-01 00:00:00
abstract::A method for the detection of bacterial pathogens in sepsis and bacterial meningitis with 16S rRNA gene- based real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) is developed. A total of 190 blood specimens and 5 cerebrospinal fluid specimens from neonates with suspected sepsis or bacterial meningit...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922809333972
更新日期:2009-07-01 00:00:00
abstract::An adolescent female with occult cystic medial necrosis died following spontaneous aortic rupture. A large saccular aortic aneurysm that had ruptured into the pericardial space was demonstrated by two-dimensional echocardiography and confirmed at surgery. Echocardiographic screening of the patient's family members rev...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288502400408
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVES:Our objective was to examine the relationship between low- and high-level depressive symptoms in mothers' and children's risks in the areas of home and car safety, monitoring, and exposure to violence. METHODS:Participants included 978 mothers of preschool-age children who were interviewed about their home ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922812473776
更新日期:2013-02-01 00:00:00
abstract::Cervical adenopathy as the sole presentation of tuberculosis is seen infrequently in the pediatric age group. Despite modern treatment and public health measures, tuberculous cervical adenitis persists, and its prompt diagnosis and treatment are important from both a clinical and preventive health perspective. The aut...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288902800905
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:Dysfunctional voiding (DV) is an extremely common pediatric complaint. The goal of this study was to examine the relationship between DV and childhood temperament. METHODS:Information about the voiding behaviors and temperaments of 50 children was examined using a case-control model. Caregivers were asked to...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922813492376
更新日期:2013-08-01 00:00:00
abstract::A case presentation of a newborn infant with intermittent, complete airway obstruction secondary to a pedunculated nasopharyngeal dermoid is presented. The differential diagnosis of obstructing nasopharyngeal lesions of the neonatal period is discussed, and an organized management strategy is proposed. ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289203100109
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:In the future, surgical management of pediatric appendicitis might become limited to nonperforating appendicitis. Thus, it becomes increasingly important to differentiate advanced from simple appendicitis and to predict perforated appendicitis among a group of children with right-sided abdominal pain, which ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922816678976
更新日期:2017-10-01 00:00:00
abstract::Topical application of ocular drugs may cause serious adverse ocular or systemic side effects. Children are at greater risk for systemic side effects because ocular dosing is not weight-adjusted, and infants are especially vulnerable as a consequence of the inability to efficiently metabolize the drug, and/or an immat...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280404300114
更新日期:2004-01-01 00:00:00