Abstract:
:From insects to cancer: N-Cyano sulfoximines were evaluated for COX inhibition and antiproliferative activity against a panel of cancer cell lines. The most active compound exhibited potent COX-2 inhibition, some selectivity for COX-2 over COX-1, only slight cytotoxicity towards healthy cells (HaCaT skin cells), and no mutagenic potential (as determined by an Ames assay).
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Park SJ,Baars H,Mersmann S,Buschmann H,Baron JM,Amann PM,Czaja K,Hollert H,Bluhm K,Redelstein R,Bolm Cdoi
10.1002/cmdc.201200403subject
Has Abstractpub_date
2013-02-01 00:00:00pages
217-20issue
2eissn
1860-7179issn
1860-7187journal_volume
8pub_type
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