Abstract:
INTRODUCTION:Checkpoint inhibitors have dramatically transformed cancer treatment. However, due to the increasing number of tumors in which they are used, there is a high number of reported adverse effects. Among them, we highlight neurological side effects. In the approbatory clinical trials, they were thought to be sparse, but they may have been underestimated. AIM:To review the physiopathology and the incidence of neurological side effects due to the use of checkpoint inhibitors, as well as the clinical practice guidelines published in the last years. DEVELOPMENT:To review the published case reports of neurological side effects since the approval of checkpoint inhibitors, and our own experience. Moreover, we summarize the main clinical practice guidelines. CONCLUSIONS:Checkpoint inhibitors neurological side effects are frequent. A wide variety of central or peripheral nervous system symptoms may develop. In the setting of brain tumors, inflammation due to immune system activation might lead to pseudoprogression. Further studies are needed to better describe these neurological side effects, and to implement clinical guidelines. TITLE:Complicaciones neurologicas de los inhibidores de punto de control inmunologico. :Introduccion. Los inhibidores de punto de control inmunologico han supuesto un nuevo paradigma en el tratamiento de diferentes tipos de neoplasias. Sin embargo, con el uso creciente de estos farmacos, se estan observando diferentes efectos adversos. Entre ellos destacan los neurologicos, puesto que su frecuencia parece haberse infraestimado en los ensayos aprobatorios. Objetivo. Revisar la fisiopatologia y la incidencia de los efectos adversos neurologicos por inhibidores de punto de control neurologicos, asi como el abordaje basandose en diferentes guias clinicas. Desarrollo. Se revisan los casos que se han publicado desde la aprobacion de los farmacos y añadimos la experiencia de nuestro centro. A su vez, se hace un resumen de las diferentes guias publicadas de forma reciente. Conclusiones. Las complicaciones derivadas del uso de los inhibidores de punto de control inmunologico son frecuentes. Incluyen multiples cuadros de diferente gravedad, y pueden afectar a cualquier parte del sistema nervioso central y periferico. Ademas, en tumores del sistema nervioso, puede observarse un fenomeno de pseudoprogresion derivado de la inflamacion asociada. Queda pendiente realizar nuevos estudios para conocer en detalle estos efectos adversos y desarrollar guias clinicas con las que optimizar el manejo.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Suay G,Bataller Ldoi
10.33588/rn.6807.2019022subject
Has Abstractpub_date
2019-04-01 00:00:00pages
301-311issue
7eissn
0210-0010issn
1576-6578pii
rn2019022journal_volume
68pub_type
杂志文章,评审abstract:TITLE:Sindrome de Wolf-Hirschhorn: simple omision al citar? Replica. ...
journal_title:Revista de neurologia
pub_type: 评论,信件
doi:
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Several studies have reported alterations in the cerebrospinal fluid biomarkers (Abeta-42, T-tau and P-tau proteins), both in Alzheimer's disease (AD) and in mild cognitive impairment (MCI). AIM:To perform a meta-analysis of the diagnostic yield of this technique for the prediction of patients with MCI wh...
journal_title:Revista de neurologia
pub_type: 杂志文章,meta分析
doi:
更新日期:2010-02-16 00:00:00
abstract::At the present time the so-called parallel or next generation sequencing (NGS) technique is rapidly expanding and developing; this process establishes a jump by several orders of magnitude in the length of the fragments sequenced and the speed with which this sequencing is carried out. NGS allows a whole human genome ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:Statins represent a group of pharmaceutical agents with proven effectiveness and scarce side effects; however, their widespread use increases the probability of the appearance of such adverse effects. DEVELOPMENT:We reviewed the articles that have been published on myotoxicity, neurotoxicity and other cas...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Purely bulbar hematomas are not common (0.25%-0.50% of all intraparenchymatous hematomas), probably because of the particular characteristics of the anatomy and hemodynamics of the bulbar circulation. CLINICAL CASES:We selected 18 cases. Three of these were our own and the purely bulbar localization was c...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-10-01 00:00:00
abstract::The medical literature contains a wide body of evidence supporting genetic involvement in neurodevelopmental disorders. Advances made in genetics and technology have increased the diagnostic cost-effectiveness of current studies from 3-5% to 30-40% in patients with intellectual disability or autism spectrum disorders....
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-02-24 00:00:00
abstract:INTRODUCTION:This paper review current literature about neurocysticercosis with emphasis on recent advances on diagnosis and therapy. DEVELOPMENT:Cysticercosis is the most common parasitic disease of the nervous system. The disease occurs when humans become the intermediate host in the life cycle of Taenia solium by i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION:Semantic dementia is a progressive, relatively selective disorder affecting the semantic system with involvement of the verbal and non-verbal functions. The clinical picture is well characterised despite the confusion that may be generated by the different ways of classifying it. AIM. To determine the clin...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-12-01 00:00:00
abstract:AIMS:The main objective of this study is to describe the different neuropsychological deficits associated to the consumption of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'), as well as the growing evidence that attributes these deficits to the selective axonal damage to serotoninergic cells brought about by th...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2005-07-16 00:00:00
abstract:OBJECTIVE:To review about this disorder, with emphasis on the intensive care of severe Guillain Barr syndrome (GBS). DEVELOPMENT:GBS is an acute immune mediated inflammatory polyneuropathy that may lead to quadriparesis, ventilatory failure, and autonomic dysfunction but also to many general medical problems that have...
journal_title:Revista de neurologia
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2002-05-16 00:00:00
abstract:INTRODUCTION:Many neuropsychological tests used in Spain have been normed on Spanish-speaking persons in the USA and South America. In addition, the normative samples often span limited age or educational ranges, potentially decreasing their representativeness of the population, the interpretation of test results, and ...
journal_title:Revista de neurologia
pub_type: 杂志文章,多中心研究
doi:
更新日期:2015-07-16 00:00:00
abstract::Based on the interrelation between science and philosophy, this article addresses the impact of neurosciences on the philosophical issues posed by today's society, especially those related with epistemology and the philosophy of science. To do so, the different approaches in the cognitive sciences are taken into accou...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2013-03-16 00:00:00
abstract:INTRODUCTION:Posconcussional syndrome is characterized by a heterogeneous group of somatic, cognitive and psychosocial symptoms, which occur in patients with head trauma, generally of mild severity. It is the neuropsychiatric postraumatic disorder more prevalent in the field of forensic medicine. DEVELOPMENT:Classical...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-05-01 00:00:00
abstract::Streptococcus pyogenes (or group A beta hemolytic streptococcus) is a pathogenic bacterium that can give rise to a range of invasive and autoimmune diseases, although it is more widely known as the cause of tonsillitis. It is particularly interesting to note that this germ only causes disease in humans. For many years...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:The signals obtained during conventional needle examination are usually assessed subjectively by the neurophysiologist. Buchthal's approach allows quantification of several motor unit parameters during mild effort. DEVELOPMENT:The automatic methods of analysis of the EMG interference pattern (IP), in part...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-03-16 00:00:00
abstract:INTRODUCTION:It is known as segmental neurofibromatosis type 1 (NF1) a type of NF1 characterized by the features circumscribed to one or more body cutaneous and/or subcutaneous segments. This entity is recognized from recently and it is related with somatic mosaicism. PATIENTS AND METHODS:43 patients (29 females and 1...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-10-16 00:00:00
abstract:TITLE:Aneurisma traumatico de la arteria meningea media en el contexto de un hematoma epidural. : ...
journal_title:Revista de neurologia
pub_type:
doi:10.33588/rn.6904.2019145
更新日期:2019-08-16 00:00:00
abstract:INTRODUCTION:In recent years, significant advances have been made in the physiology and the pharmacology of vestibular disorders. It is now possible to elaborate an approximation of the mechanisms of action of the drugs used in the symptomatic treatment of vertigo. DEVELOPMENT:These drugs usually have a number of diff...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-16 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic efficacy of an intra-arterial electroencephalographic recording and determine which patients obtain most benefit from this technique, to compare the results obtained using other recording techniques and to establish a standard for recording. PATIENTS AND METHODS:We made 64 intra-a...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:INTRODUCTION:The implementation of an on-call neurology service at our hospital prompted us to analyse the health care it offers. PATIENTS AND METHODS:We conducted a retrospective descriptive study by reviewing the status report of the on-call services performed between 15 April 2002 and 14 April 2003. The data collec...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-07-16 00:00:00
abstract:INTRODUCTION:Chronic intoxication due to carbon monoxide (CO) is a condition in which the frequency is underestimated since the clinical features are nonspecific. It is important since serious neurological sequelae may result: an extrapyramidal syndrome, dementia or a vegetative state. The diagnosis is established when...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-02-16 00:00:00
abstract:INTRODUCTION:The progress made in perinatal health care in recent years has changed the epidemiology of neurological diseases during the neonatal period. The reduction in neonatal mortality has been accompanied by an increasingly large number of patients suffering from disabling diseases or with a risk of suffering fro...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::An accurate diagnosis of a mentally retarded patient is a crucial step to design a successful treatment. The effects of genetic and environmental influences have to be clarified in the etiological approach. For that reason, we have to record a more appropriate family information, detailed prenatal, birth and postnatal...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract:INTRODUCTION:In recent years, the non-motor symptoms of Parkinson's disease, including those of a psychiatric nature, have been receiving greater attention from the scientific community. DEVELOPMENT:In this paper we analyse the pathophysiological bases underlying the different psychiatric symptoms, examining the dopam...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:The ionic channels are complex glycoprotein structures, which cross the lipidic cellular membrane and allow the passage of electrically charged ions from one side of it to the other, thanks to the electrochemical gradient. A channelopathy is a disorder due to anomalous function of the ionic channels. DEVE...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-01-16 00:00:00
abstract::Luis Simarro is considered to be the great precursor of Spanish Neurology, Neurohistology and Psychology. Together with Cajal he was one of the most outstanding figures of the Spanish freemasons in the field of medicine, where he reached the highest rank: Grand Master of the Spanish Great Orient. These historical note...
journal_title:Revista de neurologia
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2001-05-16 00:00:00
abstract:INTRODUCTION:The neurological concept of learning is approached from a cybernetic point of view, taking into account that a child should recognize a fact, learn it semantically and decided whether it is worth storing; the dynamic aspect of memory is the true motor of the ability to learn and all this is modulated by th...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-08-01 00:00:00
abstract:AIM:To document reversible cognitive deterioration associated to high doses of zonisamide, using the Reliable Change Index to control practice effects derived from repetitive neuropsychological assessments. CASE REPORT:A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated wi...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2015-01-16 00:00:00
abstract:AIMS:In the search for new, potentially treatable, vascular risk factors, one of the most recent to be put forward is the presence of increased total homocysteine (tHc) levels in blood plasma and this has also given rise to a large amount of literature and controversy. The origin of this hypothesis lies in the observat...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2004-02-16 00:00:00
abstract:INTRODUCTION:It may be difficult to determine the adequate mement, the information content and the most convenient person to inform patients with chronic, incurable disorders with uncertain prognosis as sclerosis multiple (MS). MATERIAL AND METHODS:To gain information on how these aspects had been carried-out and the ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00