Image-based 3D modeling study of the influence of vessel density and blood hemoglobin concentration on tumor oxygenation and response to irradiation.

Abstract:

PURPOSE:Hypoxia is one of the most important factors influencing clinical outcome after radiotherapy. Improved knowledge of factors affecting the levels and distribution of oxygen within a tumor is needed. The authors constructed a theoretical 3D model based on histological images to analyze the influence of vessel density and hemoglobin (Hb) concentration on the response to irradiation. METHODS:The pancreases of a Rip-Tag2 mouse, a model of malignant insulinoma, were excised, cryosectioned, immunostained, and photographed. Vessels were identified by image thresholding and a 3D vessel matrix assembled. The matrix was reduced to functional vessel segments and enlarged by replication. The steady-state oxygen tension field of the tumor was calculated by iteratively employing Green's function method for diffusion and the Michaelis-Menten model for consumption. The impact of vessel density on the radiation response was studied by removing a number of randomly selected vessels. The impact of Hb concentration was studied by independently changing vessel oxygen partial pressure (pO(2)). For each oxygen distribution, the oxygen enhancement ratio (OER) was calculated and the mean absorbed dose at which the tumor control probability (TCP) was 0.99 (D(99)) was determined using the linear-quadratic cell survival model (LQ model). RESULTS:Decreased pO(2) shifted the oxygen distribution to lower values, whereas decreased vessel density caused the distribution to widen and shift to lower values. Combined scenarios caused lower-shifted distributions, emphasising log-normal characteristics. Vessel reduction combined with increased blood pO(2) caused the distribution to widen due to a lack of vessels. The most pronounced radiation effect of increased pO(2) occurred with tumor tissue with 50% of the maximum vessel density used in the simulations. A 51% decrease in D(99), from 123 to 60 Gy, was found between the lowest and highest pO(2) concentrations. CONCLUSIONS:Our results indicate that an intermediate vascular density region exists where enhanced blood oxygen concentration may be beneficial for radiation response. The results also suggest that it is possible to distinguish between diffusion-limited and anemic hypoxia from the characteristics of the pO(2) distribution.

journal_name

Med Phys

journal_title

Medical physics

authors

Lagerlöf JH,Kindblom J,Cortez E,Pietras K,Bernhardt P

doi

10.1118/1.4773886

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

024101

issue

2

eissn

0094-2405

issn

2473-4209

journal_volume

40

pub_type

杂志文章
  • Comparison of ROC and AFC methods in a visual detection task.

    abstract::The visual observer performance for detecting low-contrast patterns by employing both the receiver operating characteristic (ROC) and the 9-alternative forced choice (9-AFC) method is investigated. For each observer and each experimental technique, the results were reproducible with respect to a repeated observation. ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596986

    authors: Herrmann C,Buhr E,Hoeschen D,Fan SY

    更新日期:1993-05-01 00:00:00

  • The Cole relaxation frequency as a parameter to identify cancer in breast tissue.

    abstract:PURPOSE:To correlate the Cole relaxation frequencies obtained from measurements of the electrical properties of breast tissue to the presence or absence of cancer. METHODS:Four-lead impedance measurements were obtained on ex vivo specimens extracted during surgery from 187 volunteer patients. Data were acquired with a...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4725172

    authors: Gregory WD,Marx JJ,Gregory CW,Mikkelson WM,Tjoe JA,Shell J

    更新日期:2012-07-01 00:00:00

  • A framework for defining FLASH dose rate for pencil beam scanning.

    abstract:PURPOSE:To develop a method of (a) calculating the dose rate of voxels within a proton field delivered using pencil beam scanning (PBS), and (b) reporting a representative dose rate for the PBS treatment field that enables correspondence between multiple treatment modalities. This method takes into account the unique s...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14456

    authors: Folkerts MM,Abel E,Busold S,Perez JR,Krishnamurthi V,Ling CC

    更新日期:2020-12-01 00:00:00

  • Dynamic detector offsets for field of view extension in C-arm computed tomography with application to weight-bearing imaging.

    abstract:PURPOSE:In C-arm computed tomography (CT), the field of view (FOV) is often not sufficient to acquire certain anatomical structures, e.g., a full hip or thorax. Proposed methods to extend the FOV use a fixed detector displacement and a 360° scan range to double the radius of the FOV. These trajectories are designed for...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4915542

    authors: Herbst M,Schebesch F,Berger M,Choi JH,Fahrig R,Hornegger J,Maier A

    更新日期:2015-05-01 00:00:00

  • A novel 3D printing method for accurate anatomy replication in patient-specific phantoms.

    abstract:PURPOSE:A novel 3D printing method has been developed, which employs human CT images to construct patient specific phantoms by controlling the filament extrusion rate. METHODS:An in-house software was developed comprising pixel-by-pixel (PbP) reading of the Hounsfield Units (HU) values in the original patient DICOM im...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13154

    authors: Okkalidis N

    更新日期:2018-10-01 00:00:00

  • A comparison of the physical imaging properties of Fuji ST-V, ST-VA, and ST-VN computed radiography image plates.

    abstract::The physical imaging performance of ST-V, ST-VA, and ST-VN computed radiography image plates, read with a Philips AC3 acquisition system, was investigated at 70 kVp with 0.5 mm of copper beam filtration for four different entrance air kerma values: 0.5, 2.6, 26, and 260 micro Gy. Measurements included characteristic r...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598412

    authors: Kengyelics SM,Davies AG,Cowen AR

    更新日期:1998-11-01 00:00:00

  • Postal intercomparison of absorbed dose for high energy x rays with thermoluminescence dosimeters.

    abstract::This study concerns the accuracy and precision of the IAEA/WHO LiF TLD system used in intercomparison by mail of absorbed doses from 60Co gamma-radiation and 4-25 MV x rays. The system employs 160 mg LiF powder in polystyrene capsules, which are placed at 5 or 7 cm depth in water and irradiated to doses close to 200 r...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594746

    authors: Bjärngard BE,Kase KR,Rudén BI,Biggs PJ,Boyer AL,Johansson KA

    更新日期:1980-09-01 00:00:00

  • Efficient generation of a magnetic field-free line.

    abstract:PURPOSE:Signal encoding in magnetic particle imaging (MPI) is achieved by moving a field-free point (FFP) through the region of interest. One way to increase the sensitivity of the method is to scan the region of interest with a field-free line (FFL) instead of the FFP. Recently, the first feasible FFL coil setup was i...

    journal_title:Medical physics

    pub_type: 信件

    doi:10.1118/1.3447726

    authors: Knopp T,Erbe M,Biederer S,Sattel TF,Buzug TM

    更新日期:2010-07-01 00:00:00

  • Actively triggered 4d cone-beam CT acquisition.

    abstract:PURPOSE:4d cone-beam computed tomography (CBCT) scans are usually reconstructed by extracting the motion information from the 2d projections or an external surrogate signal, and binning the individual projections into multiple respiratory phases. In this "after-the-fact" binning approach, however, projections are uneve...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4817479

    authors: Fast MF,Wisotzky E,Oelfke U,Nill S

    更新日期:2013-09-01 00:00:00

  • Variability of tumor area measurements for response assessment in malignant pleural mesothelioma.

    abstract:PURPOSE:The measurement of malignant pleural mesothelioma is critical to the assessment of tumor response to therapy. Current response assessment standards utilize summed linear measurements acquired on three computed tomography (CT) sections. The purpose of this study was to evaluate manual area measurements as an alt...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4810940

    authors: Labby ZE,Straus C,Caligiuri P,MacMahon H,Li P,Funaki A,Kindler HL,Armato SG 3rd

    更新日期:2013-08-01 00:00:00

  • Transverse tomosynthesis on a digital simulator.

    abstract::The availability of digital radiographic imaging on simulators has led to the investigation of a number of new imaging possibilities, including digital linear tomography (tomosynthesis). It has been shown that a single set of projections in this case is sufficient to reconstruct images from multiple planes, including ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598006

    authors: Zwicker RD,Atari NA

    更新日期:1997-06-01 00:00:00

  • Physics process level discrimination of detections for GATE: assessment of contamination in SPECT and spurious activity in PET.

    abstract::The GEANT4 application for tomographic emission (GATE) is one of the most detailed Monte Carlo simulation tools for SPECT and PET. It allows for realistic phantoms, complex decay schemes, and a large variety of detector geometries. However, only a fraction of the information in each particle history is available for p...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3078045

    authors: De Beenhouwer J,Staelens S,Vandenberghe S,Verhaeghe J,Van Holen R,Rault E,Lemahieu I

    更新日期:2009-04-01 00:00:00

  • Regularized iterative weighted filtered backprojection for helical cone-beam CT.

    abstract::Contemporary reconstruction methods employed for clinical helical cone-beam computed tomography (CT) are analytical (noniterative) but mathematically nonexact, i.e., the reconstructed image contains so called cone-beam artifacts, especially for higher cone angles. Besides cone artifacts, these methods also suffer from...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2966353

    authors: Sunnegårdh J,Danielsson PE

    更新日期:2008-09-01 00:00:00

  • Estimated spectrum of a 4-MV therapeutic beam.

    abstract::We have made a comparative investigation of the estimated spectra obtained by the Laplace transform analysis of the transmitted exposure data measured in an absorption study of a 4-MV x-ray beam. Four transform pair models currently used with this method have been evaluated. It has been determined that the Archer-Wagn...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595878

    authors: Ahuja SD,Steward PG,Roy TS,Slessinger ED

    更新日期:1986-05-01 00:00:00

  • Discrimination analysis of breast calcifications using x-ray dark-field radiography.

    abstract:BACKGROUND:X-ray dark-field radiography could enhance mammography by providing more information on imaged tissue and microcalcifications. The dark field signal is a measure of small angle scattering and can thus provide additional information on the imaged materials. This information can be useful for material distinct...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14043

    authors: Rauch T,Rieger J,Pelzer G,Horn F,Erber R,Wunderle M,Emons J,Nabieva N,Fuhrich N,Michel T,Hartmann A,Fasching PA,Anton G

    更新日期:2020-04-01 00:00:00

  • Effects of point configuration on the accuracy in 3D reconstruction from biplane images.

    abstract::Two or more angiograms are being used frequently in medical imaging to reconstruct locations in three-dimensional (3D) space, e.g., for reconstruction of 3D vascular trees, implanted electrodes, or patient positioning. A number of techniques have been proposed for this task. In this simulation study, we investigate th...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2008467

    authors: Dmochowski J,Hoffmann KR,Singh V,Xu J,Nazareth DP

    更新日期:2005-09-01 00:00:00

  • SU-E-T-450: An Evaluation Study of Dose Calculation Algorithms for Stereotactic Body Radiation Therapy in Heterogeneous Phantom.

    abstract:PURPOSE:In Stereotactic body radiation therapy (SBRT) higher dose per fraction is delivered to patients and thus the need for an accurate dose computation is further elevated. However under such conditions of small field geometries, the electronic equilibrium can be lost, making it challenging for the dose-calculation ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735539

    authors: Shosha M,Deiab N,Eldib A,Tohamy K

    更新日期:2012-06-01 00:00:00

  • Absorbed dose in the presence of contrast agents during pediatric cardiac catheterization.

    abstract::Administration of x-ray contrast agents during heart catheterization examination increases the absorbed radiation dose in tissue. To estimate the dose absorbed by the blood of children undergoing diagnostic heart catheterization and angiocardiography, a number of measurements and calculations were conducted. First, en...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594613

    authors: Callisen HH,Norman A,Adams FH

    更新日期:1979-11-01 00:00:00

  • Investigation of intensity-modulated radiotherapy optimization with gEUD-based objectives by means of simulated annealing.

    abstract::Inverse treatment planning of intensity-modulated radiation therapy (IMRT) is complicated by several sources of error, which can cause deviations of optimized plans from the true optimal solution. These errors include the systematic and convergence error, the local minima error, and the optimizer convergence error. We...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2896070

    authors: Hartmann M,Bogner L

    更新日期:2008-05-01 00:00:00

  • Technical Note: Study of the electron transport parameters used in PENELOPE for the Monte Carlo simulation of Linac targets.

    abstract:PURPOSE:The Monte Carlo simulation of electron transport in Linac targets using the condensed history technique is known to be problematic owing to a potential dependence of absorbed dose distributions on the electron step length. In the PENELOPE code, the step length is partially determined by the transport parameters...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4916686

    authors: Rodriguez M,Sempau J,Brualla L

    更新日期:2015-06-01 00:00:00

  • Reduction of ring artifacts in CBCT: detection and correction of pixel gain variations in flat panel detectors.

    abstract:PURPOSE:In using flat panel detectors (FPD) for cone beam computed tomography (CBCT), pixel gain variations may lead to structured nonuniformities in projections and ring artifacts in CBCT images. Such gain variations can be caused by change in detector entrance exposure levels or beam hardening, and they are not accou...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4893278

    authors: Altunbas C,Lai CJ,Zhong Y,Shaw CC

    更新日期:2014-09-01 00:00:00

  • Comparison of exposure standards in the mammography x-ray region.

    abstract::Direct comparisons of the National Institute of Standards and Technology's (NIST) Ritz 20 kV to 100 kV standard free-air ionization chamber and a portable variable-length free-air ionization chamber designed by the University of Wisconsin-Madison Accredited Dosimetry Calibration Laboratory (UW-ADCL) were made on NISTs...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598148

    authors: Coletti JG,Pearson DW,DeWerd LA,O'Brien CM,Lamperti PJ

    更新日期:1997-08-01 00:00:00

  • On the efficiency of photon beam treatment head simulations.

    abstract::The paper presents a theoretical derivation of the photon fluence simulation efficiency in photon beam treatment head simulations without and with bremsstrahlung splitting. The expressions obtained provide a rigorous explanation of the efficiency dependence on scoring zone size and splitting number and explain the lar...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1943808

    authors: Kawrakow I

    更新日期:2005-07-01 00:00:00

  • A Monte Carlo study on the collimation of pencil beam scanning proton therapy beams.

    abstract:PURPOSE:The lateral edge of a proton therapy beam is commonly used to achieve conformality to the treatment volume where critical structures reside close to the target. However, when treating shallow depths, the lateral edge of a pencil beam scanning (PBS) system may be broader than that of a double scattered (DS) syst...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4941957

    authors: Charlwood FC,Aitkenhead AH,Mackay RI

    更新日期:2016-03-01 00:00:00

  • On the development of consensus values of reference dosimetry parameters for interstitial brachytherapy sources.

    abstract::The American Association of Physicists in Medicine recommends that the reference dose-rate distribution, used for treatment planning for low-energy photon brachytherapy sources in routine clinical use, must be based on at least two independent determinations: one using experimentally measured dose rates and one using ...

    journal_title:Medical physics

    pub_type: 指南,杂志文章

    doi:10.1118/1.1690712

    authors: Chan GH,Nath R,Williamson JF,American Association of Physicists in Medicine.

    更新日期:2004-05-01 00:00:00

  • Displacement and strain estimation for evaluation of arterial wall stiffness using a familial hypercholesterolemia swine model of atherosclerosis.

    abstract:PURPOSE:To track variations in the deformation of the arterial wall noninvasively by estimating the accumulated displacement and strain over a cardiac cycle may provide useful indicators of vascular health. METHODS:In this paper, we propose an approach to track a region of interest (ROI) locally and estimate arterial ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4722746

    authors: Ge W,Krueger CG,Weichmann A,Shanmuganayagam D,Varghese T

    更新日期:2012-07-01 00:00:00

  • SU-E-J-139: Feasibility of Using EPID for Real-Time Target Localization during Treatment.

    abstract:PURPOSE:This study aims to investigate the feasibility of using the images of the treatment fields acquired by an electronic portal imaging device (EPID) for real-time target localization. METHODS:Forty one patients treated with IMRT and RapidArc were recruited in this study including 37 prostate patients and 4 lung p...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4734975

    authors: Xu Q,Lin M,Chen X,Tong X,Fan J,Dong Z,Chen L,Ma C

    更新日期:2012-06-01 00:00:00

  • Technical Note: Identification of an optimal electromagnetic sensor for in vivo electromagnetic-tracked scintillation dosimeter for HDR brachytherapy.

    abstract:PURPOSE:Brachytherapy is a treatment modality which delivers large doses of radiation in a reduced number of visits. Since a small number of large dose-per-fraction is administered in high dose rate brachytherapy, ensuring the right dose is delivered is highly critical. In this work, a scintillation detector is coupled...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13508

    authors: Tho D,Beaulieu L

    更新日期:2019-05-01 00:00:00

  • A moving slanted-edge method to measure the temporal modulation transfer function of fluoroscopic systems.

    abstract::Lag in fluoroscopic systems introduces a frame-averaging effect that reduces measurements of image noise and incorrectly inflates measurements of the detective quantum efficiency (DQE). A correction can be implemented based on measurements of the temporal modulation transfer function (MTF). We introduce a method of me...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2919724

    authors: Friedman SN,Cunningham IA

    更新日期:2008-06-01 00:00:00

  • Spectral analysis of mammographic images using a multitaper method.

    abstract:PURPOSE:Power spectral analysis in radiographic images is conventionally performed using a windowed overlapping averaging periodogram. This study describes an alternative approach using a multitaper technique and compares its performance with that of the standard method. This tool will be valuable in power spectrum est...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3676740

    authors: Wu G,Mainprize JG,Yaffe MJ

    更新日期:2012-02-01 00:00:00