Abstract：
:Mucormycosis mostly affects immunocompromised patients and is associated with a high morbidity and mortality despite currently available treatments. In that context, combination therapy might be the key to a better outcome for these patients. Purpose of this review is to summarise and to discuss the current combination data obtained in vitro, in vivo in animal models of mucormycosis, and in patients. In vitro combination studies showed that most of the interactions between antifungal drugs were indifferent, even though that some synergistic interactions were achieved for the combination of echinocandins with either azoles or amphotericin B. Importantly, antagonism was never observed. Animal models of mucormycosis focused on infections caused by Rhizopus arrhizus, neglecting most other species responsible for human disease. In these experimental animal models, no strong interactions have been demonstrated, although a certain degree of synergism has been reported in some instances. Combinations of antifungals with non-antifungal drugs have also been largely explored in vitro and in animal models and yielded interesting results. In patients with ketoacidosis and rhino-orbito-cerebral infection, combination of polyene with caspofungin was effective. In contrast, despite promising experimental data, adjunctive therapy with the iron chelator deferasirox was unfavourable and was associated with a higher mortality than monotherapy with liposomal amphotericin B. More combinations have to be tested in vitro and a much larger panel of Mucorales species has to be tested in vivo to give a valuable statement if antifungal combination therapy could be an effective treatment strategy in patients with mucormycosis.
journal_name
Mycosesjournal_title
Mycosesauthors
Schwarz P,Cornely OA,Dannaoui Edoi
10.1111/myc.12909subject
Has Abstractpub_date
2019-09-01 00:00:00pages
746-760issue
9eissn
0933-7407issn
1439-0507journal_volume
62pub_type
杂志文章,评审相关文献
MYCOSES文献大全abstract：:Scedosporium prolificans infections of normal hosts usually require extensive debridement and sometimes amputation to effect cure, due to the intrinsic resistance of this species to available antifungal agents. Newer agents have not tested favourably. Variable results are obtained with voriconazole, and 100% resistanc...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1046/j.1439-0507.2003.00878.x
更新日期：2003-06-01 00:00:00
abstract：:In pooled samples of faeces from 25 pet bird flocks in Thuringia, a high rate of contamination with Cryptococcus neoformans var. neoformans was found. The prevalence of Cr. neoformans in the bird-breeding establishments correlated with the numbers of the different pet bird species in these flocks. The differentiation ...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1046/j.1439-0507.2000.00534.x
更新日期：2000-01-01 00:00:00
abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most common pharmacological agents. They have three primary therapeutic properties including anti-inflammatory, anti-pyretic and analgesic effects. Seven NSAIDs were tested against two species of dermatophytes. Percentage inhibition was determined for effec...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.2010.01945.x
更新日期：2011-09-01 00:00:00
abstract：:A clinical trial of once-daily administration of a 125-mg tablet of terbinafine, an oral antimycotic agent, was performed on patients with tinea unguium to evaluate its efficacy, safety, possible side-effects and its incorporation into nails and hair. Thirty-four patients were recruited into the study. For the statist...
journal_title：Mycoses
pub_type： 临床试验,杂志文章
doi：10.1111/j.1439-0507.1995.tb00037.x
更新日期：1995-03-01 00:00:00
abstract：:The role of Malassezia furfur adherence to human stratum corneum cells in vitro was studied. The adherence assay was performed with one strain of M. furfur and stratum corneum cells from 30 healthy individuals and from 28 patients with seborrhoeic dermatitis. Stratum corneum cells from patients with seborrhoeic dermat...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.1994.tb00303.x
更新日期：1994-06-01 00:00:00
abstract：:A double-blind trial was undertaken in Karonga District, Northern Malawi comparing Whitfield's cream (3% salicylic acid and 6% benzoylic acid) and clotrimazole cream in the treatment of dermatophyte infections of the skin. To date, 138 patients have been reviewed; 65 of these patients received Whitfield's cream and 73...
journal_title：Mycoses
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The incidence and prevalence of fungal infections in Tanzania remains unknown. We assessed the annual burden in the general population and among populations at risk. Data were extracted from 2012 reports of the Tanzanian AIDS program, WHO, reports, Tanzanian census, and from a comprehensive PubMed search. We used mode...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12390
更新日期：2015-10-01 00:00:00
abstract：:With advances in medical sciences, an increase in survival rates of low birth weight; increased incidence in use of catheter and antibiotics, and total parenteral nutrition are reported, therefore, the rate of fungal infections in late and very late onset neonatal sepsis have increased. Although fungal endocarditis ra...
journal_title：Mycoses
pub_type： 杂志文章,评审
doi：10.1111/myc.12359
更新日期：2015-10-01 00:00:00
abstract：:Reconstituted multilayered oesophageal epithelium appears to be a good basis to test the efficacy of voriconazole (VOR) and fluconazole (FLU) in the tissue. The resulting model of a Candida oesophagitis was approaching the in vivo situation. We infected the tissue with 2 x 10(6) cfu of the Candida albicans strain SC53...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.2004.01004.x
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:The incidence of fungal keratitis has increased in recent years. While the epidemiology and clinical roles of various Candida and Fusarium species have been relatively well-identified in infections of the eye, data regarding keratitis caused by Aspergillus species are scant. Accurate and rapid diagnosis is i...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12855
更新日期：2019-02-01 00:00:00
abstract：:Exophiala is a genus of black fungi isolated worldwide from environmental and clinical specimens. Data on antifungal susceptibility of Exophiala isolates are limited and the methodology on susceptibility testing is not yet standardised. In this study, we investigated in vitro antifungal susceptibilities of environment...
journal_title：Mycoses
pub_type： 杂志文章,评审
doi：10.1111/myc.12779
更新日期：2018-08-01 00:00:00
abstract：:Posaconazole is indicated for prophylaxis and treatment of invasive aspergillosis. Therapeutic drug monitoring (TDM) of posaconazole is used to optimise drug exposure. The aim of this study was to analyse and describe the TDM practices and exposure of posaconazole tablets. Patients who received posaconazole for treatm...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12948
更新日期：2019-08-01 00:00:00
abstract：:Chronic vegetating pyoderma is usually associated with staphylococci and streptococci. A case that started as a therapeutically resistant tinea of the hand caused by Trichophyton mentagrophytes is described. The vegetating skin lesion was associated with low immunoglobulin levels and impaired phagocytosis. It healed a...
journal_title：Mycoses
pub_type： 信件
doi：10.1111/j.1439-0507.2006.01191.x
更新日期：2006-03-01 00:00:00
abstract：:Fusarium species have emerged as an important human pathogen in skin disease, onychomycosis, keratitis and invasive disease. Onychomycosis caused by Fusarium spp. The infection has been increasingly described in the immunocompetent and immunosuppressed hosts. Considering onychomycosis is a difficult to treat infection...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12638
更新日期：2017-09-01 00:00:00
abstract：:Eighteen adult white male patients with cutaneous sporotrichosis were treated with itraconazole following different daily dose schemes. Cure was obtained in all cases after periods of 15-75 days (median 44 days) with total doses between 3.1 and 14.8 g (median 8.4 g). No serious side effects were observed and no relaps...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.1992.tb00836.x
更新日期：1992-05-01 00:00:00
abstract：:Disseminated histoplasmosis (DH) is the most current revelation mode of AIDS in French Guiana. We describe the clinical and paraclinical presentation of DH, diagnostic tools, evolution and factors associated with 1-year mortality in HIV-infected patients from western French Guiana. Microbiologically proven AIDS-relate...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12293
更新日期：2015-03-01 00:00:00
abstract：:Colonisation of the gastrointestinal tract is influenced by primary microbial exposure and bioactive factors in breastmilk. The aim was to explore the prevalence of oral Candida in the first year of life in relation to selected exposures. Oral Candida was studied in 100 healthy infants at 4 and 8 weeks, 3, 6 and 12 mo...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12355
更新日期：2015-09-01 00:00:00
abstract：:The molecular characterization of Malassezia spp. isolates from animals and humans has not been thoroughly studied. We have analysed the DNA profile by random amplified polymorphic DNA (RAPD)-PCR to compare the genetic diversity between isolates from the external ears of cattle, dogs and humans. The analysis of electr...
journal_title：Mycoses
pub_type： 杂志文章,评审
doi：10.1111/j.1439-0507.2008.01658.x
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Cryptococcal meningitis accounts for 15% of all AIDS mortality globally. Most cases in low- and middle-income countries are treated with fluconazole monotherapy, which is associated with a high mortality. New available therapies are needed. Short-course amphotericin B has been shown to be a safe and efficien...
journal_title：Mycoses
pub_type： 临床试验,杂志文章
doi：10.1111/myc.12995
更新日期：2019-12-01 00:00:00
abstract：:The minimum inhibitory concentrations (MIC, microg ml-1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in ...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.2004.00988.x
更新日期：2004-08-01 00:00:00
abstract：:In this prospective study 197 serum and 152 urine samples were collected from 40 bone marrow and solid organ transplant recipients with clinically suspected invasive fungal infection before, during and after empirical treatment with lipid formulation of amphotericin B or fluconazole. Serum was analysed by Candida poly...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1046/j.1439-0507.1999.00451.x
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Pulmonary cryptococcosis (PC) is not considered an rare, opportunistic infection anymore. The immunocompetent population accounts for an increasing proportion of the morbidity. OBJECTIVE:This study investigated the clinical characteristics of PC patients spanning 20 years, in a referral centre of China. PA...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12966
更新日期：2019-10-01 00:00:00
abstract：:One hundred and fifty cases of corneal ulcers from the Government Ophthalmic Hospital, Madras, were investigated during 1980-1982 for the mycoflora. 68 cases (45%) were positive for fungi, comprising species of Aspergillus (36 cases), Penicillium, Fusarium (8 cases each), Curvularia (4 cases), Candida albicans and Muc...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.1989.tb02183.x
更新日期：1989-11-01 00:00:00
abstract：:In this study, 36 extracts derived from 29 plant species selected using an ethnobotanical approach were tested for antifungal activity against a taxonomically diverse group of 13 human pathogenic fungi. We compared the inhibitory characteristics of these plant extracts with those of the commonly used antifungals, amph...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1046/j.1439-0507.2003.00838.x
更新日期：2003-02-01 00:00:00
abstract：:A case is presented of an 8-year-old boy suffering from disseminated verrucous lesions with some purulent drainage on his right foot, shank, thigh, scrotum, penis, perianal area and abdomen. Epidermophyton floccosum was isolated from these lesions. The patient was treated with oral ketoconazole for 4 months and the le...
journal_title：Mycoses
pub_type： 信件
doi：
更新日期：2001-01-01 00:00:00
abstract：:The MIC values of the antifungal drug ketoconazole were evaluated on 66 Candida albicans strains. These strains were isolated from 26 HIV-1 infected patients with oral recurrent candidosis. Each episode of oral candidosis observed in these patients was orally treated with ketoconazole (200 mg/day) until the clinical d...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.1992.tb00819.x
更新日期：1992-01-01 00:00:00
abstract：:A 38-year-old woman infected with human immunodeficiency virus (HIV) presented with persistent oral candidosis in which non-albicans Candida strains were the predominant yeasts in most of the examinations performed over a period of 6 years. Oral treatment with fluconazole had no effect on clinical signs of oral candid...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/j.1439-0507.1998.tb00347.x
更新日期：1998-09-01 00:00:00
abstract：:Paracoccidioidomycosis (PCM) is a neglected fungal disease that elicits an important granulomatous inflammatory reaction which aims to isolate the fungi and resolve the infection; besides the innate cellular response, the patients' sera may contain different levels of antibodies directed against PCM's pathogenic agent...
journal_title：Mycoses
pub_type： 杂志文章
doi：10.1111/myc.12325
更新日期：2015-06-01 00:00:00
abstract：:To date, there has been only one published report on the infectious sclerokeratitis caused by Metarhizium anisopliae, which is an entomopathogenic fungus. Regarding corneal infection, three reports have been published to date. Although the prognoses of the corneal infections are favourable, prognosis when scleral infe...
journal_title：Mycoses
pub_type： 杂志文章,评审
doi：10.1111/myc.12279
更新日期：2015-02-01 00:00:00
abstract：:The sensitivity of a sandwich enzyme-linked immunosorbent assay (ELISA) for detecting Aspergillus galactomannan was evaluated with 66 serum samples and 113 specimens of the respiratory tract obtained from 52 patients with pulmonary diseases. The patients were divided into five groups: proven invasive pulmonary aspergi...
journal_title：Mycoses
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
