The statin-iron nexus: anti-inflammatory intervention for arterial disease prevention.

Abstract:

OBJECTIVES:We postulated the existence of a statin-iron nexus by which statins improve cardiovascular disease outcomes at least partially by countering proinflammatory effects of excess iron stores. METHODS:Using data from a clinical trial of iron (ferritin) reduction in advanced peripheral arterial disease, the Iron and Atherosclerosis Study, we compared effects of ferritin levels versus high-density lipoprotein to low-density lipoprotein ratios (both were randomization variables) on clinical outcomes in participants receiving and not receiving statins. RESULTS:Statins increased high-density lipoprotein to low-density lipoprotein ratios and reduced ferritin levels by noninteracting mechanisms. Improved clinical outcomes were associated with lower ferritin levels but not with improved lipid status. CONCLUSIONS:There are commonalities between the clinical benefits of statins and the maintenance of physiologic iron levels. Iron reduction may be a safe and low-cost alternative to statins.

journal_name

Am J Public Health

authors

Zacharski LR,DePalma RG,Shamayeva G,Chow BK

doi

10.2105/AJPH.2012.301163

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

e105-12

issue

4

eissn

0090-0036

issn

1541-0048

journal_volume

103

pub_type

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