Synthetic biology: programming cells for biomedical applications.

Abstract:

:The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry.

journal_name

Perspect Biol Med

authors

Hörner M,Reischmann N,Weber W

doi

10.1353/pbm.2012.0042

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

490-502

issue

4

eissn

0031-5982

issn

1529-8795

pii

S1529879512400035

journal_volume

55

pub_type

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