Abstract:
:The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry.
journal_name
Perspect Biol Medjournal_title
Perspectives in biology and medicineauthors
Hörner M,Reischmann N,Weber Wdoi
10.1353/pbm.2012.0042subject
Has Abstractpub_date
2012-01-01 00:00:00pages
490-502issue
4eissn
0031-5982issn
1529-8795pii
S1529879512400035journal_volume
55pub_type
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2012.0002
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2003.0094
更新日期:2003-10-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.0.0045
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0032
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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