Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium.


:The use of a serum-free culture system for assessing the growth factor responsiveness of malignant glial cells is described. The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138). Each of the three had high-affinity EGF receptors and all responded in a dose-dependent fashion to physiological concentrations of EGF. These cell lines also showed a pronounced mitogenic response to PDGF which equaled or exceeded that achieved with EGF. Simultaneous stimulation with both factors produced an additive response, which approximated that obtained in medium supplemented with 10% fetal calf serum. The authors conclude that functional EGF and PDGF receptors were present in the human malignant glial tumors studied. The response of the human glioma lines to these growth factors in many respects parallels the response seen in fetal astrocytes tested under similar conditions. In contrast, the behavior of two chemically induced rat gliomas (9L and C6) differed significantly from that seen in the human lines, suggesting that the rat lines may not be entirely acceptable as models for studying the growth characteristics of human malignant glial tumors.


J Neurosurg


Journal of neurosurgery


Pollack IF,Randall MS,Kristofik MP,Kelly RH,Selker RG,Vertosick FT




Has Abstract


1990-07-01 00:00:00












  • Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases.

    abstract:OBJECT:The goal of this study was to investigate the protective effects of long-term (3-14 days) mild hypothermia therapy (33-35 degrees C) on outcome in 87 patients with severe traumatic brain injury (TBI) (Glasgow Coma Scale score < or = 8). METHODS:In 43 patients assigned to a mild hypothermia group, body temperatu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Jiang J,Yu M,Zhu C

    更新日期:2000-10-01 00:00:00

  • Thrombin-triggered angiogenesis in rat brains following experimental intracerebral hemorrhage.

    abstract:OBJECT:Angiogenesis occurs after intracerebral hemorrhage (ICH). Thrombin mediates mitogenesis and survival in endothelial cells and induces angiogenesis. The present study aimed to clarify whether thrombin is involved in triggering ICH-related angiogenesis. METHODS:In the first part of the experiment, autologous bloo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zhou HJ,Tang T,Cui HJ,Yang AL,Luo JK,Lin Y,Yang QD,Li XQ

    更新日期:2012-11-01 00:00:00

  • Use of transcranial Doppler sonography to predict development of a delayed ischemic deficit after subarachnoid hemorrhage.

    abstract::Blood flow velocity was recorded from the middle or anterior cerebral and extracranial internal carotid arteries using transcranial Doppler sonography (TCD) in 121 unselected consecutive patients with acute aneurysmal subarachnoid hemorrhage (SAH). Recordings were made daily or every 2nd day after SAH for a 14-day per...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Grosset DG,Straiton J,McDonald I,Cockburn M,Bullock R

    更新日期:1993-02-01 00:00:00

  • Cushing's legacy to transsphenoidal surgery.

    abstract::Cushing's experience with the surgical treatment of pituitary adenomas and other lesions producing the chiasmal syndrome is reviewed. The conclusion is that his ultimate rejection of the transsphenoidal route was not due to his dissatisfaction with this procedure, but rather came about because of the transfrontal rout...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章


    authors: Rosegay H

    更新日期:1981-04-01 00:00:00

  • Safety and accuracy of incisionless transcranial MR-guided focused ultrasound functional neurosurgery: single-center experience with 253 targets in 180 treatments.

    abstract::OBJECTIVESince the first clinical application of the incisionless magnetic resonance-guided focused ultrasound (MRgFUS) technology only small series of patients have been reported, and thus only extrapolations of the procedure-related risks could be offered. In this study, the authors analyze side-effects and targetin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Gallay MN,Moser D,Jeanmonod D

    更新日期:2018-05-01 00:00:00

  • Prediction of tolerance to carotid artery occlusion using transcranial Doppler ultrasound.

    abstract::Surgical sacrifice of the carotid artery is a frequently anticipated event during the treatment of certain aneurysms and tumors. The ability to predict tolerance to carotid artery occlusion is therefore of benefit when planning procedures in which the carotid artery is at risk. A trial of carotid artery occlusion usin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Giller CA,Mathews D,Walker B,Purdy P,Roseland AM

    更新日期:1994-07-01 00:00:00

  • The natural history and management of symptomatic and asymptomatic vertebral hemangiomas.

    abstract::Fifty-nine cases of vertebral hemangioma were seen at the Mayo Clinic between 1980 and 1990. Vertebral hemangiomas were discovered incidentally in 35 patients, while pain was the presenting complaint in 13 patients. Five patients presented directly with progressive neurological deficit requiring surgery, and six patie...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fox MW,Onofrio BM

    更新日期:1993-01-01 00:00:00

  • Diagnostic value of 201Tl-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas.

    abstract:OBJECT:The 201Tl uptake index was evaluated for its usefulness in formulating a diagnosis of hemangioblastoma. Thallium-201-single-photon emission computerized tomography (SPECT) studies were performed in nine patients harboring hemangioblastomas in the posterior fossa and in five patients (six lesions) with gliomas in...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Kondo T,Kumabe T,Maruoka S,Yoshimoto T

    更新日期:2001-08-01 00:00:00

  • Aneurysmal subarachnoid hemorrhage in young adults: a comparison between patients in the third and fourth decades of life.

    abstract:OBJECT:Aneurysmal subarachnoid hemorrhage rarely occurs in young adults. The aim of this work was to clarify the clinical characteristics of ruptured aneurysms in young adults in the third and fourth decades of life and to compare these two age groups. METHODS:The authors retrospectively investigated 2493 patients who...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Horiuchi T,Tanaka Y,Hongo K,Kobayashi S

    更新日期:2003-08-01 00:00:00

  • Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.

    abstract::In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age. Patients treated with irradiation plus ...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Krischer JP,Ragab AH,Kun L,Kim TH,Laurent JP,Boyett JM,Cornell CJ,Link M,Luthy AR,Camitta B

    更新日期:1991-06-01 00:00:00

  • Toward better balance.

    abstract::The AANS was founded in 1931 as an educational and scientific organization whose principal purpose was to foster optimum neurosurgical care. Because socioeconomic and political pressures on medicine generally and neurosurgery specifically have escalated in recent years, the American Association of Neurological Surgeon...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hoff JT

    更新日期:1994-11-01 00:00:00

  • Awake surgery for WHO Grade II gliomas within "noneloquent" areas in the left dominant hemisphere: toward a "supratotal" resection. Clinical article.

    abstract:OBJECT:It has been demonstrated that an extensive resection (total or subtotal) may significantly increase the overall survival in patients with WHO Grade II gliomas (low-grade gliomas [LGGs]). Yet, recent data have shown that conventional MR imaging underestimates the spatial extent of LGG, since tumor cells were foun...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yordanova YN,Moritz-Gasser S,Duffau H

    更新日期:2011-08-01 00:00:00

  • Three-dimensional SPACE fluid-attenuated inversion recovery at 3 T to improve subthalamic nucleus lead placement for deep brain stimulation in Parkinson's disease: from preclinical to clinical studies.

    abstract::OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for motor symptoms in patients with pharmacoresistant Parkinson's disease (PD). However, the procedure, which requires multimodal perioperative exploration such as imaging, electrophysiology, or clinical examination d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Senova S,Hosomi K,Gurruchaga JM,Gouello G,Ouerchefani N,Beaugendre Y,Lepetit H,Lefaucheur JP,Badin RA,Dauguet J,Jan C,Hantraye P,Brugières P,Palfi S

    更新日期:2016-08-01 00:00:00

  • Intraoperative ventricular puncture during supraorbital craniotomy via an eyebrow incision. Technical note.

    abstract::The authors determined the landmarks and coordinates for intraoperative ventricular puncture directly from the supraorbital craniotomy opening via an eyebrow incision. Fifty magnetic resonance (MR) imaging studies were obtained from patients with no pathological cerebral characteristics or ventricular distortion. The ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Menovsky T,De Vries J,Wurzer JA,Grotenhuis JA

    更新日期:2006-09-01 00:00:00

  • Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions.

    abstract::Mean hemispheric cerebral blood flow (CBF) and intracranial pressure (ICP) were measured in 19 severely head-injured patients treated with barbiturate coma. The CBF was calculated from the clearance of tracer substance monitored by extracranial scintillation detectors after intravenous administration of xenon-133. In ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nordström CH,Messeter K,Sundbärg G,Schalén W,Werner M,Ryding E

    更新日期:1988-03-01 00:00:00

  • Spontaneous regression of a cerebral arteriovenous malformation in a child with hereditary hemorrhagic telangiectasia. Case report.

    abstract::Patients with hereditary hemorrhagic telangiectasia (HHT) are at risk for the development of cerebral arteriovenous malformations (AVMs). The authors report a case of a spontaneously regressing cerebral AVM in a patient with HHT. The lesion was diagnosed on the basis of findings on screening magnetic resonance imaging...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Leung KM,Agid R,terBrugge K

    更新日期:2006-11-01 00:00:00

  • Dystonic tics induced by deep brain stimulation of the posterior subthalamic area for essential tremor.

    abstract::OBJECTIVE The posterior subthalamic area (PSA) is a promising target of deep brain stimulation (DBS) for medication-refractory essential tremor (ET). This case series describes a novel adverse effect manifesting as dystonic tics in patients with ET undergoing DBS of the PSA. METHODS Six patients with ET received elect...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章


    authors: Chandran AS,Joshi S,Thorburn M,Stell R,Lind CR

    更新日期:2017-02-01 00:00:00

  • Cerebral acid-base homeostasis after severe traumatic brain injury.

    abstract:OBJECT:Brain tissue acidosis is known to mediate neuronal death. Therefore the authors measured the main parameters of cerebral acid-base homeostasis, as well as their interrelations, shortly after severe traumatic brain injury (TBI) in humans. METHODS:Brain tissue pH, PCO2, PO2, and/or lactate were measured in 151 pa...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Clausen T,Khaldi A,Zauner A,Reinert M,Doppenberg E,Menzel M,Soukup J,Alves OL,Bullock MR

    更新日期:2005-10-01 00:00:00

  • Analysis of 7-tesla diffusion-weighted imaging in the prediction of pituitary macroadenoma consistency.

    abstract:OBJECTIVE:Endoscopic surgery is an effective treatment strategy for pituitary adenomas; however, intrinsic tumor properties such as tumor consistency can challenge or preclude gross-total resection. Preoperative characterization of tumor consistency may help to guide the surgical approach and to predict the extent of r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rutland JW,Loewenstern J,Ranti D,Tsankova NM,Bellaire CP,Bederson JB,Delman BN,Shrivastava RK,Balchandani P

    更新日期:2020-02-28 00:00:00

  • Extended transsphenoidal approach.

    abstract::The authors have developed an extended transsphenoidal approach with submucosal posterior ethmoidectomy for resection of tumors located in the cavernous sinus or the suprasellar region that are difficult to remove via the conventional transsphenoidal approach. Surgery was performed using this approach in 14 patients w...

    journal_title:Journal of neurosurgery

    pub_type: 评论,信件


    authors: Frank G,Pasquini E,Mazzatenta D

    更新日期:2001-11-01 00:00:00

  • Cadaveric fibula, locking plate, and allogeneic bone matrix for anterior cervical fusions after cervical discectomy for radiculopathy or myelopathy.

    abstract:OBJECT:The authors have previously reported that the results of using cadaveric fibula and locking plate (CF/LP) fusion following anterior cervical discectomy (ACD) for cervical spondylotic radiculopathy and myelopathy are superior to those obtained using autologous iliac crest (AIC) grafts in the short term. The long-...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Shapiro S,Connolly P,Donnaldson J,Abel T

    更新日期:2001-07-01 00:00:00

  • A reassessment of vascular endothelial growth factor in central nervous system pathology.

    abstract::Overexpression of vascular endothelial growth factor (VEGF) is associated with several central nervous system (CNS) diseases and abnormalities, and is often postulated as a causative factor and promising therapeutic target in these settings. The authors' goal was to reassess the contribution of VEGF to the biology and...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Merrill MJ,Oldfield EH

    更新日期:2005-11-01 00:00:00

  • Cerebral sparganosis diagnosed and treated with stereotactic techniques. Report of two cases.

    abstract::Infestation of the central nervous system with sparganum, the larva of Spirometra mansoni, is rare. Only 27 cases have been reported in the literature; however, the true incidence might be underestimated. Two cases are reported that were definitively diagnosed by stereotactic biopsy techniques. Without a positive hist...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tsai MD,Chang CN,Ho YS,Wang AD

    更新日期:1993-01-01 00:00:00

  • Imaging studies of cerebral hyperperfusion after carotid endarterectomy. Case report.

    abstract::A case is reported of severe unilateral hemispheric edema and localized hemorrhage associated with seizures following endarterectomy of an ipsilateral high-grade carotid stenosis. Imaging studies including angiography, computerized tomography (CT), magnetic resonance imaging/angiography, and xenon-CT, suggested postop...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Penn AA,Schomer DF,Steinberg GK

    更新日期:1995-07-01 00:00:00

  • Experimental intraoperative localization of retained intracerebral bone fragments using transdural ultrasound.

    abstract::Precise intraoperative localization of retained bone fragments and foreign bodies avoids extensive brain disseciton, cerebral edema, damage to vital structures, incomplete debridement, and prolonged surgical procedures. Such localization after head trauma is often hampered by cerebral distortion, previous incomplete d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wood JH,Parver M,Doppman JL,Ommaya AK

    更新日期:1977-01-01 00:00:00

  • Medical treatment decision making after total avulsion brachial plexus injury: a qualitative study.

    abstract:OBJECT:Complete avulsion traumatic brachial plexus injuries (BPIs) can be treated using nerve and musculoskeletal reconstruction procedures. However, these interventions are most viable within certain timeframes, and even then they cannot restore all lost function. Little is known about how patients make decisions rega...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Franzblau LE,Maynard M,Chung KC,Yang LJ

    更新日期:2015-06-01 00:00:00

  • Comparison of techniques for ventriculoperitoneal shunting in 523 patients with subarachnoid hemorrhage.

    abstract:OBJECTIVE:It is common practice to use a new contralateral bur hole for ventriculoperitoneal shunt (VPS) placement in subarachnoid hemorrhage (SAH) patients with an existing ventriculostomy. At Thomas Jefferson University and Jefferson Hospital for Neuroscience, the authors have primarily used the ventriculostomy site ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Chalouhi N,Whiting A,Anderson EC,Witte S,Zanaty M,Tjoumakaris S,Gonzalez LF,Hasan D,Starke RM,Hann S,Ghobrial GM,Rosenwasser R,Jabbour P

    更新日期:2014-10-01 00:00:00

  • Multicenter study of the feasibility and safety of using the memotherm carotid arterial stent for extracranial carotid artery stenosis.

    abstract:OBJECT:Carotid artery (CA) angioplasty with stent placement has been proposed as an alternative technique for revascularization in cases of CA stenosis. In this report the authors review the results of a multicenter Phase I study in which they evaluated the safety and feasibility of using a new self-expanding nitinol s...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Qureshi AI,Suri MF,New G,Wadsworth DC Jr,Dulin J,Hopkins LN

    更新日期:2002-05-01 00:00:00

  • Combining endovascular and neurosurgical treatments of high-risk dural arteriovenous fistulas in the lateral sinus and the confluence of the sinuses.

    abstract:OBJECT:The authors describe the use of a systemic approach to treat dural arteriovenous fistulas (DAVFs) in the lateral sinus and the confluence of sinuses in 17 patients who presented with signs and symptoms related to intracranial hemorrhage, infarction, and diffuse brain swelling. METHODS:Angiographic examination r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Goto K,Sidipratomo P,Ogata N,Inoue T,Matsuno H

    更新日期:1999-02-01 00:00:00

  • Stereotaxic implantation of dispersed cell suspensions into brain. A systematic appraisal of cell placement and survival.

    abstract::The application of several recent advances in cell biology, brain implantation, and cell-mediated tumor immunotherapy requires successful and reproducible placement of viable cell suspensions into brain. Stereotaxic implantation is being used to inject cytotoxic lymphocytes into gliomas and to replace dopaminergic cel...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Plunkett RJ,Weber RJ,Oldfield EH

    更新日期:1988-08-01 00:00:00