Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium.

Abstract:

:The use of a serum-free culture system for assessing the growth factor responsiveness of malignant glial cells is described. The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138). Each of the three had high-affinity EGF receptors and all responded in a dose-dependent fashion to physiological concentrations of EGF. These cell lines also showed a pronounced mitogenic response to PDGF which equaled or exceeded that achieved with EGF. Simultaneous stimulation with both factors produced an additive response, which approximated that obtained in medium supplemented with 10% fetal calf serum. The authors conclude that functional EGF and PDGF receptors were present in the human malignant glial tumors studied. The response of the human glioma lines to these growth factors in many respects parallels the response seen in fetal astrocytes tested under similar conditions. In contrast, the behavior of two chemically induced rat gliomas (9L and C6) differed significantly from that seen in the human lines, suggesting that the rat lines may not be entirely acceptable as models for studying the growth characteristics of human malignant glial tumors.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Pollack IF,Randall MS,Kristofik MP,Kelly RH,Selker RG,Vertosick FT

doi

10.3171/jns.1990.73.1.0106

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

106-12

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

73

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:10.3171/2012.8.JNS12358

    authors: Turner RC,Naser ZJ,Bailes JE,Smith DW,Fisher JA,Rosen CL

    更新日期:2012-12-01 00:00:00

  • Microsurgical lesioning in the dorsal root entry zone for pain due to brachial plexus avulsion: a prospective series of 55 patients.

    abstract:OBJECT:Most patients with preganglionic lesions after brachial plexus injuries suffer pain that is hard to control through medication or neuromodulation. Lesioning in the dorsal root entry zone (DREZ) is undeniably effective. Fifty-five patients who had undergone the so-called microsurgical DREZotomy (MDT) procedure we...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2005.102.6.1018

    authors: Sindou MP,Blondet E,Emery E,Mertens P

    更新日期:2005-06-01 00:00:00

  • Theodore Brown Rasmussen (1910-2002): epilepsy surgeon, scientist, and teacher.

    abstract::Theodore Brown Rasmussen succeeded Wilder Penfield as director of the Montreal Neurological Institute (MNI) and held this post from 1960 to 1972. During his career, Rasmussen probably performed more operations for epilepsy than any other surgeon of his time; he became the foremost authority in this field. His meticulo...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/jns.2003.98.3.0631

    authors: Feindel W

    更新日期:2003-03-01 00:00:00

  • A historical case of beaten-copper cranium.

    abstract::The authors present the oldest historical case of a so-called beaten-copper cranium. The typical pattern was identified on a skull from a child, probably a boy, who died at approximately 6 years of age and was buried in a provisional cemetery used during the siege of Hanau, Germany, in 1635 and 1636. Morphological and...

    journal_title:Journal of neurosurgery

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    doi:10.3171/ped.2007.106.1.71

    authors: Rühli FJ,Nicklisch N,Alt KW

    更新日期:2007-01-01 00:00:00

  • Shunts in normal-pressure hydrocephalus: do we place too many or too few?

    abstract:OBJECT:The average 65-year-old patient with moderate dementia can look forward to only 1.4 quality-adjusted life years (QALYs), that is, longevity times quality of life. Some of these patients suffer from normal-pressure hydrocephalus (NPH) and respond dramatically to shunt insertion. Currently, however, NPH cannot be ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.6.815

    authors: Stein SC,Burnett MG,Sonnad SS

    更新日期:2006-12-01 00:00:00

  • Ultra-early surgery for aneurysmal subarachnoid hemorrhage: outcomes for a consecutive series of 391 patients not selected by grade or age.

    abstract:OBJECT:This study was undertaken to determine the outcomes in an unselected group of patients treated with semiurgent surgical clipping of aneurysms following subarachnoid hemorrhage (SAH). METHODS:A clinical management outcome audit was conducted to determine outcomes in a group of 391 consecutive patients who were t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.2.0250

    authors: Laidlaw JD,Siu KH

    更新日期:2002-08-01 00:00:00

  • Effect of the novel high-affinity glycine-site N-methyl-D-aspartate antagonist ACEA-1021 on 125I-MK-801 binding after subdural hematoma in the rat: an in vivo autoradiographic study.

    abstract::Acute subdural hematoma (SDH) complicates 20% of severe human head injuries and causes death or severe disability in 60% of these cases, due to brain swelling and high intracranial pressure. Although the mechanisms for these phenomena are unknown, previous studies have implicated excitatory amino acid-mediated mechani...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.4.0655

    authors: Di X,Bullock R

    更新日期:1996-10-01 00:00:00

  • Transcranial puncture through the parietal and mastoid foramina for the treatment of dural fistulas. Report of four cases.

    abstract::In this report the authors describe the endovascular treatment of dural arteriovenous fistulas (DAVFs) through transcranial puncture of the feeding arteries. Four patients had DAVFs that were fed by occipital arteries (OAs) that supplied blood to the intracranial meningeal arteries via the transcranial branches and co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2007.106.5.912

    authors: Chapot R,Saint-Maurice JP,Narata AP,Rogopoulos A,Moreau JJ,Houdart E,Maubon A

    更新日期:2007-05-01 00:00:00

  • Late complications of Silastic duraplasty: low-virulence infections. Case report.

    abstract::The authors describe three patients with expanding hemorrhagic mass lesions who presented 13 to 18 years after undergoing Silastic duraplasty. In all patients, results of bacteriological cultures of the masses obtained intraoperatively were positive, revealing low-virulence bacteria. Two of the patients were treated w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.90.3.0559

    authors: Ekseth K,Boström S

    更新日期:1999-03-01 00:00:00

  • Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.9.JNS182001

    authors: Asquier N,Bouchoux G,Canney M,Martin C,Law-Ye B,Leclercq D,Chapelon JY,Lafon C,Idbaih A,Carpentier A

    更新日期:2019-02-01 00:00:00

  • Floating C-shaped orbital osteotomy for orbital rim advancement in craniosynostosis: preliminary report.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.72.1.0022

    authors: Persing JA,Jane JA,Park TS,Edgerton MT,Delashaw JB

    更新日期:1990-01-01 00:00:00

  • Induction of tolerance against ischemia/reperfusion injury in the rat brain by preconditioning with the endotoxin analog diphosphoryl lipid A.

    abstract:OBJECT:Inflammatory responses and oxygen free radicals have increasingly been implicated in the development of ischemic brain injury. In some cases, an attenuation of inflammation or free-radical injury can provide tissue protection. Diphosphoryl lipid A (DPL) is a detoxified derivative of a lipopolysaccharide (endotox...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.92.3.0435

    authors: Toyoda T,Kassell NF,Lee KS

    更新日期:2000-03-01 00:00:00

  • Longitudinal survey of cranial case log entries during neurological surgery residency training.

    abstract::OBJECTIVEThe purpose of this study was to analyze national trends in adult cranial cases performed by neurological surgery residents as logged into the Accreditation Council for Graduate Medical Education (ACGME) system.METHODSThe ACGME resident case logs were retrospectively reviewed for the years 2009-2017. In these...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.2.JNS172734

    authors: Agarwal N,White MD,Cohen J,Lunsford LD,Hamilton DK

    更新日期:2018-07-01 00:00:00

  • Arachnoid membranes in the posterior half of the incisural space: an inverted Liliequist membrane-like arachnoid complex.

    abstract:OBJECT:The aim of this study was to describe the similarity of configuration between the arachnoid complex in the posterior half of the incisural space and the Liliequist membrane. METHODS:Microsurgical dissection and anatomical observation were performed in 20 formalin-fixed adult cadaver heads. The origin, distribut...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.3.JNS132206

    authors: Zhang XA,Qi ST,Fan J,Huang GL,Peng JX

    更新日期:2014-08-01 00:00:00

  • Reliability of left and right indicators in CT scanning of the head. Case report.

    abstract::A case is described in which incorrect preliminary programming of a computerized tomography (CT) machine caused transposition of the left- and right-side indicators in a CT scan, which led to craniotomy on the normal side. The possible mechanism for this is incorrect pre-scan programming of the CT scanner with respect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.2.0291

    authors: Luessenhop AJ,Schellinger D

    更新日期:1987-08-01 00:00:00

  • Acrylic spinal fusion. A 20-year clinical series and technical note.

    abstract::Methyl methacrylate (acrylic) was used in fusion techniques in 82 patients, most of whom had metastatic disease, between 1959 and 1979. In all cases the acrylic was used to supplement stabilization with Meurig-Williams stainless steel plates or with wire. In cases involving a decompressive laminectomy and excisional b...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.5.0606

    authors: Hansebout RR,Blomquist GA Jr

    更新日期:1980-11-01 00:00:00

  • Diagnosis and treatment of vertebral aneurysms.

    abstract::The intracranial vertebral artery and its branches are a common site of aneurysms in the posterior fossa. Ninety-four aneurysms in 86 patients were analyzed for their clinical manifestation, diagnosis, and treatment. There were three distinct varieties of aneurysm in this group: 56 (60%) saccular aneurysms, 26 (28%) d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.69.3.0345

    authors: Yamaura A

    更新日期:1988-09-01 00:00:00

  • A new microclip for vascular occlusion. Technical note.

    abstract::A new microclip for use on blood vessels 300 mu to 1 mm in diameter is described. This clip is suitable for either temporary or permanent occlusion and has been used in experimental applications. Potential clinical applications are described. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.5.0822

    authors: Andrews BT,Lutz A,Bederson JB,Pitts LH

    更新日期:1986-05-01 00:00:00

  • Frequency of thromboembolic events associated with endovascular aneurysm treatment: retrospective case series.

    abstract:OBJECT:There is little evidence addressing whether procedures requiring adjunctive devices lead to an increased frequency of thromboembolic complications. The authors report their experience with 155 aneurysms treated with and without adjunctive devices. METHODS:The authors retrospectively reviewed their last 155 aneu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/6/1095

    authors: Brooks NP,Turk AS,Niemann DB,Aagaard-Kienitz B,Pulfer K,Cook T

    更新日期:2008-06-01 00:00:00

  • Tectal plate lesions in children.

    abstract:OBJECT:The authors characterized the clinical course of tectal plate lesions in a group of pediatric patients to identify the prognostic factors at presentation that predict progression, in an attempt to differentiate tectal hamartomas from tumors. METHODS:A retrospective review was conducted of the management of tect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2006.104.6.369

    authors: Ternier J,Wray A,Puget S,Bodaert N,Zerah M,Sainte-Rose C

    更新日期:2006-06-01 00:00:00

  • Distribution of genes for bone morphogenetic protein-4, -6, growth differentiation factor-5, and bone morphogenetic protein receptors in the process of experimental spondylosis in mice.

    abstract:OBJECT:Because little is known about the molecular mechanisms underlying the process of spondylosis, the authors examined the extent of genetic localization of several members of bone morphogenetic protein (BMP) and BMP receptors in chondrogenesis during the process of inducing spondylosis in their previously establish...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2001.94.1.0068

    authors: Nakase T,Ariga K,Miyamoto S,Okuda S,Tomita T,Iwasaki M,Yonenobu K,Yoshikawa H

    更新日期:2001-01-01 00:00:00

  • The value of repeat pan-angiography in cases of unexplained subarachnoid hemorrhage.

    abstract::Four-vessel angiography was repeated in 56 patients with confirmed subarachnoid hemorrhage in whom the initial investigation was negative. Only one aneurysm was demonstrated. The results suggested that, with good technique, careful observation, and a complete four-vessel cerebral angiography, a false negative rate of ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.5.0712

    authors: Forster DM,Steiner L,Hakanson S,Bergvall U

    更新日期:1978-05-01 00:00:00

  • Motor areas of the frontal cortex in patients with motor eloquent brain lesions.

    abstract::OBJECTIVE Because of its huge clinical potential, the importance of premotor areas for motor function itself and plastic reshaping due to tumors or ischemic brain lesions has received increased attention. Thus, in this study the authors used navigated transcranial magnetic stimulation (nTMS) to investigate whether tum...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.11.JNS152103

    authors: Bulubas L,Sabih J,Wohlschlaeger A,Sollmann N,Hauck T,Ille S,Ringel F,Meyer B,Krieg SM

    更新日期:2016-12-01 00:00:00

  • Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.1.0080

    authors: Yasuhara T,Shingo T,Muraoka K,Kobayashi K,Takeuchi A,Yano A,Wenji Y,Kameda M,Matsui T,Miyoshi Y,Date I

    更新日期:2005-01-01 00:00:00

  • Intraparenchymal embolization for obliteration of an intramedullary AVM of the spinal cord. Technical note.

    abstract::A new technique is presented in which expandable compressed Ivalon sponge emboli were used to obliterate an intramedullary arteriovenous malformation of the spinal cord by intraparenchymal embolization. A case is described in which this method was used. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.47.1.0119

    authors: Ausman JI,Gold LH,Tadavarthy SM,Amplatz K,Chou SN

    更新日期:1977-07-01 00:00:00

  • White matter fiber dissection of the optic radiations of the temporal lobe and implications for surgical approaches to the temporal horn.

    abstract:OBJECT:The aim of this anatomical study was to define more fully the three-dimensional (3D) relationships between the optic radiations and the temporal horn and superficial anatomy of the temporal lobe by using the Klingler white matter fiber dissection technique. These findings were correlated with established surgica...

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    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.5.0739

    authors: Sincoff EH,Tan Y,Abdulrauf SI

    更新日期:2004-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.1.0031

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    更新日期:2003-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3171/jns.1990.73.2.0217

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    更新日期:1990-08-01 00:00:00

  • Congenital ventriculocisternostomy. Case report.

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    更新日期:1976-03-01 00:00:00