Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium.

Abstract:

:The use of a serum-free culture system for assessing the growth factor responsiveness of malignant glial cells is described. The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138). Each of the three had high-affinity EGF receptors and all responded in a dose-dependent fashion to physiological concentrations of EGF. These cell lines also showed a pronounced mitogenic response to PDGF which equaled or exceeded that achieved with EGF. Simultaneous stimulation with both factors produced an additive response, which approximated that obtained in medium supplemented with 10% fetal calf serum. The authors conclude that functional EGF and PDGF receptors were present in the human malignant glial tumors studied. The response of the human glioma lines to these growth factors in many respects parallels the response seen in fetal astrocytes tested under similar conditions. In contrast, the behavior of two chemically induced rat gliomas (9L and C6) differed significantly from that seen in the human lines, suggesting that the rat lines may not be entirely acceptable as models for studying the growth characteristics of human malignant glial tumors.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Pollack IF,Randall MS,Kristofik MP,Kelly RH,Selker RG,Vertosick FT

doi

10.3171/jns.1990.73.1.0106

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

106-12

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

73

pub_type

杂志文章
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    doi:10.3171/jns.2000.93.4.0546

    authors: Jiang J,Yu M,Zhu C

    更新日期:2000-10-01 00:00:00

  • Thrombin-triggered angiogenesis in rat brains following experimental intracerebral hemorrhage.

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    doi:10.3171/2012.8.JNS112152

    authors: Zhou HJ,Tang T,Cui HJ,Yang AL,Luo JK,Lin Y,Yang QD,Li XQ

    更新日期:2012-11-01 00:00:00

  • Use of transcranial Doppler sonography to predict development of a delayed ischemic deficit after subarachnoid hemorrhage.

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    doi:10.3171/jns.1993.78.2.0183

    authors: Grosset DG,Straiton J,McDonald I,Cockburn M,Bullock R

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    authors: Rosegay H

    更新日期:1981-04-01 00:00:00

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    doi:10.3171/2017.12.JNS172054

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    doi:10.3171/jns.1994.81.1.0015

    authors: Giller CA,Mathews D,Walker B,Purdy P,Roseland AM

    更新日期:1994-07-01 00:00:00

  • The natural history and management of symptomatic and asymptomatic vertebral hemangiomas.

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    doi:10.3171/jns.1993.78.1.0036

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  • Diagnostic value of 201Tl-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas.

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    doi:10.3171/jns.2001.95.2.0292

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    更新日期:2001-08-01 00:00:00

  • Aneurysmal subarachnoid hemorrhage in young adults: a comparison between patients in the third and fourth decades of life.

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    doi:10.3171/jns.2003.99.2.0276

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    更新日期:2003-08-01 00:00:00

  • Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.

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  • Toward better balance.

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    doi:10.3171/2011.3.JNS101333

    authors: Yordanova YN,Moritz-Gasser S,Duffau H

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  • Three-dimensional SPACE fluid-attenuated inversion recovery at 3 T to improve subthalamic nucleus lead placement for deep brain stimulation in Parkinson's disease: from preclinical to clinical studies.

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    更新日期:2016-08-01 00:00:00

  • Intraoperative ventricular puncture during supraorbital craniotomy via an eyebrow incision. Technical note.

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  • Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions.

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    authors: Nordström CH,Messeter K,Sundbärg G,Schalén W,Werner M,Ryding E

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  • Spontaneous regression of a cerebral arteriovenous malformation in a child with hereditary hemorrhagic telangiectasia. Case report.

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    doi:10.3171/ped.2006.105.5.428

    authors: Leung KM,Agid R,terBrugge K

    更新日期:2006-11-01 00:00:00

  • Dystonic tics induced by deep brain stimulation of the posterior subthalamic area for essential tremor.

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  • Cerebral acid-base homeostasis after severe traumatic brain injury.

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    pub_type: 评论,信件

    doi:10.3171/jns.2001.95.5.0917

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    更新日期:2001-11-01 00:00:00

  • Cadaveric fibula, locking plate, and allogeneic bone matrix for anterior cervical fusions after cervical discectomy for radiculopathy or myelopathy.

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  • Imaging studies of cerebral hyperperfusion after carotid endarterectomy. Case report.

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