Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244.

abstract：:Hyperglycemia is an established risk factor of coronary artery disease (CAD). However, hyperglycemia with preserved pancreatic β cell function induces hyperinsulinemia to correct the glucose profile and may even result in reactive hypoglycemia (RH), which induces an inflammatory response. In this study, the incidence ...

journal_title：International heart journal

authors： Murata M,Adachi H,Oshima S,Kurabayashi M

更新日期：2018-07-31 00:00:00

abstract：:The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and ...

journal_title：International heart journal

authors： Kinugawa K,Inomata T,Sato N,Yasuda M,Shimakawa T,Bando K,Fukuta Y

更新日期：2017-02-07 00:00:00

abstract：:The literature on malignant cardiac tumors is relatively limited because they are rare, especially among the Chinese population. We analyzed 14 patients diagnosed with malignant cardiac tumors in Fuwai Hospital and present the results of surgical treatments on the tumors. The mean age at tumor diagnosis was 47 years i...

journal_title：International heart journal

authors： Guo GR,Wang X,Yang J,Chen L,Song JP,Wang LQ

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP) level has been shown to increase in patients with chronic atrial fibrillation (CAF) without overt heart failure (HF). Although atrial electrical remodeling associated with CAF has been described, little is known about the effects of the BNP level on the electrophysiological pr...

journal_title：International heart journal

authors： Okumura Y,Watanabe I,Ashino S,Kofune M,Takagi Y,Kofune T,Okubo K,Hashimoto K,Shindo A,Sugimura H,Nakai T,Kasamaki Y,Saito S

更新日期：2007-07-01 00:00:00

abstract：:Prognosis of patients with heart failure (HF) remains unclear in Japan and should be determined in a prospective fashion. A prospective cohort of The Shinken Database comprised details on all of the new patients, including both inpatients and outpatients, who visited The Cardiovascular Institute Hospital in 2004-2005....

journal_title：International heart journal

authors： Goda A,Yamashita T,Suzuki S,Ohtsuka T,Uejima T,Oikawa Y,Yajima J,Koike A,Nagashima K,Kirigaya H,Sagara K,Ogasawara K,Isobe M,Sawada H,Aizawa T

更新日期：2009-09-01 00:00:00

abstract：:The usefulness of coronary magnetic resonance angiography (cMRA) has been reported, although the difference in the diagnostic accuracy of different protocols has not been established.We compared conventional coronary angiography (CAG) and cMRA, conducted within 6 months in 24 consecutive patients between September 201...

journal_title：International heart journal

authors： Namba Y,Fuke S,Kashihara Y,Tanaka M,Yumoto A,Saito H,Sato T

更新日期：2016-09-28 00:00:00

abstract：:A 19 year-old woman who underwent corrective surgery for an atrial septal defect (ASD) and ventricular septal defect (VSD) 12 years previously presented with pulmonary hypertension. Cardiac catheterization showed a fistula between the right subclavian artery and vena jugularis interna. In this case, a rare example of ...

journal_title：International heart journal

authors： Tayyareci G,Dayi SU,Akgöz H,Terzi S,Akbulut T,Aydin A,Tuygun A

更新日期：2005-05-01 00:00:00

abstract：:Cardiac output (CO) is often desirable for assessing the hemodynamic condition of a patient, especially in critically ill cardiac patients. Various noninvasive methods are available for this purpose. Inert gas rebreathing (IGR) and 2D-Doppler echocardiography methods have been validated. Based on the relationship betw...

journal_title：International heart journal

authors： Raissuni Z,Zores F,Henriet O,Dallest S,Roul G

更新日期：2013-01-01 00:00:00

abstract：:Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we ai...

journal_title：International heart journal

authors： Huang M,Zheng J,Chen Z,You C,Huang Q

更新日期：2020-01-31 00:00:00

abstract：:A 24 year-old woman had a congenital solitary kidney with renovascular hypertension due to fibromuscular dysplasia. She had been treated as having essential hypertension until she developed preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome at 28 weeks of gestation. Plasma reni...

journal_title：International heart journal

authors： Hayashida M,Watanabe N,Imamura H,Kumazaki S,Kitabayashi H,Takahashi W,Uchikawa S,Yazaki Y,Kubo K

更新日期：2005-03-01 00:00:00

abstract：:Exhaled acetone concentration is one of the expected compounds to be a breath biomarker in heart failure. However, it has not been clarified how exhaled acetone concentration changes in clinical course of heart failure.To investigate whether exhaled acetone concentration changes after treatment in acute decompensated ...

journal_title：International heart journal

authors： Yokokawa T,Sato T,Suzuki S,Oikawa M,Yoshihisa A,Kobayashi A,Yamaki T,Kunii H,Nakazato K,Suzuki H,Saitoh SI,Ishida T,Shimouchi A,Takeishi Y

更新日期：2018-07-31 00:00:00

abstract：:Heart failure (HF) is a disease with high morbidity and mortality. In patients with HF, decreased cardiac output and blood redistribution results in decreased intestinal perfusion and destruction of intestinal barrier. Microorganisms and endotoxins can migrate into the blood circulation, aggravating systemic inflammat...

journal_title：International heart journal

authors： Jin B,Ji F,Zuo A,Liu H,Qi L,He Y,Wang Q,Zhao P

更新日期：2020-03-28 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They wer...

journal_title：International heart journal

authors： Kim MC,Ahn Y,Cho KH,Lee MG,Ko JS,Park KH,Sim DS,Yoon NS,Yoon HJ,Kim KH,Hong YJ,Park HW,Kim JH,Jeong MH,Cho JG,Park JC,Kang JC

更新日期：2011-01-01 00:00:00

abstract：:To investigate the combination of high-sensitivity C-reactive protein (hs-CRP) and Low-density lipoprotein (LDL)-C as the targets for statin treatment in patients with acute coronary syndrome (ACS). This single-center, prospective, randomized study was performed in 400 patients treated with atorvastatin 40 mg/day for ...

journal_title：International heart journal

authors： Fang M,Qian Q,Zhao Z,Zhu L,Su J,Li X

更新日期：2018-03-30 00:00:00

abstract：:Pulmonary hypertension (PH) induced by pulmonary tumor thrombotic microangiopathy (PTTM) can be fatal because its rapid progression confounds diagnosis, and it is difficult to control with therapy. Here we describe a woman with symptomatic PTTM-PH accompanying gastric cancer that was suspected from perfusion scintigra...

journal_title：International heart journal

authors： Minatsuki S,Miura I,Yao A,Abe H,Muraoka H,Tanaka M,Imamura T,Inaba T,Maki H,Hatano M,Kinugawa K,Yao T,Fukayama M,Nagai R,Komuro I

更新日期：2015-01-01 00:00:00

abstract：:We present a 16-year-old male patient with hypoplastic left heart syndrome who developed protein-losing enteropathy (PLE) and plastic bronchitis (PB) after a Fontan operation. He received medical therapies, including albumin infusion, unfractionated heparin, and high-dose anti-aldosterone therapy but could not obtain ...

journal_title：International heart journal

authors： Okada S,Muneuchi J,Nagatomo Y,Nonaka K,Iida C,Shirouzu H,Matsuoka R,Watanabe M,Joo K

更新日期：2018-07-31 00:00:00

abstract：:A male patient with tetralogy of Fallot accompanied by aortic regurgitation had maintained sufficient exercise capacity for a number of decades with the status of acyanotic tetralogy of Fallot. When he was 67 years old, he suffered a posterior wall acute myocardial infarction and direct percutaneous coronary angioplas...

journal_title：International heart journal

authors： Izawa A,Sekimura N,Uchikawa S,Yazaki Y,Kinoshita O,Owa M,Kubo K,Ikeda U,Sekiguchi M,Kitahara H,Amano J,Imamura H

更新日期：2005-01-01 00:00:00

abstract：:Flexible, in vivo maneuverable electrophysiology mapping techniques are not available in rat models. A novel cardiac stereotactic electrophysiology epicardial mapping system (CREAMS) allows for various measurements, including: (1) recording unipolar electrograms at multiple sites; (2) positioning of mapped sites and p...

journal_title：International heart journal

authors： Fan B,Wang H,Wu T,Li Y,Lin Z,Li M,Li Q,Zhang W,Zheng Q

更新日期：2019-03-20 00:00:00

abstract：:Bilirubin has been considered an antioxidant, with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. The case group was composed of 100 patients with coronary artery disease and the control group 100 patients with normal...

journal_title：International heart journal

authors： Ghem C,Sarmento-Leite RE,de Quadros AS,Rossetto S,Gottschall CA

更新日期：2010-03-01 00:00:00

abstract：:To investigate parameters which were related with long-term mortality in patients hospitalized for acute heart failure (AHF).A total of 287 patients with AHF presenting to the First Affiliated Hospital of Nanjing Medical University were enrolled into the registry from April 2012 to January 2015. The primary endpoint w...

journal_title：International heart journal

authors： Jin M,Wei S,Gao R,Wang K,Xu X,Yao W,Zhang H,Zhou Y,Xu D,Zhou F,Li X

更新日期：2017-05-31 00:00:00

abstract：:Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer's disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines a...

journal_title：International heart journal

authors： Nakagami H,Koriyama H,Morishita R

更新日期：2014-01-01 00:00:00

abstract：:Steam pop and intramural charring have been reported during cooled-tip radiofrequency catheter ablation (RFCA). We studied the feasibility of temperature-controlled cooled-tip RFCA in the canine heart.An internally cooled ablation catheter was inserted into the left ventricle. A custom-made radiofrequency (RF) generat...

journal_title：International heart journal

authors： Watanabe I,Nuo M,Okumura Y,Ohkubo K,Ashino S,Kofune M,Kofune T,Nakai T,Kasamaki Y,Hirayama A

更新日期：2010-05-01 00:00:00

abstract：:Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. ...

journal_title：International heart journal

authors： Xie Q,Zhang D

更新日期：2017-02-07 00:00:00

abstract：:Supraventricular tachycardia (SVT) was observed in a 13-year-old male patient with complex clinical features that included univentricular heart with single atrium, pulmonary atresia, and polysplenia syndrome. During electrophysiologic study, atrial burst stimuli reproducibly induced and terminated the SVT, while the o...

journal_title：International heart journal

authors： Ajiki K,Hayami N,Kasaoka Y,Imai Y,Fujiu K,Murakawa Y

更新日期：2007-03-01 00:00:00

abstract：:Everolimus (EVL), one of the mammalian targets of rapamycin, is a next generation immunosuppressant that may have accessory anti-proliferative effects in heart transplant (HTx) recipients. However, little is known about the clinical relationship between EVL and regression of cardiac hypertrophy. A total of 42 HTx reci...

journal_title：International heart journal

authors： Imamura T,Kinugawa K,Nitta D,Kinoshita O,Nawata K,Ono M

更新日期：2016-01-01 00:00:00

abstract：:Five patients who had had previous cardiac operations underwent minimally invasive beating heart mitral valve operations via a right minithoracotomy between November 2006 and February 2009. The mean age was 64 ± 10 years and 4 were female. Under general anesthesia with single-lumen ventilation, cardiopulmonary bypass ...

journal_title：International heart journal

authors： Kitamura T,Stuklis RG,Edwards J

更新日期：2011-01-01 00:00:00

abstract：:Coronary heart disease (CHD) is recognized as a lifestyle-related disease and is the second leading cause of death in Japan. However, the cardiac risk factor profile of young patients with CHD has not been clarified in suburban areas of Japan. Our study aimed to determine metabolic and lifestyle risk factors in young ...

journal_title：International heart journal

authors： Azegami M,Hongo M,Yanagisawa S,Yamazaki A,Sakaguchi K,Yazaki Y,Imamura H

更新日期：2006-05-01 00:00:00

abstract：:Activation of mineralocorticoid receptor (MR) is shown in resistant hypertension including diabetes mellitus. Although protein kinase C (PKC) signaling is involved in the pathogenesis of diabetic complications, an association between PKC and MR is not known. Activation of PKCα and PKCβ by TPA (12-O-Tetradecanoylphorbo...

journal_title：International heart journal

authors： Hayashi T,Shibata H,Kurihara I,Yokota K,Mitsuishi Y,Ohashi K,Murai-Takeda A,Jo R,Ohyama T,Sakamoto M,Tojo K,Tajima N,Utsunomiya K,Itoh H

更新日期：2017-10-21 00:00:00

abstract：:The 5-hydroxytryptamine2A receptor antagonist sarpogrelate hydrochloride exerts its effect not only by inhibition of platelet aggregation, but also by some pleiotropic effects. We have reported that a low serum lipoprotein lipase (LPL) mass level reflects insulin resistance and may be a risk factor for atherosclerotic...

journal_title：International heart journal

authors： Nagayama D,Ohira M,Saiki A,Shirai K,Tatsuno I

更新日期：2014-01-01 00:00:00

abstract：:The significance of pulse pressure (PP) and mean blood pressure (MBP) for blood pressure (BP) control is unclear. The aim of this study was to examine the relationship between PP and MBP and BP control. We obtained home BP measurements for 117 patients aged 40-75 years with either office systolic BP (SBP) >or= 140 mmH...

journal_title：International heart journal

authors： Yoshitomi Y,Nagakura C,Miyauchi A

更新日期：2005-07-01 00:00:00