Abstract：
BACKGROUND:HDL is quantitatively the most important lipoprotein in most species and mechanistic evidence points toward a role for HDL in normal immune function. We tested the hypothesis that concentrations of HDL cholesterol are associated with risk of autoimmune disease. METHODS:From 2 studies of the general population-the Copenhagen General Population Study and the Copenhagen City Heart study-we included 107954 and 9387 individuals with baseline measurements of HDL cholesterol. These were followed with the national Danish Patient Registry from baseline in 2003-2015 or 1991-1994 through 2017, during which time 4078 and 1101 individuals developed autoimmune disease in the 2 studies. RESULTS:In the Copenhagen General Population Study, compared to individuals with HDL cholesterol ≥2.0 mmol/L (77 mg/dL), the multifactorially adjusted hazard ratios for any autoimmune disease were 1.06 (95% CI, 0.94-1.19) for individuals with HDL cholesterol of 1.5-1.99 mmol/L (58-77 mg/dL), 1.18 (95% CI, 1.04-1.35) for individuals with HDL cholesterol of 1.0-1.49 mmol/L (39-58 mg/dL), and 1.84 (95% CI, 1.52-2.22) for individuals with HDL cholesterol <1.0 mmol/L (39 mg/dL) (P for trend <0.001). These results were similar when excluding events within 5 years of baseline, in women and men separately, for events at baseline, irrespective of low-grade inflammation or triglyceride concentrations, for the apolipoprotein A1 part of HDL, and for more restrictive end point definitions. Finally, the Copenhagen City Heart Study provided independent confirmation. CONCLUSIONS:Low HDL cholesterol level is associated with high risk of autoimmune disease in individuals from the general population. Our observational findings cannot determine causality.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Madsen CM,Varbo A,Nordestgaard BGdoi
10.1373/clinchem.2018.299636subject
Has Abstractpub_date
2019-05-01 00:00:00pages
644-652issue
5eissn
0009-9147issn
1530-8561pii
clinchem.2018.299636journal_volume
65pub_type
杂志文章abstract：:Organic anions accumulated in blood serum of patients with chronic renal failure were separated by a novel technique: closed-system capillary zone electrophoresis (CZE) in a pH6 carrier-electrolyte system. Hippuric acid (HA), p-hydroxyhippuric acid, and uric acid were identified by their co-elution with standards prep...
journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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doi：
更新日期：1981-05-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1980-08-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1980-06-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1985-10-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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doi：10.1373/clinchem.2008.103721
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journal_title：Clinical chemistry
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doi：
更新日期：1981-03-01 00:00:00
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doi：10.1373/clinchem.2008.107508
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1979-11-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1978-10-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1979-06-01 00:00:00
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doi：10.1373/clinchem.2005.065789
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journal_title：Clinical chemistry
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doi：
更新日期：1985-04-01 00:00:00
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doi：10.1373/clinchem.2006.068205
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journal_title：Clinical chemistry
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doi：
更新日期：1983-02-01 00:00:00
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doi：
更新日期：1986-10-01 00:00:00
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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doi：
更新日期：1992-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1991-10-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1977-05-01 00:00:00
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更新日期：2009-10-01 00:00:00
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journal_title：Clinical chemistry
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更新日期：2016-11-01 00:00:00
