Abstract:
:Seminal plasma proteins contributed by secretions of accessory glands plays a copious role in fertilization. Their role is overlooked for decades and even now, as Artificial Reproduction Techniques (ART) excludes the plasma components in the procedures. Recent evidences suggest the importance of these proteins starting from imparting fertility status to men, fertilization and till successful implantation of the conceptus in the female uterus. Seminal plasma is rich in diverse proteins, but a major part of the seminal plasma is constituted by very lesser number of proteins. This makes isolation and further research on non abundant protein a tough task. With the advent of much advanced proteomic techniques and bio informatics tools, studying the protein component of seminal plasma has become easy and promising. This review is focused on the role of seminal plasma proteins on various walks of fertilization process and thus, the possible exploitation of seminal plasma proteins for understanding the etiology of male related infertility issues. In addition, a compilation of seminal plasma proteins and their functions has been done.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Kumar A,Sridharn TB,Rao KAdoi
10.2174/0929866526666190208112152subject
Has Abstractpub_date
2019-01-01 00:00:00pages
238-250issue
4eissn
0929-8665issn
1875-5305pii
PPL-EPUB-96507journal_volume
26pub_type
杂志文章,评审abstract::Infections by antibiotic-resistant bacteria are becoming a great risk for human health, leading to an urgent need for new efficient antibacterial therapies. The short, proline-rich antimicrobial peptides from insects gained a lot of interest as a potential antibacterial treatment, having a low toxicity profile and bei...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/09298665113206660110
更新日期:2014-04-01 00:00:00
abstract::Glycation, a non-enzymatic reaction between glucose and protein is the primary cause of diabetic complications. Albumin, the most abundant plasma protein undergoes glycation both in vivo and in vitro. The influence of albumin on glycation of less abundant proteins has not been addressed. For the first time, we show th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785133690
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Nε-acetyl L-α lysine is an unusual acetylated di-amino acid synthesized and accumulated by certain halophiles under osmotic stress. Osmolytes are generally known to protect proteins and other cellular components under various stress conditions. OBJECTIVE:The structural and functional stability imparted by N...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191105130041
更新日期:2020-01-01 00:00:00
abstract::The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in m...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511009011436
更新日期:2010-11-01 00:00:00
abstract::Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better un...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866043406409
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Radical Probe Mass Spectrometry (RP-MS) describes a pioneering methodology in structural biology that enables the study of protein structures, their interactions, and dynamics on fast timescales (down to sub-milliseconds). Hydroxyl radicals (•OH) generated directly from water within aqueous solutions induce ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866526666181128124241
更新日期:2019-01-01 00:00:00
abstract::Identification and elimination of noise peaks in mass spectra from large proteomics data streams simultaneously improves the accuracy of peptide identification and significantly decreases the size of the data. There are a number of peak filtering strategies that can achieve this goal. Here we present a simple algorith...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/09298665113209990065
更新日期:2014-01-01 00:00:00
abstract::The cytotoxicity of hPrP[173-195] prion peptide against a neuroblastoma cell model was found independent of its tendency to aggregate over time. Cytosolic and nuclear inclusions of peptide were highlighted by confocal microscopy, suggesting a role as a transcription factor in activating signal transduction pathways in...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789353655
更新日期:2009-01-01 00:00:00
abstract::Antimicrobial peptides (AMPs) are short, cationic, membrane-interacting proteins that exhibit broad-spectrum antimicrobial activity, and are hence of significant biomedical interest. They exert their activity by selectively binding to and lysing target cell membranes, but the precise molecular details of their mechani...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866511009011313
更新日期:2010-11-01 00:00:00
abstract::There is a growing body of evidence that the formation and accumulation of advanced glycation end products (AGE) have been known to progress under diabetic conditions, thereby being involved in diabetic vascular complications. Further, we, along with others, have recently found AGE could disturb insulin actions in cul...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760423
更新日期:2010-09-01 00:00:00
abstract::Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate. In this paper, we examined the sequences and structures of the MutT/Nudix...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608783330350
更新日期:2008-01-01 00:00:00
abstract::The study of rat proteins is an indispensable task in experimental medicine and drug development. The function of a rat protein is closely related to its subcellular location. Based on the above concept, we construct the benchmark rat proteins dataset and develop a combined approach for predicting the subcellular loca...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611795222768
更新日期:2011-06-01 00:00:00
abstract::In this paper, a 3D map of protein fold space was produced using Dali structure alignment and nonmetric multidimensional scaling. The fold space comprises four radial clusters, which correspond to the four classes of SCOP. The overall structure of the protein fold space is largely determined by three factors: secondar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866054395257
更新日期:2005-07-01 00:00:00
abstract::G-protein betagamma dimers are prime regulators transmitting extracellular signals to wide-ranging cellular effectors including phosphoinositide 3-kinase (PI3K) isoforms beta and gamma. Recombinant Gbetagamma purified from Sf9 cells via metal-affinity and anion exchange chromatography exhibited a wortmannin-insensitiv...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789055340
更新日期:2009-01-01 00:00:00
abstract::An efficient preparation of Periplaneta americana nymphae allergen, Cr PI (54 kDa) is described. It was expressed as a GST-tag fusion protein in Escherichia coli, strain BL21 (DE3). Expression of recombinant Cr PI (rCr PI), denaturation/renaturation of the inclusion bodies and the effects of protein and L-arginine con...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607782110266
更新日期:2007-01-01 00:00:00
abstract::Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642760
更新日期:2011-12-01 00:00:00
abstract::The Saccaromices cerevisiae D-serine dehydratase is a pyridoxal 5'-phosphate dependent enzyme that requires zinc for its function. It catalyses the conversion of D-serine into pyruvate and ammonia with the K(m) and k(cat) values of 0.39 mM and 13.1 s(-1) respectively. In this work, a new methodology for monitoring D-s...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612800494002
更新日期:2012-06-01 00:00:00
abstract::The outcome of protein crystallization attempts is often uncertain due to inherent features of the protein or to the crystallization process that are not fully under control of the experimentalist. The aim of this contribution is to propose user-friendly tools that can increase the success rate of a protein crytalliza...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986612800793127
更新日期:2012-07-01 00:00:00
abstract::Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is known to interact with different biomolecules and was implicated in many novel cellular activities including programmed cell death, nuclear RNA transport unrelated to the commonly known carbohydrate metabolism. We reported here the purification of GAPDH from Chironom...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320090002
更新日期:2013-09-01 00:00:00
abstract::In this article we review the current status of our understanding of membrane mediated interactions from theory and experiment. Phenomenological mean field and molecular models will be discussed and compared to recent experimental results from dynamical neutron scattering and atomic force microscopy. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986611794653941
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Reversibly glycosylated polypeptide (RGP), a kind of hydrosoluble and plasmodesmal-associated protein found in plants, plays a crucial role in the development of pollen. OBJECTIVE:A novel RGP 2 was isolated and identified from rape (Brassica napus L.) bee pollen. METHOD:RGP2 was isolated and purified by io...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666201103161302
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:The heterologous production of antimicrobial peptides in bacterial models can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to increase the expression and solubility of these types of proteins with varying degrees of success. OBJECTIVES:Here, we demonstrate the...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200610133407
更新日期:2020-06-10 00:00:00
abstract::A halophilic nucleoside diphosphate kinase from a moderate halophile, Halomonas sp. 593 (593NDK), was found to be resistant to heat treatment, as indicated by the high level of activity recovery after heating at high temperatures. This is due to reversibility of thermal unfolding, not the high melting temperature, of ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606776819628
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides have been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180530122835
更新日期:2018-01-01 00:00:00
abstract::The small heat shock protein SsHSP14.1 from the hyper-thermophilic archeaon, Sulfolobus solfataricus (S. solfataricus) was able to protect proteins from thermal aggregation and prevent enzymes from heat induced inactivation. According to the 3D (dimensional) structural model of SsHSP14.1 developed by us before, the re...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794578369
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer. OBJECTIVE:This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866524666170815161621
更新日期:2017-11-17 00:00:00
abstract::Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molec...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607780363989
更新日期:2007-01-01 00:00:00
abstract::Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We ca...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200129160136
更新日期:2020-01-01 00:00:00
abstract::We report the physical-chemical characterization of the major alcohol-soluble proteins present in seeds of pearl millet (Pennisetum glaucum) by SDS-PAGE, bidimensional gel electrophoresis, MALDI-TOF/MS and RP-HPLC. We demonstrate the presence of three major prolamins, called A-, B- and C-pennisetin with mass values ar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408724
更新日期:2002-06-01 00:00:00
abstract::The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, s...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180917163142
更新日期:2019-01-01 00:00:00