Predicted microRNAs for mammalian circadian rhythms.


:There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of conserved miRs in mammals. Besides 23 miRs previously associated with circadian rhythms, we found a number of interesting candidate genes, equally predicted by the 3 software programs used, including miR-9, miR-24, miR25, miR-26, miR-27, miR-29, miR-93, miR-211, miR-302, and miR-346. Moreover, several miRs are predicted to be regulated by circadian transcription factors, such as CLOCK/BMAL, DEC2, and REV-ERBalpha. Using real-time PCR we demonstrated that the selected candidate miR-27b showed a daily variation in human leukocytes. This study presents predicted feedback loops for mammalian molecular clock and the first description of an miR with in vivo daily variation in humans.


J Biol Rhythms


Figueredo Dde S,Barbosa MR,Gitaí DL,de Andrade TG




Has Abstract


2013-04-01 00:00:00














  • Phase determination of circadian gene expression in Synechococcus elongatus PCC 7942.

    abstract::The authors analyzed the upstream regulatory region of purF, a gene that is expressed in a minority phase that peaks at dawn (class 2 circadian phasing) in Synechococcus elongatus, to determine whether specific cis elements are responsible for this characteristic expression pattern. Fusions of various promoter-bearing...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Min H,Liu Y,Johnson CH,Golden SS

    更新日期:2004-04-01 00:00:00

  • Translational and transcriptional inhibitors block serotonergic phase advances of the suprachiasmatic nucleus circadian pacemaker in vitro.

    abstract::The mammalian circadian pacemaker is located in the suprachiasmatic nucleus (SCN). Various inputs modulate pacemaker phase, including the serotonergic (5HTergic) input from the midbrain raphe. 5HT phase-advances the SCN pacemaker when applied during mid subjective day. In vitro studies indicate that 5HT advances the m...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jovanovska A,Prosser RA

    更新日期:2002-04-01 00:00:00

  • Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).

    abstract::Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Joye DAM,Rohr KE,Keller D,Inda T,Telega A,Pancholi H,Carmona-Alcocer V,Evans JA

    更新日期:2020-08-01 00:00:00

  • Revealing Oft-cited but Unpublished Papers of Colin Pittendrigh and Coworkers.

    abstract::Among the scientific resources that Colin Pittendrigh passed on to his colleagues after his death in 1996 were two unpublished papers. These manuscripts, developed first in the mid-1960s and continually updated and refined through the late 1970s, centered on the development and experimental exploration of a model of c...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Tackenberg MC,Johnson CH,Page TL,Daan S

    更新日期:2017-08-01 00:00:00

  • The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.

    abstract::The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Richier B,Michard-Vanhée C,Lamouroux A,Papin C,Rouyer F

    更新日期:2008-04-01 00:00:00

  • Circadian Vision in Zebrafish: From Molecule to Cell and from Neural Network to Behavior.

    abstract::Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Li L

    更新日期:2019-10-01 00:00:00

  • The intergeniculate leaflet partially mediates effects of light on circadian rhythms.

    abstract::Photic signals affect circadian activity rhythms by both phasic and tonic mechanisms that modulate pacemaker phase and period. In mammals, the effects of light on circadian activity are mediated by the retina, which communicates with the suprahiasmatic nucleus (SCN) by two different anatomical routes: the retino-hypot...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Pickard GE,Ralph MR,Menaker M

    更新日期:1987-04-01 00:00:00

  • Hibernation: when good clocks go cold.

    abstract::Hibernating animals have been a successful model system for elucidating fundamental properties of many physiological systems. Over the past 50 years, a diverse literature has emerged on the role of the circadian system in control and expression of winter torpor in several orders of birds and mammals. This body of rese...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Ruby NF

    更新日期:2003-08-01 00:00:00

  • Circadian regulation of agonistic behavior in groups of parthenogenetic marbled crayfish, Procambarus sp.

    abstract::Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Farca Luna AJ,Hurtado-Zavala JI,Reischig T,Heinrich R

    更新日期:2009-02-01 00:00:00

  • Daily and photoperiodic melatonin binding changes in the suprachiasmatic nuclei, paraventricular thalamic nuclei, and pars tuberalis of the female Siberian hamster (Phodopus sungorus).

    abstract::Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Recio J,Pévet P,Vivien-Roels B,Míguez JM,Masson-Pévet M

    更新日期:1996-12-01 00:00:00

  • Photoperiodic and food signals control expression pattern of the clock gene, period, in the linden bug, Pyrrhocoris apterus.

    abstract::The temporal expression pattern of the circadian clock gene period was compared between heads of the linden bug, Pyrrhocoris apterus , kept under diapause-promoting short days (SD) and diapause-preventing long days (LD) using a real-time PCR quantification. Diapause or reproduction was programmed by photoperiod during...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Dolezel D,Sauman I,Kost'ál V,Hodkova M

    更新日期:2007-08-01 00:00:00

  • Suprachiasmatic Nucleus and Subparaventricular Zone Lesions Disrupt Circadian Rhythmicity but Not Light-Induced Masking Behavior in Nile Grass Rats.

    abstract::The ventral subparaventricular zone (vSPVZ) receives direct retinal input and influences the daily patterning of activity in rodents, making it a likely candidate for the mediation of acute behavioral responses to light (i.e., masking). We performed chemical lesions aimed at the vSPVZ of diurnal grass rats (Arvicanthi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Gall AJ,Shuboni DD,Yan L,Nunez AA,Smale L

    更新日期:2016-04-01 00:00:00

  • Fbxl11 Is a Novel Negative Element of the Mammalian Circadian Clock.

    abstract::In mammals, molecular circadian rhythms are generated by autoregulatory transcriptional-translational feedback loops with PERIOD/CRYPTOCHROME containing complexes inhibiting the transcription of their own genes. Although the major circadian oscillator components seem to be identified, an increasing number of additiona...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Reischl S,Kramer A

    更新日期:2015-08-01 00:00:00

  • Microarray analysis of natural socially regulated plasticity in circadian rhythms of honey bees.

    abstract::Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rodriguez-Zas SL,Southey BR,Shemesh Y,Rubin EB,Cohen M,Robinson GE,Bloch G

    更新日期:2012-02-01 00:00:00

  • Circadian synchronization and rhythmicity in larval photoperception-defective mutants of Drosophila.

    abstract::A single light episode during the first larval stage can set the phase of adult Drosophila activity rhythms, showing that a light-sensitive circadian clock is functional in larvae and is capable of keeping time throughout development. These behavioral data are supported by the finding that neurons expressing clock pro...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Malpel S,Klarsfeld A,Rouyer F

    更新日期:2004-02-01 00:00:00

  • Temperature sensitivity of the suprachiasmatic nucleus of ground squirrels and rats in vitro.

    abstract::Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ruby NF,Heller HC

    更新日期:1996-06-01 00:00:00

  • Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.

    abstract::The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diu...

    journal_title:Journal of biological rhythms

    pub_type: 信件


    authors: Besing RC,Paul JR,Hablitz LM,Rogers CO,Johnson RL,Young ME,Gamble KL

    更新日期:2015-04-01 00:00:00

  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • Saturation of enzyme kinetics in circadian clock models.

    abstract::From the mathematical study of simple models for circadian rhythm, the authors identified a clear effect of saturation in the enzyme kinetics on the promotion or suppression of a sustained oscillation. In the models, a clock gene (per gene) is transcribed to produce mRNAs, which are translated to produce proteins in t...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kurosawa G,Iwasa Y

    更新日期:2002-12-01 00:00:00

  • Age-related changes in acute and phase-advancing responses to monochromatic light.

    abstract::Reduced sensitivity to short-wavelength (blue) light with age has been shown for light-induced melatonin suppression. The current research aimed to determine if a similar age-related reduction occurs in subjective alertness, mood, and circadian phase-advancing responses. Young (n = 11, 23.0 +/- 2.9 years) and older (n...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Sletten TL,Revell VL,Middleton B,Lederle KA,Skene DJ

    更新日期:2009-02-01 00:00:00

  • Photoperiodic regulation of gonadal growth and pulsatile luteinizing hormone secretion in male ferrets.

    abstract::Testicular growth was monitored in male ferrets subjected to one of the following photoperiodic treatments begun at weaning (8 weeks of age): 8 hr light/day (short days), 18 hr light/day (long days), or short days followed by transition to long days at either 10, 12, or 14 weeks of age. Mean ages to achieve adult test...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Sisk CL

    更新日期:1990-10-01 00:00:00

  • Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.

    abstract::We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, sim...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Leloup JC,Gonze D,Goldbeter A

    更新日期:1999-12-01 00:00:00

  • Importance of photoperiods in determining temporal pattern of annual testicular events in rose-ringed parakeet (Psittacula krameri).

    abstract::Male rose-ringed parakeets (Psittacula krameri) were transferred to a long photoperiod (LP; LD 16:8) or a short photoperiod (SP; LD 8:16) for 45 or 90 days on four dates corresponding to the beginnings of different reproductive phases in an annual testicular cycle, and testicular responsiveness was evaluated by compar...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Maitra SK,Dey M

    更新日期:1992-04-01 00:00:00

  • The fruit fly Drosophila melanogaster favors dim light and times its activity peaks to early dawn and late dusk.

    abstract::The light preferences of fruit flies were tested by 2 different means. First, flies were allowed to choose between different illuminations, and their favorite resting, grooming, and feeding places were determined with an infrared-sensitive camera. Second, the activity levels of the animals during their main daily acti...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rieger D,Fraunholz C,Popp J,Bichler D,Dittmann R,Helfrich-Förster C

    更新日期:2007-10-01 00:00:00

  • Circannual alterations in the circadian rhythm of melatonin secretion.

    abstract::To determine if a circadian rhythm known to be functionally related to the reproductive axis varies on a circannual basis, we monitored the circadian secretion of melatonin at monthly intervals for 2 years in four ovariectomized, estradiol-implanted ewes held in a constant short-day photoperiod. Prior to the study, ew...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Thrun LA,Moenter SM,O'Callaghan D,Woodfill CJ,Karsch FJ

    更新日期:1995-03-01 00:00:00

  • Binocular interactions in the entrainment and phase shifting of locomotor activity rhythms in Syrian hamsters.

    abstract::To assess binocular interactions and possible ocular dominance in entrainment of circadian rhythms, Syrian hamsters maintained in LL were subjected for several weeks to schedules of eye occlusion with opaque contact lenses. In separate groups, the opaque lens was inserted into the left or right eye for 12 h at the sam...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Park JH,Paul MJ,Butler MP,Zucker I

    更新日期:2005-02-01 00:00:00

  • Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.

    abstract::Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral osc...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Slawik H,Stoffel M,Riedl L,Veselý Z,Behr M,Lehmberg J,Pohl C,Meyer B,Wiegand M,Krieg SM

    更新日期:2016-02-01 00:00:00

  • Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks.

    abstract::In Drosophila melanogaster, disruption of night by even short light exposures results in degradation of the clock protein TIMELESS (TIM), leading to shifts in the fly molecular and behavioral rhythms. Several lines of evidence indicate that light entrainment of the brain clock involves the blue-light photoreceptor cry...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ivanchenko M,Stanewsky R,Giebultowicz JM

    更新日期:2001-06-01 00:00:00

  • Genetic differences in human circadian clock genes among worldwide populations.

    abstract::The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ciarleglio CM,Ryckman KK,Servick SV,Hida A,Robbins S,Wells N,Hicks J,Larson SA,Wiedermann JP,Carver K,Hamilton N,Kidd KK,Kidd JR,Smith JR,Friedlaender J,McMahon DG,Williams SM,Summar ML,Johnson CH

    更新日期:2008-08-01 00:00:00

  • Vasoactive intestinal polypeptide entrains circadian rhythms in astrocytes.

    abstract::Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocyt...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Marpegan L,Krall TJ,Herzog ED

    更新日期:2009-04-01 00:00:00