Abstract:
PURPOSE:Upgrade and benchmarking of a research 4D treatment planning system (4DTPS) suitable for realistic patient treatment planning and treatment simulations taking into account specific requirements for scanned ion beam therapy, i.e., modeling of dose heterogeneities due to interplay effects and range changes caused by patient motion and dynamic beam delivery. METHODS:The 4DTPS integrates data interfaces to 4D computed tomography (4DCT), deformable image registration and clinically used motion monitoring devices. The authors implemented a novel data model for 4D image segmentation using Boolean mask volume datasets and developed an algorithm propagating a manually contoured reference contour dataset to all 4DCT phases. They further included detailed treatment simulation and dose reconstruction functionality, based on the irregular patient motion and the temporal structure of the beam delivery. The treatment simulation functionality was validated against experimental data from irradiation of moving radiographic films in air, 3D moving ionization chambers in a water phantom, and moving cells in a biological phantom with a scanned carbon ion beam. The performance of the program was compared to results obtained with predecessor programs. RESULTS:The measured optical density distributions of the radiographic films were reproduced by the simulations to (-2 ± 12)%. Compared to earlier versions of the 4DTPS, the mean agreement improved by 2%, standard deviations were reduced by 7%. The simulated dose to the moving ionization chambers in water showed an agreement with the measured dose of (-1 ± 4)% for the typical beam configuration. The mean deviation of the simulated from the measured biologically effective dose determined via cell survival was (617 ± 538) mGy relative biological effectiveness corresponding to (10 ± 9)%. CONCLUSIONS:The authors developed a research 4DTPS suitable for realistic treatment planning on patient data and capable of simulating dose delivery to a moving patient geometry for scanned ion beams. The accuracy and reliability of treatment simulations improved considerably with respect to earlier versions of the 4DTPS.
journal_name
Med Physjournal_title
Medical physicsauthors
Richter D,Schwarzkopf A,Trautmann J,Krämer M,Durante M,Jäkel O,Bert Cdoi
10.1118/1.4800802subject
Has Abstractpub_date
2013-05-01 00:00:00pages
051722issue
5eissn
0094-2405issn
2473-4209journal_volume
40pub_type
杂志文章相关文献
MEDICAL PHYSICS文献大全abstract::Francis Bacon, who with Rene Decartes laid the intellectual foundations for Western science in the seventeenth century, asserted that the purpose of all knowledge is "action in the production of works for ... the relief of man's estate." We assess briefly several aspects of a few of the current efforts directed to the...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1555493
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to characterize the Hounsfield unit (HU) distributions of mesothelioma and other tissues present in contrast-enhanced thoracic CT scans, to compare the HU distributions of mesothelioma, muscle, and liver by scanner and reconstruction filter/kernel combination, and to assess interpa...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3537610
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:Planning for the delivery of intensity-modulated radiation therapy (IMRT) to a moving target, referred to as four-dimensional (4D) IMRT planning, is a crucial step for achieving the treatment objectives for sites that move during treatment delivery. The authors proposed a simplistic method that accounts for bot...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3319498
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:As the predominant driver of respiratory motion, the diaphragm represents a key surrogate for motion management during the irradiation of thoracic cancers. Existing approaches to diaphragm tracking often produce phase-based estimates, suffer from lateral side failures or are not executable in real-time. In this...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13738
更新日期:2019-10-01 00:00:00
abstract::The BrachySeed model LS-1 is one of the latest in a series of new brachytherapy 125I seeds that have recently become available commercially for interstitial implants. The dosimetric properties of the seed were investigated analytically, experimentally, and by Monte Carlo simulation. Following the AAPM Task Group 43 fo...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1445411
更新日期:2002-02-01 00:00:00
abstract::We believe that, for the purpose of evaluation and optimization of treatment plans, quasirandom sampling is superior to grid sampling and should be the method of choice. We believe it to be on average more efficient than grid sampling (i.e., more accurate for any given number of dose estimates) and, even more importan...
journal_title:Medical physics
pub_type: 评论,信件
doi:10.1118/1.597103
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:To compare reconstructed volumes calculated via planimetry and frustum algorithms in the context of stepped transrectal ultrasound (US) imaging, and to estimate the reconstruction error for prostate volumes. METHODS:Prostate contours for 40 permanent implant patients were delineated on magnetic resonance (MR) ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4789920
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:We studied the sensitivity of a novel transmission fiber scintillator array designed and built for in line treatment verification. The purpose of this project is to assess the capability of the fiber detector array technology to detect treatment errors in real time without false positives to enhance patient saf...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735217
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:A nanodosimeter is a type of detector which measures single ionizations in a small gaseous volume in order to obtain ionization cluster size probability distributions for characterization of radiation types. Working nanodosimeter detectors are usually bulky machines which require a lot of space. In this work, t...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14738
更新日期:2021-01-28 00:00:00
abstract::Dose calculations for treatment planning of photon beam radiotherapy require a model of the beam to drive the dose calculation models. The beam shaping process involves scattering and filtering that yield radiation components which vary with collimator settings. The necessity to model these components has motivated th...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1898485
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:To automatically detect and isolate areas of low and high stiffness temporal stability in shear wave elastography (SWE) image sequences and define their impact in chronic liver disease (CLD) diagnosis improvement by means of clinical examination study and deep learning algorithm employing convolutional neural n...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13521
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To measure the calibration curves of EBT3 dosimetry films in photon and proton beams and to quantify the related uncertainties from one beam type to another. METHODS:EBT3 Gafchromic films have similar properties than EBT2 with a symmetric construction and a matte polyester substrate to prevent Newton's ring ar...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735176
更新日期:2012-06-01 00:00:00
abstract::The photon spectra in vacuum around four types of 192Ir HDR brachytherapy sources are calculated using the Monte Carlo code EGS4 and the most recent spectral information on 192Ir decay. The air-kerma strengths per unit activity are calculated based on the photon fluence around a bare 192Ir source and around each of fo...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598763
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:In dose guided radiation therapy, incident fluence is one of the important parameters for both influence verification and dose reconstruction. The objective of this investigation was to develop a method to obtain the incident fluence for dose reconstruction in dose guided radiation therapy (DGRT). METHODS:An i...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735593
更新日期:2012-06-01 00:00:00
abstract::Inherent in the line-spread function approach in modulation transfer function (MTF) determinations is the use of a microdensitometer to scan the density pattern resulting from the line exposure. In such a procedure, loss of fidelity in the distribution being scanned is expected. This loss is due in part to the use of ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.594187
更新日期:1975-09-01 00:00:00
abstract::The ability of Leksell GammaPlan to perform stereotactic space localizations with image sets where there is misalignment of the patient's head (stereotactic frame and fiducial apparatus) relative to the computed tomography (CT) scanner coordinate system was studied. Misalignment is sometimes necessary for patient comf...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2179751
更新日期:2006-04-01 00:00:00
abstract::In the case of non-small cell lung cancer, doses typically prescribed (60-66 Gy) are not sufficient to ensure a satisfactory tumor control probability. Dose escalation needs to be realized, but dose to organs at risk (OARs) must be kept under widely accepted clinical thresholds. Also, lung functionality is not homogen...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2965976
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:To determine the accuracy and reproducibility of the automatic- setup procedure of a 3D water scanner (3D SCANNER, Sun Nuclear Corp). The procedure automatically aligns the scanner's coordinate system to the Linac coordinate system. A unique off-center detector holder extends the scan range to 630 mm, eliminati...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4734668
更新日期:2012-06-01 00:00:00
abstract::Administration of x-ray contrast agents during heart catheterization examination increases the absorbed radiation dose in tissue. To estimate the dose absorbed by the blood of children undergoing diagnostic heart catheterization and angiocardiography, a number of measurements and calculations were conducted. First, en...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.594613
更新日期:1979-11-01 00:00:00
abstract:PURPOSE:An optimized air ventilation system design for a treatment room in Heavy-ion Medical Facility is an important issue in the aspects of nuclear safety because the activated air produced in a treatment room can directly affect the medical staff and the general public in the radiation-free area. METHODS:Optimized ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12914
更新日期:2018-06-01 00:00:00
abstract::Limiting spatial resolution is a key metric of the quality of magnetic resonance (MR) images, which can provide an indication of the smallest region that can effectively be imaged. In this paper a novel methodology for measuring the limiting spatial resolution of MR images is mathematically analyzed and successfully i...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3097633
更新日期:2009-05-01 00:00:00
abstract::Digital tomosynthesis is an imaging technique to produce a tomographic image from a series of angular digital images in a manner similar to conventional focal plane tomography. Unlike film focal plane tomography, the acquisition of the data in a C-arm geometry causes the image receptor to be positioned at various angl...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2219090
更新日期:2006-08-01 00:00:00
abstract:PURPOSE:The aim of in vivo skin dosimetry was to measure the absorbed dose to the skin during radiotherapy, when treatment planning calculations cannot be relied on. It is of particularly importance in hypo-fractionated stereotactic modalities, where excessive dose can lead to severe skin toxicity. Currently, commercia...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12469
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Using a new linear accelerator with high dose rate (800 MU/min), fast MLC motions (5.0 cm/s), fast gantry rotation (15 s/rotation), and 1 cm wide MLCs, we aimed to quantify the effects of complexity, arc number, and fractionation on interplay for breast and lung treatments under target motion. METHODS:To study...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12899
更新日期:2018-06-01 00:00:00
abstract::Both the design considerations and the dosimetric properties of the Siemens Model 5800 linear accelerator are discussed. This unit is of such an energy (3.3 MV) as to imitate Cobalt-60 teletherapy depth doses. A linear relation of dmax to depth dose at low energies was found for various wave guides and targets. The en...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596487
更新日期:1990-05-01 00:00:00
abstract::The dose distribution for an ovoid with a new tungsten shielding design was determined using Monte Carlo simulation. Standard Cesium-137 tube sources, tungsten shielding, and aluminum ovoid applicator were each modeled as a collection of solid objects. Dose was calculated in planes above, below, in front of, and on th...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598459
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:To improve the efficiency of atlas-based segmentation without compromising accuracy, and to demonstrate the validity of the proposed method on MRI-based prostate segmentation application. METHODS:Accurate and efficient automatic structure segmentation is an important task in medical image processing. Atlas-bas...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4867855
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:High-spatial-resolution x-ray imaging in the few-ten-keV range is becoming increasingly important in several applications, such as small-animal imaging and phase-contrast imaging. The detector properties critically influence the quality of such imaging. Here the authors present a quantitative comparison of scin...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4948687
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:X-ray microbeam radiation therapy is a preclinical concept for tumor treatment promising tissue sparing and enhanced tumor control. With its spatially separated, periodic micrometer-sized pattern, this method requires a high dose rate and a collimated beam typically available at large synchrotron radiation faci...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14433
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To examine schemes to grade the severity of metal susceptibility artifacts on image quality using cardiac MRI pulse sequences. METHODS:A post-thoracotomy patient was simulated with a stainless steel sternal wire (Syneture,MA; size=6, diameter=48mm), placed securely on an ACR MRI phantom. Phantom was scanned on...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4734785
更新日期:2012-06-01 00:00:00