Abstract:
:Childhood brain development begins before birth, and obstetric management, tests, and technologies designed to diagnose and treat fetal conditions can have an impact on development. Preconception counseling for maternal diabetes and hypertension affect the risk of fetal congenital anomalies and growth restriction. Patients with risk factors for pre-existing maternal diabetes are offered early diabetic screening because earlier diagnosis and treatment can decrease the risk of fetal and neonatal complications. Screening for chromosomal abnormalities in the first or second trimester is offered to all females regardless of age. Cell-free fetal DNA screening can be used to test for fetal genetic abnormalities as early as 9 weeks of gestation with results available in 10 days. Ultrasound performed around 20 weeks' gestation can identify the 3% of fetuses that have a major congenital malformation. Fetal magnetic resonance imaging can be used to better assess fetal central nervous system abnormalities when neurosonography is inconclusive. Doppler ultrasound can be used to assess blood flow in the umbilical artery and fetal middle cerebral artery to aid in the management of the growth-restricted fetus. In summary, diagnosis and treatment of maternal and fetal conditions from the preconception period throughout pregnancy are important for optimizing fetal health and provide the best opportunity for optimal child development. WHAT THIS PAPER ADDS: Cell-free fetal DNA screening can identify fetal genetic abnormalities as early as 9 weeks' gestation. Ultrasound performed around 20 weeks' gestation can detect major fetal congenital malformations. Fetal magnetic resonance imaging can aid neurosonography in the assessment of fetal central nervous system abnormalities. Doppler ultrasound to assess fetal blood flow is used to successfully manage the growth-restricted fetus. :MANEJO OBSTÉTRICO, PRUEBAS Y TECNOLOGÍAS QUE IMPACTAN EL DESARROLLO INFANTIL: El desarrollo infantil comienza antes del nacimiento, y el manejo obstétrico, las pruebas y las tecnologías diseñadas para diagnosticar y tratar las afecciones fetales pueden tener un impacto en el desarrollo. El asesoramiento previo a la concepción para la diabetes materna y la hipertensión puede modificar el riesgo de anomalías congénitas fetales y la restricción del crecimiento. A los pacientes con factores de riesgo para la diabetes materna preexistente se les ofrece la detección temprana de la diabetes debido a que un diagnóstico y tratamiento tempranos pueden disminuir el riesgo de complicaciones fetales y neonatales. El examen de detección de anomalías cromosómicas en el primer o segundo trimestre se ofrece a todas las mujeres, independientemente de su edad. La prueba de detección de ADN fetal sin células se puede usar para detectar anomalías genéticas fetales tan pronto como a las 9 semanas de gestación, con resultados disponibles en 10 días. La ecografía realizada alrededor de las 20 semanas de gestación puede identificar el 3% de los fetos que tienen una malformación congénita importante. La resonancia magnética fetal puede usarse para evaluar mejor las anomalías del sistema nervioso central fetal cuando la neurosonografía no es concluyente. La ecografía Doppler se puede usar para evaluar el flujo sanguíneo en la arteria umbilical y la arteria cerebral media fetal para ayudar en el manejo del feto con restricción de crecimiento. En resumen, el diagnóstico y el tratamiento de las afecciones maternas y fetales desde el período previo a la concepción, y durante todo el embarazo, son importantes para optimizar la salud fetal y ofrecen la mejor oportunidad para el desarrollo óptimo del niño. :MANEJO OBSTÉTRICO, TESTES E TECNOLOGIAS QUE IMPACTAM O DESENVOLVIMENTO INFANTIL.: O desenvolvimento infantil começa antes do nascimento, e o manejo obstétrico, testes e tecnologias projetados para diagnosticar e tratar condições fetais podem ter impacto no desenvolvimento. Aconselhamento pré-concepcional para diabetes materna e hipertensão afetam o risco de anomalias congênitas fetais e restrição do crescimento. Pacientes com fatores de risco para diabetes materna pré-existente recebem oferta de monitoramento precoce para diabetes porque o diagnóstico e tratamento precoces podem diminuir o risco de complicações fetais e neonatais. O monitoramento para anormalidades cromossômicas no primeiro ou segundo trimestre é oferecido para todas as mulheres independente da idade. A avaliação sem células do DNA fetal pode ser usada para testar anormalidades genéticas tão cedo como 9 semanas de gestação, com resultados disponíveis em 10 dias. O ultra-som realizado por volta de 20 semanas de gestação pode identificar os 3% de fetos que têm uma malformação congênita importante. Imagem por ressonância magnética fetal pode ser usada mara melhor avaliar anormalidades do sistema nervoso central quando a neurosonografia é inconcusiva. Ultra-som Doppler pode ser usado para avaliar o fluxo sanguíneo na artéria umbilical e artéria cerebral média fetal para ajudar no manejo de fetos com restrição de crescimento. Em resumo, o diagnóstico e tratamento de condições maternas e fetais no período pré-concepcional e durante toda a gestação são importantes para otimizar a saúde do feto e proporcionar a melhor oportunidade para o desenvolvimento infantil ótimo.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Novak CM,Graham EMdoi
10.1111/dmcn.14160subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1002-1007issue
9eissn
0012-1622issn
1469-8749journal_volume
61pub_type
杂志文章,评审abstract:AIM:To explore associations between clinical variables and decline in motor capacity in adolescents with cerebral palsy (CP). METHOD:Participants included 76 males and 59 females, whose mean age at the beginning of the study was 14 years 6 months (SD 2.4, range 11.6-17.9); 51 at Gross Motor Function Classification Sys...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2010.03632.x
更新日期:2010-07-01 00:00:00
abstract::Ataxia-telangiectasia is a rare, neurodegenerative, and multisystem disease, characterized by cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, progressive respiratory failure, and an increased risk of malignancies. It demands specialized care tailored to the individual patient's needs. Besides the c...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,实务指引,评审
doi:10.1111/dmcn.13424
更新日期:2017-07-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.14182
更新日期:2019-10-01 00:00:00
abstract::Minor neurological dysfunctions (MND) have frequently been reported as an outcome of preterm birth. Behavioural and learning difficulties are a known feature, but coordination problems are especially described in preterm infants at later ages. All preterm infants in our study were born with a gestational age of <32 we...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201002298
更新日期:2002-06-01 00:00:00
abstract::Cutaneomuscular reflexes were recorded from the first dorsal interosseous muscles of 21 children with spastic cerebral palsy. The reflex responses in children with cerebral palsy were consistent with dysfunction of the pyramidal system, but differed from those seen in adults with central nervous lesions. This provides...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1991.tb14919.x
更新日期:1991-06-01 00:00:00
abstract:AIM:To investigate longitudinal changes of habitual physical activity (HPA) and sedentary time in children with cerebral palsy (CP) aged 1 year 6 months to 5 years across all functional abilities. METHOD:At study entry, 95 children (62 males, 33 females) were classified using the Gross Motor Function Classification Sy...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.13439
更新日期:2017-08-01 00:00:00
abstract::The use of intramuscular alcohol in treating cerebral-palsied children has led to reduced spasticity for varying periods of time, although the periods diminish with each subsequent injection. During the period of reduced spasticity there is an opportunity for therapists and orthopaedic surgeons to determine whether co...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1980.tb04354.x
更新日期:1980-08-01 00:00:00
abstract::This review aimed to synthesize current research evidence to determine the effectiveness of conservative interventions for infants with positional plagiocephaly. A systematic review was conducted, where papers were sourced from 13 library and internet databases. Research was included if published in English between 19...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1017/s0012162205001118
更新日期:2005-08-01 00:00:00
abstract::This research examined family stress and sibling reactions in families of children with 5p- (cri du chat) syndrome aged 1 to 18 years who were living at home. In Study 1, 99 parents reported on themselves and their child with 5p-, as well as on family demographics, social supports, and stress. The best predictor of fa...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1997.tb07378.x
更新日期:1997-11-01 00:00:00
abstract::A 13-year-old boy with Hodgkin's disease developed acute polyneuropathy and autoimmune hemolytic anemia. Sural nerve biopsy and postmortem examination demonstrated no metastatic involvement and a lack of cellular inflammatory infiltration in the nervous system. There was significant axonal degeneration in peripheral n...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1980.tb04329.x
更新日期:1980-04-01 00:00:00
abstract::This study evaluated the effectiveness of soft splints made from polyurethane foam in reducing severe knee-flexion contractures of patients with cerebral palsy. The splints were applied nightly over a period of 10 months. Knee-flexion contractures were reduced by an average of 24 degrees in all patients. Younger patie...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1988.tb04777.x
更新日期:1988-08-01 00:00:00
abstract::AIM This prospective multicenter study assessed performance and changes over time, with and without surgical intervention, in the modified Timed Up and Go (mTUG) and One-Minute Walk tests (1MWT) in children with bilateral cerebral palsy (CP). Minimum clinically important differences (MCIDs) were established for these ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/dmcn.12325
更新日期:2014-05-01 00:00:00
abstract::Self-injury is a defining feature of lesch-nyhan disease (LND) but does not occur in the less severely affected Lesch-Nyhan variants (LNV). The aim of this study was to quantify behavioral and emotional abnormalities in LND and LNV. Thirty-nine informants rated 22 patients with LND (21 males, 1 female), 11 males with ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/S0012162205001374
更新日期:2005-10-01 00:00:00
abstract::A prospective 14-year outcome study of two children meeting DSM-IV criteria for childhood disintegrative disorder is presented. Their ages at first evaluation were 4 years 7 months and 6 years 3 months. Both are now adults and continue to have a severe pervasive developmental disorder, mental retardation, seizure diso...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1998.tb12331.x
更新日期:1998-10-01 00:00:00
abstract::Progressive calcification of the brain and the spinal cord at early infantile onset was observed in two siblings. They showed growth failure, psychomotor deterioration, deafness, vestibular dysfunction, microcytic hypochromic anemia, abnormal ratios of lymphocyte subpopulations, and slightly decreased bicarbonate on b...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1997.tb07410.x
更新日期:1997-03-01 00:00:00
abstract::Thirty-five schoolchildren who share a common history of early undernutrition and who were reared after recovery by adoptive families (16), in institutional care (eight) or by their biological families (11) were assessed for physical and intellectual outcome. The adopted children had mean normal weight and height for ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1992.tb11492.x
更新日期:1992-07-01 00:00:00
abstract::The clinical course and outcome of eight term infants with intracranial hemorrhage are reported. Before computerized tomography became available, term infants with intracranial hemorrhage were usually diagnosed only at autopsy and the hemorrhage was associated with a trauamtic birth or severe asphyxia. In contrast, si...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1979.tb01694.x
更新日期:1979-12-01 00:00:00
abstract::Homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency may present with variable neurological manifestations. Radiological features include white matter changes (leukoencephalopathy). Clinical, biochemical, and radiological response to treatment may again be variable. Here we present a 12-year follo...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162205000095
更新日期:2005-01-01 00:00:00
abstract::The diagnosis of Rett syndrome is currently determined by a series of criteria, the first three of which are concerned with the initial period of normality. Using the Australian Rett Syndrome Database, information about this early period was obtained by questionnaires to paediatricians and families. For girls born bet...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract:AIM:To assess the risk of developing cerebral palsy in relation to pregnancy disorders and preterm birth. METHOD:By linking the Medical Birth Registry of Norway to other national registries, we identified all live births in Norway from 1967 through to 2001. Risks of cerebral palsy (CP) after preterm delivery and pregn...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.12430
更新日期:2014-08-01 00:00:00
abstract::Long-term continuous intrathecal baclofen (CITB) infusion is a treatment option used to manage otherwise intractable spasticity and is delivered via an implantable pump. The purpose of this single-center multidisciplinary review was to report on the long-term safety and efficacy of CITB in the treatment of 21 children...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201002729
更新日期:2002-10-01 00:00:00
abstract:AIM:To evaluate studies on the psychometric properties of measurement tools used to quantify functional mobility in children with hereditary spastic paraplegia (HSP) and other childhood neurological conditions. METHOD:Two independent reviewers identified measures previously used by clinicians to quantify functional mo...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1469-8749.2012.04284.x
更新日期:2012-07-01 00:00:00
abstract::Victimization by peers affects 10 to 20% of school children under the age of 12 years. Physical, verbal, and psychological victimization (being pushed, hit, called names, teased, being the target of rumours, theft, extortion) is associated with short- and long-term adjustment problems, such as peer rejection, social w...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162204000854
更新日期:2004-08-01 00:00:00
abstract:AIM:To collect preliminary functional data on ataxia telangiectasia and create a disease specific scale: the Ataxia Telangiectasia Functional Scale (ATFS). METHOD:Retrospective information on patients with ataxia telangiectasia referred to the Assistive Technology Unit was included. Functional mobility scales (the Gro...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.14334
更新日期:2020-02-01 00:00:00
abstract:AIM:To evaluate presence and severity of social impairments in alternating hemiplegia of childhood (AHC) and determine factors that are associated with social impairments. METHOD:This was a retrospective analysis of 34 consecutive patients with AHC (19 females, 15 males; mean age: 9y 7mo, SD 8y 2mo, range 2y 7mo-40y),...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.14473
更新日期:2020-07-01 00:00:00
abstract::Nine children (five males, four females; age range 6 years 1 month to 11 years 1 month) affected by benign epilepsy of childhood with centrotemporal or Rolandic spikes (BECRS) with EEG evidence of marked activation of interictal epileptic discharges (IEDs) during sleep, and nine unaffected control children matched for...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201000755
更新日期:2001-06-01 00:00:00
abstract::Rud syndrome is a rare disorder of childhood characterized by ichthyosis, mental retardation, epilepsy and hypogonadism. The authors report a family with this autosomal recessive disorder, review the clinical and dermatopathological findings, and contrast Rud syndrome with the other major neuro-ichthyosiform dermatose...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1985.tb04545.x
更新日期:1985-06-01 00:00:00
abstract:AIM:The aim of this systematic review was to investigate the effects of functional gait training on walking ability in children and young adults with cerebral palsy (CP). METHOD:The review was conducted using standardized methodology, searching four electronic databases (PubMed, Embase, CINAHL, Web of Science) for rel...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/dmcn.13708
更新日期:2018-09-01 00:00:00
abstract:AIM:This population-based study aimed to estimate the impact of neonatal seizures on subsequent neurological outcomes, regardless of underlying etiology. METHOD:We performed a retrospective cohort study (1st January 2009-31st December 2014), using a USA nationwide claims database. Newborn infants enrolled in 2009 were...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.14174
更新日期:2019-06-01 00:00:00
abstract:AIM:To examine the neurobiology of long-term neuropsychological deficits after neonatal extracorporeal membrane oxygenation (ECMO). METHOD:This cross-sectional study assessed white matter integrity and hippocampal volume of ECMO survivors (8-15y) and healthy children (8-17y) using diffusion tensor imaging (DTI) and st...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.13309
更新日期:2017-03-01 00:00:00