An adaptive response to alkylating agents in Aspergillus nidulans.

Abstract:

:A simple method is described for demonstrating adaptation to alkylation damage in Aspergillus nidulans. One wild type, two MNNG-sensitive, and one MNNG-resistant strain all showed improvement in colony growth when challenged with MNNG following appropriate inducing pretreatments. Other alkylating agents (MMS, EMS) could also adapt mycelium to later MNNG challenge, while 4NQO and UV could not. The inducible effect was not transmissible through conidia. A standard reversion assay based upon methG proved impractical for studying mutation frequencies during alkylation treatments owing to variations in MNNG resistance amongst revertants.

journal_name

Curr Genet

journal_title

Current genetics

authors

Hooley P,Shawcross SG,Strike P

doi

10.1007/BF00521267

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

445-9

issue

5

eissn

0172-8083

issn

1432-0983

journal_volume

14

pub_type

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