Abstract:
:The efficacy of gentamicin given intravenously once daily in a single, individually-adapted dose in form of a short infusion was confirmed in 30 patients with febrile urogenitary infections, taking nephrotoxicity into consideration. Antibiotic therapy was given for 7 days in each case, the individual dose of gentamicin being chosen from the dosage schedule according to Mawer. Depending on weight, age and renal function we used daily doses ranging from 160 to 480 mg (i.e. 2 to 5 mg/kg) of gentamicin. All patients were cured and all gram-negative bacteria were eliminated; no nephrotoxicity was recorded, as verified by constantly low serum levels of gentamicin (below the recommended peak level of 2 micrograms/ml) and non-significant changes in serum creatinine level. According to our results and to the findings of other investigations cited in the literature we conclude that in gentamicin therapy the once-daily individually--adapted intravenous dosage regimen is superior to to continuous administration by means of repeated daily doses with regard to efficacy and absence of nephrotoxicity.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Huber G,Riedl CR,Zinnbauer Bsubject
Has Abstractpub_date
1990-05-25 00:00:00pages
329-33issue
11eissn
0043-5325issn
1613-7671journal_volume
102pub_type
杂志文章abstract::According the literature atrio-ventricular blockade (AVB) is the most frequent and well-known symptom of Lyme carditis. Typical signs of complete AVB include fatigue, lethargy and syncope- Morgagni-Adams-Stokes syndrome (MAS). The authors present their results and experience with 5 patients selected from a long-term s...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1999-12-10 00:00:00
abstract::Urea and cyanate, spontaneously transformed from urea, are increased with decreased renal function becoming potential toxins. Isocyanic acid, the active form of cyanate, carbamoylates proteins, amino acids and other molecules, changing molecular structure and function in vivo. Carbamoylation can occur at multiple site...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1998-08-21 00:00:00
abstract::The application of hybridoma technology to the preparation of monoclonal antibodies has had a strong stimulatory effect on many areas of virological research. This development has expanded our knowledge with respect to antigenic variation among viruses and detailed analysis of complex antigenic structures of virus pro...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1985-03-01 00:00:00
abstract::Hereditary fructose intolerance (HFI) was diagnosed in a 61 year-old male patient on account of liver dysfunction followed by prolonged shock immediately after the administration of a fructose and lactose infusion postoperatively. The diagnosis of HFI was based on an increased value of fructose, hypoglycaemia, lactic ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-03-31 00:00:00
abstract::Radiotherapy is extensively used in the treatment of Hodgkin's disease. One of its untoward effects is on heart. Coronary arteries and heart valves can be adversely affected from radiotherapy. However, co-existence of both conditions is very rare. In this report, we present a patient with Hodgkin's disease who develop...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-014-0505-9
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The motor performance of children and adolescents declines. We questioned whether there are differences of motor performance and weight status between preschool children with and without migration background. METHODS:A total of 1,063 4- to 5-year-old children were recruited from 41 kindergartens in Tyrol, A...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-013-0474-4
更新日期:2014-02-01 00:00:00
abstract::We evaluated the overnight urinary excretion of 6-sulfatoxymelatonin in a group of 347 women (range: 18-69 years). 26 women (range 20-29 years) with normogonadotrophic, hypoestrogenemic amenorrhoea (WHO II) were selected and compared with a group of 26 women menstruating normally (range: 19-30 years) with respect to u...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1997-10-03 00:00:00
abstract:PURPOSE:Patients with localized prostate cancer are treated with 3D radiotherapy using a rectal balloon catheter for internal immobilization of the prostate, thereby reducing the radiation dose to the dorsal rectal wall. The purpose of the study was to investigate clinical feasibility and the influence of acute rectal ...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00508-006-0588-z
更新日期:2006-05-01 00:00:00
abstract::Supplement with keto acids/amino acids (KA) and erythropoietin can independently improve the metabolic sequels of chronic renal insufficiency. Our study was designed to establish whether a supplementation with keto acids/amino acids (KA) exerts additional beneficial metabolic effects in patients with chronic renal ins...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2001-09-17 00:00:00
abstract::This review gives a historical overview about the development of today's understanding of benign thyroid diseases and the possibilities of their treatment.Little was known about the thyroid gland until the nineteenth century: the state of knowledge was (1) that something in food, especially in seaweed, avoided the dev...
journal_title:Wiener klinische Wochenschrift
pub_type: 历史文章,杂志文章
doi:10.1007/s00508-014-0515-7
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The aim of this retrospective single center cohort study was to assess the occurrence of bradycardia during implantable loop recorder (ILR) monitoring in patients with unexplained syncope and negative conventional testing and to identify clinical predictors of bradycardia and pacemaker implantation. METHODS...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-017-1197-8
更新日期:2017-07-01 00:00:00
abstract::The prevalence and significance of cardiac amyloidosis have been considerably underestimated in the past; however, the number of patients diagnosed with cardiac amyloidosis has increased significantly recently due to growing awareness of the disease, improved diagnostic capabilities and demographic trends. Specific th...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-020-01781-z
更新日期:2020-12-01 00:00:00
abstract::Zinc uptake and/or possible exchange by isolated lymphocytes from normal persons and from patients with chronic lymphatic leukemia and chronic myeloid leukemia were studied in an in vitro model. The uptake of zinc per 10(9) lymphocytes of normal persons was 60 +/- 10 nanomoles and 120 +/- 15 nanomoles during incubatio...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1977-05-27 00:00:00
abstract::187 patients were checked up over 4 years by the secretin-ceruletide test. Independently of the test results they were assigned to various disease groups on the basis of clinical assessment. 131 subjects were divided in a pilot investigation into: subjects with a healthy pancreas (n = 55); subjects with chronic pancre...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::An increased incidence of infections, especially during periods of poor metabolic control is well known in patients with insulin-dependent diabetes mellitus. Therefore, we studied polymorphonuclear chemotaxis and its dependence on the degree of diabetic control in 49 patients with insulin-dependent diabetes mellitus i...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-10-27 00:00:00
abstract::Insulin resistance is a common characteristic of women with polycystic ovary syndrome (PCOS) who are known to differ in their in-vitro fertilization outcomes compared to non-PCOS patients. As insulin resistance can be found in a considerable proportion of normal individuals, we assessed its contribution to ovarian res...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2002-06-28 00:00:00
abstract::The immunological reactivity of 19 operated cases of breast cancer (14 T1 2, 5T3) was investigated before and at 3-weekly intervals up to 12 weeks after radiotherapy by means of a large panel of techniques. The results were compared with two groups of identically-investigated patients, one consisting of 11 cases of ce...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1976-08-13 00:00:00
abstract::The therapeutic potential of sodium dichloroacetate (DCA) formerly called vitamin B 15, has already been under investigation for the past few years. The predominant property of DCA underlying its therapeutic action is activation of pyruvate dehydrogenase. The potential therapeutic use of DCA in the treatment of lactic...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1990-02-02 00:00:00
abstract::This report on 24 cases of sex offences on girls under 14 years of age examined and treated at the 2nd University Department of Obstetrics and Gynaecology in Vienna covers the period between 1984 and 1987. Experience gained in these cases led to the development of a specially devised mode of management which ranges fr...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1988-04-29 00:00:00
abstract:BACKGROUND:Addressing the growing burden of mental diseases is a public health priority. Nevertheless, many countries lack reliable estimates of the proportion of the population affected, which are crucial for health and social policy planning. This study aimed to collect existing evidence on the prevalence of mental d...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-018-1316-1
更新日期:2018-02-01 00:00:00
abstract::Although glucocorticoids have been universally implemented to stimulate fetal lung maturity, their effectiveness and side effects are still widely contested. In search of alternative drugs a double-blind study was conducted between June 1981 and June 1984 comparing betamethasone, a conventional corticoid, and ambroxol...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-08-03 00:00:00
abstract::A clinical-laboratory survey of 1952 patients with acute feverish diseases developing after tick bite was carried out in the Pre-Ural region of Russia, which is endemic for tick-borne encephalitis and ixodid tick-borne borreliosis, in 1999-2001. Enzyme-linked immunosorbent assay and indirect immunofluorescence assay w...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2002-07-31 00:00:00
abstract::Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal myeloid disorders characterized by morphologic dysplasia in one or more cell lineages. Dysplasia in MDS is associated with insufficient production of blood cells and consecutive cytopenia(s). The natural course and prognosis of MDS vary among pat...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/BF03041035
更新日期:2003-08-14 00:00:00
abstract::Idiopathic bronchiolitis obliterans organizing pneumonia (idiopathic BOOP) and idiopathic CD4+ T lymphocytopenia are syndromes of unknown origins which have been characterized in recent years. An important feature of both syndromes is the good prognosis. The clinical and histological features of idiopathic BOOP are un...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::As a result of progress in the modern treatment of burns, systemic candidosis (CA), in the sense of "surviving mycoses", has become increasingly frequent. The site of entry is not usually the wound, but the intestinal tract, which becomes overgrown by the yeasts as a consequence of the requisite therapy with antibacte...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1976-11-12 00:00:00
abstract::A well-defined, characteristic disease has been observed in babies at the Department of Dermatology, Innsbruck University, over the past 7 years. On account of the localisation and probable pathogenesis of the condition the term "Windelsoor" (napkin thrush) has been coined by us for it. The clinical picture, the mycol...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1975-03-07 00:00:00
abstract::A double-blind trial was carried out in 80 patients, whereby jopamidol, the first stabilized non-ionic contrast medium, and meglumine iodamine were compared in 40 patients undergoing cranial computed tomography and 40 patients subjected to cerebral angiography. There was no difference in the quality of the radiographs...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章
doi:
更新日期:1983-01-21 00:00:00
abstract::The tissue polypeptide antigen test (TPA) was carried out in 25 patients with tumours of the maxillofacial region before and after surgery. Further control determination were performed for up to 14 months. A decrease in TPA values was found in only 4 patients after surgery, but a steep rise in TPA values was found wit...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1984-10-12 00:00:00
abstract::The Poison Control Centre in Vienna registered 4018 inquires regarding possible poisoning in children over a two-year period. The peak incidence occurred in the age group between 2 and 3 years and poisoning chiefly took place in the mornings and in the afternoons, the most frequently ingested substances being househol...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-01-06 00:00:00
abstract::The pharmacodynamic interaction between lumefantrine and its monodesbutyl analogue (DBB) has been investigated in 35 fresh isolates of Plasmodium falciparum. Both compounds showed highly significant activity correlation. The geometric mean values for complete inhibition of schizont maturation (GMCOC) were 536,8 nM for...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-008-1080-8
更新日期:2008-01-01 00:00:00