Abstract:
OBJECTIVES:This study investigated the determinants and outcomes of acute insertion of a second transcatheter prosthetic valve (TV) within the first (TV-in-TV) or transcatheter valve embolization (TVE) after transcatheter aortic valve replacement (TAVR). BACKGROUND:TAVR failure can occur with both TV-in-TV and TVE as a consequence of TAVR malpositioning. Only case reports and limited series pertaining to these complications have been reported to date. METHODS:Patients undergoing TAVR in the PARTNER (Placement of AoRTic TraNscathetER Valve Trial Edwards SAPIEN Transcatheter Heart Valve) randomized trial (cohorts A and B) and accompanying registries were studied. Data were dichotomized for those with and without TV-in-TV or TVE, respectively. RESULTS:From a total of 2,554 consecutive patients, 63 (2.47%) underwent TV-in-TV and 26 (1.01%) TVE. The indication for TV-in-TV was significant aortic regurgitation in most patients, often due not only to malpositioning but also to leaflet dysfunction. Despite similar aortic valve function on follow-up echoes, TV-in-TV was an independent predictor of 1-year cardiovascular mortality (hazard ratio [HR]: 1.86, 95% confidence interval [CI]: 1.03 to 3.38, p = 0.041), with a nonsignificant trend toward greater all-cause mortality (HR: 1.43, 95% CI: 0.88 to 2.33, p = 0.15). Technical and anatomical reasons accounted for most cases of TVE. A multivariable analysis found TVE to be an independent predictor of 1-year mortality (HR: 2.68, 95% CI: 1.34 to 5.36, p = 0.0055) but not cardiovascular mortality (HR: 1.30, 95% CI: 0.48 to 3.52, p = 0.60). CONCLUSIONS:Acute TV-in-TV and TVE are serious sequelae of TAVR, often resulting in multiple valve implants. They carry an excess of mortality and are caused by anatomic and technical factors, which may be avoidable with judicious procedural planning.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Makkar RR,Jilaihawi H,Chakravarty T,Fontana GP,Kapadia S,Babaliaros V,Cheng W,Thourani VH,Bavaria J,Svensson L,Kodali S,Shiota T,Siegel R,Tuzcu EM,Xu K,Hahn RT,Herrmann HC,Reisman M,Whisenant B,Lim S,Beohar N,Madoi
10.1016/j.jacc.2013.04.037subject
Has Abstractpub_date
2013-07-30 00:00:00pages
418-30issue
5eissn
0735-1097issn
1558-3597pii
S0735-1097(13)01879-2journal_volume
62pub_type
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