Limitations of nerve repair of segmental defects using acellular conduits.

Abstract:

:The authors present the case of a 20-year-old man who, 3 months after his initial injury, underwent repair of a 1.7-cm defect of the ulnar nerve at the wrist; repair was performed with an acellular nerve allograft. Given the absence of clinical or electrophysiological recovery at 8 months postrepair, the patient underwent reexploration, excision of the "regenerated cable," and rerepair of the ulnar nerve with sural nerve autografts. Histology of the cable demonstrated minimal axonal regeneration at the midpoint of the repair. At the 6- and 12-month follow-ups of the sural nerve graft repair, clinical and electrophysiological evidence of both sensory and motor reinnervation of the ulnar nerve and associated hand muscles was demonstrated. In this report, the authors describe a single case of failed acellular nerve allograft and correlate the results with basic science and human studies reporting length and diameter limitations in human nerve repair utilizing grafts or conduits devoid of viable Schwann cells.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Berrocal YA,Almeida VW,Levi AD

doi

10.3171/2013.4.JNS121938

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

733-8

issue

3

eissn

0022-3085

issn

1933-0693

journal_volume

119

pub_type

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