Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans.

Abstract:

:In humans, functional magnetic resonance imaging (fMRI) activity in the anterior cingulate cortex (ACC) and the nucleus accumbens (NAc) appears to reflect affective and motivational aspects of pain. The responses of this reward-aversion circuit to relief of pain, however, have not been investigated in detail. Moreover, it is not clear whether brain processing of the affective qualities of pain in animals parallels the mechanisms observed in humans. In the present study, we analyzed fMRI blood oxygen level-dependent (BOLD) activity separately in response to an onset (aversion) and offset (reward) of a noxious heat stimulus to a dorsal part of a limb in both humans and rats. We show that pain onset results in negative activity change in the NAc and pain offset produces positive activity change in the ACC and NAc. These changes were analogous in humans and rats, suggesting that translational studies of brain circuits modulated by pain are plausible and may offer an opportunity for mechanistic investigation of pain and pain relief.

journal_name

J Neurophysiol

authors

Becerra L,Navratilova E,Porreca F,Borsook D

doi

10.1152/jn.00284.2013

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1221-6

issue

5

eissn

0022-3077

issn

1522-1598

pii

jn.00284.2013

journal_volume

110

pub_type

杂志文章
  • Multiple modes of action potential initiation and propagation in mitral cell primary dendrite.

    abstract::The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00057.2002

    authors: Chen WR,Shen GY,Shepherd GM,Hines ML,Midtgaard J

    更新日期:2002-11-01 00:00:00

  • Rhythmically discharging basal forebrain units comprise cholinergic, GABAergic, and putative glutamatergic cells.

    abstract::The basal forebrain plays important roles in arousal, learning, and memory by stimulating cortical activation characterized by rhythmic slow theta and high-frequency beta-gamma activities. Although cholinergic neurons play a significant part in these roles, other, including GABAergic, neurons appear to contribute. Usi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00938.2002

    authors: Manns ID,Alonso A,Jones BE

    更新日期:2003-02-01 00:00:00

  • Contractile differences between muscle units in the medial rectus and lateral rectus muscles in the cat.

    abstract::Conjugate eye movements in the horizontal plane are accomplished by the coactivation of the medial rectus (MR) muscle of one orbit and the lateral rectus (LR) muscle of the other. While control of these excursions has been thought to be effected by identical inputs to these muscles, recent studies have demonstrated th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.1.50

    authors: Meredith MA,Goldberg SJ

    更新日期:1986-07-01 00:00:00

  • Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.

    abstract::Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now descr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00174.2016

    authors: Brown MR,El-Hassar L,Zhang Y,Alvaro G,Large CH,Kaczmarek LK

    更新日期:2016-07-01 00:00:00

  • Potassium currents in octopus cells of the mammalian cochlear nucleus.

    abstract::Octopus cells in the posteroventral cochlear nucleus (PVCN) of mammals are biophysically specialized to detect coincident firing in the population of auditory nerve fibers that provide their synaptic input and to convey its occurrence with temporal precision. The precision in the timing of action potentials depends on...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.5.2299

    authors: Bal R,Oertel D

    更新日期:2001-11-01 00:00:00

  • Recruitment order of cat abducens motoneurons and internuclear neurons.

    abstract::Abducens neurons undergo a dose-dependent synaptic blockade (either disinhibition or complete blockade) when tetanus neurotoxin (TeNT) is injected into the lateral rectus muscle at either a low (0.5) or a high dose (5 ng/kg). We studied the firing pattern and recruitment order in abducens neurons both in control and a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00402.2003

    authors: Pastor AM,Gonzalez-Forero D

    更新日期:2003-10-01 00:00:00

  • Subthreshold frequency selectivity in avian auditory thalamus.

    abstract::1. We studied the frequency responses of neurons in the nucleus ovoidalis (OV), the principal thalamic auditory relay nucleus of the chicken, in the subthreshold range of membrane potentials. The frequency response is the impedance amplitude profile evident in the voltage response to a broadband stimulus. The stimulus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.4.1361

    authors: Ströhmann B,Schwarz DW,Puil E

    更新日期:1994-04-01 00:00:00

  • Participation of the thalamic CM-Pf complex in attentional orienting.

    abstract::The centre médian-parafascicular (CM-Pf) complex is located at the posterior intralaminar nuclei of the thalamus and forms part of the nonspecific thalamocortical projection system and the internal circuit of the basal ganglia. However, the functional roles of this complex remain to be fully elucidated. Here we have e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.87.6.3090

    authors: Minamimoto T,Kimura M

    更新日期:2002-06-01 00:00:00

  • Connections of midbrain periaqueductal gray in the monkey. I. Ascending efferent projections.

    abstract::1. To obtain a comprehensive map of the ascending projection of the midbrain periaqueductal gray, small amounts of [3H]leucine were injected into discrete regions of the periaqueductal gray (PAG) of the monkey. 2. Despite the fact that different regions of the PAG were injected in separate animals, the majority of the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.49.3.567

    authors: Mantyh PW

    更新日期:1983-03-01 00:00:00

  • Noninvasive brain stimulation can elucidate and interact with the mechanisms underlying motor learning and retention: implications for rehabilitation.

    abstract::Seminal work in animals indicates that learning a motor task results in long-term potentiation (LTP) in primary motor cortex (M1) and a subsequent occlusion of LTP induction (Rioult-Pedotti et al. J Neurophysiol 98: 3688-3695, 2007). Using various forms of noninvasive brain stimulation in conjunction with a motor lear...

    journal_title:Journal of neurophysiology

    pub_type: 评论,杂志文章

    doi:10.1152/jn.00766.2013

    authors: Hinder MR,Reissig P,Fujiyama H

    更新日期:2014-03-01 00:00:00

  • Regional specification of threshold sensitivity and response time in CBA/CaJ mouse spiral ganglion neurons.

    abstract::Previous studies of spiral ganglion neuron electrophysiology have shown that specific parameters differ according to cochlear location, with apical neurons being distinctly different from basal neurons. To align these features more precisely along the tonotopic axis of the cochlea, we developed a novel spiral ganglion...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00284.2007

    authors: Liu Q,Davis RL

    更新日期:2007-10-01 00:00:00

  • Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus.

    abstract::The primate posterior thalamus has been proposed to contribute to pain sensation, but its precise role is unclear. This is in part because spinothalamic tract (STT) neurons that project to the posterior thalamus have received little attention. In this study, antidromic mapping was used to identify individual STT neuro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90810.2008

    authors: Davidson S,Zhang X,Khasabov SG,Simone DA,Giesler GJ Jr

    更新日期:2008-10-01 00:00:00

  • Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.

    abstract::Electrically excitable cells have voltage-dependent ion channels on the plasma membrane that regulate membrane permeability to specific ions. Voltage-gated Ca(2+) channels (VGCCs) are especially important as Ca(2+) serves as both a charge carrier and second messenger. Zebrafish (Danio rerio) are an important model ver...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00625.2010

    authors: Won YJ,Ono F,Ikeda SR

    更新日期:2011-01-01 00:00:00

  • Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis.

    abstract::The cardiac ganglion (CG) of Homarus americanus is a central pattern generator that consists of two oscillatory groups of neurons: "small cells" (SCs) and "large cells" (LCs). We have shown that SCs and LCs begin their bursts nearly simultaneously but end their bursts at variable phases. This variability contrasts wit...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01010.2012

    authors: Williams AH,Kwiatkowski MA,Mortimer AL,Marder E,Zeeman ML,Dickinson PS

    更新日期:2013-05-01 00:00:00

  • Activity of hindlimb motor units during locomotion in the conscious rat.

    abstract::This paper compares the activity of hindlimb motor units from muscles mainly composed of fast-twitch muscle fibers (medial and lateral gastrocnemius: MG/LG, tibialis anterior: TA) to motor units from a muscle mainly composed of slow-twitch muscle fibers (soleus: SOL) during unrestrained walking in the conscious rat. S...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2002

    authors: Gorassini M,Eken T,Bennett DJ,Kiehn O,Hultborn H

    更新日期:2000-04-01 00:00:00

  • Activity of primate V1 cortical neurons during blinks.

    abstract::Every time we blink our eyes, the image on the retina goes almost completely dark. And yet we hardly notice these interruptions, even though an external darkening is startling. Intuitively it would seem that if our perception is continuous, then the neuronal activity on which our perceptions are based should also be c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.5.2691

    authors: Gawne TJ,Martin JM

    更新日期:2000-11-01 00:00:00

  • Neural substrates of graphomotor sequence learning: a combined FMRI and kinematic study.

    abstract::The goal of this study was to characterize the dynamics and functional connectivity of brain networks associated with fast (short-term) learning of handwriting using functional magnetic resonance imaging. Participants (n = 12) performed a graphomotor sequence learning task (naïve subjects learning to draw simple, 3-st...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00449.2009

    authors: Swett BA,Contreras-Vidal JL,Birn R,Braun A

    更新日期:2010-06-01 00:00:00

  • Receptive-field properties of rat ventral posterior medial neurons before and after selective kainic acid lesions of the trigeminal brain stem complex.

    abstract::Single neurons were recorded from the ventral posteromedial thalamic nucleus (VPM) of urethan-anesthetized rats. Six of these animals were intact, 28 sustained kainic acid (KA) lesions of trigeminal nucleus principalis (PrV), and 9 received similar lesions of trigeminal subnucleus interpolaris (SpVi). Four animals sus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.5.1577

    authors: Rhoades RW,Belford GR,Killackey HP

    更新日期:1987-05-01 00:00:00

  • Long-term potentiation is mediated by multiple kinase cascades involving CaMKII or either PKA or p42/44 MAPK in the adult rat dentate gyrus in vitro.

    abstract::The induction of NMDA-receptor-dependent long-term potentiation (LTP) in adult CA1 is contingent on activation of Ca/calmodulin-dependent protein kinase II (CaMKII). However, little is known about kinase mediation of LTP in the dentate gyrus. In the present study, the involvement of the kinases CaMKII, PKA, and MAPK i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01235.2005

    authors: Wu J,Rowan MJ,Anwyl R

    更新日期:2006-06-01 00:00:00

  • Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease.

    abstract::Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01107.2006

    authors: Tang JK,Moro E,Mahant N,Hutchison WD,Lang AE,Lozano AM,Dostrovsky JO

    更新日期:2007-08-01 00:00:00

  • Neural mechanisms for sigh generation during prenatal development.

    abstract::The respiratory network of the preBötzinger complex (preBötC), which controls inspiratory behavior, can in normal conditions simultaneously produce two types of inspiration-related rhythmic activities: the eupneic rhythm composed of monophasic, low-amplitude, and relatively high-frequency bursts, interspersed with sig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00314.2018

    authors: Thoby-Brisson M

    更新日期:2018-09-01 00:00:00

  • Frequency organization of delay-sensitive neurons in the auditory cortex of the FM bat, Myotis lucifugus.

    abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.366

    authors: Paschal WG,Wong D

    更新日期:1994-07-01 00:00:00

  • Encoding of sound-source location and movement: activity of single neurons and interactions between adjacent neurons in the monkey auditory cortex.

    abstract::1. Neuronal mechanisms for decoding sound azimuth and angular movement were studied by recordings of several single units in parallel in the core areas of the auditory cortex of the macaque monkey. The activity of 180 units was recorded during the presentation of moving and static sound stimuli. Both the activity of s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.67.1.203

    authors: Ahissar M,Ahissar E,Bergman H,Vaadia E

    更新日期:1992-01-01 00:00:00

  • Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons.

    abstract::The lability of the responses of mammalian central neurons to gamma-aminobutyric acid (GABA) was studied using neurons acutely dissociated from the CA1 region of the adult guinea pig hippocampus as a model system. GABA was applied to the neuronal somata by pressure ejection and the resulting current (IGABA) recorded u...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.1.1

    authors: Huguenard JR,Alger BE

    更新日期:1986-07-01 00:00:00

  • Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunits.

    abstract::The stress hormone corticosterone increases the amplitude of the slow afterhyperpolarization (sAHP) in CA1 pyramidal neurons, without affecting resting membrane potential, input resistance, or action potential characteristics. We here examined how corticosterone affects these properties in the basolateral amygdala (BL...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01137.2007

    authors: Liebmann L,Karst H,Sidiropoulou K,van Gemert N,Meijer OC,Poirazi P,Joëls M

    更新日期:2008-02-01 00:00:00

  • Cortical columnar processing in the rat whisker-to-barrel system.

    abstract::Controlled whisker stimulation and single-unit recordings were used to elucidate response transformations that occur during the processing of tactile information from ventral posterior medial thalamus (VPM) through cortical columns in the rat whisker/barrel cortex. Whiskers were either deflected alone, using punctate ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.4.1808

    authors: Brumberg JC,Pinto DJ,Simons DJ

    更新日期:1999-10-01 00:00:00

  • Structure-function relationships in the primate superior colliculus. II. Morphological identity of presaccadic neurons.

    abstract::1. Microelectrodes filled with horseradish peroxidase (HRP) were inserted in the superior colliculus (SC) of alert squirrel monkeys. Spontaneous eye movements were monitored in the dark during recording and intraaxonal injection of fibers carrying presaccadic signals. 2. Analysis of the relationship between neuronal a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.1.263

    authors: Moschovakis AK,Karabelas AB,Highstein SM

    更新日期:1988-07-01 00:00:00

  • Presynaptic activity and Ca2+ entry are required for the maintenance of NMDA receptor-independent LTP at visual cortical excitatory synapses.

    abstract::We have shown that some neural activity is required for the maintenance of long-term potentiation (LTP) at visual cortical inhibitory synapses. We tested whether this was also the case in N-methyl-d-aspartate (NMDA) receptor-independent LTP of excitatory connections in layer 2/3 cells of developing rat visual cortex. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00602.2003

    authors: Liu HN,Kurotani T,Ren M,Yamada K,Yoshimura Y,Komatsu Y

    更新日期:2004-08-01 00:00:00

  • Kinematic analysis of cat hindlimb stepping.

    abstract::1. The purpose of this study is to analyze the kinematics of stepping from the point of view of limb control by attempting to dissociate the various neuronal and mechanical factors that shape actual movements observed experimentally. The cat hindlimb, like the primate arm, is a multijointed mechanical system with redu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.6.2266

    authors: Shen L,Poppele RE

    更新日期:1995-12-01 00:00:00

  • Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons.

    abstract::Fast-spiking GABAergic interneurons of the neocortex and hippocampus fire high-frequency trains of brief action potentials with little spike-frequency adaptation. How these striking properties arise is unclear, although recent evidence suggests K(+) channels containing Kv3.1-Kv3.2 proteins play an important role. We i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.5.2476

    authors: Erisir A,Lau D,Rudy B,Leonard CS

    更新日期:1999-11-01 00:00:00