Abstract：
:White matter tracts connecting areas involved in speech and motor control were examined using diffusion-tensor imaging in a sample of people who stutter (n=29) who were heterogeneous with respect to age, sex, handedness and stuttering severity. The goals were to replicate previous findings in developmental stuttering and to extend our knowledge by evaluating the relationship between white matter differences in people who stutter and factors such as age, sex, handedness and stuttering severity. We replicated previous findings that showed reduced integrity in white matter underlying ventral premotor cortex, cerebral peduncles and posterior corpus callosum in people who stutter relative to controls. Tractography analysis additionally revealed significantly reduced white matter integrity in the arcuate fasciculus bilaterally and the left corticospinal tract and significantly reduced connectivity within the left corticobulbar tract in people who stutter. Region-of-interest analyses revealed reduced white matter integrity in people who stutter in the three pairs of cerebellar peduncles that carry the afferent and efferent fibers of the cerebellum. Within the group of people who stutter, the higher the stuttering severity index, the lower the white matter integrity in the left angular gyrus, but the greater the white matter connectivity in the left corticobulbar tract. Also, in people who stutter, handedness and age predicted the integrity of the corticospinal tract and peduncles, respectively. Further studies are needed to determine which of these white matter differences relate to the neural basis of stuttering and which reflect experience-dependent plasticity.
journal_name
Brain Langjournal_title
Brain and languageauthors
Connally EL,Ward D,Howell P,Watkins KEdoi
10.1016/j.bandl.2013.05.013subject
Has Abstractpub_date
2014-04-01 00:00:00pages
25-35eissn
0093-934Xissn
1090-2155pii
S0093-934X(13)00111-9journal_volume
131pub_type
杂志文章abstract：:The aim of the present study was to uncover a possible common neural organizing principle in spoken and written communication, through the coupling of perceptual and motor representations. In order to identify possible shared neural substrates for processing the basic units of spoken and written language, a sparse sam...
journal_title：Brain and language
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journal_title：Brain and language
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journal_title：Brain and language
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journal_title：Brain and language
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journal_title：Brain and language
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doi：10.1006/brln.1999.2108
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pub_type： 杂志文章
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journal_title：Brain and language
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journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
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doi：10.1016/j.bandl.2007.02.006
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journal_title：Brain and language
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journal_title：Brain and language
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doi：10.1016/j.bandl.2011.09.009
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1998.1961
更新日期：1998-09-01 00:00:00
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journal_title：Brain and language
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journal_title：Brain and language
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doi：10.1016/j.bandl.2004.11.004
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journal_title：Brain and language
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doi：10.1006/brln.1998.2049
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pub_type： 杂志文章
doi：10.1006/brln.1997.1751
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(88)90109-5
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journal_title：Brain and language
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2011.01.003
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1998.1999
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abstract：:Ten aphasic and five control subjects were administered an auditory comprehension task similar to Levels I-IV of the Revised Token Test under conditions of 0, 5, 10, and 20 sec of imposed response delay. Responses were evaluated in terms of performance accuracy and response time. Aphasic subjects' response accuracy wa...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(86)90054-4
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